Revisiting the role of alkylating agents in multiple myeloma: Up-to-date evidence and future perspectives
Abstract
From the 1960s to the early 2000s, alkylating agents (e.g., melphalan, cyclophosphamide, and bendamustine) remained a key component of standard therapy for newly-diagnosed or relapsed/refractory multiple myeloma (MM). Later on, their associated toxicities (including second primary malignancies) and the unprecedented efficacy of novel therapies have led clinicians to increasingly consider alkylator-free approaches. Meanwhile, new alkylating agents (e.g., melflufen) and new applications of old alkylators (e.g., lymphodepletion before chimeric antigen receptor T-cell [CAR-T] therapy) have emerged in recent years. Given the expanding use of antigen-directed modalities (e.g., monoclonal antibodies, bispecific antibodies, and CAR-T therapy), this review explores the current and future role of alkylating agents in different treatment settings (e.g., induction, consolidation, stem cell mobilization, pre-transplant conditioning, salvage, bridging, and lymphodepleting chemotherapy) to ellucidate the role of alkylator-based regimens in modern-day MM management.
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Several non-targeted drugs have been approved for MM treatment, including alkylating agents, corticosteroids, immunomodulatory imide drugs, proteasome inhibitors, histone deacetylase inhibitors, and XPO1 inhibitor.
“Over the past few decades, several non-targeted drugs have been approved for the treatment of multiple myeloma, including alkylating agents [40], corticosteroids [41–43], immunomodulatory imide drugs (IMiDs) [44–47], proteasome inhibitors (PIs) [42, 48–51], histone deacetylases (iHDACs) inhibitors [37, 52, 53], and XPO1 inhibitor [54–56] (Table 1).”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [40]
Cites
Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma.
Munshi, N. C., Anderson, L. D., Shah, N., Madduri, D., Berdeja, J., Lonial, S., Raje, N., Lin, Y., Siegel, D., Oriol, A., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2024850 · Cited by 2,560 · see citing works
Attal, M., Harousseau, J.-L., Stoppa, A.-M., Sotto, J.-J., Fuzibet, J.-G., Rossi, J.-F., Casassus, P., Maisonneuve, H., Facon, T., Ifrah, N., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199607113350204 · Cited by 2,548 · see citing works
Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma
San Miguel, J. F., Schlag, R., Khuageva, N. K., Dimopoulos, M. A., Shpilberg, O., Kropff, M., Spicka, I., Petrucci, M. T., Palumbo, A., Samoilova, O. S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0801479 · Cited by 1,899 · see citing works
High-Dose Chemotherapy with Hematopoietic Stem-Cell Rescue for Multiple Myeloma
Child, J. A., Morgan, G. J., Davies, F. E., Owen, R. G., Bell, S. E., Hawkins, K., Brown, J., Drayson, M. T., & Selby, P. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022340 · Cited by 1,768 · see citing works
Berdeja, J. G., Madduri, D., Usmani, S. Z., Jakubowiak, A., Agha, M., Cohen, A. D., Stewart, A. K., Hari, P., Htut, M., Lesokhin, A., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00933-8 · Cited by 1,756 · see citing works
Teclistamab in Relapsed or Refractory Multiple Myeloma
Moreau, P., Garfall, A. L., van de Donk, N. W. C. J., Nahi, H., San-Miguel, J. F., Oriol, A., Nooka, A. K., Martin, T., Rosinol, L., Chari, A., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2203478 · Cited by 1,269 · see citing works
Lenalidomide, Bortezomib, and Dexamethasone with Transplantation for Myeloma
Attal, M., Lauwers-Cances, V., Hulin, C., Leleu, X., Caillot, D., Escoffre, M., Arnulf, B., Macro, M., Belhadj, K., Garderet, L., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1611750 · Cited by 1,257 · see citing works
Kumar, S. K., Rajkumar, S. V., Kyle, R. A., van Duin, M., Sonneveld, P., Mateos, M., Gay, F., & Anderson, K. C. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.46 · Cited by 1,235 · see citing works
Cyclophosphamide and cancer: golden anniversary
Emadi, A., Jones, R. J., & Brodsky, R. A. (2009) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.146 · Cited by 1,058 · see citing works
Diagnosis and Management of Multiple Myeloma
Cowan, A. J., Green, D. J., Kwok, M., Lee, S., Coffey, D. G., Holmberg, L., Tuazon, S. A., Gopal, A. K., & Libby, E. N. (2022) · JAMA · doi:10.1001/jama.2022.0003 · Cited by 1,054 · see citing works
Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma
Facon, T., Kumar, S., Plesner, T., Orlowski, R. Z., Moreau, P., Bahlis, N., Basu, S., Nahi, H., Hulin, C., Quach, H., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1817249 · Cited by 1,027 · see citing works
Daratumumab plus Bortezomib, Melphalan, and Prednisone for Untreated Myeloma
Mateos, M., Dimopoulos, M. A., Cavo, M., Suzuki, K., Jakubowiak, A. J., Knop, S. T., Doyen, C., Lúcio, P., Nagy, Z., Kaplan, P., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1714678 · Cited by 991 · see citing works
Single versus Double Autologous Stem-Cell Transplantation for Multiple Myeloma
Attal, M., Harousseau, J.-L., Facon, T., Guilhot, F., Doyen, C., Fuzibet, J.-G., Monconduit, M., Hulin, C., Caillot, D., Bouabdallah, R., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa032290 · Cited by 984 · see citing works
Durie, B. G. M., Hoering, A., Abidi, M. H., Rajkumar, S. V., Epstein, J., Kahanic, S. P., Thakuri, M., Reu, F., Reynolds, C. M., Sexton, R., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(16)31594-x · Cited by 908 · see citing works
Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†
Dimopoulos, M. A., Moreau, P., Terpos, E., Mateos, M. V., Zweegman, S., Cook, G., Delforge, M., Hájek, R., Schjesvold, F., Cavo, M., et al. (2021) · Annals of Oncology · doi:10.1016/j.annonc.2020.11.014 · Cited by 900 · see citing works
Facon, T. T. F., Mary, J., Hulin, C., Benboubker, L., Attal, M., Pegourié, B., Renaud, M., Harousseau, J. L., Guillerm, G., Chaleteix, C., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61537-2 · Cited by 865 · see citing works
Palumbo, A., Bringhen, S., Caravita, T., Merla, E., Capparella, V., Callea, V., Cangialosi, C., Grasso, M., Rossini, F., Galli, M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68338-4 · Cited by 806 · see citing works
Miguel, J. F. S., Weisel, K. C., Moreau, P., Lacy, M. Q., Song, K., Delforge, M., Karlin, L., Goldschmidt, H., Banos, A., Oriol, A., et al. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70380-2 · Cited by 800 · see citing works
Lenalidomide and Dexamethasone in Transplant-Ineligible Patients with Myeloma
Benboubker, L., Dimopoulos, M. A., Dispenzieri, A., Catalano, J., Belch, A. R., Cavo, M., Pinto, A., Weisel, K., Ludwig, H., Bahlis, N., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402551 · Cited by 793 · see citing works
Continuous Lenalidomide Treatment for Newly Diagnosed Multiple Myeloma
Palumbo, A. P., Hájek, R., Delforge, M., Kropff, M. H., Petrucci, M. T., Catalano, J. V., Gisslinger, H., Wiktor-Jędrzejczak, W., Zodelava, M., Weisel, K. C., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1112704 · Cited by 739 · see citing works
Morgan, G. J., Davies, F. E., Gregory, W. M., Cocks, K., Bell, S., Szubert, A. J., Navarro-Coy, N. C., Drayson, M. T., Owen, R. G., Feyler, S., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)62051-x · Cited by 575 · see citing works
Moreau, P. (2002) · Blood · doi:10.1182/blood.v99.3.731 · Cited by 568 · see citing works
Pasquali, S., Maqueo, J. D., Vela, J. E., Kyle, R. A., Leong, T. L., Fritz, E., Suciu, S., Palva, I. P., Oivanen, T., Corrado, C., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.12.3832 · Cited by 547 · see citing works
HIGH-DOSE INTRAVENOUS MELPHALAN FOR PLASMA-CELL LEUKAEMIA AND MYELOMA
