Association of selected adipokines with metabolic syndrome and cardio-metabolic risk factors in young males
Abstract
The study aimed to investigate association of circulating leptin, adiponectin, chemerin, and omentin-1 with metabolic syndrome (MetS) and cardio-metabolic risk factors in youths. Thirty eight young males were enrolled. Participants underwent anthropometric and blood pressure measures, and fasting blood sampling. Plasma leptin, adiponectin, chemerin, omentin-1 and insulin were measured by ELISA methods. Multiple linear regression models, adjusting for age, MetS traits, C-reactive protein (CRP) and homeostasis model assessment of insulin resistance (HOMA-IR), were applied to determine correlates for each adipokine. Eleven participants meet criteria of MetS. These individuals had higher leptin and chemerin and lower adiponectin plasma concentrations than those without MetS. Plasma leptin and chemerin were positively related, and adiponectin and omentin-1 were inversely related to cardio-metabolic traits. In multivariate models, predictors of leptin were age (β, 0.20, P = 0.01), abdominal obesity (β, 0.24, P = 0.06), raised blood pressure (β, 0.40, P = 0.01), raised triglycerides (β, 0.19, P = 0.01) and CRP (β, 0.31, P = 0.01). Chemerin was associated with abdominal obesity (β, 0.33, P = 0.09) and CRP (β, 0.29, P = 0.04), and adiponectin was associated with raised triglycerides (β, -0.26, P = 0.05), decreased HDL-C (β, -0.28, P = 0.06) and CRP (β, -0.48, P = 0.01). HOMA-IR (β, -0.39, P = 0.09) was the only predictor for omentin. MetS is associated with an altered plasma adipokines profile, with increased leptin and chemerin and decreased adiponectin circulating levels. These findings suggest a beneficial potential of adiponectin and omentin, but a detrimental potential of leptin and chemerin. Further research is needed to lighten the role of adipose tissue-derived adipokines in cardio-metabolic health.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Assessment of circulating adipokines may be relevant in the analysis of cardiometabolic risk.
“Therefore, the assessment of circulating adipokines may be relevant in the analysis of cardiometabolic risk [110].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [110]
Elevated levels of leptin and chemerin may be negatively associated with cardiometabolic health.
“Elevated levels of leptin and chemerin, for example, may be negatively associated with cardiometabolic health, just as adiponectin and omentin-1 may be positively associated.”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [110]
Adiponectin and omentin-1 may be positively associated with cardiometabolic health.
“Elevated levels of leptin and chemerin, for example, may be negatively associated with cardiometabolic health, just as adiponectin and omentin-1 may be positively associated.”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [110]
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529 · see citing works
Adipokines in health and disease
Fasshauer, M., & Blüher, M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.04.014 · Cited by 1,050 · see citing works
Yang, R.-Z., Lee, M.-J., Hu, H., Pray, J., Wu, H.-B., Hansen, B. C., Shuldiner, A. R., Fried, S. K., McLenithan, J. C., & Gong, D.-W. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00572.2004 · Cited by 884 · see citing works
Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes
Wolf, A. M., Wolf, D. G. F., Rumpold, H. F., Enrich, B., & Tilg, H. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.145 · Cited by 821 · see citing works
Omentin Plasma Levels and Gene Expression Are Decreased in Obesity
