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Moving and positioning the endolysosomal system

Bonifacino, Juan S, Neefjes, Jacques·2017·Current Opinion in Cell Biology

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Crossref · 10.1016/j.ceb.2017.01.008

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  • The spatio-temporal distribution of lysosomes depends on active transport driven by the anterograde and retrograde motors kinesin and dynein.

    “Their spatio-temporal distribution depends on active transport driven by the anterograde-and retrograde motors kinesin and dynein, respectively (Bonifacino and Neefjes, 2017;Saftig and Puertollano, 2021).”
  • More recent work shows compelling evidence for an important physiological function of lysosomes or related LAMP1+ organelles in the axon.

    “more recent work shows compelling evidence for an important physiological function of lysosomes or related LAMP1 + -organelles in the axon (Adnan et al., 2020;Bonifacino and Neefjes, 2017;Cason et al., 2022;Cheng et al., 2018;De Pace et al., 2020;Farfel-Becker et al., 2019;Farias et al., 2015;Farias et al., 2017a;Roney et al., 2022;Winckler et al., 2018).”
  • Lysosomal positioning is critical in various cell types for the maintenance of cellular homeostasis.

    “Lysosomal positioning is critical in various cell types for the maintenance of cellular homeostasis (Ballabio and Bonifacino, 2020;Bonifacino and Neefjes, 2017).”

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Metadata

Authors
Bonifacino, J. S., & Neefjes, J.
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2017-08
Volume
47
Pages
1-8
ISSN
0955-0674
Cited by
253
References
7
Language
en
Funders
  • Intramural Program of NICHD
  • NIH
  • ERC Advanced Grant

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