Muscle as a paracrine and endocrine organ

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,406

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388

Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway

Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

Ellingsgaard, H., Hauselmann, I., Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T., Eppler, E., Bouzakri, K., Wueest, S., Muller, Y. D., et al. (2011) · Nature Medicine · doi:10.1038/nm.2513 · Cited by 922

Voluntary running suppresses tumor growth through epinephrine- and IL-6-dependent NK cell mobilization and redistribution

Pedersen, L., Idorn, M., Olofsson, G. H., Lauenborg, B., Nookaew, I., Hansen, R. H., Johannesen, H. H., Becker, J. C., Pedersen, K. S., Dethlefsen, C., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.011 · Cited by 888

Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802

Muscles and their myokines

Pedersen, B. K. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048074 · Cited by 668

The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk

Pedersen, B. K. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179515 · Cited by 631

Running-induced systemic cathepsin B secretion is associated with memory function

Moon, H. Y., Becke, A., Berron, D., Becker, B., Sah, N., Benoni, G., Janke, E., Lubejko, S. T., Greig, N. H., Mattison, J. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.025 · Cited by 628

Prognostic Role of "Radiological" Sarcopenia in Lymphoma: A Systematic Review

Albano, D., Dondi, F., Ravanelli, M., Tucci, A., Farina, D., Giubbini, R., Treglia, G., & Bertagna, F. (2021) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2021.11.006 · Cited by 26

Sarcopenia using muscle mass prediction model and cognitive impairment: A longitudinal analysis from the English longitudinal study on ageing

Maniscalco, L., Veronese, N., Ragusa, F. S., Vernuccio, L., Dominguez, L. J., Smith, L., Matranga, D., & Barbagallo, M. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105160 · Cited by 25

Regulation of Acetylcholine Quantal Release by Coupled Thrombin/BDNF Signaling in Mouse Motor Synapses

Gaydukov, A. E., Bogacheva, P. O., Tarasova, E., Molchanova, А. I., Miteva, A. S., Pravdivceva, E., & Balezina, O. P. (2019) · Cells · doi:10.3390/cells8070762 · Cited by 27

CRISPRa‐based activation of Fgf21 and Fndc5 ameliorates obesity by promoting adipocytes browning

Zhu, H., Liu, D., Sui, M., Zhou, M., Wang, B., Qi, Q., Wang, T., Zhang, G., Wan, F., & Zhang, B. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1326 · Cited by 27

Myostatin/SMAD4 signaling-mediated regulation of miR-124-3p represses glucocorticoid receptor expression and inhibits adipocyte differentiation

Liu, K., Zhang, X., Wei, W., Liu, X., Tian, Y., Han, H., Zhang, L., Wu, W., & Chen, J. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00405.2018 · Cited by 25

Distinct microRNA and protein profiles of extracellular vesicles secreted from myotubes from morbidly obese donors with type 2 diabetes in response to electrical pulse stimulation

Aas, V., Øvstebø, R., Brusletto, B. S., Aspelin, T., Trøseid, A. S., Qureshi, S., Eid, D. S. O., Olstad, O. K., Nyman, T. A., & Haug, K. B. F. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1143966 · Cited by 25

Cervical Cancer HeLa Cell Autocrine Apoptosis Induced by Coimmobilized IFN-γ plus TNF-α Biomaterials

Li, J., Zhang, Y., Chen, L., Lu, X., Li, Z., Xue, Y., & Guan, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18277 · Cited by 24

Effects of Padel Competition on Brain Health-Related Myokines

de la Fuente, F. P., Gallardo, M. P. C., Nestares, T., Martínez-Díaz, I. C., & Páez, L. C. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18116042 · Cited by 27

Evidence of a Muscle–Brain Axis by Quantification of the Neurotrophic Myokine METRNL (Meteorin-Like Protein) in Human Cerebrospinal Fluid and Serum

