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Cited by 523Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Establishment of axon-dendrite polarity in developing neurons.

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Barnes, Anthony P., Polleux, Franck·2009·Annual Review of Neuroscience
DOI 10.1146/annurev.neuro.31.060407.125536PMC PMC3170863
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Abstract

Neurons are among the most highly polarized cell types in the body, and the polarization of axon and dendrites underlies the ability of neurons to integrate and transmit information in the brain. Significant progress has been made in the identification of the cellular and molecular mechanisms underlying the establishment of neuronal polarity using primarily in vitro approaches such as dissociated culture of rodent hippocampal and cortical neurons. This model has led to the predominant view suggesting that neuronal polarization is specified largely by stochastic, asymmetric activation of intracellular signaling pathways. Recent evidence shows that extracellular cues can play an instructive role during neuronal polarization in vitro and in vivo. In this review, we synthesize the recent data supporting an integrative model whereby extracellular cues orchestrate the intracellular signaling underlying the initial break of neuronal symmetry leading to axon-dendrite polarization.

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  • A crucial step in neuronal differentiation is the transition from an unpolarized neuron with multiple short neurites to a polarized neuron with a single axon.

    “A crucial step in neuronal differentiation is the transition from an unpolarized neuron with multiple short neurites to a polarized neuron with a single axon (Barnes and Polleux, 2009).”

    From Rassf5 and Ndr kinases act in a novel pathway regulating neuronal polarity through Par3 phosphorylation (2014) · cites this paper as Barnes and Polleux, 2009

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Cited by

Sorted by citations

Authors
Barnes, A. P., & Polleux, F.
Affiliations
  • Oregon Health & Science University (US)
  • University of North Carolina at Chapel Hill (US)
ORCID
Venue
Annual Review of Neuroscience
Publisher
Annual Reviews
Published
2009-06-01
Volume
32
Issue
1
Pages
347-381
ISSN
  • 0147-006X (ISSN-L)
  • 1545-4126
DOI
10.1146/annurev.neuro.31.060407.125536
PMC
PMC3170863
OpenAlex
W2095711264
Cited by
523
References
11
Citations by year
2026: 11 · 2025: 14 · 2024: 23 · 2023: 19 · 2022: 33 · 2021: 28 · 2020: 34 · 2019: 23 · 2018: 26 · 2017: 36 · 2016: 36 · 2015: 26 · 2014: 40 · 2013: 52 · 2012: 42
Type
conference abstract
Language
en
Open access
Locations
  • Annual Review of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (R01AG031524)
  • National Institute of Mental Health (K01MH080259)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
neuronal polarity, axon-dendrite polarity, neuronal differentiation, extracellular cues, intracellular signaling, hippocampal neurons, cortical neurons
MeSH terms
Animals, Axons, Brain, Cell Communication, Cell Differentiation, Dendrites, Humans, Signal Transduction, Extracellular Matrix Proteins, Cell Polarity, Neurogenesis

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