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Cancer stem cell in breast cancer therapeutic resistance

Bai, Xupeng, Ni, Jie, Beretov, Julia, Graham, Peter, Li, Yong·2018·Cancer Treatment Reviews

DOI 10.1016/j.ctrv.2018.07.004

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Abstract

Development of therapeutic resistance and metastasis is a major challenge with current breast cancer (BC) therapy. Mounting evidence suggests that a subpopulation of cancer stem cells (CSCs) contribute to the cancer therapeutic resistance and metastasis, leading to the recurrence and death in patients. Breast cancer stem cells (BCSCs) are not only a consequence of mutations that overactivate the self-renewal ability of normal stem cells or committed progenitors but also a result of the de-differentiation of cancer cells induced by somatic mutations or microenvironmental components under treatment. Eradication of BCSCs may bring hope and relief to patients whose lives are threatened by recurrent BCs. Therefore, a better understanding of the generation, regulatory mechanisms, and identification of CSCs in BC therapeutic resistance and metastasis will be imperative for developing BCSC-targeted strategies. Here we summarize the latest studies about cell surface markers and signalling pathways that sustain the stemness of BCSC and discuss the associations of mechanisms behind these traits with phenotype and behavior changes in BCSCs. More importantly, their implications for future study are also evaluated and potential BCSC-targeted strategies are proposed to break through the limitation of current therapies.

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Cancer Statistics, 2017.
Siegel, R. L., Miller, K. D., & Jemal, A. (2017) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21387 · Cited by 14,712
Prospective identification of tumorigenic breast cancer cells
Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,370
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Bonnet, D., & Dick, J. E. (1997) · Nature Medicine · doi:10.1038/nm0797-730 · Cited by 5,864
Involvement of chemokine receptors in breast cancer metastasis
Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340
Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials
(2005) · The Lancet · doi:10.1016/s0140-6736(05)67887-7 · Cited by 5,127
ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome
Ginestier, C., Hur, M. H., Charafe-Jauffret, E., Monville, F., Dutcher, J., Brown, M., Jacquemier, J., Viens, P., Kleer, C. G., Liu, S., et al. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.014 · Cited by 4,012
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
Polyak, K., & Weinberg, R. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2620 · Cited by 3,302
Cancer Stem Cells—Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells
Clarke, M. F., Dick, J. E., Dirks, P. B., Eaves, C. J., Jamieson, C. H. M., Jones, D. L., Visvader, J., Weissman, I. L., & Wahl, G. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-3126 · Cited by 3,051
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555
Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
Gupta, P. B., Onder, T. T., Jiang, G., Tao, K., Kuperwasser, C., Weinberg, R. A., & Lander, E. S. (2009) · Cell · doi:10.1016/j.cell.2009.06.034 · Cited by 2,389
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
kConFab, Lim, E., Vaillant, F., Wu, D., Forrest, N. C., Pal, B., Hart, A. H., Asselin-Labat, M.-L., Gyorki, D. E., Ward, T., et al. (2009) · Nature Medicine · doi:10.1038/nm.2000 · Cited by 1,492
Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., Yamamoto, M., & Motohashi, H. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.016 · Cited by 1,395
Molecular Definition of Breast Tumor Heterogeneity
Shipitsin, M., Campbell, L. L., Argani, P., Weremowicz, S., Bloushtain-Qimron, N., Yao, J., Nikolskaya, T., Serebryiskaya, T., Beroukhim, R., Hu, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.013 · Cited by 1,353