Batista, C. M. D. S., Yang, R.-Z., Lee, M., Glynn, N. M., Yu, D.-Z., Pray, J., Ndubuizu, K., Patil, S. P., Schwartz, A. B., Kligman, M. D., et al. (2007) · Diabetes · doi:10.2337/db06-1506 · Cited by 760 · see citing works
Adiponectin regulation and function
Fang, H., & Judd, R. L. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170046 · Cited by 631 · see citing works
Magge, S. N., Goodman, E., Armstrong, S., ENDOCRINOLOGY, S. O., OBESITY, S. O., Daniels, S. R., Corkins, M. R., de Ferranti, S. D., Golden, N. H., Kim, J. H., et al. (2017) · PEDIATRICS · doi:10.1542/peds.2017-1603 · Cited by 400 · see citing works
Adiponectin signaling and function in insulin target tissues
Ruan, H., & Dong, L. Q. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw014 · Cited by 395 · see citing works
Leptin in inflammation and autoimmunity
Cava, A. L. (2017) · Cytokine · doi:10.1016/j.cyto.2016.10.011 · Cited by 343 · see citing works
Chemerin: a multifaceted adipokine involved in metabolic disorders
Helfer, G., & Wu, Q. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0174 · Cited by 317 · see citing works
Takahashi, M., Takahashi, Y., Takahashi, K. P., Zolotaryov, F. N., Hong, K. S., Kitazawa, R., Iida, K., Okimura, Y., Kaji, H., Kitazawa, S., et al. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.01.023 · Cited by 299 · see citing works
Metabolic syndrome is an inflammatory disorder: A conspiracy between adipose tissue and phagocytes
Reddy, P., Lent-Schochet, D., Ramakrishnan, N., McLaughlin, M., & Jialal, I. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.06.019 · Cited by 297 · see citing works
Chemerin Exacerbates Glucose Intolerance in Mouse Models of Obesity and Diabetes
Ernst, M. C., Issa, M. E., Goralski, K. B., & Sinal, C. J. (2010) · Endocrinology · doi:10.1210/en.2009-1098 · Cited by 260 · see citing works
Luangsay, S., Wittamer, V., Bondue, B., Henau, O. D., Rouger, L., Brait, M., Franssen, J.-D., de Nadaı̈, P., Huaux, F., & Parmentier, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901037 · Cited by 256 · see citing works
Omentin: A Novel Link Between Inflammation, Diabesity, and Cardiovascular Disease
Tan, B. K., Adya, R., & Randeva, H. S. (2010) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2010.12.002 · Cited by 255 · see citing works
Chakaroun, R., Raschpichler, M., Klöting, N., Oberbach, A., Flehmig, G., Kern, M., Schön, M. R., Shang, E., Lohmann, T., Dreßler, M., et al. (2011) · Metabolism · doi:10.1016/j.metabol.2011.10.008 · Cited by 234 · see citing works
Hart, R., & Greaves, D. R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902154 · Cited by 175 · see citing works
Rao, S., Hu, Y., Xie, P., Cao, J., Wang, Z., Liu, J., Yin, H., Huang, J., Tan, Y., Luo, J., et al. (2018) · Bone Research · doi:10.1038/s41413-018-0012-0 · Cited by 163 · see citing works
Jialal, I., Devaraj, S., Kaur, H., ADAMS-HUET, B. A., & Bremer, A. A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3673 · Cited by 155 · see citing works
Counteractive effects of omentin-1 against atherogenesis
Watanabe, K., Watanabe, R., Konii, H., Shirai, R., Sato, K., Matsuyama, T., Ishibashi‐Ueda, H., Koba, S., Kobayashi, Y., Hirano, T., et al. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw016 · Cited by 143 · see citing works
Interleukin-1ß induces the novel adipokine chemerin in adipocytes in vitro
Kralisch, S., Weise, S., Sommer, G., Lipfert, J., Lössner, U., Blüher, M., Stümvoll, M., & Faßhauer, M. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.02.010 · Cited by 139 · see citing works
Kumari, R., Kumar, S., & Kant, R. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.06.005 · Cited by 138 · see citing works
A novel adipocytokine, chemerin exerts anti-inflammatory roles in human vascular endothelial cells
