Adiponectin regulation and function

Fang, Han; Judd, Robert L.

doi:10.1002/cphy.c170046

Cited by 632Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Adiponectin regulation and function

Fang, Han, Judd, Robert L.·2018·Comprehensive physiology

DOI 10.1002/cphy.c170046

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Abstract

Adipose tissue is now recognized as an important endocrine organ, capable of secreting a large number of endocrine factors which regulate a wide variety of physiological functions. Adiponectin is one such factor, secreted in large quantities primarily from adipose tissue. Adiponectin is posttranslationally modified from a 30-kDa monomeric protein into different multimers (low molecular weight or trimer, middle molecular weight or hexamer, and high molecular weight) and secreted into the circulation. Upon binding to its receptors, AdipoR1 and R2, adiponectin initiates a series of tissue-dependent signal transduction events, including phosphorylation of adenosine monophosphate (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK), and increased peroxisome proliferator-activated receptor alpha (PPARα) ligand activity. These signal transduction events are regulated by adaptor protein containing a pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif (APPL1), which binds directly to the intracellular regions of AdipoR1 and R2. AdipoR1 and R2 also possesses inherent ceramidase activity, resulting in a decrease in intracellular ceramide, a sphingolipid that has been implicated in insulin resistance, cell death, inflammation, and atherosclerosis. Adiponectin stimulates fatty acid oxidation in skeletal muscle and inhibits glucose production in the liver, resulting in an improvement in whole-body energy homeostasis. Adiponectin is also a classic anti-inflammatory agent, reducing inflammation in various cell types through AdipoR1 and R2 signaling mechanisms. Adiponectin's anti-inflammatory and anti-apoptotic properties results in protection of the vasculature, heart, lung, and colon. In this review, we provide a comprehensive overview of the discovery, protein structure, receptors, expression, regulation, and physiological functions of adiponectin. © 2017 American Physiological Society. Compr Physiol 8:1031-1063, 2018.

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“It directly suppresses the secretion of TNF-α, MCP-1, and IL-6, while increasing IL-10 and the polarization to M2 and reducing β-cell apoptosis [230].”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [230]

