Omics approaches for understanding heavy metal responses and tolerance in plants

Jamla, Monica; Khare, Tushar; Joshi, Shrushti; Patil, Suraj; Penna, Suprasanna; Kumar, Vinay

doi:10.1016/j.cpb.2021.100213

Cited by 154Plant Stress Responses and ToleranceHeavy metals in environmentAluminum toxicity and tolerance in plants and animals

Omics approaches for understanding heavy metal responses and tolerance in plants

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Jamla, Monica, Khare, Tushar, Joshi, Shrushti, Patil, Suraj, Penna, Suprasanna, Kumar, Vinay·2021·Current Plant Biology

DOI 10.1016/j.cpb.2021.100213

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Abstract

Recent years have witnessed a gradual increase in the bioavailability and groundwater leaching of toxic heavy metals (HMs) in the environment, driven mainly by anthropogenic invasions. HMs, especially ranked as toxic/carcinogenic non-essential ones including Cadmium (Cd), Arsenic (As), Aluminium (Al), Mercury (Hg) and Lead (Pb) have emerged as the major soil, air and water contaminants affecting food production, quality and security worldwide. HMs affect plant growth and crop yield. Plants have developed intricate defense mechanisms for safeguarding themselves against the toxic effects imposed by HMs, including compartmentalization and sequestration in cell-organelles, inactivation by complex formation with the organic ligands and their exclusion using transporters, ion channels, transcription factors and signaling molecules, beside others. Omics approaches have generated significant resources and updates on the plant genome, transcriptome and metabolome plasticity against HM-induced stress stimuli. Omics technologies are pragmatic and seen as feasible approaches for characterizing the roles of genomes (genomics), coding (transcriptomics) and non-coding (miRNAomics) RNA transcripts, and metabolites (metabolomics) including metals (metallomics), which can ultimately be used for improving stress tolerance or generating resilience plant systems. This review aims to summarize the current understandings on the mechanistic insights of selected toxic (Cd, As, Al, Hg and Pb) HM-plant interactions, including their uptake, transport, toxicity and chelation/sequestration in cellular components, besides how plants respond and adapt to these stress factors. State-of-the-art in Omics approaches including genomics, transcriptomics, metabolomics, miRNAomics and metallomics for plant HM research have been presented. Present status, challenges and future prospects are also discussed.

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The transport of HMs from roots to aerial parts involves active transporters found in the plasma membrane and vacuolar membrane, these transporters require energy, usually in form of ATP to concentrate metal ions into storage organelles, such as vacuoles.
“Consequently, the transport of HMs from roots to aerial parts involves active transporters found in the plasma membrane and vacuolar membrane, these transporters require energy, usually in form of ATP to concentrate metal ions into storage organelles, such as vacuoles ( Figure 3 ).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Jamla et al., 2021
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Inactive accumulation of metals occurs from the soil through roots and their transport through the xylem to the aerial parts of plants, such as stems, leaves, and other parts of shoots, by diverse classes of metal ion transporters.