McElwain, T. J. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90739-0 · Cited by 514 · see citing works
Triplet Therapy, Transplantation, and Maintenance until Progression in Myeloma
Richardson, P. G., Jacobus, S. J., Weller, E. A., Hassoun, H., Lonial, S., Raje, N. S., Medvedova, E., McCarthy, P. L., Libby, E. N., Voorhees, P. M., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2204925 · Cited by 487 · see citing works
Mateos, M.-V., Oriol, A., Martínez-López, J., Gutiérrez, N., Teruel, A.-I., de Paz, R., García-Laraña, J., Bengoechea, E., Martín, A., Mediavilla, J. D., et al. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70187-x · Cited by 458 · see citing works
Clinical Pharmacokinetics of Cyclophosphamide
de Jonge, M. E., Huitema, A. D. R., Rodenhuis, S., & Beijnen, J. H. (2005) · Clinical Pharmacokinetics · doi:10.2165/00003088-200544110-00003 · Cited by 447 · see citing works
Mateos, M., Cavo, M., Bladé, J., Dimopoulos, M. A., Suzuki, K., Jakubowiak, A. J., Knop, S. T., Doyen, C., Lúcio, P., Nagy, Z., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)32956-3 · Cited by 447 · see citing works
Kumar, S., Flinn, I., Richardson, P. G., Hari, P., Callander, N., Noga, S. J., Stewart, A. K., Turturro, F., Rifkin, R., Wolf, J., et al. (2012) · Blood · doi:10.1182/blood-2011-11-395749 · Cited by 446 · see citing works
Palumbo, A., Bringhen, S., Rossi, D., Cavalli, M., Larocca, A., Ria, R., Offidani, M., Patriarca, F., Nozzoli, C., Guglielmelli, T., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.29.8216 · Cited by 423 · see citing works
Giralt, S. A., Costa, L. J., Schriber, J. R., DiPersio, J. F., Maziarz, R. T., McCarty, J. M., Shaughnessy, P. J., Snyder, E. L., Bensinger, W., Copelan, E. A., et al. (2013) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2013.10.013 · Cited by 408 · see citing works
Usmani, S. Z., Weiss, B. M., Plesner, T., Bahlis, N. J., Belch, A., Lonial, S., Lokhorst, H. M., Voorhees, P. M., Richardson, P. G., Chari, A., et al. (2016) · Blood · doi:10.1182/blood-2016-03-705210 · Cited by 407 · see citing works
Treatment for Multiple Myeloma
Alexanian, R. (1969) · JAMA · doi:10.1001/jama.1969.03160090040009 · Cited by 395 · see citing works
Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma
Ramos, C. A., Grover, N. S., Beaven, A., Lulla, P., Wu, M.-F., Ivanova, A., Wang, T., Shea, T. C., Rooney, C. M., Dittus, C. E., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.01342 · Cited by 389 · see citing works
Mateos, M., Hernández, J., Hernández, M.-T., Gutierrez, N. C., Palomera, L., Fuertes, M., Diaz‐Mediavilla, J., Lahuerta, J. J., de la Rubia, J., Terol, M. J., et al. (2006) · Blood · doi:10.1182/blood-2006-04-019778 · Cited by 387 · see citing works
Cavo, M., Gay, F., Beksaç, M., Pantani, L., Petrucci, M. T., Dimopoulos, M. A., Dozza, L., van der Holt, B., Zweegman, S., Oliva, S., et al. (2020) · The Lancet Haematology · doi:10.1016/s2352-3026(20)30099-5 · Cited by 381 · see citing works
Hulin, C., Facon, T. T. F., Rodon, P., Pegourié, B., Benboubker, L., Doyen, C., Dib, M., Guillerm, G., Salles, B., Eschard, J., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.21.0948 · Cited by 379 · see citing works
Reeder, C. B., Reece, D. E., Kukreti, V., Chen, C. L., Trudel, S., Hentz, J. G., Noble, B. N., Pirooz, N. A., Spong, J., Píza, J., et al. (2009) · Leukemia · doi:10.1038/leu.2009.26 · Cited by 371 · see citing works
Facon, T., Kumar, S. K., Plesner, T., Orlowski, R. Z., Moreau, P., Bahlis, N., Basu, S., Nahi, H., Hulin, C., Quach, H., et al. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00466-6 · Cited by 370 · see citing works
Leoni, L. M., Bailey, B., Reifert, J. R., Bendall, H. H., Zeller, R. W., Corbeil, J., Elliott, G. T., & Niemeyer, C. C. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1061 · Cited by 369 · see citing works
Palumbo, A., Bringhen, S., Liberati, A. M., Caravita, T., Falcone, A. P., Callea, V., Montanaro, M., Ria, R., Capaldi, A., Zambello, R., et al. (2008) · Blood · doi:10.1182/blood-2008-04-149427 · Cited by 357 · see citing works
Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function
Kintzel, P. E. (1995) · Cancer Treatment Reviews · doi:10.1016/0305-7372(95)90010-1 · Cited by 357 · see citing works
Jackson, G. H., Davies, F. E., Pawlyn, C., Cairns, D. A., Striha, A., Collett, C., Hockaday, A., Jones, J. R., Kishore, B., Garg, M. K., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30687-9 · Cited by 350 · see citing works
High-dose melphalan with autologous bone marrow transplantation for multiple myeloma
Barlogie, B., Hall, R., Zander, A., Dicke, K. A., & Alexanian, R. (1986) · Blood · doi:10.1182/blood.v67.5.1298.1298 · Cited by 336 · see citing works
Barlogie, B., Anaissie, E. J., van Rhee, F., Haessler, J., Hollmig, K. A., Pineda‐Roman, M., Cottler‐Fox, M., Mohiuddin, A., Alsayed, Y. M., Tricot, G. J. K., et al. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06639.x · Cited by 330 · see citing works
Ninomiya, S., Narala, N., Huye, L. E., Yagyu, S., Savoldo, B., Dotti, G., Heslop, H. E., Brenner, M. K., Rooney, C. M., & Ramos, C. A. (2015) · Blood · doi:10.1182/blood-2015-01-621474 · Cited by 317 · see citing works
Palumbo, A. P., Falco, P., Corradini, P., Falcone, A. P., Raimondo, F. D., Giuliani, N., Crippa, C., Ciccone, G., Omedè, P., Ambrosini, M. T., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.3463 · Cited by 317 · see citing works
Moreau, P., Hulin, C., Macro, M., Caillot, D., Chaleteix, C., Roussel, M., Garderet, L., Royer, B., Bréchignac, S., Tiab, M., et al. (2016) · Blood · doi:10.1182/blood-2016-01-693580 · Cited by 278 · see citing works
Duell, J., Dittrich, M. T., Bedke, T., Mueller, T., Eisele, F., Rosenwald, A., Rasche, L., Hartmann, E., Dandekar, T., Einsele, H., et al. (2017) · Leukemia · doi:10.1038/leu.2017.41 · Cited by 278 · see citing works
Facon, T., Dimopoulos, M. A., Dispenzieri, A., Catalano, J. V., Belch, A., Cavo, M., Pinto, A., Weisel, K., Ludwig, H., Bahlis, N. J., et al. (2018) · Blood · doi:10.1182/blood-2017-07-795047 · Cited by 271 · see citing works
Fayers, P. M., Palumbo, A., Hulin, C., Waage, A., Wijermans, P., Beksaç, M., Bringhen, S., Mary, J., Gimsing, P., Termorshuizen, F., et al. (2011) · Blood · doi:10.1182/blood-2011-03-341669 · Cited by 271 · see citing works
Bendamustine: Rebirth of an Old Drug
Cheson, B. D., & Rummel, M. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.7252 · Cited by 266 · see citing works
Miguel, J. F. S., Schlag, R., Khuageva, N. K., Dimopoulos, M. A., Shpilberg, O., Kropff, M. H., Špıčka, I., Petrucci, M. T., Palumbo, A. P., Samoilova, O. S., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.41.6180 · Cited by 263 · see citing works
Stadtmauer, E. A., Pasquini, M. C., Blackwell, B., Hari, P., Bashey, A., Devine, S., Efebera, Y., Ganguly, S., Gasparetto, C., Geller, N., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.18.00685 · Cited by 259 · see citing works
Wijermans, P., Schaafsma, M. R., Termorshuizen, F., Ammerlaan, R., Wittebol, S. H., Sinnige, H. A. M., Zweegman, S., Kooy, M. V. M., van der Griend, R., Lokhorst, H. M., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.1610 · Cited by 259 · see citing works
Gay, F., Musto, P., Rota-Scalabrini, D., Bertamini, L., Belotti, A., Galli, M., Offidani, M., Zamagni, E., Ledda, A., Grasso, M., et al. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00535-0 · Cited by 258 · see citing works
Multiple myeloma treated with high dose intravenous melphalan
Selby, P. J., McElwain, T. J., Nandi, A., Perren, T. J., Powles, R., Tillyer, C. R., Osborne, R. J., Slevin, M. L., & Malpas, J. S. (1987) · British Journal of Haematology · doi:10.1111/j.1365-2141.1987.tb06890.x · Cited by 248 · see citing works
Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myeloma.