Berghoff, M., Höpfinger, A., Rajendran, R., Karrasch, T., Schmid, A., & Schäffler, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153271 · Cited by 23

Organokines and Exosomes: Integrators of Adipose Tissue Macrophage Polarization and Recruitment in Obesity

Wang, Y. Y., Wang, Y., Qi, X.-Y., Liao, Z., Mai, Y.-N., & Xiao, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.839849 · Cited by 24

Causal associations of obesity related anthropometric indicators and body compositions with knee and hip arthritis: A large-scale genetic correlation study

Wang, C., Zhu, Y., Liu, Z., Long, H., Ruan, Z., & Zhao, S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1011896 · Cited by 24

Factors Influencing Immunotherapy Outcomes in Cancer: Sarcopenia and Systemic Inflammation

Üçgül, E., Güven, D. C., Ucgul, A. N., Özbay, Y., Onur, M. R., & Akın, S. (2024) · Cancer Control · doi:10.1177/10732748241302248 · Cited by 25

The role and mechanisms of myokines in sarcopenia: new intervention strategies for the challenges of aging

Cui, X., Liu, H., Liu, Y., Yu, Z., Wang, D., Wei, W., & Wang, S. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1665708 · Cited by 24

Inflammation—Insulin Resistance Crosstalk and the Central Role of Myokines

Dobre, M.-Z., Vîrgolici, B., Stefan, D. C. A., Doicin, I.-C., & Stănescu-Spînu, I.-I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010060 · Cited by 23

“Ferrocrinology”—Iron Is an Important Factor Involved in Gluco- and Lipocrinology

Szklarz, M., Gontarz-Nowak, K., Matuszewski, W., & Bandurska-Stankiewicz, E. M. (2022) · Nutrients · doi:10.3390/nu14214693 · Cited by 21

Effects of Probiotics Supplementation on the Intestinal Metabolites, Muscle Fiber Properties, and Meat Quality of Sunit Lamb

Liu, T., Bai, Y., Wang, C., Zhang, T., Su, R., Wang, B., Duan, Y., Sun, L., Jin, Y., & Su, L. C. (2023) · Animals · doi:10.3390/ani13040762 · Cited by 22

Recent advances in the crosstalk between adipose, muscle and bone tissues in fish

Hue, I., Capilla, E., Rosell-Moll, E., Balbuena-Pecino, S., Goffette, V., Gabillard, J., & Navarro, I. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1155202 · Cited by 23

Tyrosol Facilitates Neovascularization by Enhancing Skeletal Muscle Cells Viability and Paracrine Function in Diabetic Hindlimb Ischemia Mice

Zhang, J., Nugrahaningrum, D. A., Marcelina, O., Ariyanti, A. D., Wang, G., Liu, C., Wu, S., & Kasim, V. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00909 · Cited by 21

Potential Importance of Immune System Response to Exercise on Aging Muscle and Bone

Cornish, S. M., Chilibeck, P. D., & Candow, D. G. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00596-1 · Cited by 22

Inverse Association of Handgrip Strength With Risk of Heart Failure

Laukkanen, J. A., Khan, H., Lavie, C. J., Voutilainen, A., Kurl, S., Jae, S. Y., & Kunutsor, S. K. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.09.040 · Cited by 25

Mechanisms of Myofibre Death in Muscular Dystrophies: The Emergence of the Regulated Forms of Necrosis in Myology

Bencze, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010362 · Cited by 20

Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia

Liu, C., Han, J., Marcelina, O., Nugrahaningrum, D. A., Huang, S. M., Zou, M., Wang, G., Miyagishi, M., He, Y., Wu, S., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00947 · Cited by 20

Dapagliflozin Promotes Neovascularization by Improving Paracrine Function of Skeletal Muscle Cells in Diabetic Hindlimb Ischemia Mice Through PHD2/HIF-1α Axis

Nugrahaningrum, D. A., Marcelina, O., Liu, C., Wu, S., & Kasim, V. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01104 · Cited by 20

