The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Cancer stem cell in breast cancer therapeutic resistance
Abstract
Development of therapeutic resistance and metastasis is a major challenge with current breast cancer (BC) therapy. Mounting evidence suggests that a subpopulation of cancer stem cells (CSCs) contribute to the cancer therapeutic resistance and metastasis, leading to the recurrence and death in patients. Breast cancer stem cells (BCSCs) are not only a consequence of mutations that overactivate the self-renewal ability of normal stem cells or committed progenitors but also a result of the de-differentiation of cancer cells induced by somatic mutations or microenvironmental components under treatment. Eradication of BCSCs may bring hope and relief to patients whose lives are threatened by recurrent BCs. Therefore, a better understanding of the generation, regulatory mechanisms, and identification of CSCs in BC therapeutic resistance and metastasis will be imperative for developing BCSC-targeted strategies. Here we summarize the latest studies about cell surface markers and signalling pathways that sustain the stemness of BCSC and discuss the associations of mechanisms behind these traits with phenotype and behavior changes in BCSCs. More importantly, their implications for future study are also evaluated and potential BCSC-targeted strategies are proposed to break through the limitation of current therapies.
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Cites
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Association of reactive oxygen species levels and radioresistance in cancer stem cells
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Cited by
Targeted Cancer Stem Cell Therapeutics: An Update
Fatima, N., Umar, M., Ambreen, S., Shaququzzaman, M., Alam, M. M., & Ali, R. (2025) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266275014240110071351 · Cited by 6
Metadata
- Authors
- Bai, X., Ni, J., Beretov, J., Graham, P., & Li, Y.
- Venue
- Cancer Treatment Reviews
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 69
- Pages
- 152-163
- ISSN
- 0305-7372 (ISSN-L)
- OpenAlex
- W2884390993
- Cited by
- 328
- References
- 98
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bai, X., Ni, J., Beretov, J., Graham, P., & Li, Y. (2018). Cancer stem cell in breast cancer therapeutic resistance. Cancer Treatment Reviews. https://doi.org/10.1016/j.ctrv.2018.07.004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