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Increased β-Oxidation but No Insulin Resistance or Glucose Intolerance in Mice Lacking Adiponectin
Ma, K., Cabrero, À., Saha, P., Kojima, H., Li, L., Chang, B. H.-J., Paul, A., & Chan, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200362200 · Cited by 284 · see citing works
Cardioprotection by Ischemic Postconditioning Is Lost in Aged and STAT3-Deficient Mice
Boengler, K., Buechert, A., Heinen, Y., Roeskes, C., Hilfiker‐Kleiner, D., Heusch, G., & Schulz, R. (2007) · Circulation Research · doi:10.1161/circresaha.107.164699 · Cited by 281 · see citing works
Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism
Bjursell, M., Ahnmark, A., Bohlooly‐Y, M., William‐Olsson, L., Rhedin, M., Peng, X., Ploj, K., Gerdin, A.-K., Arnerup, G., Elmgren, A., et al. (2007) · Diabetes · doi:10.2337/db06-1432 · Cited by 277 · see citing works
Essential role of mitochondrial function in adiponectin synthesis in adipocytes
Koh, E. H., Park, J.-Y., Park, H.-S., Jeon, M. J., Ryu, J. W., Kim, M., Kim, S. Y., Kim, M.-S., Kim, S.-W., Park, I. S., et al. (2007) · Diabetes · doi:10.2337/db07-0510 · Cited by 275 · see citing works
Adiponectin: Regulation of its production and its role in human diseases
Shehzad, A., Iqbal, W., Shehzad, O., & Lee, Y. S. (2012) · HORMONES · doi:10.1007/bf03401534 · Cited by 272 · see citing works
Expression of adiponectin receptors in pancreatic β cells
Kharroubi, I., Rasschaert, J., Eizirik, D. L., & Cnop, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.042 · Cited by 270 · see citing works
Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARα, PPARγ, and LXR
Chinetti, G., Zawadski, C., Fruchart, J., & Staels, B. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.058 · Cited by 267 · see citing works
Adiponectin inhibits Toll‐like receptor family‐induced signaling
Yamaguchi, N., Argueta, J. G. M., Masuhiro, Y., Kagishita, M., Nonaka, K., Saito, T., Hanazawa, S., & Yamashita, Y. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.11.019 · Cited by 259 · see citing works
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes
Civitarese, A. E., Jenkinson, C. P., Richardson, D. K., Bajaj, M., Cusi, K. J., Kashyap, S. R., Berria, R., Belfort, R., DeFronzo, R. A., Mandarino, L. J., et al. (2004) · Diabetologia · doi:10.1007/s00125-004-1359-x · Cited by 258 · see citing works
Cardioprotection by Adiponectin
Ouchi, N., Shibata, R., & Walsh, K. X. (2006) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2006.03.001 · Cited by 257 · see citing works
Molecular Mechanism for Adiponectin-dependent M2 Macrophage Polarization
Mandal, P., Pratt, B. T., Barnes, M. A., McMullen, M. R., & Nagy, L. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204644 · Cited by 256 · see citing works
Post-translational Modifications of the Four Conserved Lysine Residues within the Collagenous Domain of Adiponectin Are Required for the Formation of Its High Molecular Weight Oligomeric Complex
Wang, Y., Lam, K. S. L., Chan, L., Chan, K. W., Lam, J. B. B., Lam, M. C., Hoo, R. L. C., Mak, W. W. N., Cooper, G. J. S., & Xu, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513907200 · Cited by 254 · see citing works
Adiponectin Inhibits Endothelial Synthesis of Interleukin-8
Kobashi, C., Urakaze, M., Kishida, M., Kibayashi, E., Kobayashi, H., Kihara, S., Funahashi, T., Takata, M., Temaru, R., Sato, A., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000194328.57164.36 · Cited by 252 · see citing works
Adiponectin, Cardiovascular Function, and Hypertension
Wang, Z. V., & Scherer, P. E. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.099424 · Cited by 247 · see citing works
Adiponectin and atherosclerotic disease
Shimada, K., Miyazaki, T., & Daida, H. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2004.02.020 · Cited by 244 · see citing works
Adiponectin: a versatile player of innate immunity
Luo, Y., & Liu, M. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw012 · Cited by 244 · see citing works
Leptin and Adiponectin Stimulate the Release of Proinflammatory Cytokines and Prostaglandins from Human Placenta and Maternal Adipose Tissue via Nuclear Factor-κB, Peroxisomal Proliferator-Activated Receptor-γ and Extracellularly Regulated Kinase 1/2
Lappas, M., Permezel, M., & Rice, G. E. (2005) · Endocrinology · doi:10.1210/en.2005-0406 · Cited by 241 · see citing works
Adiponectin: a manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease?
Fisman, E. Z., & Tenenbaum, A. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-103 · Cited by 240 · see citing works
Physiological, Pharmacological, and Nutritional Regulation of Circulating Adiponectin Concentrations in Humans
Swarbrick, M. M., & Havel, P. J. (2008) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2007.0029 · Cited by 237 · see citing works
Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism
LIAO, Y., TAKASHIMA, S., MAEDA, N., OUCHI, N., KOMAMURA, K., SHIMOMURA, I., HORI, M., MATSUZAWA, Y., FUNAHASHI, T., & KITAKAZE, M. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.04.018 · Cited by 236 · see citing works
Adiponectin and Resistin in Human Cerebrospinal Fluid and Expression of Adiponectin Receptors in the Human Hypothalamus
Kos, K., Harte, A. L., da Silva, N. F., Tonchev, A. B., Chaldakov, G., James, S. G., Snead, D. R. J., Hoggart, B., O’Hare, J. P., McTernan, P. G., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1841 · Cited by 234 · see citing works
Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-α
Wang, B., Jenkins, J. R., & Trayhurn, P. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00475.2004 · Cited by 233 · see citing works
Ceramide Mediates Insulin Resistance by Tumor Necrosis Factor-α in Brown Adipocytes by Maintaining Akt in an Inactive Dephosphorylated State
