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BORC, a Multisubunit Complex that Regulates Lysosome Positioning
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Anterograde movement of lysosomes is regulated by BORC, Arl8, and SKIP, which links lysosomes to kinesin.
“Anterograde movement of lysosomes is regulated by the multi-subunit complex BORC, the small GTPase Arl8, and its effector SKIP, which directly interacts with the kinesin light chain, thus linking lysosomes to the plus-end-directed microtubule motor kinesin19,20.”
From TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes (2017) · cites this paper as [20]
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Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
Bar-Peled, L., Schweitzer, L. D., Zoncu, R., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.07.032 · Cited by 918 · cited 1×
“We also found previously unreported interactors, including the five subunits of Ragulator (LAMTOR1–5; Table S1), a multimeric complex that regulates activation of the target of rapamycin complex 1 (mTORC1) kinase at the lysosomal membrane (Bar-Peled et al., 2012).”
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Metadata
- Authors
- Pu, J., Schindler, C., Jia, R., Jarnik, M., Backlund, P., & Bonifacino, J. S.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 33
- Issue
- 2
- Pages
- 176-188
- ISSN
- 1534-5807
- PMC
- PMC4788105
- Cited by
- 406
- References
- 2
- Language
- en
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