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Moving and positioning the endolysosomal system
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The spatio-temporal distribution of lysosomes depends on active transport driven by the anterograde and retrograde motors kinesin and dynein.
“Their spatio-temporal distribution depends on active transport driven by the anterograde-and retrograde motors kinesin and dynein, respectively (Bonifacino and Neefjes, 2017;Saftig and Puertollano, 2021).”
From TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles (2026) · cites this paper as Bonifacino and Neefjes, 2017
More recent work shows compelling evidence for an important physiological function of lysosomes or related LAMP1+ organelles in the axon.
“more recent work shows compelling evidence for an important physiological function of lysosomes or related LAMP1 + -organelles in the axon (Adnan et al., 2020;Bonifacino and Neefjes, 2017;Cason et al., 2022;Cheng et al., 2018;De Pace et al., 2020;Farfel-Becker et al., 2019;Farias et al., 2015;Farias et al., 2017a;Roney et al., 2022;Winckler et al., 2018).”
From TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles (2026) · cites this paper as Bonifacino and Neefjes, 2017
Lysosomal positioning is critical in various cell types for the maintenance of cellular homeostasis.
“Lysosomal positioning is critical in various cell types for the maintenance of cellular homeostasis (Ballabio and Bonifacino, 2020;Bonifacino and Neefjes, 2017).”
From TMEM55B promotes anterograde transport and distal axonal distribution of LAMP1-positive organelles (2026) · cites this paper as Bonifacino and Neefjes, 2017
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Kinesin superfamily motor proteins and intracellular transport
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Metadata
- Authors
- Bonifacino, J. S., & Neefjes, J.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 47
- Pages
- 1-8
- ISSN
- 0955-0674
- PMC
- PMC5537022
- Cited by
- 253
- References
- 7
- Language
- en
- Funders
- Intramural Program of NICHD
- NIH
- ERC Advanced Grant
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