The Response of CD24 −/low /CD44 + Breast Cancer–Initiating Cells to Radiation
Phillips, T. M., McBride, W. H., & Pajonk, F. (2006) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djj495 · Cited by 1,309
Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty
Magee, J. A., Piskounova, E., & Morrison, S. J. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.03.003 · Cited by 1,101
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
Baccelli, I., Schneeweiss, A., Riethdorf, S., Stenzinger, A., Schillert, A., Vogel, V., Klein, C., Saini, M., Bäuerle, T., Wallwiener, M., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2576 · Cited by 1,047
The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells
Liu, R., Wang, X., Chen, G. Y., Dalerba, P., Gurney, A., Hoey, T., Sherlock, G., Lewicki, J., Shedden, K., & Clarke, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063994 · Cited by 985
Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content
Pece, S., Tosoni, D., Confalonieri, S., Mazzarol, G., Vecchi, M., Ronzoni, S., Bernard, L., Viale, G., Pelicci, P. G., & Di Fiore, P. P. (2010) · Cell · doi:10.1016/j.cell.2009.12.007 · Cited by 947
NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations
Serra, V., Markman, B., Scaltriti, M., Eichhorn, P. J. A., Valero, V., Guzman, M., Botero, M. L., Llonch, E., Atzori, F., Di Cosimo, S., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1385 · Cited by 787
The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells
Cicalese, A., Bonizzi, G., Pasi, C. E., Faretta, M., Ronzoni, S., Giulini, B., Brisken, C., Minucci, S., Di Fiore, P. P., & Pelicci, P. G. (2009) · Cell · doi:10.1016/j.cell.2009.06.048 · Cited by 696
Most Early Disseminated Cancer Cells Detected in Bone Marrow of Breast Cancer Patients Have a Putative Breast Cancer Stem Cell Phenotype
Balic, M., Lin, H., Young, L., Hawes, D., Giuliano, A., McNamara, G., Datar, R. H., & Cote, R. J. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0169 · Cited by 681
Brca1 breast tumors contain distinct CD44+/CD24- and CD133+cells with cancer stem cell characteristics
Wright, M. H., Calcagno, A. M., Salcido, C. D., Carlson, M. D., Ambudkar, S. V., & Varticovski, L. (2008) · Breast Cancer Research · doi:10.1186/bcr1855 · Cited by 642
Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype
Ricardo, S., Vieira, A. F., Gerhard, R., Leitão, D., Pinto, R., Cameselle-Teijeiro, J. F., Milanezi, F., Schmitt, F., & Paredes, J. (2011) · Journal of Clinical Pathology · doi:10.1136/jcp.2011.090456 · Cited by 619
Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells
Li, Y., Zhang, T., Korkaya, H., Liu, S., Lee, H.-F., Newman, B., Yu, Y., Clouthier, S. G., Schwartz, S. J., Wicha, M. S., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2937 · Cited by 559
Self-citation
High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability
Croker, A. K., Goodale, D., Chu, J., Postenka, C., Hedley, B. D., Hess, D. A., & Allan, A. L. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00455.x · Cited by 525
Sox2 expression in breast tumours and activation in breast cancer stem cells
Leis, O., Eguiara, A., Lopez-Arribillaga, E., Alberdi, M. J., Hernandez-Garcia, S., Elorriaga, K., Pandiella, A., Rezola, R., & Martin, A. G. (2012) · Oncogene · doi:10.1038/onc.2011.338 · Cited by 514
Interstitial flow influences direction of tumor cell migration through competing mechanisms
Polacheck, W. J., Charest, J. L., & Kamm, R. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103581108 · Cited by 509
Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis
Marcato, P., Dean, C. A., Pan, D., Araslanova, R., Gillis, M., Joshi, M., Helyer, L., Pan, L., Leidal, A., Gujar, S., et al. (2011) · Stem Cells · doi:10.1002/stem.563 · Cited by 483
Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models