Waage, A., Gimsing, P., Fayers, P., Abildgaard, N., Ahlberg, L., Björkstrand, B., Carlson, K., Dahl, I., Forsberg, K., Gulbrandsen, N., et al. (2010) · Blood · doi:10.1182/blood-2009-08-237974 · Cited by 242 · see citing works
Current status of autologous stem cell transplantation for multiple myeloma
Hamed, R. A., Bazarbachi, A. H., Malard, F., Harousseau, J., & Mohty, M. (2019) · Blood Cancer Journal · doi:10.1038/s41408-019-0205-9 · Cited by 240 · see citing works
Case, D. C., Lee, B. J., & Clarkson, B. D. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90543-5 · Cited by 218 · see citing works
Palumbo, A. P., Bringhen, S., Larocca, A., Rossi, D., Raimondo, F. D., Magarotto, V., Patriarca, F. F., Levi, A., Benevolo, G., Vincelli, I. D., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.52.0023 · Cited by 207 · see citing works
Pönisch, W., Mitrou, P. S., Merkle, K., Herold, M. J., Aßmann, M., Wilhelm, G., Dachselt, K., Richter, P., Schirmer, V., Schulze, A., et al. (2006) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-005-0074-4 · Cited by 186 · see citing works
Facon, T. T. F. (2005) · Blood · doi:10.1182/blood-2005-04-1588 · Cited by 180 · see citing works
Moreau, P., Hulin, C., Perrot, A., Arnulf, B., Belhadj, K., Benboubker, L., Béné, M. C., Zweegman, S., Caillon, H., Caillot, D., et al. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00428-9 · Cited by 178 · see citing works
Lee, C., Barlogie, B., Munshi, N. C., Zangari, M., Fassas, A., Jacobson, J. L., van Rhee, F., Cottler‐Fox, M., Muwalla, F., & Tricot, G. J. K. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.01.055 · Cited by 175 · see citing works
Pineda‐Roman, M., Zangari, M., Haessler, J., Anaissie, E. J., Tricot, G. J. K., van Rhee, F., Crowley, J. J., Shaughnessy, J. D., & Barlogie, B. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06921.x · Cited by 166 · see citing works
Kropff, M. H., Bisping, G., Schuck, E., Liebisch, P., Lang, N., Hentrich, M., Dechow, T. N., Kröger, N. M., Salwender, H. J., Metzner, B., et al. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06656.x · Cited by 166 · see citing works
Yamamoto, J., Ito, T., Yamaguchi, Y., & Handa, H. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00116k · Cited by 164 · see citing works
Baz, R., Martin, T. G., Lin, H., Zhao, X., Shain, K. H., Cho, H. J., Wolf, J. L., Mahindra, A. K., Chari, A., Sullivan, D. M., et al. (2016) · Blood · doi:10.1182/blood-2015-11-682518 · Cited by 159 · see citing works
Melflufen and Dexamethasone in Heavily Pretreated Relapsed and Refractory Multiple Myeloma
Richardson, P. G. G., Oriol, A., Larocca, A., Bladé, J., Cavo, M., Rodríguez‐Otero, P., Leleu, X. P., Nadeem, O., Hiemenz, J. W., Hassoun, H., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.02259 · Cited by 157 · see citing works
Morgan, G. J., Davies, F. E., Gregory, W. M., Bell, S. E., Szubert, A. J., Cook, G., Drayson, M. T., Owen, R. G., Ross, F. M., Jackson, G. H., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3211 · Cited by 153 · see citing works
Bringhen, S., Petrucci, M. T., Larocca, A., Conticello, C., Rossi, D., Magarotto, V., Musto, P., Boccadifuoco, L., Offidani, M., Omedè, P., et al. (2014) · Blood · doi:10.1182/blood-2014-03-563759 · Cited by 152 · see citing works
p53 and MDM2 alterations in osteosarcomas
Lonardo, F., Ueda, T., Huvos, A. G., Healey, J. H., & Ladanyi, M. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970415)79:8 · Cited by 147 · see citing works
Mai, E. K., Bertsch, U., Dürig, J., Kunz, C., Haenel, M., Blau, I. W., Munder, M., Jauch, A. T., Schurich, B., Hielscher, T., et al. (2015) · Leukemia · doi:10.1038/leu.2015.80 · Cited by 141 · see citing works
Therapy for Relapsed Multiple Myeloma
Dingli, D., Ailawadhi, S., Bergsagel, P. L., Buadi, F. K., Dispenzieri, A. A., Fonseca, R., Gertz, M. A., Gonsalves, W. I., Hayman, S. R., Kapoor, P., et al. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.01.003 · Cited by 140 · see citing works
CLINICAL EXPERIENCES WITH SARCOLYSIN IN NEOPLASTIC DISEASES
Blokhin, N. N., Lf, L., Переводчикова, Н. И., Chebotareva, L., & Merkulova, N. A. (1958) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1958.tb42675.x · Cited by 140 · see citing works
Facon, T. T. F., Lee, J. H., Moreau, P., Niesvizky, R., Dimopoulos, M. A., Hájek, R., Pour, L., Jurczyszyn, A. J., Qiu, L., Klippel, Z. K., et al. (2019) · Blood · doi:10.1182/blood-2018-09-874396 · Cited by 129 · see citing works
CAR-T efficacy: is conditioning the key?