“In addition, inactive accumulation of metals occurs from the soil through roots and their transport through the xylem to the aerial parts of plants, such as stems, leaves, and other parts of shoots, by diverse classes of metal ion transporters (Feki et al., 2021; Jamla et al., 2021).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Jamla et al., 2021
Section 2, “Plant-heavy metal interactions” (page unavailable), describes root-to-shoot metal uptake involving transporters and movement through xylem to above-ground plant parts. It does not describe that process as “inactive accumulation”; its reference to passive adsorption concerns metals at the rhizosphere, not their accumulation in shoots. (LLM, conf=0.85)
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Cadmium, Copper, and Lead Accumulation and Bioconcentration in the Vegetative and Reproductive Organs of Raphanus sativus: Implications for Plant Performance and Pollination
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Review: Metabolomics as a Prediction Tool for Plants Performance under Environmental Stress
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Omics Studies and Systems Biology Perspective towards Abiotic Stress Response in Plants
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Variations in the antioxidant and free radical scavenging under induced heavy metal stress expressed as proline content in chickpea
Bhagyawant, S. S., Narvekar, D. T., Gupta, N., Bhadkaria, A., Koul, K. K., & Srivastava, N. (2019) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-019-00667-3 · Cited by 54 · see citing works
Comparative transcriptome combined with metabolome analyses revealed key factors involved in nitric oxide (NO)-regulated cadmium stress adaptation in tall fescue
Zhu, H., Ai, H., Hu, Z., Du, D., Sun, J., Chen, K., & Chen, L. (2020) · BMC Genomics · doi:10.1186/s12864-020-07017-8 · Cited by 53 · see citing works
Transcriptome Analyses Reveal Candidate Genes Potentially Involved in Al Stress Response in Alfalfa
Liu, W., Xiong, C., Yan, L., Zhang, Z., Ma, L., Wang, Y., Liu, Y., & Liu, Z. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.00026 · Cited by 52 · see citing works
An efficient antioxidant system and heavy metal exclusion from leaves make Solanum cheesmaniae more tolerant to Cu than its cultivated counterpart
Branco‐Neves, S., Soares, C., de Sousa, A., Martins, V., Azenha, M., Gerós, H., & Fidalgo, F. (2017) · Food and Energy Security · doi:10.1002/fes3.114 · Cited by 52 · see citing works
Transcriptome Profiling of Abiotic Stress-Responsive Genes During Cadmium Chloride-Mediated Stress in Two Indica Rice Varieties
Paul, S., & Roychoudhury, A. (2017) · Journal of Plant Growth Regulation · doi:10.1007/s00344-017-9762-y · Cited by 52 · see citing works
Comparative Transcriptome Profiling Under Cadmium Stress Reveals the Uptake and Tolerance Mechanism in Brassica juncea
Thakur, S., Choudhary, S., & Bhardwaj, P. (2019) · Journal of Plant Growth Regulation · doi:10.1007/s00344-019-09919-8 · Cited by 52 · see citing works
Heavy Metal Transporters-Associated Proteins in Solanum tuberosum: Genome-Wide Identification, Comprehensive Gene Feature, Evolution and Expression Analysis
He, G., Qin, L., Tian, W., Meng, L., He, T., & Zhao, D. (2020) · Genes · doi:10.3390/genes11111269 · Cited by 52 · see citing works
Metallomics: The Science of Biometals and Biometalloids
Maret, W. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-90143-5_1 · Cited by 51 · see citing works
Demethylation of methylmercury in growing rice plants: An evidence of self-detoxification
Xu, X., Zhao, J., Li, Y., Fan, Y., Zhu, N., Gao, Y., Li, Y., Liu, H., & Li, Y. (2015) · Environmental Pollution · doi:10.1016/j.envpol.2015.12.013 · Cited by 50 · see citing works
