The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiation
Published version of a preprint
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Notably, in genes aligning with the dorsal-ventral gradient of D//, Olfm1 and Sept5 were implicated in the morphogenesis of pyramidal neurons.47”
From A spatial imaging-transcriptomics paradigm for deciphering the molecular basis of microscopic MRI in the normal brain and Alzheimer’s disease (2025) · cites this paper as [47]
Experimental — accuracy not yet measuredIn the citing paper
“and influence axodendritic extension”
From A spatial imaging-transcriptomics paradigm for deciphering the molecular basis of microscopic MRI in the normal brain and Alzheimer’s disease (2025) · cites this paper as [47]
In the citing paper
“both of which are involved in the morphogenesis of pyramidal neurons”
From A spatial imaging-transcriptomics paradigm for deciphering the molecular basis of microscopic MRI in the normal brain and Alzheimer’s disease (2025) · cites this paper as [47]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mohan, H., Verhoog, M. B., Doreswamy, K. K., Eyal, G., Aardse, R., Lodder, B. N., Goriounova, N. A., Asamoah, B., B. Brakspear, A. B. C., Groot, C., et al. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv188 · Cited by 280
Pennington, K., Beasley, C. L., Dicker, P., Fagan, A., English, J., Pariante, C. M., Wait, R., Dunn, M. J., & Cotter, D. R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002098 · Cited by 227
Research works printed but not linked: 76
- Spruston, 2008, Pyramidal neurons: dendritic structure and synaptic integration, Nat. Rev. Neurosci., 9, 206, 10.1038/nrn2286 · DOI · Paper page
- Kulkarni, 2012, The dendritic tree and brain disorders, Mol. Cell. Neurosci., 50, 10, 10.1016/j.mcn.2012.03.005 · DOI · Paper page
- Copf, 2016, Impairments in dendrite morphogenesis as etiology for neurodevelopmental disorders and implications for therapeutic treatments, Neurosci. Biobehav. Rev., 68, 946, 10.1016/j.neubiorev.2016.04.008 · DOI
- Liu, 2020, Mechanisms of neurite repair, Curr. Opin. Neurobiol., 63, 53, 10.1016/j.conb.2020.02.010 · DOI
- Prem, 2020, Dysregulation of neurite outgrowth and cell migration in autism and other neurodevelopmental disorders, Adv. Neurobiol., 25, 109, 10.1007/978-3-030-45493-7_5 · DOI
- Sainath, 2015, Cytoskeletal and signaling mechanisms of neurite formation, Cell Tissue Res., 359, 267, 10.1007/s00441-014-1955-0 · DOI · Paper page
- Miller, 2018, An integrated cytoskeletal model of neurite outgrowth, Front. Cell. Neurosci., 12, 447, 10.3389/fncel.2018.00447 · DOI · Paper page
- da Silva, 2002, Breaking the neuronal sphere: regulation of the actin cytoskeleton in neuritogenesis, Nat. Rev. Neurosci., 3, 694, 10.1038/nrn918 · DOI
- Takano, 2019, Neuronal polarity: positive and negative feedback signals, Front. Cell Dev. Biol., 7, 69, 10.3389/fcell.2019.00069 · DOI
- Barnes, 2009, Establishment of axon-dendrite polarity in developing neurons, Annu. Rev. Neurosci., 32, 347, 10.1146/annurev.neuro.31.060407.125536 · DOI · Paper page
- Namba, 2014, Pioneering axons regulate neuronal polarization in the developing cerebral cortex, Neuron, 81, 814, 10.1016/j.neuron.2013.12.015 · DOI
- Dotti, 1988, The establishment of polarity by hippocampal neurons in culture, J. Neurosci., 8, 1454, 10.1523/JNEUROSCI.08-04-01454.1988 · DOI · Paper page
