The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Molecular ultrasound imaging: current status and future directions
Open accessAbstract
Targeted contrast-enhanced ultrasound (molecular ultrasound) is an emerging imaging strategy that combines ultrasound technology with novel molecularly-targeted ultrasound contrast agents for assessing biological processes at the molecular level. Molecular ultrasound contrast agents are nano- or micro-sized particles that are targeted to specific molecular markers by adding high-affinity binding ligands onto the surface of the particles. Following intravenous administration, these targeted ultrasound contrast agents accumulate at tissue sites overexpressing specific molecular markers, thereby enhancing the ultrasound imaging signal. High spatial and temporal resolution, real-time imaging, non-invasiveness, relatively low costs, lack of ionizing irradiation and wide availability of ultrasound systems are advantages compared to other molecular imaging modalities. In this article we review current concepts and future directions of molecular ultrasound imaging, including different classes of molecular ultrasound contrast agents, ongoing technical developments of preclinical and clinical ultrasound systems , the potential of molecular ultrasound for imaging different diseases at the molecular level, and the translation of molecular ultrasound into the clinic.
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Metadata
- Authors
- Deshpande, N., Needles, A., & Willmann, J. K.
- Venue
- Clinical Radiology
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 65
- Issue
- 7
- Pages
- 567-581
- ISSN
- 0009-9260 (ISSN-L)
- OpenAlex
- W2142945000
- Cited by
- 306
- References
- 48
- FWCI
- 12.01
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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