Conditioned media from contracting skeletal muscle potentiates insulin secretion and enhances mitochondrial energy metabolism of pancreatic beta-cells

Barlow, J. P., & Solomon, T. P. J. (2018) · Metabolism · doi:10.1016/j.metabol.2018.11.004 · Cited by 21

Exercise-induced AMPK activation and IL-6 muscle production are disturbed in adiponectin knockout mice

Diniz, T. A., Aquino‐Junior, J. C. J., Mosele, F. C., Cabral‐Santos, C., de Lima, E. A., Teixeira, A. A. D. S., Lira, F. S., & Neto, J. C. R. (2019) · Cytokine · doi:10.1016/j.cyto.2019.03.009 · Cited by 20

Physical Activity, Obesity and Weight Loss Maintenance

Brandt, C., & Pedersen, B. K. (2022) · Handbook of experimental pharmacology · doi:10.1007/164_2021_575 · Cited by 21

Molecular Basis of Irisin Regulating the Effects of Exercise on Insulin Resistance

Lin, J., Liu, X., Zhou, Y., Zhu, B., Wang, Y., Cui, W., Peng, Y., Wang, B., Chen, Z., & Zhao, R. (2022) · Applied Sciences · doi:10.3390/app12125837 · Cited by 22

Next Stage Approach to Tissue Engineering Skeletal Muscle

Reid, G., Magarotto, F., Marsano, A., & Pozzobon, M. (2020) · Bioengineering · doi:10.3390/bioengineering7040118 · Cited by 18

Transcriptomic adaptation during skeletal muscle habituation to eccentric or concentric exercise training

Willis, C. R. G., Deane, C. S., Ames, R. M., Bass, J. J., Wilkinson, D. J., Smith, K., Phillips, B. E., Szewczyk, N. J., Atherton, P. J., & Etheridge, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-03393-7 · Cited by 18

Biomarkers for immunotherapy in esophageal cancer

Wang, X., Wang, P., Huang, X., Han, Y., & Zhang, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1117523 · Cited by 17

Identification of CCL5/RANTES as a novel contraction-reducible myokine in mouse skeletal muscle

Ishiuchi, Y., Sato, H., Komatsu, N., Kawaguchi, H., Matsuwaki, T., Yamanouchi, K., Nishihara, M., & Nedachi, T. (2018) · Cytokine · doi:10.1016/j.cyto.2018.03.012 · Cited by 17

Modification of Muscle-Related Hormones in Women with Obesity: Potential Impact on Bone Metabolism

Maı̈moun, L., Mura, T., Attalin, V., Dupuy, A., Cristol, J., Avignon, A., Mariano‐Goulart, D., & Sultan, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041150 · Cited by 17

The effect of sarcopenia and serum myokines on prognosis and survival in cirrhotic patients: a multicenter cross-sectional study

Boğa, S., Yildirim, A. E., Uçbılek, E., Köksal, A. R., Şişman, S. T., Durak, I., Şen, İ., Doğu, B., Serin, E., Ucbilek, A. B., et al. (2022) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002461 · Cited by 16

Physical activity, physical frailty and depressive symptoms among Chinese male and female older adults: do different indicators make a difference?

Wang, Y., Wang, X., Zhu, X., Sun, Y.-W., Han, B., & Chen, T. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1280952 · Cited by 16

Bta-miR-181d and Bta-miR-196a mediated proliferation, differentiation, and apoptosis in Bovine Myogenic Cells

Chengcheng, L., Raza, S. H. A., Yang, Z., Wang, S., Shengchen, Y., Aloufi, B. H., Li, B., & Zan, L. (2024) · Journal of Animal Science · doi:10.1093/jas/skae142 · Cited by 15

The effects of myokines on osteoclasts and osteoblasts

Lee, J. Y., Park, S. J., Han, S. A., Lee, S. H., Koh, J., Hamrick, M. W., & Kim, B. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.07.127 · Cited by 15

