Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials
Open accessAbstract
Objectives Clinical evidence suggests the beneficial effects of Berberine (BER) on inflammatory markers. However, these results are controversial. The aim of this systematic review was to assess the effects of BER on C-reactive protein (CRP) using clinical trials in adults.Design Systematic review and meta-analysis.Main outcome measures We searched randomized controlled trials in PubMed and Scopus up to November 2018. The mean differences (MD) and confidence interval (CI) of CRP (mg/L) concentrations were pooled with a random- or a fixed-effects model depending on the results of heterogeneity tests.Results Of 1242 studies identified, 5 were included in the meta-analysis. Pooled analysis showed that serum levels of CRP were decreased after BER supplementation (MD:-0.64 mg/L, 95% CI(-0.67 to -0.61) P < 0.001)) without any significant heterogeneity (I 2 = 0.0% and P = 0.984).Conclusion This meta-analysis showed BER supplementation may ameliorate the state of chronic inflammation. Patients with cardiovascular disease and diabetes are two important groups which may benefit from BER supplementation. Further well-designed investigations with larger samples are needed to ascertain the long-term effects of BER on chronic inflammation.
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Berberine is a chronic inflammation regulator.
“Berberine has been demonstrated as a chronic inflammation regulator as well [73].”
From The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials (2021) · cites this paper as [73]
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- Authors
- Beba, M., Djafarian, K., & Shab-Bidar, S.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Venue
- Complementary Therapies in Medicine
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 46
- Pages
- 81-86
- ISSN
- 0965-2299 (ISSN-L)
- OpenAlex
- W2966679311
- Cited by
- 15
- References
- 38
- Citations by year
- 2025: 2 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 1
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Complementary Therapies in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Deakin Research Online (Deakin University)
- Topics
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
- Keywords
- berberine, C-reactive protein, chronic inflammation, anti-inflammatory activity, cardiovascular disease, diabetes mellitus
- MeSH terms
- Berberine, C-Reactive Protein, Humans, Inflammation, Biomarkers, Randomized Controlled Trials as Topic, Dietary Supplements
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