Yamawaki, H., Kameshima, S., Usui, T., Okada, M., & Hara, Y. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.05.103 · Cited by 90 · see citing works
Dimitriadis, G. K., Kaur, J., Adya, R., Miras, A. D., Mattu, H. S., Hattersley, J. G., Kaltsas, G., Tan, B. K., & Randeva, H. S. (2018) · Oncotarget · doi:10.18632/oncotarget.24659 · Cited by 73 · see citing works
Chemerin as an independent predictor of cardiovascular event risk
İnci, S., Aksan, G., & Doğan, P. (2016) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018816629894 · Cited by 57 · see citing works
Omentin-1 and risk of myocardial infarction and stroke: Results from the EPIC-Potsdam cohort study
Menzel, J., di Giuseppe, R., Biemann, R., Wittenbecher, C., Aleksandrova, K., Pischon, T., Fritsche, A., Schulze, M. B., Boeing, H., Isermann, B., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.06.003 · Cited by 53 · see citing works
Li, G., Xu, L., Zhao, Y., Li, L., Fu, J., Zhang, Q., Li, N., Xiao, X., Li, C., Mi, J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186222 · Cited by 52 · see citing works
Ouerghi, N., Fradj, M. K. B., Bezrati, I., Feki, M., Kaabachi, N., & Bouassida, A. (2017) · Obesity Facts · doi:10.1159/000471882 · Cited by 39 · see citing works
Adiponectin as a Target in Obesity-related Inflammatory State
Ohashi, K., Yuasa, D., Shibata, R., Murohara, T., & Ouchi, N. (2015) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530315666150316122709 · Cited by 36 · see citing works
Omentin-1, Adiponectin, and the Risk of Developing Type 2 Diabetes
Wittenbecher, C., Menzel, J., Carstensen‐Kirberg, M., Biemann, R., di Giuseppe, R., Fritsche, A., Isermann, B., Herder, C., Aleksandrova, K., Boeing, H., et al. (2016) · Diabetes Care · doi:10.2337/dc15-2702 · Cited by 33 · see citing works
Hatziagelaki, E. E., Herder, C., Tsiavou, A., Teichert, T., Chounta, A., Nowotny, P., Pacini, G., Dimitriadis, G., & Roden, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124935 · Cited by 24 · see citing works
Proinflammatory Activities of Leptin in Non-Autoimmune Conditions
Cava, A. L. (2012) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152812800959031 · Cited by 24 · see citing works
Ouerghi, N., Fradj, M. K. B., Khammassi, M., Feki, M., Kaabachi, N., & Bouassida, A. (2017) · PubMed · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The role of adipokines in health and disease
Clemente-Suárez, V. J., Redondo-Flórez, L., Beltrán-Velasco, A. I., Martín-Rodríguez, A., Martínez-Guardado, I., Navarro-Jiménez, E., Laborde-Cárdenas, C. C., & Tornero-Aguilera, J. F. (2023) · Biomedicines · doi:10.3390/biomedicines11051290 · Cited by 463 · see citing works
Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions
de Oliveira dos Santos, A. R., de Oliveira Zanuso, B., Miola, V. F. B., Barbalho, S. M., Santos Bueno, P. C., Flato, U. A. P., Detregiachi, C. R. P., Buchaim, D. V., Buchaim, R. L., Tofano, R. J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052639 · Cited by 189 · see citing works
Role of chemerin in the control of glucose homeostasis
Léniz, A., González, M. A., Besné-Eseverri, I., Carr-Ugarte, H., Gómez-García, I., & Portillo, M. P. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111504 · Cited by 34 · see citing works
Ouerghi, N., Fradj, M. K. B., Duclos, M., Bouassida, A., Feki, M., Weiss, K., & Knechtle, B. (2022) · Biology · doi:10.3390/biology11060853 · Cited by 21 · see citing works
Chrigui, S., Taieb, S. H., Jemai, H., Mbarek, S., Benlarbi, M., Feki, M., Haouas, Z., Zemmel, A., Chaouacha‐Chekir, R. B., & Boudhrioua, N. M. (2023) · Foods · doi:10.3390/foods12061185 · Cited by 18 · see citing works
