The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep
Open accessAbstract
Summary People commonly increase sleep duration on the weekend to “recover” from sleep loss incurred during the workweek. Whether ad libitum weekend recovery sleep prevents metabolic dysregulation caused by recurrent insufficient sleep is unknown. Here, we assessed sleep, circadian timing, energy intake, weight-gain, and insulin sensitivity during sustained insufficient sleep (9 nights) and during recurrent insufficient sleep following ad libitum weekend recovery sleep. Healthy, young adults were randomly assigned to one of three groups. 1) control (CON; 9h sleep opportunities, n=8), 2) sleep restriction without weekend recovery sleep (SR; 5h sleep opportunities, n=14), and 3) sleep restriction with weekend recovery sleep (WR; insufficient sleep for 5-d workweek, then 2 days weekend recovery, then 2 nights insufficient sleep, n=14). For SR and WR groups, insufficient sleep increased after-dinner energy intake and body weight versus baseline. During ad libitum weekend recovery sleep, participants cumulatively slept ~1.1h more than baseline and after-dinner energy intake decreased versus insufficient sleep. However, during recurrent insufficient sleep following the weekend, circadian phase was delayed and after-dinner energy intake and body weight increased versus baseline. In SR, whole-body insulin sensitivity decreased ~13% during insufficient sleep versus baseline, and in WR, whole-body, hepatic, and muscle insulin sensitivity decreased ~9–27%, during recurrent insufficient sleep versus baseline. Furthermore, during the weekend, total sleep duration was lower in women versus men, and energy intake decreased to baseline levels in women but not men. Our findings suggest weekend recovery sleep is not an effective strategy to prevent metabolic dysregulation associated with recurrent insufficient sleep.
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“Sleep debt, circadian misalignment and sleep disruption from obstructive sleep apnea is widespread in modern society and accumulates with life because recovery sleep is not completely restorative.”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [6]
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“However, ' catch-up ' weekend sleep alone is not enough to reverse the impact of insuf fi cient sleep (126).”
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Davies, M. J., Aroda, V. R., Collins, B. S., Gabbay, R. A., Green, J., Maruthur, N. M., Rosas, S. E., Del Prato, S., Mathieu, C., Mingrone, G., et al. (2022) · Diabetes Care · doi:10.2337/dci22-0034 · Cited by 2,104
Davies, M. J., Aroda, V. R., Collins, B. S., Gabbay, R. A., Green, J., Maruthur, N. M., Rosas, S. E., Del Prato, S., Mathieu, C., Mingrone, G., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05787-2 · Cited by 1,048
Chronotype and Social Jetlag: A (Self-) Critical Review
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The role of insufficient sleep and circadian misalignment in obesity
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Self-citationEffects of the COVID-19 lockdown on human sleep and rest-activity rhythms
Blume, C., Schmidt, M. H., & Cajochen, C. (2020) · Current Biology · doi:10.1016/j.cub.2020.06.021 · Cited by 298
Metadata
- Authors
- Depner, C. M., Melanson, E. L., Eckel, R. H., Snell-Bergeon, J. K., Perreault, L., Bergman, B. C., Higgins, J. A., Guerin, M. K., Stothard, E. R., Morton, S. J., & Wright, K. P.
- Affiliations
- University of Colorado Boulder (US)
- University of Colorado Anschutz (US)
- Corresponding author
- Wright, Kenneth P.
- ORCID
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 29
- Issue
- 6
- Pages
- 957-967.e4
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC12798825
- OpenAlex
- W2915822548
- Semantic Scholar
- a6f8b411c00a9cdaebb52e74b08db9af794d31cc
- Cited by
- 203
- References
- 75
- Citations by year
- 2026: 17 · 2025: 30 · 2024: 25 · 2023: 24 · 2022: 32 · 2021: 26 · 2020: 37 · 2019: 12
- FWCI
- 31.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Funders
- NIH (HL109706, DK111161, TR001082, DK048520)
- Sleep Research Society Foundation (011-JP-16)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- insufficient sleep, sleep restriction, metabolic dysfunction, insulin sensitivity, circadian timing, circadian phase delay, energy intake, weight gain, sex differences in sleep, hepatic insulin sensitivity, skeletal muscle insulin sensitivity, young adults
- MeSH terms
- Adult, Energy Intake, Circadian Rhythm, Female, Humans, Insulin Resistance, Male, Sleep, Sleep Deprivation, Weight Gain, Young Adult
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