Intramuscular injection of sotagliflozin promotes neovascularization in diabetic mice through enhancing skeletal muscle cells paracrine function

Luo, L., Han, J., Wu, S., & Kasim, V. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00889-4 · Cited by 16

Mechanisms of interorgan crosstalk in health and disease

Herrlich, A., Kefaloyianni, E., & Rose‐John, S. (2022) · FEBS Letters · doi:10.1002/1873-3468.14313 · Cited by 15

Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β

Shi, X., Xia, B., Zhang, J. F., Zhang, R. X., Zhang, D. Y., Liu, H., Xie, B., Wang, Y., & Wu, J. W. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001619 · Cited by 15

Metabolic interaction between purine nucleotide cycle and oxypurine cycle during skeletal muscle contraction of different intensities: a biochemical reappraisal

Ipata, P. L., & Pesi, R. (2018) · Metabolomics · doi:10.1007/s11306-018-1341-0 · Cited by 15

Transcriptional Changes Involved in Atrophying Muscles during Prolonged Fasting in Rats

Ibrahim, M., Wasselin, T., Challet, É., DORSSELAER, A. V., Maho, Y. L., Raclot, T., & Bertile, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175984 · Cited by 15

The role of exercise in enhancing brain and cerebrovascular health via the bone–brain axis: implications for surgical and clinical interventions

Shi, H., Huang, L., Wang, Q., Zhang, N., Lv, C., Lin, C., Shao, L., Xia, D., Zhao, Z., Yang, G., et al. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000003030 · Cited by 15

Exercise-Induced Molecular Adaptations in Chronic Non-Communicable Diseases—Narrative Review

Fuentes-Barría, H., Aguilera-Eguía, R. A., Alarcón-Rivera, M., López-Soto, O., Aristizábal-Hoyos, J. A., Roco-Videla, Á., Caviedes-Olmos, M., & Rojas-Gómez, D. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262412096 · Cited by 15

Mechanosensors control skeletal muscle mass, molecular clocks, and metabolism

Vanmunster, M., Rojo‐García, A. V., Pacolet, A., Dalle, S., Koppo, K., Jonkers, I., Lories, R. J. U., & Suhr, F. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04346-7 · Cited by 14

Mustn1 ablation in skeletal muscle results in increased glucose tolerance concomitant with upregulated GLUT expression in male mice

Kim, C. J., Singh, C., Lee, C., DiMagno, K., O'Donnell, M., Kaczmarek, M., Ahmed, A., Salvo‐Schaich, J., Perez, A. M., Letsou, W., et al. (2023) · Physiological Reports · doi:10.14814/phy2.15674 · Cited by 12

Rehabilitation Training after Spinal Cord Injury Affects Brain Structure and Function: From Mechanisms to Methods

He, L., Guo, X.-J., Zhao, C., & Rao, J. (2023) · Biomedicines · doi:10.3390/biomedicines12010041 · Cited by 15

Semiquantitative 2-[18F]FDG PET/CT-based parameters role in lymphoma

Albano, D., Ravanelli, M., Durmo, R., Versari, A., Filice, A., Rizzo, A., Racca, M., Pizzuto, D. A., Bertagna, F., & Annunziata, S. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1515040 · Cited by 15

Sarcopenia—a geriatric pandemic

Köller, M. D. (2022) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-022-00927-0 · Cited by 16

In patients with anorexia nervosa, myokine levels are altered but are not associated with bone mineral density loss and bone turnover alteration

Maı̈moun, L., Mariano‐Goulart, D., Huguet, H., Renard, É., Lefebvre, P., Picot, M., Dupuy, A., Cristol, J., Courtet, P., Boudousq, V., et al. (2022) · Endocrine Connections · doi:10.1530/ec-21-0488 · Cited by 16

RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure

Yang, L., Shi, H., Hu, Y., Yao, R., Liu, P., Yang, Y., & Li, S. (2022) · Cell Stress and Chaperones · doi:10.1007/s12192-022-01297-7 · Cited by 14

Physiological and Molecular Adaptations to Strength Training

Ahtiainen, J. P. (2018) · Springer eBooks · doi:10.1007/978-3-319-75547-2_5 · Cited by 16

Impact of diets rich in olive oil, palm oil or lard on myokine expression in rats

Gauze-Gnagne, C., Raynaud, F., Djohan, Y. F., Lauret, C., Feillet‐Coudray, C., Coudray, C., Monde, A., Koffi, G., Morena-Carrere, M., Camara-Cissé, M., et al. (2020) · Food & Function · doi:10.1039/d0fo01269f · Cited by 13

Axis “microbiota - muscle”

Zavyalova, A. N., Новикова, В. П., & Ignatova, P. D. (2023) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-207-11-60-69 · Cited by 13

Association Between Pretreatment Skeletal Muscle and Outcomes After CAR T-Cell Therapy

Lee, K., Iukuridze, A., He, T., Bosworth, A., Lindenfeld, L., Teh, J. B., Echevarria, M., Albanese, S., Atencio, L., Bhandari, R., et al. (2023) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2022.7100 · Cited by 13

Current Progress in the Creation, Characterization, and Application of Human Stem Cell-derived in Vitro Neuromuscular Junction Models

Lynch, E. M., Peek, E., Reilly, M. L., FitzGibbons, C., Robertson, S., & Suzuki, M. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10201-2 · Cited by 13

Exercise‐evoked intramuscular neutrophil‐endothelial interactions support muscle performance and GLUT4 translocation: a mouse gnawing model study

Chaweewannakorn, C., Nyasha, M. R., Chen, W., Sekiai, S., Tsuchiya, M., Hagiwara, Y., Bouzakri, K., Sasaki, K., & Kanzaki, M. (2019) · The Journal of Physiology · doi:10.1113/jp278564 · Cited by 13

Short and long-term effects of high-intensity interval training applied alone or with whole-body cryostimulation on glucose homeostasis and myokine levels in overweight to obese subjects

Flis, M., Rodziewicz-Flis, E. A., Micielska, K., Kortas, J. A., Jaworska, J., Borkowska, A., Sansoni, V., Perego, S., Lombardi, G., & Ziemann, E. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/5015 · Cited by 16

Validity of ultrasonography-derived predictions for estimating skeletal muscle volume: a systematic literature review

Liegnell, R., Wessman, F., Shalabi, A., & Harringe, M. L. (2021) · BMC Medical Imaging · doi:10.1186/s12880-021-00638-9 · Cited by 12

Relationship Between Sarcopenia and Electrocardiographic Abnormalities in Older People: The Bushehr Elderly Health Program

Heshmat, R., Shafiee, G., Ostovar, A., Fahimfar, N., Birjandi, S. M., Jabbari, M., Sharifi, F., Nabipour, I., & Larijani, B. A. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.656181 · Cited by 12

Emerging evidence of the relationship between fat-free mass and ghrelin, glucagon-like peptide-1, and peptide-YY

Graybeal, A. J., Willis, J. L., Morales, E., Tinsley, G. M., Messiah, S. E., & Shah, M. (2022) · Nutrition · doi:10.1016/j.nut.2022.111815 · Cited by 12

Exerkines: A Crosstalk between Lactate Production, Exercise and Mental Health

Filho, A. S. S., Barsanulfo, S. R., Faria, S. S., Inácio, P. A., Tafti, F. A., & Machado, S. E. D. C. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273250928231009054658 · Cited by 12

A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system

Aleman, J., Ravikumar, K., Wiegand, C., Schurdak, M. E., Vernetti, L. A., Gavlock, D. C., Reese, C. E., DeBiasio, R., LaRocca, G., Angarita, Y. D., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-07006-7 · Cited by 12