Neelapu, S. S. (2019) · Blood · doi:10.1182/blood-2019-03-900928 · Cited by 129 · see citing works
Bergsagel, D. E., Cc, S., AUSTIN, C., & Griffith, K. M. (1962) · PubMed · Cited by 125 · see citing works
Boccadoro, M., Marmont, F., Tribalto, M., Avvisati, G., Andriani, A., Barbui, T., Cantonetti, M., Carotenuto, M., Comotti, B., & Dammacco, F. (1991) · Journal of Clinical Oncology · doi:10.1200/jco.1991.9.3.444 · Cited by 122 · see citing works
Lentzsch, S., O'Sullivan, A., Kennedy, R. C., Abbas, M., Dai, L., Pregja, S. L., Burt, S., Boyiadzis, M. M., Roodman, G. D., Mapara, M. Y., et al. (2012) · Blood · doi:10.1182/blood-2011-12-395715 · Cited by 119 · see citing works
Fifty Years of Melphalan Use in Hematopoietic Stem Cell Transplantation
Bayraktar, U. D., Bashir, Q., Qazilbash, M. H., Champlin, R. E., & Ciurea, S. O. (2012) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2012.08.011 · Cited by 119 · see citing works
Zweegman, S., van der Holt, B., Mellqvist, U., Salomo, M., Bos, G. M. J., Levin, M., Visser-Wisselaar, H. A., Hansson, M., van der Velden, A. W. G., Deenik, W., et al. (2016) · Blood · doi:10.1182/blood-2015-11-679415 · Cited by 115 · see citing works
Meermeier, E. W., Welsh, S. J., Sharik, M. E., Du, M. T., Garbitt, V. M., Riggs, D. L., Shi, C., Stein, C. K., Bergsagel, M., Chau, B. H., et al. (2021) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-21-0038 · Cited by 112 · see citing works
Lahuerta, J. J., Mateos, M. V., Martínez‐López, J., Grande, C., de la Rubia, J., Rosiñol, L., Sureda, A. M., García‐Laraña, J., Díaz-Mediavilla, J., Hernández‐Garcia, M. T., et al. (2010) · Haematologica · doi:10.3324/haematol.2010.028027 · Cited by 111 · see citing works
Caraccio, C., Krishna, S., Phillips, D. J., & Schürch, C. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00501 · Cited by 106 · see citing works
Morgan, G. J., Schey, S., Wu, P., Srikanth, M., Phekoo, K. J., Jenner, M. W., & Davies, F. E. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06538.x · Cited by 102 · see citing works
Mateos, M., Oriol, A., Martínez‐López, J., Teruel, A. I., de la Guía, A. L., López, J., Bengoechea, E., Pérez, M., Martínez, R., Palomera, L., et al. (2014) · Blood · doi:10.1182/blood-2014-05-573733 · Cited by 101 · see citing works
Reece, D. E., Rodriguez, G. P., Chen, C. I., Trudel, S., Kukreti, V., Mikhael, J. R., Pantoja, M. A., Xu, W., & Stewart, A. K. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.14.2372 · Cited by 101 · see citing works
Chauhan, D., Ray, A., Viktorsson, K., Spira, J., Paba‐Prada, C. E., Munshi, N. C., Richardson, P. G. G., Lewensohn, R., & Anderson, K. C. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3752 · Cited by 101 · see citing works
Ludwig, H., Kasparu, H., Leitgeb, C., Rauch, E., Linkesch, W., Zojer, N., Greil, R., Seebacher, A., Pour, L., Weißmann, A., et al. (2013) · Blood · doi:10.1182/blood-2013-08-521468 · Cited by 100 · see citing works
Ghilardi, G., Chong, E. A., Svoboda, J., Wohlfarth, P., Nasta, S. D., Williamson, S., Landsburg, J. D., Gerson, J. N., Barta, S. K., Pajarillo, R., et al. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2022.05.521 · Cited by 99 · see citing works
Jayaweera, S. P. E., Kanakanamge, S. P. W., Rajalingam, D., & Silva, G. N. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.740796 · Cited by 98 · see citing works
Jb, H., Pajak, T., McIntyre, O. R., Kochwa, S., Cooper, M., Coleman, M., & Cuttner, J. (1979) · Blood · doi:10.1182/blood.v54.1.13.13 · Cited by 97 · see citing works
Bashir, Q., Thall, P. F., Milton, D. R., Fox, P. S., Kawedia, J. D., Kebriaei, P., Shah, N. D., Patel, K. K., Andersson, B. S., Nieto, Y. L., et al. (2019) · The Lancet Haematology · doi:10.1016/s2352-3026(19)30023-7 · Cited by 95 · see citing works
Knop, S. T., Straka, C., Haen, M., Schwedes, R., Hebart, H. F., & Einsele, H. (2005) · PubMed · Cited by 94 · see citing works
Palumbo, A., Bringhen, S., Bruno, B., Falcone, A. P., Liberati, A. M., Grasso, M., Ria, R., Pisani, F., Cangialosi, C., Caravita, T., et al. (2009) · Blood · doi:10.1182/blood-2009-09-241737 · Cited by 94 · see citing works
Auner, H. W., Iacobelli, S., Sbianchi, G., Knol, C., Blaise, D., Russell, N. H., Apperley, J. F., Pohlreich, D., Browne, P., Kobbe, G., et al. (2017) · Haematologica · doi:10.3324/haematol.2017.181339 · Cited by 94 · see citing works
Magarotto, V., Bringhen, S., Offidani, M., Benevolo, G., Patriarca, F. F., Mina, R., Falcone, A. P., Paoli, L. D., Pietrantuono, G., Gentili, S., et al. (2016) · Blood · doi:10.1182/blood-2015-08-662627 · Cited by 92 · see citing works
Melflufen - a peptidase-potentiated alkylating agent in clinical trials
Wickström, M., Nygren, P., Larsson, R. L., Harmenberg, J., Lindberg, J., Sjöberg, P. J. R., Jerling, M., Lehmann, F., Richardson, P. G. G., Anderson, K. C., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18420 · Cited by 89 · see citing works
Stewart, A. K., Jacobus, S. J., Fonseca, R., Weiss, M., Callander, N. S., Chanan-Khan, A. A., & Rajkumar, S. V. (2015) · Blood · doi:10.1182/blood-2014-12-613927 · Cited by 88 · see citing works
Durie, B. G. M., Dixon, D. O., Carter, S. K., Stephens, R. L., Rivkin, S. E., Bonnet, J. D., Salmon, S. E., Dabich, L., Files, J. C., & Costanzi, J. J. (1986) · Journal of Clinical Oncology · doi:10.1200/jco.1986.4.8.1227 · Cited by 88 · see citing works
Mateos, M., Hernández‐Rivas, J. M., Hernández, M., Gutierrez, N. C., Palomera, L., Fuertes, M., Garcia-Sanchez, P., Lahuerta, J. J., de la Rubia, J., Terol, M. J., et al. (2008) · Haematologica · doi:10.3324/haematol.12106 · Cited by 86 · see citing works
Larocca, A., Montefusco, V., Bringhen, S., Rossi, D., Crippa, C., Mina, R., Galli, M., Marcatti, M., Verde, G. L., Giuliani, N., et al. (2013) · Blood · doi:10.1182/blood-2013-03-488676 · Cited by 85 · see citing works
Richardson, P. G. G., Bringhen, S., Voorhees, P. M., Plesner, T., Mellqvist, U., Reeves, B., Paba‐Prada, C. E., Zubair, H., Byrne, C., Chauhan, D., et al. (2020) · The Lancet Haematology · doi:10.1016/s2352-3026(20)30044-2 · Cited by 83 · see citing works
Schjesvold, F. H., Dimopoulos, M. A., Delimpasi, S., Robak, P., Coriu, D., Legiec, W., Pour, L., Špička, I., Masszi, T., Doronin, V., et al. (2022) · The Lancet Haematology · doi:10.1016/s2352-3026(21)00381-1 · Cited by 82 · see citing works
Roué, G., López‐Guerra, M., Milpied, P. J., Pérez‐Galán, P., Villamor, N., Montserrat, E., Campo, E., & Colomer, D. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0388 · Cited by 82 · see citing works