Liu, H., Patel, M. R., Prescher, J. A., Patsialou, A., Qian, D., Lin, J., Wen, S., Chang, Y.-F., Bachmann, M. H., Shimono, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006732107 · Cited by 465
Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression
Godar, S., Ince, T. A., Bell, G. W., Feldser, D., Donaher, J. L., Bergh, J., Liu, A., Miu, K., Watnick, R. S., Reinhardt, F., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.006 · Cited by 456
Acquisition of epithelial–mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance
Chang, L., Graham, P. H., Hao, J., Ni, J., Bucci, J., Cozzi, P. J., Kearsley, J. H., & Li, Y. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.407 · Cited by 377
Self-citation
Blockade of A 2A receptors potently suppresses the metastasis of CD73 + tumors
Beavis, P. A., Divisekera, U., Paget, C., Chow, M. T., John, L. B., Devaud, C., Dwyer, K., Stagg, J., Smyth, M. J., & Darcy, P. K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308209110 · Cited by 345
Identification of multipotent mammary stem cells by protein C receptor expression
Wang, D., Cai, C., Dong, X., Yu, Q. C., Zhang, X.-O., Yang, L., & Zeng, Y. A. (2015) · Nature · doi:10.1038/nature13851 · Cited by 341
Hyaluronan Oligosaccharides Inhibit Anchorage-independent Growth of Tumor Cells by Suppressing the Phosphoinositide 3-Kinase/Akt Cell Survival Pathway
Ghatak, S., Misra, S., & Toole, B. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202404200 · Cited by 332
β1 Integrin Inhibitory Antibody Induces Apoptosis of Breast Cancer Cells, Inhibits Growth, and Distinguishes Malignant from Normal Phenotype in Three Dimensional Cultures and In vivo
Park, C. C., Zhang, H., Pallavicini, M., Gray, J. W., Baehner, F., Park, C. J., & Bissell, M. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3071 · Cited by 326
Hyaluronan-CD44 Interaction with Protein Kinase Cϵ Promotes Oncogenic Signaling by the Stem Cell Marker Nanog and the Production of MicroRNA-21, Leading to Down-regulation of the Tumor Suppressor Protein PDCD4, Anti-apoptosis, and Chemotherapy Resistance in Breast Tumor Cells
Bourguignon, L. Y. W., Spevak, C. C., Wong, G., Xia, W., & Gilad, E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.027466 · Cited by 316
The Mammary Progenitor Marker CD61/β3 Integrin Identifies Cancer Stem Cells in Mouse Models of Mammary Tumorigenesis
Vaillant, F., Asselin-Labat, M.-L., Shackleton, M., Forrest, N. C., Lindeman, G. J., & Visvader, J. E. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1949 · Cited by 314
Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis
Battula, V. L., Shi, Y., Evans, K. W., Wang, R.-Y., Spaeth, E. L., Jacamo, R. O., Guerra, R., Sahin, A. A., Marini, F. C., Hortobagyi, G., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59735 · Cited by 302
The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
Liu, B. Y., McDermott, S. P., Khwaja, S. S., & Alexander, C. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400699101 · Cited by 293
Epithelial-to-mesenchymal transition leads to loss of EpCAM and different physical properties in circulating tumor cells from metastatic breast cancer
Hyun, K.-A., Koo, G.-B., Han, H., Sohn, J., Choi, W., Kim, S.-I., Jung, H.-I., & Kim, Y.-S. (2016) · Oncotarget · doi:10.18632/oncotarget.8250 · Cited by 274
CD133+ cells with cancer stem cell characteristics associates with vasculogenic mimicry in triple-negative breast cancer
Liu, T. J., Sun, B. C., Zhao, X. L., Zhao, X. M., Sun, T., Gu, Q., Yao, Z., Dong, X. Y., Zhao, N., & Liu, N. (2013) · Oncogene · doi:10.1038/onc.2012.85 · Cited by 269
RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule
Shigdar, S., Lin, J., Yu, Y., Pastuovic, M., Wei, M., & Duan, W. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.01897.x · Cited by 240
Multiple Lineages of Human Breast Cancer Stem/Progenitor Cells Identified by Profiling with Stem Cell Markers