The relationship between changes in serum myostatin and adiponectin levels in patients with obesity undergoing a weight loss program

Takao, N., Kurose, S., Miyauchi, T., Onishi, K., Tamanoi, A., Tsuyuguchi, R., Fujii, A., Yoshiuchi, S., Takahashi, K., Tsutsumi, H., et al. (2021) · BMC Endocrine Disorders · doi:10.1186/s12902-021-00808-4 · Cited by 13

Tryptophan-Kynurenine Metabolites in Exercise and Mental Health

Valente‐Silva, P., & Ruas, J. L. (2017) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-319-72790-5_7 · Cited by 13

The interrelationship between physical activity and metabolic regulation of breast cancer progression in obesity via cytokine control

Guennec, D. L., & Rossary, A. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.02.001 · Cited by 12

Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration

Benissan‐Messan, D., Zhu, H., Zhong, W., Tan, T., Ma, J., & Lee, P. H. U. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.583393 · Cited by 12

Circulating Myonectin and Irisin Levels in Gestational Diabetes Mellitus – A Case-control Study

Onat, T., & İnandıklıoğlu, N. (2021) · Zeitschrift für Geburtshilfe und Neonatologie · doi:10.1055/a-1404-4323 · Cited by 12

Subacute cadmium exposure changes different metabolic functions, leading to type 1 and 2 diabetes mellitus features in female rats

da Costa, C. S., de Oliveira, T. F., Santos, F. C. F. D., Padilha, A. S., Krause, M., Carneiro, M. T. W. D., Miranda‐Alves, L., & Graceli, J. B. (2024) · Environmental Toxicology · doi:10.1002/tox.24306 · Cited by 11

Acoustofluidic bioassembly induced morphogenesis for therapeutic tissue fabrication

Kang, B., Jeong, E., Han, S. Y., Heo, J. H., Lee, Y., Choi, S., Choi, Y., Kang, D., Hwang, Y.-H., Lee, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59026-4 · Cited by 14

Impact of Ageing on Female Metabolic Flexibility: A Cross-Sectional Pilot Study in over-60 Active Women

Monferrer-Marín, J., Roldán, A., Monteagudo, P., Chulvi‐Medrano, I., & Blasco-Lafarga, C. (2022) · Sports Medicine - Open · doi:10.1186/s40798-022-00487-y · Cited by 12

What Muscle Signals Mediate the Beneficial Effects of Exercise on Cognition?

Benarroch, E. E. (2022) · Neurology · doi:10.1212/wnl.0000000000201049 · Cited by 12

Vitamin D Merging into Immune System-Skeletal Muscle Network: Effects on Human Health

Crescioli, C. (2020) · Applied Sciences · doi:10.3390/app10165592 · Cited by 12

Exercise-induced modulation of Interferon-signature: a therapeutic route toward management of Systemic Lupus Erythematosus

Spinelli, F. R., Berti, R., Farina, G., Ceccarelli, F., Conti, F., & Crescioli, C. (2023) · Autoimmunity Reviews · doi:10.1016/j.autrev.2023.103412 · Cited by 10

Mustn1 in Skeletal Muscle: A Novel Regulator?

Kim, C. J., & Hadjiargyrou, M. (2024) · Genes · doi:10.3390/genes15070829 · Cited by 10

Influence of Body Composition Assessed by Computed Tomography on Mortality Risk in Young Women with Breast Cancer

Bezerra, Á. D. D. L., Pereira, J. P. D. C., Soares, I. F. D. M., Ferreira, G. M. C., Miranda, A. L., de Medeiros, G. O. C., Verde, S. M. M. L., & Fayh, A. P. T. (2024) · Nutrients · doi:10.3390/nu16183175 · Cited by 12

Mild Cognitive Impairment and Sarcopenia: Effects of Resistance Exercise Training on Neuroinflammation, Cognitive Performance, and Structural Brain Changes

