The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes
Open accessAbstract
Summary Recycling endosomes consist of a tubular network that emerges from vacuolar sorting endosomes and diverts cargoes toward the cell surface, the Golgi or lysosome-related organelles. How recycling tubules are formed remains unknown. We show that recycling endosome biogenesis requires the protein complex BLOC-1. Mutations in BLOC-1 subunits underlie an inherited disorder characterized by albinism, the Hermansky-Pudlak Syndrome, and are associated with schizophrenia risk. We show here that BLOC-1 coordinates the kinesin KIF13A-dependent pulling of endosomal tubules along microtubules to the Annexin A2/actin-dependent stabilization and detachment of recycling tubules. These components cooperate to extend, stabilize and form tubular endosomal carriers that function in cargo recycling and in the biogenesis of pigment granules in melanocytic cells. By shaping recycling endosomal tubules, our data reveal that dysfunction of the BLOC-1-KIF13A-Annexin A2 molecular network underlies the pathophysiology of neurological and pigmentary disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED: A BLOC-1 Mutation Screen Reveals that PLDN Is Mutated in Hermansky-Pudlak Syndrome Type 9
Cullinane, A. R., Curry, J. A., Carmona‐Rivera, C., Summers, C. G., Ciccone, C., Cardillo, N., Dorward, H. M., Hess, R. A., White, J. G., Adams, D. R., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.05.009 · Cited by 106
RetractedMaxfield, F. R., & McGraw, T. E. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1315 · Cited by 1,729
Pathways and mechanisms of endocytic recycling
Grant, B. D., & Donaldson, J. G. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2755 · Cited by 1,424
Annexins: linking Ca2+ signalling to membrane dynamics
Gerke, V., Creutz, C. E., & Moss, S. E. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1661 · Cited by 1,410
Actin-based plasticity in dendritic spines
Matus, A. (2000) · Science · doi:10.1126/science.290.5492.754 · Cited by 815
Kinesin Superfamily Motor Protein KIF17 and mLin-10 in NMDA Receptor-Containing Vesicle Transport
Setou, M., Nakagawa, T., Seog, D.-H., & Hirokawa, N. (2000) · Science · doi:10.1126/science.288.5472.1796 · Cited by 708
The Arp2/3 Activator WASH Controls the Fission of Endosomes through a Large Multiprotein Complex
Derivery, E., Sousa, C., Gautier, J. J., Lombard, B., Loew, D., & Gautreau, A. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.09.010 · Cited by 602
Melanosomes — dark organelles enlighten endosomal membrane transport
Raposo, G., & Marks, M. S. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2258 · Cited by 591
Self-citationLi, W., Zhang, Q., Oiso, N., Novak, E. K., Gautam, R., O'Brien, E. P., Tinsley, C. L., Blake, D. J., Spritz, R. A., Copeland, N. G., et al. (2003) · Nature Genetics · doi:10.1038/ng1229 · Cited by 433
BORC, a Multisubunit Complex that Regulates Lysosome Positioning
Pu, J., Schindler, C., Jia, R., Jarnik, M., Backlund, P., & Bonifacino, J. S. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.02.011 · Cited by 406
Cited by
Population genomics for wildlife conservation and management
Hohenlohe, P. A., Funk, W. C., & Rajora, O. P. (2021) · Molecular Ecology · doi:10.1111/mec.15720 · Cited by 702
To degrade or not to degrade: Mechanisms and significance of endocytic recycling
Cullen, P. J., & Steinberg, F. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0053-7 · Cited by 590
Cryptic species as a window into the paradigm shift of the species concept
Fišer, C., Robinson, C. T., & Malard, F. (2018) · Molecular Ecology · doi:10.1111/mec.14486 · Cited by 574
Neurofeedback with fMRI: A critical systematic review
Thibault, R. T., MacPherson, A., Lifshitz, M., Roth, R. R., & Raz, A. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.12.071 · Cited by 312
Moving and positioning the endolysosomal system
Bonifacino, J. S., & Neefjes, J. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.01.008 · Cited by 253
Metadata
- Authors
- Delevoye, C., Heiligenstein, X., Ripoll, L., Gilles-Marsens, F., Dennis, M. K., Linares, R. A., Derman, L., Gokhale, A., Morel, E., Faundez, V., Marks, M. S., & Raposo, G.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 26
- Issue
- 1
- Pages
- 1-13
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2221092372
- Cited by
- 441
- References
- 47
- FWCI
- 32.68
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes. https://app.cochat.ai/papers/10.1016/j.cub.2015.11.020
- The paper
- Delevoye, C., Heiligenstein, X., Ripoll, L., Gilles-Marsens, F., Dennis, M. K., Linares, R. A., Derman, L., Gokhale, A., Morel, E., Faundez, V., Marks, M. S., & Raposo, G. (2016). BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes. Current Biology. https://doi.org/10.1016/j.cub.2015.11.020
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