Hwang-Verslues, W. W., Kuo, W.-H., Chang, P.-H., Pan, C.-C., Wang, H.-H., Tsai, S.-T., Jeng, Y.-M., Shew, J.-Y., Kung, J. T., Chen, C.-H., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008377 · Cited by 223
Reduced miR-128 in Breast Tumor–Initiating Cells Induces Chemotherapeutic Resistance via Bmi-1 and ABCC5
Zhu, Y., Yu, F., Jiao, Y., Feng, J., Tang, W., Yao, H., Gong, C., Chen, J., Su, F., Zhang, Y., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0071 · Cited by 221
Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer
Schwab, L. P., Peacock, D. L., Majumdar, D., Ingels, J. F., Jensen, L. C., Smith, K. D., Cushing, R. C., & Seagroves, T. N. (2012) · Breast Cancer Research · doi:10.1186/bcr3087 · Cited by 220
Retinoid signaling regulates breast cancer stem cell differentiation
Ginestier, C., Wicinski, J., Cervera, N., Monville, F., Finetti, P., Bertucci, F., Wicha, M. S., Birnbaum, D., & Charafe-Jauffret, E. (2009) · Cell Cycle · doi:10.4161/cc.8.20.9761 · Cited by 217
Alpha‐6 integrin is necessary for the tumourigenicity of a stem cell‐like subpopulation within the MCF7 breast cancer cell line
Cariati, M., Naderi, A., Brown, J. P., Smalley, M. J., Pinder, S. E., Caldas, C., & Purushotham, A. D. (2008) · International Journal of Cancer · doi:10.1002/ijc.23103 · Cited by 214
Hyaluronan-CD44 Interaction Promotes c-Src-mediated Twist Signaling, MicroRNA-10b Expression, and RhoA/RhoC Up-regulation, Leading to Rho-kinase-associated Cytoskeleton Activation and Breast Tumor Cell Invasion
Bourguignon, L. Y. W., Wong, G., Earle, C., Krueger, K., & Spevak, C. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.162305 · Cited by 213
Anti-CD73 in Cancer Immunotherapy: Awakening New Opportunities
Antonioli, L., Yegutkin, G. G., Pacher, P., Blandizzi, C., & Haskó, G. (2016) · Trends in Cancer · doi:10.1016/j.trecan.2016.01.003 · Cited by 213
Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells
Luker, K. E., Lewin, S. A., Mihalko, L. A., Schmidt, B. T., Winkler, J. S., Coggins, N. L., Thomas, D. G., & Luker, G. D. (2012) · Oncogene · doi:10.1038/onc.2011.633 · Cited by 198
CD133-targeted paclitaxel delivery inhibits local tumor recurrence in a mouse model of breast cancer
Swaminathan, S. K., Roger, E., Toti, U., Niu, L., Ohlfest, J. R., & Panyam, J. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.07.014 · Cited by 196
CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel
Muntimadugu, E., Kumar, R., Saladi, S., Rafeeqi, T. A., & Khan, W. (2016) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2016.03.075 · Cited by 181
CD44posCD49fhiCD133/2hi Defines Xenograft-Initiating Cells in Estrogen Receptor–Negative Breast Cancer
Meyer, M. J., Fleming, J. M., Lin, A. F., Hussnain, S. A., Ginsburg, E., & Vonderhaar, B. K. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3619 · Cited by 180
Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer
Sansone, P., Ceccarelli, C., Berishaj, M., Chang, Q., Rajasekhar, V. K., Perna, F., Bowman, R. L., Vidone, M., Daly, L., Nnoli, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms10442 · Cited by 176
RNA aptamers targeting cancer stem cell marker CD133
Shigdar, S., Qiao, L., Zhou, S.-F., Xiang, D., Wang, T., Li, Y., Lim, L. Y., Kong, L., Li, L., & Duan, W. (2013) · Cancer Letters · doi:10.1016/j.canlet.2012.11.032 · Cited by 174
Self-citation
Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors
Valenti, G., Quinn, H. M., Heynen, G. J. J. E., Lan, L., Holland, J. D., Vogel, R., Wulf-Goldenberg, A., & Birchmeier, W. (2017) · Cancer Research · doi:10.1158/0008-5472.can-15-3490 · Cited by 171
Breast Cancer — Loss of PTEN Predicts Resistance to Treatment
Pandolfi, P. P. (2004) · New England Journal of Medicine · doi:10.1056/nejmcibr043143 · Cited by 167
CD44 Acts Both as a Growth‐ and Invasiveness‐Promoting Molecule and as a Tumor‐Suppressing Cofactor
HERRLICH, P., MORRISON, H., SLEEMAN, J., ORIAN‐ROUSSEAU, V., KÖNIG, H., WEG‐REMERS, S., & PONTA, H. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06704.x · Cited by 166
Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters
Bai, X., Chen, Y., Hou, X., Huang, M., & Jin, J. (2016) · Drug Metabolism Reviews · doi:10.1080/03602532.2016.1197239 · Cited by 164
Self-citation
Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer
O'Toole, S. A., Machalek, D. A., Shearer, R. F., Millar, E. K. A., Nair, R., Schofield, P., McLeod, D., Cooper, C. L., McNeil, C. M., McFarland, A., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3738 · Cited by 163
CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin–TGFβ signaling
Lo, P.-K., Kanojia, D., Liu, X., Singh, U. P., Berger, F. G., Wang, Q., & Chen, H. (2012) · Oncogene · doi:10.1038/onc.2011.439 · Cited by 161
The clinicopathologic and prognostic significance of CD44+/CD24−/low and CD44−/CD24+ tumor cells in invasive breast carcinomas
Mylona, E. E., Giannopoulou, I., Fasomytakis, E., et al. (2008) · Human Pathology · doi:10.1016/j.humpath.2007.12.003 · Cited by 152
Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles
Sansone, P., Berishaj, M., Rajasekhar, V. K., Ceccarelli, C., Chang, Q., Strillacci, A., Savini, C., Shapiro, L., Bowman, R. L., Mastroleo, C., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2129 · Cited by 139
KRT19 directly interacts with β-catenin/RAC1 complex to regulate NUMB-dependent NOTCH signaling pathway and breast cancer properties
Saha, S. K., Choi, H., Kim, B.-W., Dayem, A. A., Yang, G.-M., Kim, K. S., Yin, Y. F., & Cho, S.-G. (2016) · Oncogene · doi:10.1038/onc.2016.221 · Cited by 136
ANTXR1, a Stem Cell-Enriched Functional Biomarker, Connects Collagen Signaling to Cancer Stem-like Cells and Metastasis in Breast Cancer
Chen, D., Bhat‐Nakshatri, P., Goswami, C. P., Badve, S., & Nakshatri, H. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1080 · Cited by 130
Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells
Yi, T., Zhai, B., Yu, Y., Yoshikawa, K., Raschle, T., Etzkorn, M., Seo, H., Nagiec, M. J., Luna, R. E., Reinherz, E. L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404943111 · Cited by 125
GD3 synthase regulates epithelial–mesenchymal transition and metastasis in breast cancer
Sarkar, T. R., Battula, V. L., Werden, S. J., Vijay, G. V., Ramirez‐Peña, E., Taube, J. H., Chang, J. T., Miura, N., Porter, W. W., Sphyris, N., et al. (2014) · Oncogene · doi:10.1038/onc.2014.245 · Cited by 121
Breast cancer stromal fibroblasts promote the generation of CD44+CD24- cells through SDF-1/CXCR4 interaction
Huang, M., Li, Y., Zhang, H., & Nan, F. (2010) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-29-80 · Cited by 116
Self-citation
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Saha, S., Mukherjee, S., Khan, P., Kajal, K., Mazumdar, M., Manna, A., Mukherjee, S., De, S., Jana, D., Sarkar, D. K., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1360 · Cited by 116
Targeting the PI3K/Akt/mTOR Pathway for Breast Cancer Therapy
Cidado, J. R., & Park, B. H. (2012) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-012-9264-2 · Cited by 108
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Wang, T., Gantier, M. P., Xiang, D., Bean, A. G. D., Bruce, M. P., Zhou, S., Khasraw, M., Ward, A. C., Wang, L., Wei, M. Q., et al. (2015) · Theranostics · doi:10.7150/thno.11692 · Cited by 107
Constitutive NOTCH3 Signaling Promotes the Growth of Basal Breast Cancers
Choy, L., Hagenbeek, T. J., Solon, M., French, D. M., Finkle, D., Shelton, A., Venook, R., Brauer, M. J., & Siebel, C. W. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-1022 · Cited by 106
Development of Mammary Tumors by Conditional Expression of GLI1
Fiaschi, M., Rozell, B., Bergström, Å., & Toftgård, R. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3938 · Cited by 103
Dual-targeting Wnt and uPA receptors using peptide conjugated ultra-small nanoparticle drug carriers inhibited cancer stem-cell phenotype in chemo-resistant breast cancer