A Comprehensive Transcriptome-Wide Identification and Screening of WRKY Gene Family Engaged in Abiotic Stress in Glycyrrhiza glabra
Goyal, P., Manzoor, M. M., Vishwakarma, R. A., Sharma, D., Dhar, M. K., & Gupta, S. (2020) · Scientific Reports · doi:10.1038/s41598-019-57232-x · Cited by 50 · see citing works
Alleviation of lead-induced physiological, metabolic, and ultramorphological changes in leaves of upland cotton through glutathione
Khan, M., Khan, M. D., Basharat, A., Khan, M. J., Azizullah, A., Muhammad, N., Muhammad, N., Rehman, Z. U., & Zhu, S. J. (2016) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-5959-4 · Cited by 47 · see citing works
Localization and quantification of Pb and nutrients in Typha latifolia by micro-PIXE
Lyubenova, L., Pongrac, P., Vogel‐Mikuš, K., Mezek, G. K., Vavpetič, P., Grlj, N., Kump, P., Nečemer, M., Regvar, M., Pelicon, P., et al. (2012) · Metallomics · doi:10.1039/c2mt00179a · Cited by 46 · see citing works
Genome-wide identification, characterization and transcriptional profiling of NHX-type (Na+/H+) antiporters under salinity stress in soybean
Joshi, S., Kaur, K., Khare, T. R., Srivastava, A. K., Suprasanna, P., & Kumar, V. (2021) · 3 Biotech · doi:10.1007/s13205-020-02555-0 · Cited by 46 · see citing works
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Genome-Wide Identification of MicroRNAs in Response to Cadmium Stress in Oilseed Rape (Brassica napus L.) Using High-Throughput Sequencing
Jian, H., Yang, B., Zhang, A., Ma, J., Ding, Y., Chen, Z., Li, J., Xu, X., & Liu, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051431 · Cited by 45 · see citing works
Bacterial heavy metal transporter MerC increases mercury accumulation in Arabidopsis thaliana
Kiyono, M., Oka, Y., Sone, Y., Nakamura, R., Sato, M. H., Sakabe, K., & Pan-Hou, H. S. K. (2012) · Biochemical Engineering Journal · doi:10.1016/j.bej.2012.11.007 · Cited by 43 · see citing works
Genome-wide identification and characterization of the metal tolerance protein (MTP) family in grape (Vitis vinifera L.)
Shirazi, Z., Abedi, A., Kordrostami, M., Burritt, D. J., & Hossain, M. A. (2019) · 3 Biotech · doi:10.1007/s13205-019-1728-2 · Cited by 43 · see citing works
Determination of public health hazard potential of wastewater reuse in crop production
Gupta, N., Khan, D. K., & Santra, S. C. (2010) · World Review of Science Technology and Sustainable Development · doi:10.1504/wrstsd.2010.032741 · Cited by 42 · see citing works
Foliar Applied Nickel on Buckwheat (Fagopyrum esculentum) Induced Phenolic Compounds as Potential Antioxidants
Sytar, O., Cai, Z., Brestič, M., Kumar, A., Prasad, M. N. V., Taran, N. Y., & Smetanska, I. (2013) · CLEAN - Soil Air Water · doi:10.1002/clen.201200512 · Cited by 41 · see citing works
MicroRNA-Mediated Responses to Cadmium Stress in Arabidopsis thaliana
Pegler, J. L., Oultram, J. M. J., Nguyen, D. Q., Grof, C. P. L., & Eamens, A. L. (2021) · Plants · doi:10.3390/plants10010130 · Cited by 40 · see citing works
Pteris umbrosa R. Br. as an arsenic hyperaccumulator: accumulation, partitioning and comparison with the established As hyperaccumulator Pteris vittata
Koller, C. E., Patrick, J. W., Rose, R. J., Offler, C. E., & MacFarlane, G. R. (2006) · Chemosphere · doi:10.1016/j.chemosphere.2006.07.029 · Cited by 39 · see citing works
A meta-analysis of transcriptomic profiles reveals molecular pathways response to cadmium stress of Gramineae
Fan, W., Liu, C., Cao, B., Ma, S., Hu, J. H., Xiang, Z., & Zhao, A. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111816 · Cited by 39 · see citing works
Transcriptome analysis highlights changes in the leaves of maize plants cultivated in acidic soil containing toxic levels of Al3+
