Necrosis: C-Type Lectins Sense Cell Death
Open accessAbstract
Recent studies have shown that C-type lectins, a family of surface receptors known to recognize microbial carbohydrate moieties, also sense products from dying cells and transduce inflammatory signals that modulate the immune system.
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Clec4e mRNA is upregulated in patients with rheumatoid arthritis.
“Interestingly, Clec4e mRNA is upregulated in patients with rheumatoid arthritis73,74.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [73]
In a model of high levels of cell death in the thymus by whole-body irradiation, CXCL2 production by thymic macrophages, as well as neutrophil infiltration into the thymus, was significantly suppressed in mice treated with a blocking antibody to CLEC4e.
“In a model of high levels of cell death in the thymus by whole-body irradiation, CXCL2 production by thymic macrophages, as well as neutrophil infiltration into the thymus, was significantly suppressed in mice treated with a blocking antibody to CLeC4e73.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [73]
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Sterile inflammation: sensing and reacting to damage
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- Authors
- Cambi, A., & Figdor, C.
- Affiliations
- Radboud University Medical Center (NL)
- Corresponding author
- Figdor, Carl
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 19
- Issue
- 9
- Pages
- R375-R378
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W1975917615
- Cited by
- 61
- References
- 21
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 7 · 2019: 8 · 2018: 2 · 2017: 2 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 6
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1538 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- C-type lectin, cell death, necrosis, inflammatory signaling, innate immunity, carbohydrate recognition, immunomodulation
- MeSH terms
- Dendritic Cells, Necrosis, Signal Transduction, Apoptosis, Models, Immunological, Lectins, C-Type
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