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The systemic inflammation-based neutrophil–lymphocyte ratio: Experience in patients with cancer

Guthrie, Graeme J.K., Charles, Kellie A., Roxburgh, Campbell S.D., Horgan, Paul G., McMillan, Donald C., Clarke, Stephen J.·2013·Critical Reviews in Oncology/Hematology

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Research works printed but not linked: 65

  1. Hanahan, 2000, The hallmarks of cancer, Cell, 100, 57, 10.1016/S0092-8674(00)81683-9 · DOI · Paper page
  2. Roxburgh, 2010, Role of systemic inflammatory response in predicting survival in patients with primary operable cancer, Future Oncology, 6, 149, 10.2217/fon.09.136 · DOI · Paper page
  3. McMillan, 2012, The systemic inflammation-based Glasgow Prognostic Score: A decade of experience in patients with cancer, Cancer Treatment Reviews
  4. Walsh, 2005, Neutrophil–lymphocyte ratio as a prognostic factor in colorectal cancer, Journal of Surgical Oncology, 91, 181, 10.1002/jso.20329 · DOI · Paper page
  5. Schmidt, 2007, Pretreatment levels of peripheral neutrophils and leukocytes as independent predictors of overall survival in patients with american joint committee on cancer stage iv melanoma: results of the EORTC 18951 biochemotherapy trial, Journal of Clinical Oncology, 25, 1562, 10.1200/JCO.2006.09.0274 · DOI · Paper page
  6. Clarke, 2011, Use of inflammatory markers to guide cancer treatment, Clinical Pharmacology and Therapeutics, 90, 475, 10.1038/clpt.2011.122 · DOI
  7. Proctor, 2011, A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study, European Journal of Cancer, 47, 2633, 10.1016/j.ejca.2011.03.028 · DOI · Paper page
  8. Proctor, M.J. Optimization of the systemic inflammation-based Glasgow prognostic score: a Glasgow inflammation outcome study. Cancer, in press.
  9. Motomura, 2013, Neutrophil–lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment, Journal of Hepatology, 58, 58, 10.1016/j.jhep.2012.08.017 · DOI · Paper page
  10. Kantola, 2012, Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma, British Journal of Cancer, 107, 1729, 10.1038/bjc.2012.456 · DOI
  11. Proctor, 2012, A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer, British Journal of Cancer, 107, 695, 10.1038/bjc.2012.292 · DOI · Paper page
  12. Ding, 2010, Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer, International Journal of Colorectal Disease, 25, 1427, 10.1007/s00384-010-1052-0 · DOI · Paper page
  13. Kwon, 2012, Clinical significance of preoperative neutrophil–lymphocyte versus platelet–lymphocyte ratio in patients with operable colorectal cancer, Biomarkers, 17, 216, 10.3109/1354750X.2012.656705 · DOI · Paper page
  14. Neal, 2011, Preoperative systemic inflammation and infectious complications after resection of colorectal liver metastases, Archives of Surgery, 146, 471, 10.1001/archsurg.2011.50 · doi:10.1001/archsurg.2011.50
  15. Leitch, 2007, Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer, British Journal of Cancer, 97, 1266, 10.1038/sj.bjc.6604027 · DOI · Paper page
  16. Mallappa, 2012, Preoperative neutrophil lymphocyte ratio greater than five is a prognostic factor for recurrent colorectal cancer, Colorectal Disease, 323
  17. Halazun, 2008, Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases, European Journal of Surgical Oncology, 34, 55, 10.1016/j.ejso.2007.02.014 · DOI · Paper page
  18. Gomez, 2008, Surgical technique and systemic inflammation influences long-term disease-free survival following hepatic resection for colorectal metastasis, Journal of Surgical Oncology, 98, 371, 10.1002/jso.21103 · DOI