- Hatanaka, 2013, Excitatory cortical neurons with multipolar shape establish neuronal polarity by forming a tangentially oriented axon in the intermediate zone, Cereb. Cortex, 23, 105, 10.1093/cercor/bhr383 · DOI
- Banker, 2018, The development of neuronal polarity: a retrospective view, J. Neurosci., 38, 1867, 10.1523/JNEUROSCI.1372-16.2018 · DOI
- Flynn, 2013, The cytoskeleton and neurite initiation, BioArchitecture, 3, 86, 10.4161/bioa.26259 · DOI
- Svitkina, 2013, Ultrastructure of protrusive actin filament arrays, Curr. Opin. Cell Biol., 25, 574, 10.1016/j.ceb.2013.04.003 · DOI
- Gautreau, 2022, Nucleation, stabilization, and disassembly of branched actin networks, Trends Cell Biol., 32, 421, 10.1016/j.tcb.2021.10.006 · DOI
- Wit, 2023, Neuronal filopodia: from stochastic dynamics to robustness of brain morphogenesis, Semin. Cell Dev. Biol., 133, 10, 10.1016/j.semcdb.2022.03.038 · DOI
- Saengsawang, 2012, The F-BAR protein CIP4 inhibits neurite formation by producing lamellipodial protrusions, Curr. Biol., 22, 494, 10.1016/j.cub.2012.01.038 · DOI
- Guerrier, 2009, The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis, Cell, 138, 990, 10.1016/j.cell.2009.06.047 · DOI
- Dent, 2007, Filopodia are required for cortical neurite initiation, Nat. Cell Biol., 9, 1347, 10.1038/ncb1654 · DOI
- Kwiatkowski, 2007, Ena/VASP is required for neuritogenesis in the developing cortex, Neuron, 56, 441, 10.1016/j.neuron.2007.09.008 · DOI
- Flynn, 2012, ADF/cofilin-mediated actin retrograde flow directs neurite formation in the developing brain, Neuron, 76, 1091, 10.1016/j.neuron.2012.09.038 · DOI
- Dehmelt, 2003, The role of microtubule-associated protein 2c in the reorganization of microtubules and lamellipodia during neurite initiation, J. Neurosci., 23, 9479, 10.1523/JNEUROSCI.23-29-09479.2003 · DOI
- Mingorance-Le Meur, 2009, Neurite consolidation is an active process requiring constant repression of protrusive activity, EMBO J., 28, 248, 10.1038/emboj.2008.265 · DOI
- Lu, 2013, Initial neurite outgrowth in Drosophila neurons is driven by kinesin-powered microtubule sliding, Curr. Biol., 23, 1018, 10.1016/j.cub.2013.04.050 · DOI
- Rao, 2018, Polarity sorting of microtubules in the axon, Trends Neurosci., 41, 77, 10.1016/j.tins.2017.11.002 · DOI
- Spiliotis, 2021, Cellular functions of actin- and microtubule-associated septins, Curr. Biol., 31, R651, 10.1016/j.cub.2021.03.064 · DOI
- Woods, 2021, The state of the septin cytoskeleton from assembly to function, Curr. Opin. Cell Biol., 68, 105, 10.1016/j.ceb.2020.10.007 · DOI
- Caudron, 2009, Septins and the lateral compartmentalization of eukaryotic membranes, Dev. Cell, 16, 493, 10.1016/j.devcel.2009.04.003 · DOI
- Radler, 2022, Right place, right time - spatial guidance of neuronal morphogenesis by septin GTPases, Curr. Opin. Neurobiol., 75, 102557, 10.1016/j.conb.2022.102557 · DOI
- Ageta-Ishihara, 2021, Developmental and postdevelopmental roles of septins in the brain, Neurosci. Res., 170, 6, 10.1016/j.neures.2020.08.006 · DOI
- Boubakar, 2017, Molecular memory of morphologies by septins during neuron generation allows early polarity inheritance, Neuron, 95, 834, 10.1016/j.neuron.2017.07.027 · DOI
- Falk, 2019, Septin functions during neuro-development, a yeast perspective, Curr. Opin. Neurobiol., 57, 102, 10.1016/j.conb.2019.01.012 · DOI
