The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Feedback-Controlled Transcranial Alternating Current Stimulation Reveals a Functional Role of Sleep Spindles in Motor Memory Consolidation
Open accessAbstract
Summary Transient episodes of brain oscillations are a common feature of both the waking and sleeping brain. Sleep spindles represent a prominent example of a poorly understood transient brain oscillation that is impaired in disorders such as Alzheimer’s disease and schizophrenia. Yet, the causal role of these bouts of thalamo-cortical oscillations remains unknown. Demonstrating a functional role of sleep spindles in cognitive processes has so far been hindered by the lack of a tool to target transient brain oscillations in real-time. Here, we show for the first time selective enhancement of sleep spindles with non-invasive brain stimulation in humans. We developed a system that detects sleep spindles in real-time and applies oscillatory stimulation. Our stimulation selectively enhanced spindle activity as determined by increased sigma activity after tACS application. This targeted modulation caused significant enhancement of motor memory consolidation that correlated with the stimulation-induced change in fast spindle activity. Strikingly, we found a similar correlation between motor memory and spindle characteristics during the sham night for the same spindle frequencies and electrode locations. Therefore, our results directly demonstrate a functional relationship between oscillatory spindle activity and cognition.
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Citations
Cites
Neuronal Oscillations in Cortical Networks
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“Besides sleep spindles, slow waves have been proposed to play an important role in memory consolidation [8].”
InfluentialBoosting slow oscillations during sleep potentiates memory
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Endogenous electric fields may guide neocortical network activity
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Self-citationScaling Brain Size, Keeping Timing: Evolutionary Preservation of Brain Rhythms
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Cited by
Sleep spindles: mechanisms and functions
Fernandez, L. M. J., & Lüthi, A. (2020) · Physiological Reviews · doi:10.1152/physrev.00042.2018 · Cited by 716
Old brains come uncoupled in sleep: slow wave-spindle synchrony, brain atrophy, and forgetting
Helfrich, R. F., Mander, B. A., Jagust, W. J., Knight, R. T., & Walker, M. P. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.020 · Cited by 497
Characterizing sleep spindles in 11,630 individuals from the National Sleep Research Resource
Purcell, S. M., Manoach, D. S., Demanuele, C., Cade, B. E., Mariani, S., Cox, R., Panagiotaropoulou, G., Saxena, R., Pan, J. Q., Smoller, J. W., et al. (2017) · Nature Communications · doi:10.1038/ncomms15930 · Cited by 439
Oscillating circuitries in the sleeping brain
Adamantidis, A. R., Gutierrez Herrera, C., & Gent, T. C. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0223-4 · Cited by 281
Memory and Sleep: How Sleep Cognition Can Change the Waking Mind for the Better
Paller, K. A., Creery, J. D., & Schechtman, E. (2021) · Annual Review of Psychology · doi:10.1146/annurev-psych-010419-050815 · Cited by 150
“Similarly, electrical stimulation with transcranial alternating current was used to boost spindle activity, also benefiting motor memory consolidation (Lustenberger et al. 2016).”
Method
Metadata
- Authors
- Lustenberger, C., Boyle, M. R., Alagapan, S., Mellin, J. M., Vaughn, B. V., & Fröhlich, F.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 26
- Issue
- 16
- Pages
- 2127-2136
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2486024398
- Cited by
- 258
- References
- 70
- FWCI
- 12.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lustenberger, C., Boyle, M. R., Alagapan, S., Mellin, J. M., Vaughn, B. V., & Fröhlich, F. (2016). Feedback-Controlled Transcranial Alternating Current Stimulation Reveals a Functional Role of Sleep Spindles in Motor Memory Consolidation. Current Biology. https://doi.org/10.1016/j.cub.2016.06.044
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