Cited by 46PARP inhibition in cancer therapyCancer survivorship and careAdvanced Breast Cancer Therapies

Risk of fatigue and anemia in patients with advanced cancer treated with olaparib: a meta-analysis of randomized controlled trials

Ruiz-Schutz, Viviane C., Gomes, Larissa M., Mariano, Rodrigo C., de Almeida, Daniel V.P., Pimenta, Juliana M., Dal Molin, Graziela Z., Kater, Fabio R., Yamamura, Rosely +3 more·2019·Critical Reviews in Oncology/Hematology

Abstract

Introduction PARP inhibitors are a new class of drugs that are currently being studied in several malignancies. Olaparib is FDA-approved for advanced breast cancer and advanced ovarian cancer patients. Fatigue and anemia are among the most common cancer and treatment-related symptoms. Therefore, we conducted a meta-analysis of randomized controlled trials (RCT) to characterize the incidence and relative risks (RRs) of fatigue and anemia associated with olaparib.Methods PubMed, Cohrane, Embase and abstracts presented at the annual meeting of the American Society of Clinical Oncology (ASCO) were searched for articles published from 2000 to June 2018. The eligible studies were phase II and III RCT of olaparib. Safety profile from each selected study was evaluated for all-grade and high-grade fatigue and anemia adverse events. Summary incidences and the RR, with 95% confidence intervals, of all-grade and high-grade events were calculated using random-effects or fixed-effects model based on the heterogeneity of selected studies.Results A total of 9 trials were selected, and included 2074 patients with advanced ovarian, gastric, prostate, lung or breast cancer. 908 patients received placebo/control treatments and 1166 received olaparib alone or combination with other active cancer treatments. The RR of all-grade and high fatigue was 1.24 (95% CI, 1.10-1.39) and 1.71 (95% CI, 1.06-2.77), respectively. The RR of all-grade and high-grade anemia was 2.10 (95% CI, 1.48-2.98) and 3.15 (95% CI, 1.73-5.71), respectively.Conclusion Our findings suggest that the olaparib treatment is associated with an increased risk of fatigue and anemia. Since fatigue and anemia are very common treatment related adverse events, and both can impair the quality of life of patients, it is important to identify them early and manage it accordingly in order to optimize the overall treatment.

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Crossref · 10.1016/j.critrevonc.2019.06.012

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Authors
Ruiz-Schutz, V. C., Gomes, L. M., Mariano, R. C., de Almeida, D. V. P., Pimenta, J. M., Dal Molin, G. Z., Kater, F. R., Yamamura, R., Correa Neto, N. F., Maluf, F. C., & Schutz, F. A.
Affiliations
  • Universidade de São Paulo (BR)
  • Beneficência Portuguesa de São Paulo (BR)
Corresponding author
Schutz, Fabio A.
Venue
Critical Reviews in Oncology/Hematology
Publisher
Elsevier BV
Published
2019-09
Volume
141
Pages
163-173
ISSN
1040-8428 (ISSN-L)
OpenAlex
W2954942413
Cited by
46
References
36
Citations by year
2026: 1 · 2025: 4 · 2024: 6 · 2023: 13 · 2022: 7 · 2021: 10 · 2020: 5
FWCI
0.52
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Reviews in Oncology/Hematology (publishedVersion)
  • PubMed (publishedVersion)
Funders
BP – A Beneficencia Portuguesa de Sao Paulo
Topics
  • Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Advanced Breast Cancer Therapies
Keywords
olaparib, PARP inhibitors, fatigue, anemia, treatment-related adverse events, advanced cancer, ovarian cancer, breast cancer, gastric cancer, prostate cancer, lung cancer, drug safety
MeSH terms
Adult, Aged, Aged, 80 and over, Anemia, Fatigue, Female, Humans, Male, Middle Aged, Neoplasms, Phthalazines, Piperazines, Quality of Life, Risk, Risk Factors, Incidence, Randomized Controlled Trials as Topic, Disease Progression, Young Adult

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