Miller‐Kleinhenz, J. M., Guo, X., Qian, W., Zhou, H., Bozeman, E. N., Zhu, L., Ji, X., Wang, Y. A., Styblo, T. M., O'Regan, R. M., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.035 · Cited by 96
BMP4 Administration Induces Differentiation of CD133+ Hepatic Cancer Stem Cells, Blocking Their Contributions to Hepatocellular Carcinoma
Zhang, L., Sun, H., Zhao, F., Lü, P., Ge, C., Li, H., Hou, H., Yan, M., Chen, T., Jiang, G., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1013 · Cited by 95
Selective inhibition of breast cancer stem cells by gold nanorods mediated plasmonic hyperthermia
Xu, Y., Wang, J., Li, X., Liu, Y., Dai, L., Wu, X., & Chen, C. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.02.035 · Cited by 91
Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells
Vassilopoulos, A., Wang, R.-H., Petrovas, C., Ambrozak, D. R., Koup, R. A., & Deng, C. (2008) · International Journal of Biological Sciences · doi:10.7150/ijbs.4.133 · Cited by 79
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
Berenjeno, I. M., Piñeiro, R., Castillo, S. D., Pearce, W. P., McGranahan, N., Dewhurst, S. M., Méniel, V. S., Birkbak, N. J., Lau, E., Sansregret, L., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02002-4 · Cited by 78
Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells
Ryoo, I.-G., Choi, B.-H., & Kwak, M. (2015) · Oncotarget · doi:10.18632/oncotarget.3047 · Cited by 75
Host-Derived Tumor Endothelial Marker 8 Promotes the Growth of Melanoma
Cullen, M., Seaman, S., Chaudhary, A., Yang, M., Hilton, M. B., Logsdon, D. L., Haines, D. C., Tessarollo, L., & Croix, B. S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1086 · Cited by 74
Stage-specific embryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significant markers for breast cancer stem cells
Cheung, S. K. C., Chuang, P.-K., Huang, H.-W., Hwang‐Verslues, W. W., Cho, C. H.-H., Yang, W., Shen, C., Hsiao, M., Hsu, T.-L., Chang, C., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522602113 · Cited by 74
The patched polymorphism Pro1315Leu (C3944T) may modulate the association between use of oral contraceptives and breast cancer risk
Chang‐Claude, J., Dunning, A. M., Schnitzbauer, U., Galmbacher, P., Tee, L. J., Wjst, M., Chalmers, J., Zemzoum, I., Harbeck, N., Pharoah, P. D. P., et al. (2002) · International Journal of Cancer · doi:10.1002/ijc.10889 · Cited by 67
Endothelial Protein C Receptor Function in Murine and Human Breast Cancer Development
Schaffner, F., Yokota, N., Carneiro-Lobo, T., Kitano, M., Schäffer, M., Anderson, G. M., Mueller, B. M., Esmon, C. T., & Ruf, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061071 · Cited by 67
Biomarker and Pharmacologic Evaluation of the γ-Secretase Inhibitor PF-03084014 in Breast Cancer Models
Zhang, C. C., Pavlíček, A., Zhang, Q., Lira, M. E., Painter, C. L., Yan, Z., Zheng, X., Lee, N. V., Ozeck, M., Qiu, M., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1379 · Cited by 67
Enhanced efficacy of chemotherapy for breast cancer stem cells by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense
Sun, M., Yang, C., Zheng, J., Wang, M., Chen, M., Le, D. Q. S., Kjems, J., & Bünger, C. E. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.09.029 · Cited by 65
Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype
Liang, Y., Wang, C.-Y., Wang, I.-A., Chen, Y., Li, L.-T., Lin, C., Ho, M., Chou, T.-L., Wang, Y., Chiou, S.-P., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17665 · Cited by 64
Non-migratory tumorigenic intrinsic cancer stem cells ensure breast cancer metastasis by generation of CXCR4+ migrating cancer stem cells
Mukherjee, S., Manna, A., Bhattacharjee, P., Mazumdar, M., Saha, S., Chakraborty, S., Guha, D., Adhikary, A., Jana, D., Gorain, M., et al. (2016) · Oncogene · doi:10.1038/onc.2016.26 · Cited by 61
Dual PI3K and Wnt pathway inhibition is a synergistic combination against triple negative breast cancer
