The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
An Emerging Role of mTOR in Lipid Biosynthesis
Open accessAbstract
Lipid biosynthesis is essential for the maintenance of cellular homeostasis. The lipids produced by cells (glycerolipids, fatty acids, phospholipids, cholesterol, spingolipids) are used as an energy source/reserve, as building blocks for membrane biosynthesis, as precursor molecules for the synthesis of various cellular products and as signaling molecules. Defects in lipid synthesis or processing contribute to the development of many diseases, including obesity, insulin resistance, type 2 diabetes, non-alcoholic fatty liver disease, and cancer. Studies published over the last few years have shown that the target of rapamycin (TOR), a conserved serine/threonine kinase playing key roles in regulating cell growth, controls lipid biosynthesis through various mechanisms. Here, we review these findings and briefly discuss their potential relevance for human health and disease.
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Cites
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Cited by
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Metadata
- Authors
- Laplante, M., & Sabatini, D. M.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 19
- Issue
- 22
- Pages
- R1046-R1052
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W1573455563
- Cited by
- 620
- References
- 48
- FWCI
- 17.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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