Pönisch, W., Rozanski, M. J., Goldschmidt, H., Hoffmann, F. A., Boldt, T., Schwarzer, A., Ritter, U., Rohrberg, R., Schwalbe, E., Uhlig, J., et al. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07076.x · Cited by 80 · see citing works
T‐cell modulation by cyclophosphamide for tumour therapy
Hughes, E., Scurr, M. J., Campbell, E., Jones, E., Godkin, A. J., & Gallimore, A. (2018) · Immunology · doi:10.1111/imm.12913 · Cited by 80 · see citing works
Hoogstraten, B., Sheehe, P. R., Cuttner, J., Cooper, T., Kyle, R. A., Oberfield, R. A., Townsend, S. R., HARLEY, J. B., Hayes, D. M., Costa, G., et al. (1967) · Blood · doi:10.1182/blood.v30.1.74.74 · Cited by 80 · see citing works
Poczta, A., Rogalska, A., & Marczak, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10091841 · Cited by 73 · see citing works
Davies, F. E., Wu, P., Jenner, M. W., Srikanth, M., Saso, R. M., & Morgan, G. J. (2007) · Haematologica · doi:10.3324/haematol.11228 · Cited by 72 · see citing works
Yimer, H. A., Melear, J. M., Faber, E. A., Bensinger, W., Burke, J. M., Narang, M., Stevens, D. A., Gunawardena, S. W., Lutska, Y., Qi, K., et al. (2019) · British Journal of Haematology · doi:10.1111/bjh.15806 · Cited by 69 · see citing works
Radivoyevitch, T., Dean, R. M., Shaw, B. E., Brazauskas, R., Tecca, H. R., Molenaar, R. J., Battiwalla, M., Savani, B. N., Flowers, M. E. D., Cooke, K. R., et al. (2018) · Leukemia Research · doi:10.1016/j.leukres.2018.07.016 · Cited by 68 · see citing works
Goldschmidt, H., Mai, E. K., Dürig, J., Scheid, C., Weisel, K. C., Kunz, C., Bertsch, U., Hielscher, T., Merz, M., Munder, M., et al. (2020) · Leukemia · doi:10.1038/s41375-020-0724-1 · Cited by 67 · see citing works
Chari, A., Rodríguez‐Otero, P., McCarthy, H. O., Suzuki, K., Hungria, V., Sureda, A. M., Perrot, A., Hulin, C., Magen, H., Iida, S., et al. (2020) · British Journal of Haematology · doi:10.1111/bjh.16980 · Cited by 66 · see citing works
Pomalidomide, cyclophosphamide, and dexamethasone for relapsed multiple myeloma
Garderet, L., Kuhnowski, F., Berge, B., Roussel, M., Escoffre‐Barbe, M., Lafon, I., Facon, T. T. F., Leleu, X. P., Karlin, L., Perrot, A., et al. (2018) · Blood · doi:10.1182/blood-2018-07-863829 · Cited by 65 · see citing works
Efficacy of VDT PACE‐like regimens in treatment of relapsed/refractory multiple myeloma
Lakshman, A., Singh, P. P., Rajkumar, S. V., Dispenzieri, A. A., Lacy, M. Q., Gertz, M. A., Buadi, F. K., Dingli, D., Hwa, Y. L., Fonder, A. L., et al. (2017) · American Journal of Hematology · doi:10.1002/ajh.24954 · Cited by 64 · see citing works
CAR T-Cell Therapy for Patients with Multiple Myeloma: Current Evidence and Challenges
Rendo, M. J., Joseph, J. J., Phan, L. M., & DeStefano, C. B. (2022) · Blood and Lymphatic Cancer Targets and Therapy · doi:10.2147/blctt.s327016 · Cited by 64 · see citing works
Mai, E. K., Benner, A., Bertsch, U., Brossart, P., Hänel, A., Kunzmann, V., Naumann, R., Neben, K., Egerer, G., Ho, A. D., et al. (2016) · British Journal of Haematology · doi:10.1111/bjh.13994 · Cited by 63 · see citing works
Kumar, S. K., Lacy, M. Q., Hayman, S. R., Stewart, K., Buadi, F. K., Allred, J. B., Laumann, K. M., Greipp, P. R., Lust, J. A., Gertz, M. A., et al. (2011) · American Journal of Hematology · doi:10.1002/ajh.22053 · Cited by 61 · see citing works
Lu, X., Ding, Z., Cao, Y., Liu, C., Habtetsion, T. G., Yu, M., Lemos, H. D. P., Salman, H., Xu, H., Mellor, A. L., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401894 · Cited by 60 · see citing works
Offidani, M., Corvatta, L., Maracci, L., Liberati, A. M., Ballanti, S., Attolico, I., Caraffa, P., Alesiani, F., di Toritto, T. C., Gentili, S., et al. (2013) · Blood Cancer Journal · doi:10.1038/bcj.2013.58 · Cited by 60 · see citing works
Bladé, J., Miguel, J. F. S., Alcalá, A., Maldonado, J., Sanz, M. Á., García-Conde, J., Moro, M. J., Alonso, C., Besalduch, J., & Zubizarreta, A. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.6.1165 · Cited by 59 · see citing works
Long-Term Physiological Side Effects After Allogeneic Bone Marrow Transplantation
Mohty, M., & Apperley, J. F. (2010) · Hematology · doi:10.1182/asheducation-2010.1.229 · Cited by 59 · see citing works
Melflufen: A Peptide–Drug Conjugate for the Treatment of Multiple Myeloma
Mateos, M., Bladé, J., Bringhen, S., Ocio, E. M., Efebera, Y. A., Pour, L., Gay, F., Sonneveld, P., Gullbo, J., & Richardson, P. G. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103120 · Cited by 58 · see citing works
Tuchman, S. A., Bacon, W., Huang, L., Long, G. D., Rizzieri, D. A., Horwitz, M. E., Chute, J. P., Sullivan, K. M., Engemann, A. M., Yopp, A., et al. (2014) · Journal of Clinical Apheresis · doi:10.1002/jca.21360 · Cited by 58 · see citing works
Sequential vs alternating administration of VMP and Rd in elderly patients with newly diagnosed MM
Mateos, M., Martínez‐López, J., Hernández, M.-T., Ocio, E. M., Rosiñol, L., Martínez, R., Teruel, A. I., Gutierrez, N. C., Ramos, M.-L. M., Oriol, A., et al. (2015) · Blood · doi:10.1182/blood-2015-08-666537 · Cited by 57 · see citing works
Bendamustine: a review of pharmacology, clinical use and immunological effects (Review)
Lalić, H., Aurer, I., Batinić, D., Višnjić, D., Smoljo, T., & Babić, A. (2022) · Oncology Reports · doi:10.3892/or.2022.8325 · Cited by 57 · see citing works
Monoclonal antibodies in multiple myeloma: Current and emerging targets and mechanisms of action
Wudhikarn, K., Wills, B., & Lesokhin, A. M. (2020) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2020.101143 · Cited by 56 · see citing works
The mutagenic impact of melphalan in multiple myeloma
Maura, F., Weinhold, N., Diamond, B. T., Kazandjian, D. G., Rasche, L., Morgan, G. J., & Landgren, O. (2021) · Leukemia · doi:10.1038/s41375-021-01293-3 · Cited by 56 · see citing works
Nijhof, I. S., Franssen, L. E., Levin, M., Bos, G. M. J., Broijl, A., Klein, S. K., Koene, H. R., Bloem, A. C., Beeker, A., Faber, L. M., et al. (2016) · Blood · doi:10.1182/blood-2016-07-729236 · Cited by 55 · see citing works
Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma
Swan, D., Gurney, M. E., Krawczyk, J., Ryan, A. E., & O'Dwyer, M. E. (2020) · HemaSphere · doi:10.1097/hs9.0000000000000350 · Cited by 55 · see citing works
How to Treat High-Risk Myeloma at Diagnosis and Relapse
Caro, J., Hadidi, S. A., Usmani, S. Z., Yee, A. J., Raje, N. S., & Davies, F. E. (2021) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_320105 · Cited by 55 · see citing works
Miettinen, J. J., Kumari, R., Traustadóttir, G. Á., Huppunen, M.-E., Sergeev, P., Majumder, M. M., Schepsky, A., Guðjónsson, Þ., Lievonen, J., Bazou, D., et al. (2021) · Cancers · doi:10.3390/cancers13071527 · Cited by 55 · see citing works