Mattiello, L., Begcy, K., da Silva, F. R., Jorge, R. A., & Menossi, M. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3709-1 · Cited by 38 · see citing works
Infiltration-RNAseq: transcriptome profiling of Agrobacterium-mediated infiltration of transcription factors to discover gene function and expression networks in plants
Bond, D. M., Albert, N. W., Lee, R. H., Gillard, G. B., Brown, C. M., Hellens, R. P., & Macknight, R. C. (2016) · Plant Methods · doi:10.1186/s13007-016-0141-7 · Cited by 38 · see citing works
Sorghum Extracellular Leucine-Rich Repeat Protein SbLRR2 Mediates Lead Tolerance in Transgenic Arabidopsis
Zhu, F., Li, L., Lam, P. Y., Chen, M., Chye, M., & Lo, C. (2013) · Plant and Cell Physiology · doi:10.1093/pcp/pct101 · Cited by 37 · see citing works
Plant abiotic stress tolerance: Insights into resilience build-up
Suprasanna, P. (2020) · Journal of Biosciences · doi:10.1007/s12038-020-00088-5 · Cited by 37 · see citing works
Arsenic Occurrence and Fate in the Environment; A Geochemical Perspective
Nikolopoulos, D. N. (2015) · Journal of Earth Science & Climatic Change · doi:10.4172/2157-7617.1000269 · Cited by 36 · see citing works
Transcriptomic analysis of Verbena bonariensis roots in response to cadmium stress
Wang, M.-Q., Bai, Z.-Y., Xiao, Y., Li, Y., Liu, Q., Zhang, L., Pan, Y., Jiang, B., & Zhang, F. (2019) · BMC Genomics · doi:10.1186/s12864-019-6152-9 · Cited by 36 · see citing works
Comparative metalloproteomic approaches for the investigation proteins involved in the toxicity of inorganic and organic forms of mercury in rice (Oryza sativa L.) roots
Li, Y., Zhao, J., Li, Y., Xu, X., Zhang, B., Liu, Y., Cui, L., Li, Y., Gao, Y., & Chai, Z. (2015) · Metallomics · doi:10.1039/c5mt00264h · Cited by 35 · see citing works
Recent trends and advances in identification and functional characterization of plant miRNAs
Zhou, X., Khare, T. R., & Kumar, V. (2020) · Acta Physiologiae Plantarum · doi:10.1007/s11738-020-3013-8 · Cited by 34 · see citing works
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Evaluation of effects of arsenic on carbon, nitrogen, and sulfur metabolism in two contrasting varieties of Brassica juncea
Pathare, V. S., Srivastava, S., & Suprasanna, P. (2013) · Acta Physiologiae Plantarum · doi:10.1007/s11738-013-1370-2 · Cited by 33 · see citing works

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Comprehensive Mechanisms of Heavy Metal Toxicity in Plants, Detoxification, and Remediation
Ghuge, S. A., Nikalje, G. C., Kadam, U. S., Suprasanna, P., & Hong, J. C. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131039 · Cited by 372 · see citing works
Heavy Metals, Their Phytotoxicity, and the Role of Phenolic Antioxidants in Plant Stress Responses with Focus on Cadmium: Review
Goncharuk, E. A., & Загоскина, Н. В. (2023) · Molecules · doi:10.3390/molecules28093921 · Cited by 295 · see citing works
The Classification, Molecular Structure and Biological Biosynthesis of Flavonoids, and Their Roles in Biotic and Abiotic Stresses
Zhuang, W., Li, Y.-H., Shu, X., Pu, Y.-T., Wang, X., Wang, T., & Wang, Z. (2023) · Molecules · doi:10.3390/molecules28083599 · Cited by 253 · see citing works
Analysis of Heavy Metal Impacts on Cereal Crop Growth and Development in Contaminated Soils
Vasilachi, I. C., Stoleru, V., & Gavrilescu, M. (2023) · Agriculture · doi:10.3390/agriculture13101983 · Cited by 210 · see citing works
Role of phytohormones in heavy metal tolerance in plants: A review
Rahman, S. U., Li, Y., Hussain, S., Hussain, B., Khan, W., Riaz, L., Ashraf, M. N., Khaliq, M. A., Du, Z., & Cheng, H. (2022) · Ecological Indicators · doi:10.1016/j.ecolind.2022.109844 · Cited by 164 · see citing works
Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential
Asiminicesei, D.-M., Ferţu, D. I., & Gavrilescu, M. C. (2024) · Plants · doi:10.3390/plants13060913 · Cited by 146 · see citing works
Advances in “Omics” Approaches for improving toxic metals/metalloids tolerance in plants
Raza, A., Tabassum, J., Zahid, Z., Charagh, S., Bashir, S., Barmukh, R., Khan, R. S. A., Barbosa, F., Zhang, C., Chen, H., et al. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2021.794373 · Cited by 132 · see citing works
Impact of industrial effluents on the environment and human health and their remediation using MOFs-based hybrid membrane filtration techniques
Saravanakumar, K., Silva, S. D., Santosh, S. S., Sathiyaseelan, A., Ganeshalingam, A., Jamla, M., Sankaranarayanan, A., Veeraraghavan, V. P., MubarakAli, D., Lee, J., et al. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.135593 · Cited by 116 · see citing works
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Survey on Multi-omics, and Multi-omics Data Analysis, Integration and Application
Shahrajabian, M. H., & Sun, W. (2023) · Current Pharmaceutical Analysis · doi:10.2174/1573412919666230406100948 · Cited by 116 · see citing works
Cadmium toxicity in medicinal plants: An overview of the tolerance strategies, biotechnological and omics approaches to alleviate metal stress
Al-Khayri, J. M., Banadka, A., Ramakrishnan, R., Nagella, P., Alessa, F. M., & Almaghasla, M. I. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2022.1047410 · Cited by 113 · see citing works
State-of-the-Art OMICS Strategies against Toxic Effects of Heavy Metals in Plants: A Review
Rahman, S. U., Nawaz, M. F., Gul, S., Yasin, G., Hussain, B., Li, Y., & Cheng, H. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113952 · Cited by 106 · see citing works
Micro/nanoplastics: Critical review of their impacts on plants, interactions with other contaminants (antibiotics, heavy metals, and polycyclic aromatic hydrocarbons), and management strategies
Khan, A. R., Ulhassan, Z., Li, G., Lou, J., Iqbal, B., Salam, A., Azhar, W., Batool, S., Zhao, T., Li, K., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169420 · Cited by 102 · see citing works
Transcriptomics, proteomics, and metabolomics interventions prompt crop improvement against metal(loid) toxicity
Raza, A., Salehi, H., Bashir, S., Tabassum, J., Jamla, M., Charagh, S., Barmukh, R., Mir, R. A., Bhat, B. A., Javed, M. A., et al. (2024) · Plant Cell Reports · doi:10.1007/s00299-024-03153-7 · Cited by 88 · see citing works
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Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration
Bhat, B. A., Rather, M. A., Bilal, T., Nazir, R., Qadir, R. U., & Mir, R. A. (2025) · Frontiers in Plant Science · doi:10.3389/fpls.2025.1631378 · Cited by 68 · see citing works
“In addition, inactive accumulation of metals occurs from the soil through roots and their transport through the xylem to the aerial parts of plants, such as stems, leaves, and other parts of shoots, by diverse classes of metal ion transporters (Feki et al., 2021; Jamla et al., 2021).”
Research progress of the detection and analysis methods of heavy metals in plants
He, S., Niu, Y., Xing, L., Liang, Z., Song, X., Ding, M., & Huang, W. (2024) · Frontiers in Plant Science · doi:10.3389/fpls.2024.1310328 · Cited by 58 · see citing works
Phytohormones-mediated strategies for mitigation of heavy metals toxicity in plants focused on sustainable production
Zhang, Y., Yang, C., Liu, S., Xie, Z., Chang, H., & Wu, T. (2024) · Plant Cell Reports · doi:10.1007/s00299-024-03189-9 · Cited by 54 · see citing works
Trends in the Application of “Omics” to Ecotoxicology and Stress Ecology
Ebner, J. N. (2021) · Genes · doi:10.3390/genes12101481 · Cited by 53 · see citing works