Solzak, J. P., Atale, R. V., Hancock, B. A., Sinn, A. L., Pollok, K. E., Jones, D. R., & Radovich, M. (2017) · npj Breast Cancer · doi:10.1038/s41523-017-0016-8 · Cited by 61
Epigenetic Silencing of TAP1 in Aldefluor+ Breast Cancer Stem Cells Contributes to Their Enhanced Immune Evasion
Sultan, M., Vidovic, D., Paine, A. S., Huynh, T. T., Coyle, K. M., Thomas, M. L., Cruickshank, B. M., Dean, C. A., Clements, D. R., Kim, Y., et al. (2018) · Stem Cells · doi:10.1002/stem.2780 · Cited by 60
Breast cancer stem cells expressing different stem cell markers exhibit distinct biological characteristics
Shao, J., Fan, W., Ma, B., & Wu, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5899 · Cited by 49
ABCG2, a novel antigen to sort luminal progenitors of BRCA1- breast cancer cells
Leccia, F., Vecchio, L. D., Mariotti, E., Noto, R. D., Morel, A., Puisieux, A., Salvatore, F., & Ansieau, S. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-213 · Cited by 38
Combining virotherapy and angiotherapy for the treatment of breast cancer
Bazán‐Peregrino, M., Sainson, R. C. A., Carlisle, R. C., Thoma, C., Waters, R., Arvanitis, C., Harris, A. L., Hernández-Alcoceba, R., & Seymour, L. W. (2013) · Cancer Gene Therapy · doi:10.1038/cgt.2013.41 · Cited by 37
IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells
Battula, V. L., Nguyen, K., Sun, J., Pitner, M. K., Yuan, B., Bartholomeusz, C., Hail, N., & Andreeff, M. (2017) · Oncotarget · doi:10.18632/oncotarget.16294 · Cited by 35
The Presence of EpCAM-/CD49f+Cells in Breast Cancer Is Associated with a Poor Clinical Outcome
Ye, F., Qiu, Y., Li, L., Yang, L., Cheng, F., Zhang, H., Wei, B., Zhang, Z., Sun, L., & Bu, H. (2015) · Journal of Breast Cancer · doi:10.4048/jbc.2015.18.3.242 · Cited by 31
A preliminary study of the role of extracellular -5′- nucleotidase in breast cancer stem cells and epithelial-mesenchymal transition
Yu, J., Liao, X., Li, L., Lv, L., Zhi, X., Yu, J., & Zhou, P. (2016) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-016-0089-y · Cited by 28
Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner
Posada, I. M. D., Lectez, B. L. P., Sharma, M., Oetken-Lindholm, C., Yetukuri, L., Zhou, Y., Aittokallio, T. A., & Abankwa, D. (2017) · Oncotarget · doi:10.18632/oncotarget.17819 · Cited by 25
Association between ALDH1+/CD133+ stem-like cells and tumor angiogenesis in invasive ductal breast carcinoma
Lv, X., Wang, Y., Song, Y., Pang, X., & Li, H. (2016) · Oncology Letters · doi:10.3892/ol.2016.4145 · Cited by 23
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Doherty, M. R., & Jackson, M. W. (2018) · DNA and Cell Biology · doi:10.1089/dna.2018.4247 · Cited by 18
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Rahal, O. M., Machado, H. L., Montales, M. T. E., Pabona, J. M. P., Heard, M. E., Nagarajan, S., & Simmen, R. C. M. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.08.006 · Cited by 10

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Gong, F., Yang, N., Wang, X., Zhao, Q., Chen, Q., Liu, Z., & Cheng, L. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100851 · Cited by 359
Triple-negative breast cancer therapeutic resistance: Where is the Achilles' heel?
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Self-citation
Targeted Cancer Stem Cell Therapeutics: An Update
Fatima, N., Umar, M., Ambreen, S., Shaququzzaman, M., Alam, M. M., & Ali, R. (2025) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266275014240110071351 · Cited by 6

See all 328

Authors: Bai, X., Ni, J., Beretov, J., Graham, P., & Li, Y.
Venue: Cancer Treatment Reviews
Publisher: Elsevier BV
Published: 2018-09
Volume: 69
Pages: 152-163
ISSN: 0305-7372 (ISSN-L)
DOI: 10.1016/j.ctrv.2018.07.004
OpenAlex: W2884390993
Cited by: 328
References: 99
FWCI: 8.43
Type: journal article
Language: en
Open access: closed

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Cancer stem cell in breast cancer therapeutic resistance

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