Dynamic expedition of leading mutations in SARS-CoV-2 spike glycoproteins
Open accessPublished version of a preprint
Abstract
The continuous evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused the recent pandemic, has generated countless new variants with varying fitness. Mutations of the spike glycoprotein play a particularly vital role in shaping its evolutionary trajectory, as they have the capability to alter its infectivity and antigenicity. We present a time-resolved statistical method, Dynamic Expedition of Leading Mutations (deLemus), to analyze the evolutionary dynamics of the SARS-CoV-2 spike glycoprotein. The proposed L -index of the deLemus method is effective in quantifying the mutation strength of each amino acid site and outlining evolutionarily significant sites, allowing the comprehensive characterization of the evolutionary mutation pattern of the spike glycoprotein.
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Flagged first, then by citations
- Authors
- Hasan, M., He, Z., Jia, M., Leung, A. C. F., Natarajan, K., Xu, W., Yap, S., Zhou, F., Chen, S., Su, H., Zhu, K., & Su, H.
- Affiliations
- Hong Kong University of Science and Technology (HK)
- Rajiv Gandhi Centre for Biotechnology (IN)
- Corresponding author
- Su, Hailei
- Zhu, Kaicheng
- Su, Haibin
- ORCID
- Venue
- Computational and Structural Biotechnology Journal
- Published
- 2024-05-30
- Volume
- 23
- Pages
- 2407-2417
- ISSN
- 2001-0370 (ISSN-L)
- PMC
- PMC11176665
- OpenAlex
- W4398765285
- Cited by
- 3
- References
- 15
- Citations by year
- 2026: 2 · 2025: 1
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Computational and Structural Biotechnology Journal (publishedVersion, cc-by-nc-nd)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- Hong Kong University of Science and Technology (R9418)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- SARS-CoV-2, spike protein, viral evolution, L-index, viral variants
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