  19. Hung, 2011, Effect of preoperative neutrophil–lymphocyte ratio on the surgical outcomes of stage II colon cancer patients who do not receive adjuvant chemotherapy, International Journal of Colorectal Disease, 26, 1059, 10.1007/s00384-011-1192-x · DOI
  20. Chiang, 2012, Can neutrophil-to-lymphocyte ratio predict the survival of colorectal cancer patients who have received curative surgery electively?, International Journal of Colorectal Disease, 1
  21. Ubukata, 2010, Evaluations of interferon-gamma/interleukin-4 ratio and neutrophil/lymphocyte ratio as prognostic indicators in gastric cancer patients, Journal of Surgical Oncology, 102, 742, 10.1002/jso.21725 · DOI
  22. Aizawa, 2011, Predictive value of baseline neutrophil/lymphocyte ratio for T4 disease in wall-penetrating gastric cancer, World Journal of Surgery, 35, 2717, 10.1007/s00268-011-1269-2 · DOI
  23. Jung, 2011, Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer, Journal of Surgical Oncology, 104, 504, 10.1002/jso.21986 · DOI
  24. Rashid, 2010, A pre-operative elevated neutrophil: lymphocyte ratio does not predict survival from oesophageal cancer resection, World Journal of Surgical Oncology, 8, 1, 10.1186/1477-7819-8-1 · DOI
  25. Wang, 2012, Comparison of the prognostic value of various preoperative inflammation-based factors in patients with stage III gastric cancer, Tumor Biology, 33, 749, 10.1007/s13277-011-0285-z · DOI
  26. Mohri, 2010, Prognostic significance of host- and tumor-related factors in patients with gastric cancer, World Journal of Surgery, 34, 285, 10.1007/s00268-009-0302-1 · DOI
  27. Shimada, 2010, High preoperative neutrophil–lymphocyte ratio predicts poor survival in patients with gastric cancer, Gastric Cancer, 13, 170, 10.1007/s10120-010-0554-3 · DOI · Paper page
  28. Garcea, 2011, Preoperative neutrophil-to-lymphocyte ratio (NLR) is associated with reduced disease-free survival following curative resection of pancreatic adenocarcinoma, World Journal of Surgery, 35, 868, 10.1007/s00268-011-0984-z · doi:10.1007/s00268-011-0984-z
  29. Bhatti, 2010, Preoperative hematologic markers as independent predictors of prognosis in resected pancreatic ductal adenocarcinoma: neutrophil–lymphocyte versus platelet–lymphocyte ratio, American Journal of Surgery, 200, 197, 10.1016/j.amjsurg.2009.08.041 · DOI · Paper page
  30. Smith, 2009, Preoperative platelet–lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma, American Journal of Surgery, 197, 466, 10.1016/j.amjsurg.2007.12.057 · DOI · Paper page
  31. Wang, 2012, Comparison of the prognostic values of various inflammation based factors in patients with pancreatic cancer, Tumour Biology, 33, 749, 10.1007/s13277-011-0285-z · DOI
  32. Gomez, 2008, Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma, Journal of Surgical Oncology, 97, 513, 10.1002/jso.21001 · DOI
  33. Kinoshita, 2012, Comparison of the prognostic value of inflammation-based prognostic scores in patients with hepatocellular carcinoma, British Journal of Cancer, 107, 988, 10.1038/bjc.2012.354 · DOI · Paper page
  34. Sakai, 2011, A clinical study of the prognostic factors for postoperative early recurrence in patients who underwent complete resection for pulmonary adenocarcinoma, Annals of Thoracic and Cardiovascular Surgery, 17, 539, 10.5761/atcs.oa.11.01660 · DOI
  35. Sarraf, 2009, Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer, Journal of Thoracic and Cardiovascular Surgery, 137, 425, 10.1016/j.jtcvs.2008.05.046 · DOI · Paper page
  36. Tomita, 2011, Preoperative neutrophil to lymphocyte ratio as a prognostic predictor after curative resection for non-small cell lung cancer, Anticancer Research, 31, 2995