- Xie, 2007, The GTP-binding protein septin 7 is critical for dendrite branching and dendritic-spine morphology, Curr. Biol., 17, 1746, 10.1016/j.cub.2007.08.042 · DOI
- Figueiredo, 2021, Endothelial cell invasion is controlled by dactylopodia, Proc. Natl. Acad. Sci. USA, 118, 10.1073/pnas.2023829118 · DOI
- Yang, 2012, Arp2/3 complex-dependent actin networks constrain myosin II function in driving retrograde actin flow, J. Cell Biol., 197, 939, 10.1083/jcb.201111052 · DOI
- Lin, 1996, Myosin drives retrograde F-actin flow in neuronal growth cones, Neuron, 16, 769, 10.1016/S0896-6273(00)80097-5 · DOI
- Alieva, 2019, Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion, Nat. Commun., 10, 3593, 10.1038/s41467-019-10964-w · DOI
- Medeiros, 2006, Myosin II functions in actin-bundle turnover in neuronal growth cones, Nat. Cell Biol., 8, 215, 10.1038/ncb1367 · DOI
- Lin, 1995, Growth cone advance is inversely proportional to retrograde F-actin flow, Neuron, 14, 763, 10.1016/0896-6273(95)90220-1 · DOI
- Hetrick, 2013, Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change, Chem. Biol., 20, 701, 10.1016/j.chembiol.2013.03.019 · DOI
- Weed, 2000, Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex, J. Cell Biol., 151, 29, 10.1083/jcb.151.1.29 · DOI
- Wu, 2015, Differentiation of apical and basal dendrites in pyramidal cells and granule cells in dissociated hippocampal cultures, PLoS One, 10
- Ageta-Ishihara, 2013, Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation, Nat. Commun., 4, 2532, 10.1038/ncomms3532 · DOI
- Hu, 2012, Septin-driven coordination of actin and microtubule remodeling regulates the collateral branching of axons, Curr. Biol., 22, 1109, 10.1016/j.cub.2012.04.019 · DOI
- Menon, 2014, Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis, PLoS Genet., 10, 10.1371/journal.pgen.1004558 · DOI
- Yang, 2011, Filopodia initiation: focus on the Arp2/3 complex and formins, Cell Adh. Migr., 5, 402, 10.4161/cam.5.5.16971 · DOI
- Tada, 2007, Role of septin cytoskeleton in spine morphogenesis and dendrite development in neurons, Curr. Biol., 17, 1752, 10.1016/j.cub.2007.09.039 · DOI
- Dolat, 2014, Septin functions in organ system physiology and pathology, Biol. Chem., 395, 123, 10.1515/hsz-2013-0233 · DOI
- Bridges, 2016, 213, 23
- Spiliotis, 2020, Masters of asymmetry - lessons and perspectives from 50 years of septins, Mol. Biol. Cell, 31, 2289, 10.1091/mbc.E19-11-0648 · DOI
- Joo, 2007, 13, 677
- Wasik, 2017, Septin 7 reduces nonmuscle myosin IIA activity in the SNAP23 complex and hinders GLUT4 storage vesicle docking and fusion, Exp. Cell Res., 350, 336, 10.1016/j.yexcr.2016.12.010 · DOI
- Case, 2015, Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch, Nat. Cell Biol., 17, 955, 10.1038/ncb3191 · DOI · Paper page
- Hylton, 2022, Cofilactin filaments regulate filopodial structure and dynamics in neuronal growth cones, Nat. Commun., 13, 2439, 10.1038/s41467-022-30116-x · DOI · Paper page
- Wiggan, 2012, ADF/cofilin regulates actomyosin assembly through competitive inhibition of myosin II binding to F-actin, Dev. Cell, 22, 530, 10.1016/j.devcel.2011.12.026 · DOI
- Elam, 2013, Competitive displacement of cofilin can promote actin filament severing, Biochem. Biophys. Res. Commun., 438, 728, 10.1016/j.bbrc.2013.07.109 · DOI
- Suarez, 2011, Cofilin tunes the nucleotide state of actin filaments and severs at bare and decorated segment boundaries, Curr. Biol., 21, 862, 10.1016/j.cub.2011.03.064 · DOI · Paper page