Oporto-Colicoi, V., Sepúlveda-Lara, A., Marzuca-Nassr, G. N., & Sepúlveda, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211036 · Cited by 10

Resistance Exercise Increases the Regulation of Skeletal Muscle FSTL1 Consequently Improving Cardiac Angiogenesis in Rats with Myocardial Infarctions

Xi, Y., Hao, M., & Tian, Z. (2019) · Journal of Science in Sport and Exercise · doi:10.1007/s42978-019-0009-4 · Cited by 11

BDNF secretion from C2C12 cells is enhanced by methionine restriction

Antony, R. M., & Li, Y. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.10.017 · Cited by 10

High-frequency blood flow-restricted resistance exercise results in acute and prolonged cellular stress more pronounced in type I than in type II fibers

Bjørnsen, T., Wernbom, M., Paulsen, G., Markworth, J. F., Berntsen, S., D’Souza, R. F., Cameron‐Smith, D., & Raastad, T. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00115.2020 · Cited by 10

The Potential Role of Myokines/Hepatokines in the Progression of Neuronal Damage in Streptozotocin and High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice

Lee, H., & Lim, Y. (2022) · Biomedicines · doi:10.3390/biomedicines10071521 · Cited by 10

Mustn1 ablation in skeletal muscle results in functional alterations

Kim, C. J., Singh, C., Kaczmarek, M., O'Donnell, M., Lee, C., DiMagno, K., Young, M. W., Letsou, W., Ramos, R. L., Granatosky, M. C., et al. (2023) · FASEB BioAdvances · doi:10.1096/fba.2023-00082 · Cited by 9

Corticosterone biosynthesis in mouse clonal myoblastic C2C12 cells

Fujiki, J., Maeda, N., Sato, M., Ieko, T., Inoue, H., Iwasaki, T., Iwano, H., & Yokota, H. (2018) · Steroids · doi:10.1016/j.steroids.2018.07.001 · Cited by 9

Free Fatty Acid Impairs Myogenic Differentiation through the AMPK α -MicroRNA 206 Pathway

Jiang, A., Guo, H., Zhang, L., Jiang, X., Zhang, X., Wu, W., & Liu, H. (2021) · Molecular and Cellular Biology · doi:10.1128/mcb.00327-21 · Cited by 10

Associations between Health-Related Physical Fitness and Cardiovascular Disease Risk Factors in Overweight and Obese University Staff

Chen, J., Zhou, Y., Pan, X., Li, X., Long, J., Zhang, H., & Zhang, J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17239031 · Cited by 11

The Different Effects of Skeletal Muscle and Fat Mass on Height Increment in Children and Adolescents Aged 6–11 Years: A Cohort Study From China

Wu, D., Shi, L., Xu, Q., Zeng, Y., Lin, X., Li, X., Zhao, H., Zhu, Z., Fu, Y., Li, H., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.915490 · Cited by 9

Multiorgan locked-state model of chronic diseases and systems pharmacology opportunities

Ung, C. Y., Correia, C., Li, H., Adams, C. M., Westendorf, J. J., & Zhu, S. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103825 · Cited by 9

What Is the Role of Body Composition Assessment in HCC Management?

Radu, P., Ebadi, M., Montaño‐Loza, A. J., & Dufour, J. (2022) · Cancers · doi:10.3390/cancers14215290 · Cited by 9

Myokine levels after resistance exercise in young adults with Prader–Willi syndrome (PWS)

Hirsch, H. J., Gross‐Tsur, V., Sabag, Y., Nice, S., Genstil, L., Benarroch, F., & Constantini, N. (2019) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.61391 · Cited by 10

The synaptosome‐associated protein 23 ( SNAP23 ) is necessary for proper myogenesis

