The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Cytokines in psoriasis
Open accessAbstract
Psoriasis is a common inflammatory skin disease with an incompletely understood etiology. The disease is characterized by red, scaly and well-demarcated skin lesions formed by the hyperproliferation of epidermal keratinocytes. This hyperproliferation is driven by cytokines secreted by activated resident immune cells, an infiltrate of T cells, dendritic cells and cells of the innate immune system, as well as the keratinocytes themselves. Psoriasis has a strong hereditary character and has a complex genetic background. Genome-wide association studies have identified polymorphisms within or near a number of genes encoding cytokines, cytokine receptors or elements of their signal transduction pathways, further implicating these cytokines in the psoriasis pathomechanism. A considerable number of inflammatory cytokines have been shown to be elevated in lesional psoriasis skin, and the serum concentrations of a subset of these also correlate with psoriasis disease severity. The combined effects of the cytokines found in psoriasis lesions likely explain most of the clinical features of psoriasis, such as the hyperproliferation of keratinocytes, increased neovascularization and skin inflammation. Thus, understanding which cytokines play a pivotal role in the disease process can suggest potential therapeutic targets. A number of cytokines have been therapeutically targeted with success, revolutionizing treatment of this disease. Here we review a number of key cytokines implicated in the pathogenesis of psoriasis.
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Cites
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Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome
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Organization of the skin immune system and compartmentalized immune responses in infectious diseases
Quaresma, J. A. S. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00034-18 · Cited by 149
Metadata
- Authors
- Baliwag, J., Barnes, D. H., & Johnston, A.
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 73
- Issue
- 2
- Pages
- 342-350
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W2063512593
- Cited by
- 373
- References
- 122
- FWCI
- 11.95
- Type
- journal article
- Language
- en
- Open access
- green
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