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Challenge in understanding size and shape dependent toxicity of gold nanomaterials in human skin keratinocytes
Open accessAbstract
As the nanotechnology field continues to develop, assessing nanoparticle toxicity is very important for advancing nanoparticles for biomedical application. Here we report cytotoxicity of gold nanomaterial of different size and shape using MTT test, absorption spectroscopy and TEM. Spherical gold nanoparticles with different sizes are not inherently toxic to human skin cells, but gold nanorods are highly toxic due to the presence of CTAB as coating material. Due to CTAB toxicity, and aggregation of gold nanomaterials in the presence of cell media, it is a real challenge to study the cytotoxicity of gold nanomaterials individually.
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Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Cited by
Khlebtsov, N., & Dykman, L. (2011) · Chem. Soc. Rev. · doi:10.1039/c0cs00018c · Cited by 1,584
Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy
Chen, G., Roy, I., Yang, C., & Prasad, P. N. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00148 · Cited by 1,499
Sharifi, S., Behzadi, S., Laurent, S., Laird Forrest, M., Stroeve, P., & Mahmoudi, M. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15188f · Cited by 1,460
Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review
Hossen, S., Hossain, M. K., Basher, M. K., Mia, M. N. H., Rahman, M. T., & Uddin, M. J. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2018.06.005 · Cited by 998
Toxicity and Environmental Risks of Nanomaterials: Challenges and Future Needs
RAY, P. C., YU, H., & FU, P. P. (2009) · Journal of Environmental Science and Health, Part C · doi:10.1080/10590500802708267 · Cited by 936
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Metadata
- Authors
- Wang, S., Lu, W., Tovmachenko, O., Rai, U. S., Yu, H., & Ray, P. C.
- Venue
- Chemical Physics Letters
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 463
- Issue
- 1-3
- Pages
- 145-149
- ISSN
- 0009-2614 (ISSN-L)
- OpenAlex
- W2083217909
- Cited by
- 363
- References
- 2
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, S., Lu, W., Tovmachenko, O., Rai, U. S., Yu, H., & Ray, P. C. (2008). Challenge in understanding size and shape dependent toxicity of gold nanomaterials in human skin keratinocytes. Chemical Physics Letters. https://doi.org/10.1016/j.cplett.2008.08.039
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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