Metal and metalloid toxicity in plants: an overview on molecular aspects
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Worldwide, the effects of metal and metalloid toxicity are increasing, mainly due to anthropogenic causes. Soil contamination ranks among the most important factors, since it affects crop yield, and the metals/metalloids can enter the food chain and undergo biomagnification, having concomitant effects on human health and alterations to the environment. Plants have developed complex mechanisms to overcome these biotic and abiotic stresses during evolution. Metals and metalloids exert several effects on plants generated by elements such as Zn, Cu, Al, Pb, Cd, and As, among others. The main strategies involve hyperaccumulation, tolerance, exclusion, and chelation with organic molecules. Recent studies in the omics era have increased knowledge on the plant genome and transcriptome plasticity to defend against these stimuli. The aim of the present review is to summarize relevant findings on the mechanisms by which plants take up, accumulate, transport, tolerate, and respond to this metal/metalloid stress. We also address some of the potential applications of biotechnology to improve plant tolerance or increase accumulation.
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When Zn is present in concentrations exceeding 10,000 mg/kg, it becomes toxic, leading to impaired growth, disrupted physiological functions, and plant death.
“However, when present in concentrations exceeding the threshold level (>10,000 mg/kg), zinc becomes toxic, leading to impaired growth, disrupted physiological functions, and even plant death.”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Angulo-Bejarano et al., 2021
Section 3.1 (page not supplied) says Zn toxicity can inhibit growth and disrupt photosynthesis, and may lead to cell death. It does not give a 10,000 mg/kg toxicity threshold or state that Zn exposure causes the death of the whole plant; instead, it says toxicity depends on bioavailability, concentration, exposure time, genotype, and developmental stage. (LLM, conf=0.88)
Experimental — accuracy not yet measuredHyperaccumulator plant species have evolved adaptations for hypertolerance and detoxification of metals and metalloids.
“In addition, these plant species have evolved to possess adaptations for hypertolerance and detoxification of metal and metalloids (Angulo-Bejarano et al., 2021; Peng et al., 2021; Rai et al., 2021).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Angulo-Bejarano et al., 2021
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- Authors
- Angulo-Bejarano, P. I., Puente-Rivera, J., & Cruz-Ortega, R.
- Affiliations
- Laboratorio de Alelopatía, Departamento de Ecología Funcional, Instituto de Ecología, Universidad Nacional Autónoma de México, UNAM, 275, Ciudad Universitaria D.F. Circuito Exterior s/n Anexo al Jardín Botánico Exterior, México City 04510, Mexico
- Instituto de Ecología (MX)
- Venue
- Plants
- Publisher
- MDPI AG
- Published
- 2021-03-27
- Volume
- 10
- Issue
- 4
- Pages
- 635
- ISSN
- 2223-7747 (ISSN-L)
- PMC
- PMC8066251
- OpenAlex
- W3151778362
- Cited by
- 357
- References
- 198
- Citations by year
- 2026: 48 · 2025: 86 · 2024: 102 · 2023: 60 · 2022: 51 · 2021: 10
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Plants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México (IN205912)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
- Keywords
- metal toxicity, metalloid toxicity, plant stress tolerance, hyperaccumulation, metal exclusion, metal chelation, metal transport, soil contamination, cadmium, lead, arsenic, zinc, copper, aluminum, biomagnification, plant biotechnology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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