Metallophenolomics: A Novel Integrated Approach to Study Complexation of Plant Phenolics with Metal/Metalloid Ions
Fedenko, V. S., Landi, M., & Shemet, S. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911370 · Cited by 50 · see citing works
Unveiling the mechanism of micro-and-nano plastic phytotoxicity on terrestrial plants: A comprehensive review of omics approaches
Jamil, A., Ahmad, A., Din, M., Zhang, Y., Zhao, Y., Chen, X., Cui, X., Tong, Y., & Liu, X. (2025) · Environment International · doi:10.1016/j.envint.2025.109257 · Cited by 45 · see citing works
Antimony-complexed heavy metal wastewater in antimony mining areas: Source, risk and treatment
Deng, S., Ren, B., Hou, B., Deng, R., & Cheng, S. (2023) · Environmental Technology & Innovation · doi:10.1016/j.eti.2023.103355 · Cited by 44 · see citing works
Advancements and prospects of CRISPR/Cas9 technologies for abiotic and biotic stresses in sugar beet
Misra, V., Mall, A. K., Pandey, H., Srivastava, S., & Sharma, A. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1235855 · Cited by 43 · see citing works
Signal Transduction in Cereal Plants Struggling with Environmental Stresses: From Perception to Response
Nykiel, M., Gietler, M., Fidler, J., Prabucka, B., Rybarczyk, A., Graska, J., Boguszewska‐Mańkowska, D., Muszyńska, E., Morkunas, I., & Labudda, M. (2022) · Plants · doi:10.3390/plants11081009 · Cited by 43 · see citing works
Land application of industrial wastes: impacts on soil quality, biota, and human health
Silva, S. D., Carson, P., Indrapala, D. V., Warwick, B., & Reichman, S. M. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-26893-7 · Cited by 41 · see citing works
Exploring Aluminum Tolerance Mechanisms in Plants with Reference to Rice and Arabidopsis: A Comprehensive Review of Genetic, Metabolic, and Physiological Adaptations in Acidic Soils
Chakraborty, N., Das, A., Pal, S., Roy, S., Sil, S. K., Adak, M. K., & Hasanuzzaman, M. (2024) · Plants · doi:10.3390/plants13131760 · Cited by 41 · see citing works
Plant Biostimulants: Mechanisms and Applications for Enhancing Plant Resilience to Abiotic Stresses
Khalid, F., Rasheed, Y., Asif, K., Ashraf, H., Maqsood, M. F., Shahbaz, M., Zulfiqar, U., Sardar, R., & Haider, F. U. (2024) · Journal of soil science and plant nutrition · doi:10.1007/s42729-024-01996-3 · Cited by 40 · see citing works
Leveraging multi-omics tools to comprehend responses and tolerance mechanisms of heavy metals in crop plants
Charagh, S., Wang, H., Wang, J., Raza, A., Hui, S., Cao, R., Zhou, L., Tang, S., Hu, P., & Hu, S. (2024) · Functional & Integrative Genomics · doi:10.1007/s10142-024-01481-1 · Cited by 37 · see citing works
Ecological and human health risk assessment of metals in soils and wheat along Sutlej river (India)
Setia, R. K., Dhaliwal, S. S., Singh, R., Singh, B. P., Kukal, S. S., & Pateriya, B. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.137331 · Cited by 33 · see citing works
Transporters and phytohormones analysis reveals differential regulation of ryegrass (Lolium perenne L.) in response to cadmium and arsenic stresses
Li, W., Li, J., Hussain, K., Peng, K., Yu, J., Xu, M., & Yang, S. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134228 · Cited by 32 · see citing works
Toxicity of copper oxide nanoparticles in barley: induction of oxidative stress, hormonal imbalance, and systemic resistances
Abbasirad, S., & Ghotbi‐Ravandi, A. A. (2025) · BMC Plant Biology · doi:10.1186/s12870-025-06213-6 · Cited by 32 · see citing works
Plant Defense Strategies and Biomarkers against Heavy Metal-Induced Stress: A Comprehensive Review
Tyagi, S., Dhiman, V. K., Dhiman, V. K., Pandey, H., Singh, D., Sharma, A., Sharma, P., Kumar, R., Lee, K.-J., & Saharan, B. S. (2024) · ACS Agricultural Science & Technology · doi:10.1021/acsagscitech.3c00271 · Cited by 30 · see citing works