High-dose cyclophosphamide. An effective treatment for advanced refractory multiple myeloma
Lenhard, R. E., Oken, M. M., Barnes, J. M., Humphrey, R. L., Glick, J. H., & Silverstein, M. N. (1984) · Cancer · doi:10.1002/1097-0142(19840401)53:7 · Cited by 54 · see citing works
Hungria, V., Martinez-Banos, D. M., Peñafiel, C. O. R., Miguel, C. E., Vela‐Ojeda, J., Remaggi, G., Duarte, F. B., Cao, C., Cugliari, M. S., SANTOS, T. M. D., et al. (2019) · British Journal of Haematology · doi:10.1111/bjh.16124 · Cited by 54 · see citing works
Melphalan hydrochloride for the treatment of multiple myeloma
Esma, F., Salvini, M., Troia, R., Boccadoro, M., Larocca, A., & Pautasso, C. (2017) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2017.1349102 · Cited by 53 · see citing works
Berenson, J. R., Yellin, O., Bessudo, A., Boccia, R. V., Noga, S. J., Gravenor, D. S., Patel‐Donnelly, D., Siegel, R. S., Kewalramani, T., Gorak, E. J., et al. (2012) · British Journal of Haematology · doi:10.1111/bjh.12129 · Cited by 52 · see citing works
Where We Were, Where We Are, Where We Are Going: Progress in Multiple Myeloma
Bergsagel, P. L. (2014) · American Society of Clinical Oncology Educational Book · doi:10.14694/edbook_am.2014.34.199 · Cited by 52 · see citing works
Gullbo, J., Wickström, M., Tullberg, M. L., Ehrsson, H., Lewensohn, R., Nygren, P., Luthman, K., & Larsson, R. L. (2003) · Journal of drug targeting · doi:10.1080/10611860310001647140 · Cited by 52 · see citing works
Olivier, T., & Prasad, V. K. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101374 · Cited by 51 · see citing works
Fenk, R. R., Schneider, P., Kropff, M. H., Huenerlituerkoglu, A.-N., Steidl, U. U., Aul, C., Hildebrandt, B., Haas, R. R., Heyll, A., Kobbe, G., et al. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05641.x · Cited by 49 · see citing works
A comparison of salvage infusional chemotherapy regimens for recurrent/refractory multiple myeloma
Griffin, P. T., Ho, V. Q., Fulp, W. J., Nishihori, T., Shain, K. H., Alsina, M., & Baz, R. (2015) · Cancer · doi:10.1002/cncr.29533 · Cited by 48 · see citing works
Hjorth, M., Hellquist, L., Holmberg, E. C., Magnusson, B., Rödjer, S., Westin, J., & for the Myeloma Group of Western Sweden (1990) · British Journal of Haematology · doi:10.1111/j.1365-2141.1990.tb02564.x · Cited by 48 · see citing works
Second malignancies in multiple myeloma; emerging patterns and future directions
Maclachlan, K. H., Diamond, B. T., Maura, F., Hillengaß, J., Turesson, I., Landgren, O., & Kazandjian, D. G. (2020) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2020.101144 · Cited by 48 · see citing works
Bendamustine in patients with relapsed or refractory multiple myeloma
Michael, M., Bruns, I., Bölke, E., Zohren, F., Czibere, A. G., Safaian, N., Neumann, F., Haas, R. R., Kobbe, G., & Fenk, R. R. (2010) · European journal of medical research · doi:10.1186/2047-783x-15-1-13 · Cited by 47 · see citing works
Mikhael, J. R., Reeder, C. B., Libby, E. N., Costa, L. J., Bergsagel, P. L., Buadi, F. K., Mayo, A., Reddy, S. K. N., Gano, K., Dueck, A. C., et al. (2015) · British Journal of Haematology · doi:10.1111/bjh.13296 · Cited by 45 · see citing works
Costa, L. J., Iacobelli, S., Pasquini, M. C., Modi, R. A., Giaccone, L., Bladé, J., Schönland, S. O., Evangelista, A., Pérez‐Simón, J. A., Hari, P., et al. (2020) · Bone Marrow Transplantation · doi:10.1038/s41409-020-0887-4 · Cited by 45 · see citing works
Party, T. K. M. M. W., Kim, Y., Sohn, S., Lee, J.-H., Yang, D.-H., Moon, J., Ahn, J.-S., Kim, H., & Lee, J. (2009) · Annals of Hematology · doi:10.1007/s00277-009-0856-x · Cited by 44 · see citing works
Damaj, G. L., Malard, F., Hulin, C., Caillot, D., Garidi, R., Royer, B., Marit, G., Stoppa, A., Baños, A., Morineau, N., et al. (2011) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2011.622422 · Cited by 44 · see citing works
Fenk, R. R., Michael, M., Zohren, F., Graef, T. T., Czibere, A. G., Bruns, I., Neumann, F., Fenk, B., Haas, R. R., & Kobbe, G. (2007) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190701694194 · Cited by 44 · see citing works
Bringhen, S., D’Agostino, M., París, L., Ballanti, S., Pescosta, N., Spada, S., Pezzatti, S., Grasso, M., Rota‐Scalabrini, D., Rosa, L. D., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.226407 · Cited by 42 · see citing works
Reeder, C. B., Reece, D. E., Kukreti, V., Mikhael, J. R., Chen, C. I., Trudel, S., Laumann, K. M., Vohra, H. S., Fonseca, R., Bergsagel, P. L., et al. (2014) · British Journal of Haematology · doi:10.1111/bjh.13004 · Cited by 42 · see citing works
HyperCVAD for VAD-resistant multiple myeloma
Dimopoulos, M. A., Weber, D., Kantarjian, H. M., Delasalle, K. B., & Alexanian, R. (1996) · American Journal of Hematology · doi:10.1002/(sici)1096-8652(199606)52:2 · Cited by 42 · see citing works
Promising Antigens for the New Frontier of Targeted Immunotherapy in Multiple Myeloma
Cho, S., Xing, L., Anderson, K. C., & Tai, Y. (2021) · Cancers · doi:10.3390/cancers13236136 · Cited by 40 · see citing works
Lazzarino, M., Corso, A., Barbarano, L., Alessandrino, E. P., Cairoli, R., Pinotti, G., Ucci, G., Uziel, L. D., Rodeghiero, F., Fava, S., et al. (2001) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1703240 · Cited by 40 · see citing works
Pönisch, W., Bourgeois, M., Moll, B., Heyn, S., Jaekel, N., Wagner, I., Rohrberg, R., Hurtz, H.-J., Schmalfeld, M., Aßmann, M., et al. (2012) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-012-1339-3 · Cited by 37 · see citing works
Jackson, G. H., Davies, F. E., Pawlyn, C., Cairns, D. A., Striha, A., Collett, C., Waterhouse, A., Jones, J. R., Kishore, B., Garg, M. K., et al. (2020) · Haematologica · doi:10.3324/haematol.2020.247130 · Cited by 36 · see citing works
Rodon, P., Hulin, C., Pegourié, B., Tiab, M., Anglaret, B., Benboubker, L., Jardel, H., Decaux, O., Kolb, B., Roussel, M., et al. (2014) · Haematologica · doi:10.3324/haematol.2014.110890 · Cited by 35 · see citing works
Grey‐Davies, E., Bosworth, J. L., Boyd, K. D., Ebdon, C., Saso, R. M., Chitnavis, D., Mercieca, J., Morgan, G. J., & Davies, F. E. (2011) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.08887.x · Cited by 35 · see citing works
An overview of the progress in the treatment of multiple myeloma
Kyle, R. A., & Rajkumar, S. V. (2014) · Expert Review of Hematology · doi:10.1586/17474086.2014.870030 · Cited by 33 · see citing works
Dimopoulos, M. A., Grosicki, S., Wiktor-Jędrzejczak, W., Nahi, H., Gruber, A., Hansson, M., Gupta, N., Byrne, C., Labotka, R., Teng, Z., et al. (2018) · European Journal of Cancer · doi:10.1016/j.ejca.2018.09.011 · Cited by 33 · see citing works
