The Fat Cadherin Acts through the Hippo Tumor-Suppressor Pathway to Regulate Tissue Size

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

Brand, A. H., & Perrimon, N. (1993) · Development · doi:10.1242/dev.118.2.401 · Cited by 9,612

Analysis of genetic mosaics in developing and adult Drosophila tissues

Xu, T., & Rubin, G. M. (1993) · Development · doi:10.1242/dev.117.4.1223 · Cited by 2,041

The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP

Huang, J., Wu, S., Barrera, J., Matthews, K., & Pan, D. (2005) · Cell · doi:10.1016/j.cell.2005.06.007 · Cited by 1,863

hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts

Wu, S., Huang, J., Dong, J., & Pan, D. (2003) · Cell · doi:10.1016/s0092-8674(03)00549-x · Cited by 1,098

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.

Justice, R. W., Zilian, O., Woods, D. F., Noll, M., & Bryant, P. J. (1995) · Genes & Development · doi:10.1101/gad.9.5.534 · Cited by 977

The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis

Harvey, K. F., Pfleger, C. M., & Hariharan, I. K. (2003) · Cell · doi:10.1016/s0092-8674(03)00557-9 · Cited by 976

salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell Lines

Tapon, N., Harvey, K. F., Bell, D. W., Wahrer, D. C. R., Schiripo, T. A., Haber, D. A., & Hariharan, I. K. (2002) · Cell · doi:10.1016/s0092-8674(02)00824-3 · Cited by 856

Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase

Xu, T., Wang, W., Zhang, S., Stewart, R. A., & Yu, W. (1995) · Development · doi:10.1242/dev.121.4.1053 · Cited by 799

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

Hamaratoglu, F., Willecke, M., Kango-Singh, M., Nolo, R., Hyun, E., Tao, C., Jafar-Nejad, H., & Halder, G. (2006) · Nature Cell Biology · doi:10.1038/ncb1339 · Cited by 767

Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

Udan, R. S., Kango-Singh, M., Nolo, R., Tao, C., & Halder, G. (2003) · Nature Cell Biology · doi:10.1038/ncb1050 · Cited by 747

Size Control in Animal Development

Conlon, I., & Raff, M. (1999) · Cell · doi:10.1016/s0092-8674(00)80563-2 · Cited by 743

Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death

Hay, B. A., Wassarman, D. A., & Rubin, G. M. (1995) · Cell · doi:10.1016/0092-8674(95)90150-7 · Cited by 729

Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics

Newsome, T. P., Åsling, B., & Dickson, B. J. (2000) · Development · doi:10.1242/dev.127.4.851 · Cited by 625

Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats

Lai, Z.-C., Wei, X., Shimizu, T., Ramos, E., Rohrbaugh, M., Nikolaidis, N., Ho, L.-L., & Li, Y. (2005) · Cell · doi:10.1016/j.cell.2004.12.036 · Cited by 568

The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila

Pantalacci, S., Tapon, N., & Léopold, P. (2003) · Nature Cell Biology · doi:10.1038/ncb1051 · Cited by 551

The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily

Mahoney, P. A., Weber, U., Onofrechuk, P., Biessmann, H., Bryant, P. J., & Goodman, C. S. (1991) · Cell · doi:10.1016/0092-8674(91)90359-7 · Cited by 453

The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis

Jia, J., Zhang, W., Wang, B., Trinko, R., & Jiang, J. (2003) · Genes & Development · doi:10.1101/gad.1134003 · Cited by 391

Regulation of Frizzled by Fat-like Cadherins during Planar Polarity Signaling in the Drosophila Compound Eye

Yang, C.-H., Axelrod, J. D., & Simon, M. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00658-x · Cited by 372

Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

Kango-Singh, M., Nolo, R., Tao, C., Verstreken, P., Hiesinger, P. R., Bellen, H. J., & Halder, G. (2002) · Development · doi:10.1242/dev.00168 · Cited by 348

From Cell Structure to Transcription: Hippo Forges a New Path

Edgar, B. A. (2006) · Cell · doi:10.1016/j.cell.2006.01.005 · Cited by 331

Fidelity in planar cell polarity signalling

Ma, D., Yang, C.-H., McNeill, H., Simon, M. A., & Axelrod, J. D. (2003) · Nature · doi:10.1038/nature01366 · Cited by 331

Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing

Matakatsu, H., & Blair, S. S. (2004) · Development · doi:10.1242/dev.01254 · Cited by 301

Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila.

Clark, H. F., Brentrup, D., Schneitz, K., Bieber, A., Goodman, C., & Noll, M. (1995) · Genes & Development · doi:10.1101/gad.9.12.1530 · Cited by 240

Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila

Mao, Y., Rauskolb, C., Cho, E., Hu, W.-L., Hayter, H., Minihan, G., Katz, F. N., & Irvine, K. D. (2006) · Development · doi:10.1242/dev.02427 · Cited by 219

The Tumor Suppressors Merlin and Expanded Function Cooperatively to Modulate Receptor Endocytosis and Signaling

Maitra, S., Kulikauskas, R. M., Gavilan, H., & Fehon, R. G. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.063 · Cited by 202

Connecting proliferation and apoptosis in development and disease

Hipfner, D. R., & Cohen, S. M. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1491 · Cited by 193

Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila

Bryant, P. J., Huettner, B., Held, L. I., Ryerse, J., & Szidonya, J. (1988) · Developmental Biology · doi:10.1016/0012-1606(88)90399-5 · Cited by 191

Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins

Matakatsu, H., & Blair, S. S. (2006) · Development · doi:10.1242/dev.02401 · Cited by 189

Nonautonomous Planar Polarity Patterning in Drosophila

Strutt, H., & Strutt, D. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00363-5 · Cited by 187

Mutations in the cadherin superfamily member gene dachsous cause a tissue polarity phenotype by altering frizzled signaling

Adler, P. N., Charlton, J., & Liu, J. (1998) · Development · doi:10.1242/dev.125.5.959 · Cited by 177

Control of growth and organ size in Drosophila

Johnston, L. A., & Gallant, P. (2002) · BioEssays · doi:10.1002/bies.10021 · Cited by 171

Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling

Cho, E., & Irvine, K. D. (2004) · Development · doi:10.1242/dev.01315 · Cited by 160

Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin.

McCartney, B. M., & Fehon, R. G. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.4.843 · Cited by 155

The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor

Fanto, M., Clayton, L., Meredith, J., Hardiman, K. E., Charroux, B., Kerridge, S., & McNeill, H. (2003) · Development · doi:10.1242/dev.00304 · Cited by 150

Developmental Compartments and Planar Polarity in Drosophila

Casal, J., Struhl, G., & Lawrence, P. A. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00974-0 · Cited by 149

Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular Localization

LaJeunesse, D., McCartney, B. M., & Fehon, R. G. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.7.1589 · Cited by 147

expanded: a gene involved in the control of cell proliferation in imaginal discs

Boedigheimer, M. J., & Laughon, A. S. (1993) · Development · doi:10.1242/dev.118.4.1291 · Cited by 138

Cell proliferation, survival, and death in the Drosophila eye

Baker, N. E. (2001) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.2001.0274 · Cited by 112

Positional Information along the Dorsal–Ventral Axis of theDrosophilaEye: Graded Expression of thefour-jointedGene

Brodsky, M. H., & Steller, H. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0038 · Cited by 93

Strabismus requires Flamingo and Prickle function to regulate tissue polarity in theDrosophilaeye

Rawls, A. S., & Wolff, T. (2003) · Development · doi:10.1242/dev.00411 · Cited by 83

Long‐range coordination of planar polarity in Drosophila

Strutt, H. L., & Strutt, D. I. (2005) · BioEssays · doi:10.1002/bies.20318 · Cited by 82

Organising cells into tissues: new roles for cell adhesion molecules in planar cell polarity

Saburi, S., & McNeill, H. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.011 · Cited by 76

Cell behaviour of Drosophila fat cadherin mutations in wing development

Garoia, F., Guerra, D., Pezzoli, C., López‐Varea, A., Cavicchi, S., & Garcı́a-Bellido, A. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00306-3 · Cited by 61

Expanded functions in the apical cell domain to regulate the growth rate of imaginal discs

Boedigheimer, M. J., Nguyen, K., & Bryant, P. J. (1997) · Developmental Genetics · Cited by 58

Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs

Nakajima, D., Nakayama, M., Kikuno, R. F., Hirosawa, M., Nagase, T., & Ohara, O. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00218-2 · Cited by 52

Tissue-specific regulation ofcyclin Etranscription duringDrosophila melanogasterembryogenesis

Jones, L., Richardson, H. E., & Saint, R. B. (2000) · Development · doi:10.1242/dev.127.21.4619 · Cited by 48

Identification of New Human Cadherin Genes Using a Combination of Protein Motif Search and Gene Finding Methods

Höng, J. C., Ivanov, N. V., Hodor, P. G., Xia, M., Wei, N., Blevins, R. A., Gerhold, D. L., Borodovsky, M. Y., & Liu, Y. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.01.026 · Cited by 38

The Drosophila tumor suppressor expanded regulates growth, apoptosis, and patterning during development

Blaumueller, C. M., & Mlodzik, M. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00246-x · Cited by 37

The dachsous gene, a member of the cadherin family, is required for Wg-dependent pattern formation in the Drosophila wing disc

Rodríguez, I. (2004) · Development · doi:10.1242/dev.01195 · Cited by 29

The tumor suppressor gene fat modulates the EGFR-mediated proliferation control in the imaginal tissues of Drosophila melanogaster

Garoia, F., Grifoni, D., Trotta, V., Guerra, D., Pezzoli, C., & Cavicchi, S. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2004.10.007 · Cited by 23

Cell-cycle regulation and cell-type specification in the developing Drosophila compound eye

Jones, C., & Moses, K. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2003.09.002 · Cited by 11

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092

Hippo pathway in organ size control, tissue homeostasis, and cancer

Yu, F.-X., Zhao, B., & Guan, K.-L. (2015) · Cell · doi:10.1016/j.cell.2015.10.044 · Cited by 2,206

The Hippo pathway: regulators and regulations.

Yu, F.-X., & Guan, K.-L. (2013) · Genes & Development · doi:10.1101/gad.210773.112 · Cited by 1,231

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

Zhao, B., Tumaneng, K., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2303 · Cited by 1,205

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

Nishioka, N., Inoue, K.-I., Adachi, K., Kiyonari, H., Ota, M., Ralston, A., Yabuta, N., Hirahara, S., Stephenson, R. O., Ogonuki, N., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.003 · Cited by 1,078