Biotechnological approaches for enhancement of heavy metal phytoremediation capacity of plants
Shourie, A., Mazahar, S., & Singh, A. (2024) · Environmental Monitoring and Assessment · doi:10.1007/s10661-024-12940-4 · Cited by 29 · see citing works
The current view on heavy metal remediation: The relevance of the plant interaction with arbuscular mycorrhizal fungi
Crișan, I., Balestrini, R., & Pagliarani, C. (2024) · Plant Stress · doi:10.1016/j.stress.2024.100439 · Cited by 27 · see citing works
Iron Plaque: A Shield against Soil Contamination and Key to Sustainable Agriculture
He, Z., Chen, J., Yuan, S., Chen, S., Hu, Y., Zheng, Y., & Li, D. (2024) · Plants · doi:10.3390/plants13111476 · Cited by 27 · see citing works
Potential implementation of trees to remediate contaminated soil in Egypt
Bedair, H., Ghosh, S., Abdelsalam, I. M., Keerio, A. A., & AlKafaas, S. S. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-22984-z · Cited by 26 · see citing works
Advanced omics approach and sustainable strategies for heavy metal microbial remediation in contaminated environments
Kumar, V., Singh, V., & Pandit, S. (2025) · Bioresource Technology Reports · doi:10.1016/j.biteb.2025.102040 · Cited by 26 · see citing works
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MicroRNA-mediated bioengineering for climate-resilience in crops
Patil, S., Joshi, S., Jamla, M., Zhou, X., Taherzadeh, M. J., Suprasanna, P., & Kumar, V. (2021) · Bioengineered · doi:10.1080/21655979.2021.1997244 · Cited by 25 · see citing works
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Navigating Through Harsh Conditions: Coordinated Networks of Plant Adaptation to Abiotic Stress
Shakespear, S., Sivaji, M., Kumar, V., Pillai, M. A., Wani, S. H., Suprasanna, P., & Yasin, J. K. (2024) · Journal of Plant Growth Regulation · doi:10.1007/s00344-023-11224-4 · Cited by 24 · see citing works
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Genome-wide identification of heavy-metal ATPases genes in Areca catechu: investigating their functionality under heavy metal exposure
Khan, N. M., Ali, A., Wan, Y., & Zhou, G. (2024) · BMC Plant Biology · doi:10.1186/s12870-024-05201-6 · Cited by 24 · see citing works
Adverse Effects of Arsenic Uptake in Rice Metabolome and Lipidome Revealed by Untargeted Liquid Chromatography Coupled to Mass Spectrometry (LC-MS) and Regions of Interest Multivariate Curve Resolution
Pérez-Cova, M., Tauler, R., & Jaumot, J. (2022) · Separations · doi:10.3390/separations9030079 · Cited by 24 · see citing works
Salinity and temperature influence removal levels of heavy metals and chloride from water by wetland plants
Schück, M., & Greger, M. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-26490-8 · Cited by 24 · see citing works
Insights into mode of action mediated responses following pharmaceutical uptake and accumulation in plants
Garduño-Jiménez, A.-L., & Carter, L. (2024) · Frontiers in Agronomy · doi:10.3389/fagro.2023.1293555 · Cited by 22 · see citing works
Microbial nanotechnology for producing stress smart crops
Shaikh, A., Jamla, M., Joshi, S., Patil, S., Oak, U., & Kumar, V. (2024) · Plant Nano Biology · doi:10.1016/j.plana.2024.100063 · Cited by 22 · see citing works
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A perspective review on medicinal plant resources for their antimutagenic potentials
Malik, S., Kaur, K., Prasad, S., Jha, N. K., & Kumar, V. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16057-w · Cited by 22 · see citing works
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Production of grains with ultra‐low heavy metal accumulation by pyramiding novel Alleles of OsNramp5 and OsLsi2 in two‐line hybrid rice