Bensinger, W., Becker, P. S., Gooley, T. A., Chauncey, T. R., Maloney, D. G., Gopal, A. K., Green, D. J., Press, O. W., Lill, M., Ifthikharuddin, J. J., et al. (2015) · Bone Marrow Transplantation · doi:10.1038/bmt.2015.211 · Cited by 33 · see citing works
Einsele, H., Engelhardt, M. M., Tapprich, C., Müller, J., Liebisch, P., Langer, C., Kropff, M. H., Muegge, L. O., Jung, W. E., Wolf, H., et al. (2017) · British Journal of Haematology · doi:10.1111/bjh.14920 · Cited by 32 · see citing works
Bringhen, S., D’Agostino, M., Paoli, L. D., Montefusco, V., Liberati, A. M., Galieni, P., Grammatico, S., Muccio, V. E., Esma, F., Angelis, C. D., et al. (2017) · Leukemia · doi:10.1038/leu.2017.327 · Cited by 32 · see citing works
Berglund, Å., Ullén, A., Lisyanskaya, A. S., Орлов, С. В., Hagberg, H., Tholander, B., Lewensohn, R., Nygren, P., Spira, J., Harmenberg, J., et al. (2015) · Investigational New Drugs · doi:10.1007/s10637-015-0299-2 · Cited by 32 · see citing works
Martino, M. V., Tripepi, G. L., Messina, G., Vincelli, I. D., Console, G., Recchia, A. G., Gentile, M., Molica, S., & Morabito, F. (2016) · Bone Marrow Transplantation · doi:10.1038/bmt.2016.94 · Cited by 32 · see citing works
Allogeneic Stem Cell Transplantation in Multiple Myeloma
Greil, C., Engelhardt, M. M., Finke, J., & Wäsch, R. (2021) · Cancers · doi:10.3390/cancers14010055 · Cited by 31 · see citing works
Brayer, J. B., & Baz, R. (2017) · Therapeutic Advances in Hematology · doi:10.1177/2040620717710171 · Cited by 30 · see citing works
Blommestein, H. M., van Beurden-Tan, C. H. Y., Franken, M. G., Groot, C. A. U., Sonneveld, P., & Zweegman, S. (2019) · Haematologica · doi:10.3324/haematol.2018.206912 · Cited by 30 · see citing works
Dadacaridou, M., Papanicolaou, X., Maltesas, D., Megalakaki, C., Patos, P., Panteli, K. E., Repousis, P., & Mitsouli-Mentzikof, C. (2007) · PubMed · Cited by 30 · see citing works
Pönisch, W., Holzvogt, B., Plötze, M., Andrea, M., Bourgeois, M., Heyn, S., Zehrfeld, T., Hammerschmidt, D., Schwarz, M., Edelmann, T., et al. (2014) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1737-9 · Cited by 29 · see citing works
Trieu, Y., Trudel, S., Pond, G. R., Mikhael, J. R., Jaksic, W., Reece, D. E., Chen, C. I., & Stewart, A. K. (2005) · Mayo Clinic Proceedings · doi:10.4065/80.12.1578 · Cited by 29 · see citing works
Bendamustine in multiple myeloma
Gentile, M., Vigna, E., Recchia, A. G., Morabito, L., Mendicino, F., Giagnuolo, G., & Morabito, F. (2015) · European Journal Of Haematology · doi:10.1111/ejh.12609 · Cited by 28 · see citing works
Efficacy and Safety of Busulfan-Based Conditioning Regimens for Multiple Myeloma
Reece, D. E., Song, K., LeBlanc, R., Mezzi, K., Olujohungbe, A., White, D. J., Zaman, F., & Belch, A. R. (2013) · The Oncologist · doi:10.1634/theoncologist.2012-0384 · Cited by 27 · see citing works
Melphalan dose intensity for autologous stem cell transplantation in multiple myeloma
Srour, S. A., Milton, D. R., Bashir, Q., Nieto, Y. L., Saini, N. Y., Daher, M., Ramdial, J., Im, J. S., Hosing, C. M., Delgado, R., et al. (2021) · Haematologica · doi:10.3324/haematol.2021.279179 · Cited by 27 · see citing works
Wang, L., Xiang, H., Yan, Y., Deng, Z., Li, H., Li, X., & Liu, J. (2021) · Annals of Hematology · doi:10.1007/s00277-020-04376-w · Cited by 26 · see citing works
Mateos, M., Oriol, A., Rosiñol, L., de Arriba, F., Puig, N., Martín, J., Martínez‐López, J., Echeveste, M. A., Sarrá, J., Ocio, E. M., et al. (2015) · Haematologica · doi:10.3324/haematol.2015.124818 · Cited by 25 · see citing works
Yong, K., Wilson, W., Tute, R. M. D., Camilleri, M., Ramasamy, K., Streetly, M. J., Sive, J. I., Bygrave, C., Benjamin, R., Chapman, M., et al. (2022) · The Lancet Haematology · doi:10.1016/s2352-3026(22)00350-7 · Cited by 25 · see citing works
Kazmi, S. M. A., Saliba, R. M., Donato, M. L., Wang, M., Hosing, C. M., Qureshi, S. R., Anderlini, P. N., Popat, U., Champlin, R. E., Giralt, S. A., et al. (2010) · Bone Marrow Transplantation · doi:10.1038/bmt.2010.160 · Cited by 25 · see citing works
A historical perspective on milestones in multiple myeloma research
Ribatti, D. (2017) · European Journal Of Haematology · doi:10.1111/ejh.13003 · Cited by 24 · see citing works
Maziarz, R. T., Diaz, A. H., Miklos, D. B., & Shah, N. N. (2022) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2022.08.002 · Cited by 24 · see citing works
Roussel, M., Lauwers‐Cancès, V., Macro, M., Leleu, X. P., Royer, B., Hulin, C., Karlin, L., Perrot, A., Touzeau, C., Chrétien, M., et al. (2022) · Blood · doi:10.1182/blood.2021014635 · Cited by 24 · see citing works
Gomez-Arteaga, A., Mark, T. M., Guarneri, D., Christos, P. J., Gergis, U. S., Greenberg, J., Hsu, J., Mayer, S. A., Niesvizky, R., Pearse, R. N., et al. (2019) · Bone Marrow Transplantation · doi:10.1038/s41409-019-0587-0 · Cited by 23 · see citing works
Kumar, S. K., Grząśko, N., Delimpasi, S., Wiktor-Jędrzejczak, W., Grosicki, S., Kyrtsonis, M., Spencer, A. G., Gupta, N., Teng, Z., Byrne, C., et al. (2018) · British Journal of Haematology · doi:10.1111/bjh.15679 · Cited by 23 · see citing works
Kumar, S. K., Krishnan, A. Y., LaPlant, B. R., Laumann, K. M., Roy, V., Zimmerman, T. M., Gertz, M. A., Buadi, F. K., Stockerl-Goldstein, K. E., Birgin, A., et al. (2015) · American Journal of Hematology · doi:10.1002/ajh.24181 · Cited by 22 · see citing works
Gourzonès, C., Bret, C., & Moreaux, J. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00861 · Cited by 21 · see citing works
Current and Novel Alkylators in Multiple Myeloma
Schjesvold, F. H., & Oriol, A. (2021) · Cancers · doi:10.3390/cancers13102465 · Cited by 21 · see citing works
Waal, E. G. M. D., de Munck, L., Hoogendoorn, M., Woolthuis, G., van der Velden, A. W. G., Tromp, Y., Vellenga, E., & Hovenga, S. (2015) · British Journal of Haematology · doi:10.1111/bjh.13653 · Cited by 20 · see citing works
Schey, S., Brown, S., Tillotson, A., Yong, K., Williams, C. D., Davies, F. E., Morgan, G. J., Cavenagh, J. D., Cook, G., Cook, M. A., et al. (2015) · British Journal of Haematology · doi:10.1111/bjh.13435 · Cited by 20 · see citing works
Mey, U., Brugger, W., Schwarb, H., Pederiva, S., Schwarzer, A., Dechow, T. N., Jehner, P., Rauh, J., Taverna, C., Schmid, M., et al. (2016) · British Journal of Haematology · doi:10.1111/bjh.14481 · Cited by 20 · see citing works
Kropff, M. H., Vogel, M., Bisping, G., Schlag, R., Weide, R., Knauf, W. U., Fiechtner, H., Kojouharoff, G., Kremers, S., & Berdel, W. E. (2017) · Annals of Hematology · doi:10.1007/s00277-017-3065-z · Cited by 20 · see citing works
Madduri, D., Dhodapkar, M. V., Lonial, S., Jagannath, S., & Cho, H. J. (2019) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2019.08.002 · Cited by 20 · see citing works
