Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention
Abstract
Summary: 1. Inflammation is central to the pathogenesis of acute coronary syndrome (ACS) and is associated with adverse clinical outcomes after percutaneous coronary intervention (PCI). Recent in vitro work has demonstrated the anti‐inflammatory effect of berberine, a primary component of the traditional C hinese medicine ‘umbellatine’. In the present study, we further tested whether berberine had any beneficial effects on ACS patients following PCI. 2.In all, 130 ACS patients undergoing PCI were recruited to the present study. Sixty‐one patients were treated with berberine (300 mg, t.i.d., for 30 days) in addition to standard therapy, whereas the remaining patients received standard therapy alone. Circulating inflammatory markers were measured by ELISA, whereas serum lipid profiles were measured by routine chemical assays. 3.In the berberine‐treated group, matrix metalloproteinase (MMP)‐9, intercellular adhesion molecule (ICAM)‐1, vascular cell adhesion molecule (VCAM)‐1, C‐reactive protein, interleukin‐6 and monocyte chemoattractant protein‐1 were significantly reduced relative to baseline values. Furthermore, the changes in MMP‐9, ICAM‐1 and VCAM‐1 from baseline to after 1 month of treatment differed significantly between the two patient groups. There was a tendency for berberine to induce a slightly greater reduction in low‐density lipoprotein cholesterol and triglycerides than standard therapy alone, without affecting high‐density lipoprotein cholesterol, but the differences failed to reach statistical significance. No severe adverse effects of berberine were observed. 4.The results of the present study provide the first clinical evidence of the anti‐inflammatory action of berberine in ACS patients following PCI. Berberine may become adjunct therapy to further improve clinical outcomes via its anti‐inflammatory effect in ACS patients.
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In patients undergoing percutaneous coronary intervention, berberine 600 mg/day versus placebo shows a marked reduction in TG (26% vs 13%, not significant) and LDL-C (24% vs 17%, p < 0.001).
“The BBR group showed a marked reduction in TG (26% BBR vs. 13% control: the difference did not reach statistical significance due to large inter-individual variations) and LDL-C (24% vs. 17% BBR control: p < 0.001) compared to the control group.”
From Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels? (2021) · cites this paper as [63]
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- Authors
- Meng, S., Wang, L., Huang, Z., Zhou, Q., Sun, Y., Cao, J., Li, Y., & Wang, C.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Departments of Laboratory Medicine
- Department of Cardiology The First Affiliated Hospital Wenzhou Medical College Wenzhou China
- Department of Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
- Departments of Cardiology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai
- Venue
- Clinical and Experimental Pharmacology and Physiology
- Publisher
- Wiley
- Published
- 2012-04-23
- Volume
- 39
- Issue
- 5
- Pages
- 406-411
- ISSN
- 0305-1870 (ISSN-L)
- 1440-1681
- OpenAlex
- W2137843059
- Cited by
- 99
- References
- 46
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 13 · 2020: 9 · 2019: 8 · 2018: 5 · 2017: 10 · 2016: 6 · 2015: 5 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical and Experimental Pharmacology and Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
- Keywords
- berberine, acute coronary syndrome, percutaneous coronary intervention, inflammation, anti-inflammatory activity, MMP-9, ICAM-1, VCAM-1, C-reactive protein, interleukin-6, MCP-1, serum lipids, LDL cholesterol, triglycerides, adjunctive therapy
- MeSH terms
- Aged, Anti-Inflammatory Agents, Non-Steroidal, Berberine, Female, Follow-Up Studies, Humans, Inflammation, Male, Middle Aged, Cohort Studies, Angioplasty, Balloon, Coronary, Inflammation Mediators, Vascular Cell Adhesion Molecule-1, Matrix Metalloproteinase 9, Acute Coronary Syndrome
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