The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
3′ UTRs Are the Primary Regulators of Gene Expression in the C. elegans Germline
Open accessAbstract
Summary How genes are regulated to produce the correct assortment of proteins for every cell type is a fundamental question in biology. For many genes, regulation begins at the DNA level using promoter sequences to control transcription. Regulation can also occur after transcription using sequences in the 3’ untranslated region (UTR) of the mRNA to affect mRNA stability and/or translation. Using a transgenic assay, we have compared the contribution of promoters and 3’UTRs to gene regulation in the C. elegans germline. We find that for most genes tested, 3’ UTRs were sufficient for regulation. With the exception of promoters activated during spermatogenesis, promoters were permissive for expression in all germ cell types (from undifferentiated progenitors to mature oocytes and sperm) and showed no cell-type specificity. In progenitors, 3’ UTRs inhibit the production of meiotic and oocyte proteins by post-transcriptional mechanisms involving two classes of RNA-binding proteins (PUF and KH domain proteins). Our findings indicate that many genes rely primarily on 3’UTRs, not promoters, for regulation during germline development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Xie, X., Lu, J., Kulbokas, E. J., Golub, T. R., Mootha, V., Lindblad-Toh, K., Lander, E. S., & Kellis, M. (2005) · Nature · doi:10.1038/nature03441 · Cited by 1,872
Creation of Low-Copy Integrated Transgenic Lines in Caenorhabditis elegans
Praitis, V., Casey, E., Collar, D., & Austin, J. (2001) · Genetics · doi:10.1093/genetics/157.3.1217 · Cited by 817
Gene regulatory networks for development
Levine, M., & Davidson, E. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408031102 · Cited by 796
A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans
Crittenden, S. L., Bernstein, D. S., Bachorik, J. L., Thompson, B. E., Gallegos, M., Petcherski, A. G., Moulder, G., Barstead, R., Wickens, M., & Kimble, J. (2002) · Nature · doi:10.1038/nature754 · Cited by 421
Pathway to Totipotency: Lessons from Germ Cells
Seydoux, G., & Braun, R. E. (2006) · Cell · doi:10.1016/j.cell.2006.11.016 · Cited by 395
Self-citationHigh-Throughput In Vivo Analysis of Gene Expression in Caenorhabditis elegans
Hunt-Newbury, R., Viveiros, R., Johnsen, R., Mah, A., Anastas, D., Fang, L., Halfnight, E., Lee, D., Lin, J., Lorch, A., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050237 · Cited by 376
Kimble, J., & Crittenden, S. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123326 · Cited by 366
Mechanisms of translational control by the 3′ UTR in development and differentiation
Moor, C. H. D., Meijer, H., & Lissenden, S. (2005) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2004.11.007 · Cited by 310
A Universal Framework for Regulatory Element Discovery across All Genomes and Data Types
Elemento, O., Slonim, N., & Tavazoie, S. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.027 · Cited by 307
Jones, A. R., Francis, R., & Schedl, T. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0293 · Cited by 268
Cited by
Single-copy insertion of transgenes in Caenorhabditis elegans
Frøkjær-Jensen, C., Wayne Davis, M., Hopkins, C. E., Newman, B. J., Thummel, J. M., Olesen, S.-P., Grunnet, M., & Jorgensen, E. M. (2008) · Nature Genetics · doi:10.1038/ng.248 · Cited by 1,163
Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination
Dickinson, D. J., Ward, J. D., Reiner, D. J., & Goldstein, B. (2013) · Nature Methods · doi:10.1038/nmeth.2641 · Cited by 957
piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans
Ashe, A., Sapetschnig, A., Weick, E.-M., Mitchell, J., Bagijn, M. P., Cording, A. C., Doebley, A.-L., Goldstein, L. D., Lehrbach, N. J., Le Pen, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.018 · Cited by 754
P-Body Purification Reveals the Condensation of Repressed mRNA Regulons
Hubstenberger, A., Courel, M., Bénard, M., Souquere, S., Ernoult-Lange, M., Chouaib, R., Yi, Z., Morlot, J.-B., Munier, A., Fradet, M., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.09.003 · Cited by 787
Formation, regulation and evolution of Caenorhabditis elegans 3′UTRs
Jan, C. H., Friedman, R. C., Ruby, J. G., & Bartel, D. P. (2011) · Nature · doi:10.1038/nature09616 · Cited by 481
Metadata
- Authors
- Merritt, C., Rasoloson, D., Ko, D., & Seydoux, G.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 18
- Issue
- 19
- Pages
- 1476-1482
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2087895896
- Cited by
- 379
- References
- 30
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: 3′ UTRs Are the Primary Regulators of Gene Expression in the C. elegans Germline. https://app.cochat.ai/papers/10.1016/j.cub.2008.08.013
- The paper
- Merritt, C., Rasoloson, D., Ko, D., & Seydoux, G. (2008). 3′ UTRs Are the Primary Regulators of Gene Expression in the C. elegans Germline. Current Biology. https://doi.org/10.1016/j.cub.2008.08.013
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