  37. Tomita, 2012, Elevated preoperative inflammatory markers based on neutrophil-to-lymphocyte ratio and C-reactive protein predict poor survival in resected non-small cell lung cancer, Anticancer Research, 32, 3535
  38. Hashimoto, 2012, Clinical significance of preoperative peripheral blood neutrophil count in patients with non-metastatic upper urinary tract carcinoma, World Journal of Urology, 10.1016/j.juro.2012.02.714 · doi:10.1016/j.juro.2012.02.714
  39. Gondo, 2012, Prognostic value of neutrophil-to-lymphocyte ratio and establishment of novel preoperative risk stratification model in bladder cancer patients treated with radical cystectomy, Urology, 79, 1085, 10.1016/j.urology.2011.11.070 · DOI · Paper page
  40. Ohno, 2012, Pretreatment neutrophil-to-lymphocyte ratio as an independent predictor of recurrence in patients with nonmetastatic renal cell carcinoma, The World Journal of Urology, 10.1016/j.juro.2011.10.026 · DOI
  41. Ohno, 2012, Followup of neutrophil-to-lymphocyte ratio and recurrence of clear cell renal cell carcinoma, The Journal of Urology, 187, 411, 10.1016/j.juro.2011.10.026 · DOI
  42. Cho, 2009, Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment, Cancer Immunology, Immunotherapy, 58, 15, 10.1007/s00262-008-0516-3 · DOI · Paper page
  43. Idowu, 2012, Clinical implication of pretreatment neutrophil to lymphocyte ratio in soft tissue sarcoma, Biomarkers, 17, 539, 10.3109/1354750X.2012.699554 · DOI
  44. Wang, 2011, A scoring model based on neutrophil to lymphocyte ratio predicts recurrence of HBV-associated hepatocellular carcinoma after liver transplantation, PLoS One, 6, e25295, 10.1371/journal.pone.0025295 · DOI
  45. Halazun, 2009, Negative impact of neutrophil–lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma, Annals of Surgery, 250, 141, 10.1097/SLA.0b013e3181a77e59 · DOI · Paper page
  46. Bertuzzo, 2011, Analysis of factors affecting recurrence of hepatocellular carcinoma after liver transplantation with a special focus on inflammation markers, Transplantation, 91, 1279, 10.1097/TP.0b013e3182187cf0 · DOI
  47. Sato, 2012, Correlation between the pretherapeutic neutrophil to lymphocyte ratio and the pathologic response to neoadjuvant chemotherapy in patients with advanced esophageal cancer, World Journal of Surgery, 36, 617, 10.1007/s00268-011-1411-1 · DOI · Paper page
  48. Miyata, 2011, Prognostic value of an inflammation-based score in patients undergoing pre-operative chemotherapy followed by surgery for esophageal cancer, Experimental Therapeutics and Medicine, 2, 879, 10.3892/etm.2011.308 · DOI
  49. Sharaiha, 2011, Elevated preoperative neutrophil:lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer, Annals of Surgical Oncology, 18, 3362, 10.1245/s10434-011-1754-8 · DOI · Paper page
  50. Carruthers, 2012, Systemic inflammatory response is a predictor of outcome in patients undergoing preoperative chemoradiation for locally advanced rectal cancer, Colorectal Disease, 14, e701, 10.1111/j.1463-1318.2012.03147.x · DOI
  51. Chua, 2012, Inflammatory markers in blood and serum tumor markers predict survival in patients with epithelial appendiceal neoplasms undergoing surgical cytoreduction and intraperitoneal chemotherapy, Annals of Surgery, 256, 342, 10.1097/SLA.0b013e3182602ad2 · doi:10.1097/sla.0b013e3182602ad2
  52. Kishi, 2009, Blood neutrophil-to-lymphocyte ratio predicts survival in patients with colorectal liver metastases treated with systemic chemotherapy, Annals of Surgical Oncology, 16, 614, 10.1245/s10434-008-0267-6 · DOI · Paper page