- Hou, 2016, Sept7 overexpression inhibits glioma cell migration by targeting the actin cytoskeleton pathway, Oncol. Rep., 35, 2003, 10.3892/or.2016.4609 · DOI
- Mostowy, 2010, Entrapment of intracytosolic bacteria by septin cage-like structures, Cell Host Microbe, 8, 433, 10.1016/j.chom.2010.10.009 · DOI
- Pfanzelter, 2018, Septins suppress the release of vaccinia virus from infected cells, J. Cell Biol., 217, 2911, 10.1083/jcb.201708091 · DOI
- Cavini, 2021, The structural biology of septins and their filaments: an update, Front. Cell Dev. Biol., 9, 765085, 10.3389/fcell.2021.765085 · DOI
- Suarez, 2015, Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex, Dev. Cell, 32, 43, 10.1016/j.devcel.2014.10.027 · DOI
- Rotty, 2015, Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways, Dev. Cell, 32, 54, 10.1016/j.devcel.2014.10.026 · DOI
- Yadav, 2017, TAOK2 kinase mediates PSD95 stability and dendritic spine maturation through Septin7 phosphorylation, Neuron, 93, 379, 10.1016/j.neuron.2016.12.006 · DOI
- Harper, 2012, Alterations of social interaction through genetic and environmental manipulation of the 22q11.2 gene Sept5 in the mouse brain, Hum. Mol. Genet., 21, 3489, 10.1093/hmg/dds180 · DOI
- Suzuki, 2009, Sept5 deficiency exerts pleiotropic influence on affective behaviors and cognitive functions in mice, Hum. Mol. Genet., 18, 1652, 10.1093/hmg/ddp086 · DOI
- Hamdan, 2020, Mapping axon initial segment structure and function by multiplexed proximity biotinylation, Nat. Commun., 11, 100, 10.1038/s41467-019-13658-5 · DOI
- Karasmanis, 2018, Polarity of neuronal membrane traffic requires sorting of kinesin motor cargo during entry into dendrites by a microtubule-associated septin, Dev. Cell, 46, 204, 10.1016/j.devcel.2018.06.013 · DOI
- Johnson, 2009, Neuronal IP3 3-kinase is an F-actin-bundling protein: role in dendritic targeting and regulation of spine morphology, Mol. Biol. Cell, 20, 5166, 10.1091/mbc.e09-01-0083 · DOI
- Beach, 2011, Analysis of the role of Ser1/Ser2/Thr9 phosphorylation on myosin II assembly and function in live cells, BMC Cell Biol., 12, 52, 10.1186/1471-2121-12-52 · DOI
- Liu, 2021, Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex, Hum. Mol. Genet., 30, 30, 10.1093/hmg/ddab003 · DOI
- Cornell, 2016, 25, 4405
- Hand, 2011, Neurogenin2 regulates the initial axon guidance of cortical pyramidal neurons projecting medially to the corpus callosum, Neural Dev., 6, 30, 10.1186/1749-8104-6-30 · DOI
- Wachi, 2016, Ablation of the 14–3-3gamma protein results in neuronal migration delay and morphological defects in the developing cerebral cortex, Dev. Neurobiol., 76, 600, 10.1002/dneu.22335 · DOI
Cited by
Sorted by citations
Shen, Y., Shen, Y., Wang, M., Jin, K., Yang, P., Cao, Z., Zhu, Q., Zhao, Z., Li, H., Han, L., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116073 · Cited by 16
Metadata
- Authors
- Radler, M. R., Liu, X., Peng, M., Doyle, B., Toyo-Oka, K., & Spiliotis, E. T.
- ORCID
- Spiliotis, Elias T.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2023-02
- Volume
- 33
- Issue
- 3
- Pages
- 434-448.e8
- ISSN
- 0960-9822
- PMC
- PMC9905282
- Cited by
- 17
- References
- 2
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 370 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review