Hu, S., Zhou, L., Wang, J., Mawia, A. M., Hui, S., Xu, B., Jiao, G., Sheng, Z., Shao, G., Wei, X., et al. (2024) · Plant Biotechnology Journal · doi:10.1111/pbi.14414 · Cited by 21 · see citing works
Unlocking Biochar’s Potential: Innovative Strategies for Sustainable Remediation of Heavy Metal Stress in Tobacco Plants
Shar, A. G., Zhang, L., Lu, A., Ahmad, M., Saqib, M., Hussain, S., Zulfiqar, U., Wang, P., Zhang, L., & Rahimi, M. (2025) · Scientifica · doi:10.1155/sci5/6302968 · Cited by 21 · see citing works
MicroRNAs and Their Exploration for Developing Heavy Metal-tolerant Plants
Jamla, M., Patil, S., Joshi, S., Khare, T. R., & Kumar, V. (2021) · Journal of Plant Growth Regulation · doi:10.1007/s00344-021-10476-2 · Cited by 21 · see citing works
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Endophytic yeast protect plants against metal toxicity by inhibiting plant metal uptake through an ethylene‐dependent mechanism
Domka, A., Jędrzejczyk, R. J., Ważny, R., Gustab, M., Kowalski, M. B., Nosek, M., Bizan, J., Puschenreiter, M., Vaculík, M., Kováč, J., et al. (2022) · Plant Cell & Environment · doi:10.1111/pce.14473 · Cited by 21 · see citing works
Duckweed: a potential phytosensor for heavy metals
Sharma, R., & Lenaghan, S. C. (2022) · Plant Cell Reports · doi:10.1007/s00299-022-02913-7 · Cited by 20 · see citing works
Nanozymes: An innovative approach to regulating heavy metal accumulation in plants and alleviating toxicity-A comprehensive review
Wang, Y., Gu, X., Zhao, L., & Zhou, D. (2025) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2024.2448048 · Cited by 20 · see citing works
Metal(loid) tolerance, accumulation, and phytoremediation potential of wetland macrophytes for multi-metal(loid)s polluted water
Khan, A. H. A., Soto, A., Rad, C., Curiel-Alegre, S., Rumbo, C., Velasco‐Arroyo, B., Wilde, H. D., Pérez‐de‐Mora, A., Martel-Martín, S., & Barros, R. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-35519-5 · Cited by 18 · see citing works
Comprehensive review of multiomics applications and remediation of plant heavy metal toxicity
Khan, T., Shah, L. R., Khan, S., Wani, O. A., Sheikh, Z. N., Afroza, B., Rashid, R., Baloch, F. S., & Mansoor, S. (2025) · Stress Biology · doi:10.1007/s44154-025-00233-w · Cited by 18 · see citing works
Integrating metabolomics and transcriptomics for SynCom-driven rhizomicrobiome engineering in salinity-stressed rice
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Authors: Jamla, M., Khare, T., Joshi, S., Patil, S., Penna, S., & Kumar, V.
Affiliations: Savitribai Phule Pune University (IN)
Corresponding author: Kumar, Vinay
ORCID: Jamla, Monica
Khare, Tushar
Joshi, Shrushti
Patil, Suraj
Penna, Suprasanna
Kumar, Vinay
Venue: Current Plant Biology
Publisher: Elsevier BV
Published: 2021-09
Volume: 27
Pages: 100213
ISSN: 2214-6628 (ISSN-L)
DOI: 10.1016/j.cpb.2021.100213
OpenAlex: W3173956329
Cited by: 152
References: 250
Citations by year: 2026: 9 · 2025: 43 · 2024: 39 · 2023: 33 · 2022: 20 · 2021: 8
FWCI: 15.17
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Current Plant Biology (publishedVersion, cc-by-nc-nd)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Department of Biotechnology, Ministry of Science and Technology, India
Department of Science and Technology, Ministry of Science and Technology, India (SR/ FST/COLLEGE-/19/568)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
Keywords: heavy metal toxicity, heavy metal tolerance, plants, cadmium, arsenic, aluminum, mercury, lead, plant stress response, transcriptomics, metabolomics, metallomics, omics approaches, metal transporters, transcription factors

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