  53. Cedres, 2012, Neutrophil to lymphocyte ratio (NLR) as an indicator of poor prognosis in stage IV non-small cell lung cancer, Clinical and Translational Oncology, 14, 864, 10.1007/s12094-012-0872-5 · DOI · Paper page
  54. Kao, 2010, High blood neutrophil-to-lymphocyte ratio is an indicator of poor prognosis in malignant mesothelioma patients undergoing systemic therapy, Clinical Cancer Research, 16, 5805, 10.1158/1078-0432.CCR-10-2245 · DOI · Paper page
  55. Yao, 2012, Pretreatment neutrophil to lymphocyte ratio is associated with response to therapy and prognosis of advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy, Cancer Immunology, Immunotherapy
  56. Lee, 2012, Early neutrophil-to-lymphocyte ratio reduction as a surrogate marker of prognosis in never smokers with advanced lung adenocarcinoma receiving gefitinib or standard chemotherapy as first-line therapy, Journal of Cancer Research and Clinical Oncology, 138, 2009, 10.1007/s00432-012-1281-4 · DOI
  57. Aliustaoglu, 2010, The effect of peripheral blood values on prognosis of patients with locally advanced gastric cancer before treatment, Medical Oncology, 27, 1060, 10.1007/s12032-009-9335-4 · DOI
  58. An, 2010, Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer, Biomarkers, 15, 516, 10.3109/1354750X.2010.491557 · DOI
  59. Keizman, 2012, The association of pre-treatment neutrophil to lymphocyte ratio with response rate, progression free survival and overall survival of patients treated with sunitinib for metastatic renal cell carcinoma, European Journal of Cancer, 48, 202, 10.1016/j.ejca.2011.09.001 · DOI
  60. Chua, 2011, Neutrophil/lymphocyte ratio predicts chemotherapy outcomes in patients with advanced colorectal cancer, British Journal of Cancer, 104, 1288, 10.1038/bjc.2011.100 · DOI · Paper page
  61. Kaneko, 2012, Elevated neutrophil to lymphocyte ratio predicts poor prognosis in advanced colorectal cancer patients receiving oxaliplatin-based chemotherapy, Oncology, 82, 261, 10.1159/000337228 · DOI
  62. McNally, 2013, Inflammatory markers are associated with outcome in patients with unresectable hepatocellular carcinoma undergoing transarterial chemoembolization, Annals of Surgical Oncology, 20, 923, 10.1245/s10434-012-2639-1 · DOI
  63. Huang, 2011, Blood neutrophil-to-lymphocyte ratio predicts survival in patients with unresectable hepatocellular carcinoma undergoing transarterial chemoembolization, Journal of Vascular and Interventional Radiology, 22, 702, 10.1016/j.jvir.2010.12.041 · DOI
  64. Jeong, 2012, Comparison of two inflammation-based prognostic scores in patients with unresectable advanced gastric cancer, Oncology, 83, 292, 10.1159/000342376 · DOI
  65. Wang, 2011, The neutrophil/lymphocyte ratio is an independent prognostic indicator in patients with bone metastasis, Oncology Letters, 2, 735, 10.3892/ol.2011.304 · DOI

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Metadata

Authors
Guthrie, G. J. K., Charles, K. A., Roxburgh, C. S. D., Horgan, P. G., McMillan, D. C., & Clarke, S. J.
Venue
Critical Reviews in Oncology/Hematology
Publisher
Elsevier BV
Published
2013-10
Volume
88
Issue
1
Pages
218-230
ISSN
1040-8428 (ISSN-L)
OpenAlex
W2085458222
Cited by
1,552
References
6
FWCI
39.21
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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Guthrie, G. J. K., Charles, K. A., Roxburgh, C. S. D., Horgan, P. G., McMillan, D. C., & Clarke, S. J. (2013). The systemic inflammation-based neutrophil–lymphocyte ratio: Experience in patients with cancer. Critical Reviews in Oncology/Hematology. https://doi.org/10.1016/j.critrevonc.2013.03.010

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