Mousavi, S. M., Heidarianpour, A., & Tavassoli, H. (2022) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2022.2070116 · Cited by 12 · see citing works
Baenas, I., Mora‐Maltas, B., Etxandi, M., Lucas, I., Granero, R., Fernández‐Aranda, F., Tovar, S. A., Solé‐Morata, N., Gómez‐Peña, M., Moragas, L., et al. (2023) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2023.152435 · Cited by 10 · see citing works
Qu, J., Fu, S., Yin, L., Zhang, Q., & Wang, X. (2024) · Cytokine · doi:10.1016/j.cyto.2024.156689 · Cited by 6 · see citing works
Achour, O., Haffani, Y. Z., Mbarek, S., Hammami, O., Feki, M., Zemmel, A., Picaud, S. A., Boudhrioua, N. M., & Chaouacha‐Chekir, R. B. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202401351 · Cited by 6 · see citing works
Krishnan, I., Ling, M. T. M., Ng, M. H., Law, J. X., Yusof, M. R. M., Thangarajah, T., Mahmood, Z., Izzati, U. Z., Rajamanickam, S., Subramani, B., et al. (2025) · Biomolecules · doi:10.3390/biom15010044 · Cited by 5 · see citing works
Chemerin, IL-18 and IL-1 Beta as Biomarkers of Metabolic Syndrome in Egyptian Obese Children
Gad, S. S., Shora, H., Abdelwahab, A., Abdou, R. M., Raouf, B. M. A., Elmikaty, H. A., Nassar, S. S., Ali, A., Ismail, H. M., & Dahshan, I. (2022) · Acta Scientific Medical Sciences · doi:10.31080/asms.2022.06.1310 · Cited by 5 · see citing works
Chemerin and Asprosin as Promising Biomarkers of Metabolic Syndrome: A Scoping Review
Ozyalcin, B., & Şanlıer, N. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00665-5 · Cited by 4 · see citing works
Asgari, A., Niyazi, A., Hoseinpour, A. N., Setayesh, S., Mousavi, R. F., & Rahimi, G. R. M. (2023) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-023-01229-w · Cited by 4 · see citing works
Ahmed, N. A., Hussein, A. A., Khalil, R. G., Yassin, N. Y. S., Abdelaziz, M. A., Geddawy, A., & Ahmed, O. M. (2026) · Biochemistry Research International · doi:10.1155/bri/1761697 · Cited by 3 · see citing works
Saadouni, H., Selmi, O., Ouerghi, N., Marzouki, H., Hattabi, S., Attig, L., Weiss, K., Rosemann, T. J., Knechtle, B., & Bouassida, A. (2026) · Clinics · doi:10.1016/j.clinsp.2026.100880 · Cited by 3 · see citing works
Chrigui, S., Mbarek, S., Taieb, S. H., Haouas, Z., Feki, M., Benlarbi, M., Zemmel, A., Chigr, F., Boudhrioua, N. M., & Chaouacha‐Chekir, R. B. (2024) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2024.2375983
Asghar, K., Taimoor, M., Ahmed, A., & Khalid, H. (2026) · Al-Najam Journal of Medical and Life Sciences · doi:10.68041/anjmls.v1i1/05
- Authors
- Ouerghi, N., Ben Fradj, M. K., Talbi, E., Bezrati, I., Feki, M., & Bouassida, A.
- Affiliations
- Tunis University (TN)
- Faculté de médecine de Tunis (TN)
- University of Jendouba (TN)
- Corresponding author
- Ouerghi, Nejmeddine
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 133
- Pages
- 155170
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W3035113683
- Cited by
- 17
- References
- 34
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 2
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of High Education and Scientific Research of Tunisia
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- adipokines, metabolic syndrome, leptin, adiponectin, chemerin, omentin-1, cardiometabolic risk factors, young men, abdominal obesity, insulin resistance, C-reactive protein, triglycerides, HDL cholesterol, blood pressure, adipose tissue, insulin, youth health, cardiovascular risk, diabetes risk, inflammatory markers
- MeSH terms
- Adipose Tissue, Adolescent, Adult, C-Reactive Protein, Humans, Insulin, Insulin Resistance, Male, Risk Factors, Triglycerides, Leptin, Metabolic Syndrome, Adipokines, Young Adult, Obesity, Abdominal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