Gramegna, D., Bertoli, D., Cattaneo, C. M., Almici, C., Re, A., Belotti, A., Borlenghi, E., Lanzi, G., Archetti, S., Verardi, R., et al. (2022) · Annals of Hematology · doi:10.1007/s00277-022-04806-x · Cited by 20 · see citing works
Miguel, J. F. S., Gutierrez, M. A. E., Špıčka, I., Mateos, M., Song, K., Craig, M., Bladé, J., Hájek, R., Chen, C. I., Bacco, A. D., et al. (2018) · Haematologica · doi:10.3324/haematol.2017.185991 · Cited by 19 · see citing works
Stem cell mutations can be detected in myeloma patients years before onset of secondary leukemias
Sridharan, A., Schinke, C., Georgiev, G. I., Ferreira, M. D. S., Thiruthuvanathan, V. J., MacArthur, I. C., Bhagat, T. D., Choudhary, G. S., Aluri, S., Chen, J., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000731 · Cited by 19 · see citing works
Veeraputhiran, M. K., Jain, T., Deol, A., Ayash, L. J., Kim, S., Dyson, G. E., Bhutani, D., Lum, L. G., Ratanatharathorn, V., Uberti, J. P., et al. (2015) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2015.05.008 · Cited by 19 · see citing works
Sivaraj, D., Bacon, W., Long, G. D., Rizzieri, D. A., Horwitz, M. E., Sullivan, K. M., Kang, Y., Li, Z., Chao, N. J. A., & Gasparetto, C. (2017) · Bone Marrow Transplantation · doi:10.1038/bmt.2017.208 · Cited by 19 · see citing works
Larocca, A., Mina, R., Offidani, M., Liberati, A. M., Ledda, A., Patriarca, F. F., Evangelista, A., Spada, S., Benevolo, G., Oddolo, D., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.220657 · Cited by 18 · see citing works
Flagged first, then by citations
1 of the 256 references couldn’t be matched to a known paper.
Cited by
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Multiple myeloma: signaling pathways and targeted therapy
Lu, Q., Yang, D., Li, H., Niu, T., & Tong, A. (2024) · Molecular biomedicine · doi:10.1186/s43556-024-00188-w · Cited by 90 · see citing works
Romagnani, P., Tang, S. C. W., Weins, A., Huber, T. B., Osafo, C., & Anders, H. (2025) · Nature Reviews Disease Primers · doi:10.1038/s41572-025-00671-w · Cited by 27 · see citing works
Role of Immune Cells and Immunotherapy in Multiple Myeloma
Radhakrishnan, V., Golla, U., & Kudva, A. K. (2024) · Life · doi:10.3390/life14040461 · Cited by 18 · see citing works
Dual-targeted NAMPT inhibitors as a progressive strategy for cancer therapy
Özgencil, F., Gunindi, H. B., & Eren, G. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107509 · Cited by 15 · see citing works
CAR T‐Cell Therapy for Multiple Myeloma: A Clinical Practice‐Oriented Review
Sadek, N. L., Costa, B. A., Nath, K., & Mailankody, S. (2023) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3057 · Cited by 13 · see citing works
Self-citationBanchi, M., Cox, M. C., & Bocci, G. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216900 · Cited by 10 · see citing works
Hu, S., Xu, J., Cui, W., Jin, H.-R., Wang, X., & Maimaitiyiming, Y. (2025) · Biomolecules · doi:10.3390/biom15050702 · Cited by 9 · see citing works
Talarico, M., Barbato, S., Maisnar, V., Delimpasi, S., Puppi, M., Rizzello, I., Pantani, L., Tacchetti, P., Martello, M., Vigliotta, I., et al. (2025) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-025-06326-3 · Cited by 4 · see citing works
Li, Q., Ma, C., Zuo, L., Xu, A., Zhang, B., Zhao, F., Liu, L., Zhao, X., Hu, Y., & Sun, C. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07065-2 · Cited by 2 · see citing works
Azadbeigi, P., Moosavinejad, N., & Rassouli, F. B. (2025) · OncoTargets and Therapy · doi:10.2147/ott.s546061 · Cited by 1 · see citing works
Research Progress on Anti-tumor Mechanism of Artesunate Combined Drugs
Shi, M., & Yang, X. (2024) · Academic Journal of Science and Technology · doi:10.54097/jhbxr864 · Cited by 1 · see citing works
Cracchiolo, M. J., Davis, L. E., Matiatos, A. P., Davini, D. W., Husnain, M., Simpson, R. J., Voudouris, V., & Katsanis, E. (2024) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-024-04688-y · Cited by 1 · see citing works
Melphalan improves toxicity of arsenic trioxide in adult T-cell leukemia/lymphoma cells
Khodadadi, F., Sadeghian, M. H., Delbari, Z., Kazemi, M., Koohpaykar, H., & Rassouli, F. B. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102109 · Cited by 1 · see citing works
Wagner, C. B., Julian, K. L., Bryan, B., Steinbach, M. N., Shewan, S., Maxwell, L., Vigil, M., Mohyuddin, G. R., Godara, A., McClune, B. L., et al. (2024) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2024.2350670
Anticancer Drug Utilization and Prescription Practices in a Saudi Cancer Center (2014-2022)
Badheeb, A. M., Munjem, M. F. A., Ahmed, F., Aljedaani, H., Assiri, N., Abdulaziz, A., Abubakar, A., AlQurayshah, M., & Badheeb, M. A. (2025) · F1000Research · doi:10.12688/f1000research.147910.2
Hu, C., Chen, W., Zhang, P., Shen, T., & Zhao, Y. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1696768
Tian, Y., Su, L., Li, Y., Ye, M., Zhang, Y., Li, Q. Q., Jiao, Y., & Wu, J. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1770120
Periplocin targets STAT3 to suppress MYC expression and inhibit multiple myeloma cell proliferation
Wei, R.-F., Chen, J., Lai, S.-P., Chen, Z.-A., Zhou, Y.-Y., Liao, Y.-P., & Chen, Y. (2026) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2026.07.002
Akrawi, D., Datta, S., Hatipoğlu, S., Wechalekar, A. D., Ghose, A., Alkhateeb, A., Walker, J. M., & Ghosh, A. K. (2026) · Current Cardiology Reports · doi:10.1007/s11886-026-02397-x
- Authors
- Costa, B. A., Mouhieddine, T. H., Ortiz, R. J., & Richter, J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Tisch Cancer Institute (US)
- Corresponding author
- Richter, Joshua
- Venue
- Critical Reviews in Oncology/Hematology
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 187
- Pages
- 104040
- ISSN
- 1040-8428 (ISSN-L)
- OpenAlex
- W4378212210
- Cited by
- 18
- References
- 256
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 6 · 2023: 1
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Critical Reviews in Oncology/Hematology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Keywords
- alkylating agents, multiple myeloma, melphalan, cyclophosphamide, bendamustine, melflufen, lymphocyte depletion, CAR T-cell therapy, second primary malignancy, relapsed/refractory multiple myeloma, stem cell mobilization, pre-transplant conditioning, consolidation therapy, bridging therapy
- MeSH terms
- Bendamustine Hydrochloride, Receptors, Chimeric Antigen, Alkylating Agents, Cyclophosphamide, Humans, Multiple Myeloma
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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