Old brains come uncoupled in sleep: slow wave-spindle synchrony, brain atrophy, and forgetting
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Summary The coupled interaction between slow wave oscillations and sleep spindles during non-rapid-eye-movement (NREM) sleep has been proposed to support memory consolidation. However, little evidence in humans supports this theory. Moreover, whether such dynamic coupling is impaired as a consequence of brain aging in later life, contributing to cognitive and memory decline, is unknown. Combining, electroencephalography (EEG), structural MRI and sleep-dependent memory assessment, we addressed these questions in cognitively normal young and older adults. Directional cross-frequency coupling analyses demonstrated that the slow wave governs a precise temporal coordination of sleep spindles, the quality of which predicts overnight memory retention. Moreover, selective atrophy within the medial frontal cortex in older adults predicted a temporal dispersion of this slow wave-spindle coupling, impairing overnight memory consolidation leading to forgetting. Prefrontal dependent deficits in the spatiotemporal coordination of NREM sleep oscillations provide a potential pathway to age-related memory decline.
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Accumulating evidence indicates the importance of precise phase-amplitude coupling between classical fast spindles and SO upstates for effective consolidation.
“As to the classical fast spindle, accumulating evidence indicates the importance of precise phase-amplitude coupling between these spindles and SO upstates for effective consolidation.61,186”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [61]
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- Authors
- Helfrich, R. F., Mander, B. A., Jagust, W. J., Knight, R. T., & Walker, M. P.
- Affiliations
- University of Oslo (NO)
- University of California, Irvine (US)
- University of California, Berkeley (US)
- Corresponding author
- Helfrich, Randolph F.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 97
- Issue
- 1
- Pages
- 221-230.e4
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5754239
- OpenAlex
- W2775812132
- Semantic Scholar
- 3d8161f2b37422e41e17e74f5e420006e46896bd
- Cited by
- 497
- References
- 60
- Citations by year
- 2026: 61 · 2025: 69 · 2024: 57 · 2023: 77 · 2022: 70 · 2021: 54 · 2020: 48 · 2019: 43 · 2018: 18
- FWCI
- 17.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Alexander von Humboldt Foundation
- Dept. of Psychology, University of Oslo (R37NS21135, R01AG034570, R01AG031164, R01AG054019, RF1AG054019, R01MH093537, F32–AG039170)
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- slow oscillations, sleep spindles, cross-frequency coupling, NREM sleep, memory consolidation, forgetting, brain aging, age-related memory decline, sleep-dependent memory, older adults
- MeSH terms
- Memory Consolidation, Aged, Aging, Atrophy, Brain, Female, Humans, Male, Sleep, Young Adult
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