Gentile, G. M., Gamarra, J. R., Engels, N. M., Blue, R. E., Hoerr, I., Wiedner, H. J., Hinkle, E. R., Cote, J. L., Leverence, E. N., Mills, C. A., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101627rr · Cited by 8

Histological and biochemical changes in lymphatic vessels after skeletal muscle injury induced by lengthening contraction in male mice

Tamura, Y., Kawashima, T., Ji, R., Agata, N., Itoh, Y., & Kawakami, K. (2024) · Physiological Reports · doi:10.14814/phy2.15950 · Cited by 8

A systematic review of “myokines and metabolic regulation”

Leon‐Ariza, H. H., Mendoza-Navarrete, M. P., Maldonado-Arango, M. I., & Botero‐Rosas, D. A. (2018) · Apunts Sports Medicine · doi:10.1016/j.apunts.2018.09.003 · Cited by 8

OGT upregulates myogenic IL-6 by mediating O-GlcNAcylation of p65 in mouse skeletal muscle under cold exposure.

Hu, Y., Liu, Y., Yang, Y., Lv, H., Lian, S., Xu, B., & Li, S. (2022) · PubMed · doi:10.1002/jcp.30612 · Cited by 7

Role of Masticatory Force in Modulating Jawbone Immunity and Bone Homeostasis: A Review

Song, Y., Yao, J., Liu, Y., & Guo, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104478 · Cited by 7

Muscle impairments in osteogenesis imperfecta: a narrative review

Ireland, A., Orlando, G., Coussens, M., Calders, P., Taipaleenmäki, H., Hesse, E., & Javaid, M. K. (2025) · JBMR Plus · doi:10.1093/jbmrpl/ziaf099 · Cited by 7

Fractalkine is a key player in skeletal muscle metabolism and pathophysiology

Swalsingh, G., Pani, P., Sadayappan, S., & Bal, N. C. (2025) · FEBS Journal · doi:10.1111/febs.70267 · Cited by 12

Identification of C-C motif chemokine ligand 5 as a heat-dependent myokine

Murata, K., Ishiuchi, Y., & Nedachi, T. (2023) · Endocrine Journal · doi:10.1507/endocrj.ej22-0611 · Cited by 7

Sarcopenia and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Narrative Review

Abenavoli, L., Statsenko, M., Scarlata, G. G. M., Morano, D., Myazin, R. G., & Emelyanov, D. (2024) · Livers · doi:10.3390/livers4040035 · Cited by 7

Low L3 skeletal muscle index and endometrial cancer: a statistic pooling analysis

Aru, N., Yang, C., Chen, Y., & Liu, J. (2025) · BMC Cancer · doi:10.1186/s12885-025-13430-7 · Cited by 7

Irisin in elderly people with hypertension, diabetes mellitus type 2, and overweight and obesity

Guo, X., Xuan, X., Zhao, B., Wang, Y., Zhong, S., Su, Y., Yu, X., Cheng, Q., Zhao, B., Wang, Y., et al. (2020) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-019-00772-9 · Cited by 7

A Comparative Peptidomic Characterization of Cultured Skeletal Muscle Tissues Derived From db/db Mice

Wu, Y., Han, M., Wang, Y., Gao, Y., Cui, X., Xu, P., Ji, C., Zhong, T., You, L., & Zeng, Y. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00741 · Cited by 7

Muscle as an Endocrine Organ

Legaard, G. E., & Pedersen, B. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814593-7.00013-x · Cited by 24

Myokines and Metabolism

Pedersen, B. K. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_31-1 · Cited by 1

Muscle as a secretory organ

Pedersen, B. K. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120033 · Cited by 516

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909

Skeletal Muscle as an Auto-, Para- and Endocrine Organ: The Role of Myokines in Muscle Metabolism and Other Metabolic Organs

Horváth, L., Pekár, M., Švagera, Z., Horká, V., Mráz, M., & Bužga, M. (2025) · Physiological Research · doi:10.33549/physiolres.935751 · Cited by 14