The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Controls of Germline Stem Cells, Entry into Meiosis, and the Sperm/Oocyte Decision in Caenorhabditis elegans
Abstract
The Caenorhabditis elegans germ line provides an exceptional model for analysis of the molecular controls governing stem cell maintenance, the cell cycle transition from mitosis to meiosis, and the choice of sexual identity—sperm or oocyte. Germline stem cells are maintained in an undifferentiated state within a well-defined niche formed by a single somatic cell, the distal tip cell (DTC). In both sexes, the DTC employs GLP-1/Notch signaling and FBF/PUF RNA-binding proteins to maintain stem cells and promote mitotic divisions, three additional RNA regulators (GLD-1/quaking, GLD-2/poly(A) polymerase, and GLD-3/Bicaudal-C) control entry into meiosis, and FOG-1/CPEB and FOG-3/Tob proteins govern sperm specification. These key regulators are part of a robust regulatory network that controls germ cell proliferation, stem cell maintenance, and sex determination. Parallels with controls in other organisms include the use of PUF proteins for stem cell maintenance and the prominence of mRNA regulation for the control of germline development.
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Citations
Cites
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A role for Wnt signalling in self-renewal of haematopoietic stem cells
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Asymmetric and symmetric stem-cell divisions in development and cancer
Morrison, S. J., & Kimble, J. (2006) · Nature · doi:10.1038/nature04956 · Cited by 1,410
Self-citationSTEM CELL NICHE: Structure and Function
Li, L., & Xie, T. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.012704.131525 · Cited by 1,229
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A Niche Maintaining Germ Line Stem Cells in the Drosophila Ovary
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Cited by
3′ UTRs Are the Primary Regulators of Gene Expression in the C. elegans Germline
Merritt, C., Rasoloson, D., Ko, D., & Seydoux, G. (2008) · Current Biology · doi:10.1016/j.cub.2008.08.013 · Cited by 379
Morris, A. R., Mukherjee, N., & Keene, J. D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00155-08 · Cited by 155
Metadata
- Authors
- Kimble, J., & Crittenden, S. L.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2007-11-01
- Volume
- 23
- Issue
- 1
- Pages
- 405-433
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2098085839
- Cited by
- 366
- References
- 110
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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