Teruel, T., Hernández, R., & Lorenzo, M. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2563 · Cited by 230 · see citing works
Adiponectin-induced ERK and Akt Phosphorylation Protects against Pancreatic Beta Cell Apoptosis and Increases Insulin Gene Expression and Secretion*
Wijesekara, N., Krishnamurthy, M., Bhattacharjee, A., Suhail, A., Sweeney, G., & Wheeler, M. B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.085084 · Cited by 229 · see citing works
Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy
Phillips, S. A., Ciaraldi, T. P., Kong, A. P. S., Bandukwala, R., Aroda, V. R., Carter, L., Baxi, S. C., Mudaliar, S. R. D., & Henry, R. R. (2003) · Diabetes · doi:10.2337/diabetes.52.3.667 · Cited by 227 · see citing works
Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum
Kusminski, C. M., McTernan, P. G., Schraw, T., Kos, K., O’Hare, J. P., Ahima, R. S., Kumar, S., & Scherer, P. E. (2007) · Diabetologia · doi:10.1007/s00125-006-0577-9 · Cited by 223 · see citing works
Insulin Signaling in the Pancreatic β-Cell
Leibiger, I. B., Leibiger, B., & Berggren, P. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155530 · Cited by 221 · see citing works
Adipose Tissue Adiponectin Production and Adiponectin Serum Concentration in Human Obesity and Insulin Resistance
Hoffstedt, J., Nordström, E. A., Sjölin, E., Wåhlén, K., & Arner, P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031458 · Cited by 220 · see citing works
Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages
Lovren, F., Pan, Y., Quan, A., Szmitko, P. E., Singh, K. K., Shukla, P. C., Gupta, M., Chan, L., Al-Omran, M. A., Teoh, H., et al. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00115.2010 · Cited by 220 · see citing works
Plasma Adiponectin Levels Are Associated with Insulin Resistance, But Do Not Predict Future Risk of Coronary Heart Disease in Women
Lawlor, D. A., Smith, G. D., Ebrahim, S. B. J., Thompson, C., & Sattar, N. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0825 · Cited by 219 · see citing works
Hypoadiponectinemia Is Associated with Insulin Resistance, Hypertriglyceridemia, and Fat Redistribution in Human Immunodeficiency Virus-Infected Patients Treated with Highly Active Antiretroviral Therapy
Addy, C., Gavrila, A., Tsiodras, S., Brodovicz, K. G., Karchmer, A. W., & Mantzoros, C. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020795 · Cited by 218 · see citing works
Crystal structures of the human adiponectin receptors
Tanabe, H., Fujii, Y., Okada‐Iwabu, M., Iwabu, M., Nakamura, Y., Hosaka, T., Motoyama, K., Ikeda, M., Wakiyama, M., Terada, T., et al. (2015) · Nature · doi:10.1038/nature14301 · Cited by 217 · see citing works
Plasma Adiponectin Complexes Have Distinct Biochemical Characteristics
Schraw, T., Wang, Z. V., Halberg, N., Hawkins, M. A., & Scherer, P. E. (2008) · Endocrinology · doi:10.1210/en.2007-1561 · Cited by 216 · see citing works
Adiponectin and Cardiovascular Disease
Shibata, R., Ouchi, N., & Murohara, T. (2009) · Circulation Journal · doi:10.1253/circj.cj-09-0057 · Cited by 214 · see citing works
Structural insights into adiponectin receptors suggest ceramidase activity
Vasiliauskaité-Brooks, I., Sounier, R., Rochaix, P., Bellot, G., Fortier, M., Hoh, F., Colibus, L. D., Bechara, C., Saied, E. M., Arenz, C., et al. (2017) · Nature · doi:10.1038/nature21714 · Cited by 214 · see citing works
Adiponectin Activates AMP-Activated Protein Kinase in Muscle Cells via APPL1/LKB1-Dependent and Phospholipase C/Ca2+/Ca2+/Calmodulin-Dependent Protein Kinase Kinase-Dependent Pathways
Zhou, L., Deepa, S. S., Etzler, J. C., Ryu, J., Mao, X., Fang, Q., Liu, D. D., Torres, J. M., Jia, W., Lechleiter, J. D., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.028357 · Cited by 212 · see citing works
Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1
Wang, C., Mao, X., Wang, L., Liu, M., Wetzel, M. D., Guan, K.-L., Dong, L. Q., & Liu, F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700098200 · Cited by 210 · see citing works
Globular adiponectin upregulates nitric oxide production in vascular endothelial cells
Hattori, Y., Suzuki, M., Hattori, S., & Kasai, K. (2003) · Diabetologia · doi:10.1007/s00125-003-1224-3 · Cited by 209 · see citing works
A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization
Liu, M., Zhou, L., Xu, A., Lam, K. S. L., Wetzel, M. D., Xiang, R., Zhang, J., Xin, X., Dong, L., & Liu, F. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806341105 · Cited by 207 · see citing works
Adiponectin induces TNF-α and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuli
Tsatsanis, C., Zacharioudaki, V., Androulidaki, A., Dermitzaki, E., Charalampopoulos, I., MINAS, V., Gravanis, A., & Margioris, A. N. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.197 · Cited by 203 · see citing works
Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease
Ohashi, K., Ouchi, N., Kihara, S., Funahashi, T., Nakamura, T., Sumitsuji, S., Kawamoto, T., Matsumoto, S., Nagaretani, H., Kumada, M., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.10.049 · Cited by 203 · see citing works
Adiponectin Inhibits the Production of CXC Receptor 3 Chemokine Ligands in Macrophages and Reduces T-Lymphocyte Recruitment in Atherogenesis
Okamoto, Y., Folco, E. J. E., Minami, M., Wara, A. K., Feinberg, M. W., Sukhova, G. K., Colvin, R. A., Kihara, S., Funahashi, T., Luster, A. D., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.164988 · Cited by 202 · see citing works
Exacerbation of Albuminuria and Renal Fibrosis in Subtotal Renal Ablation Model of Adiponectin-Knockout Mice
Ohashi, K., Iwatani, H., Kihara, S., Nakagawa, Y., Komura, N., Fujita, K., Maeda, N., Nishida, M., Katsube, F., Shimomura, I., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.147645 · Cited by 201 · see citing works
Inhibition of PKB/Akt1 by C2-Ceramide Involves Activation of Ceramide-Activated Protein Phosphatase in PC12 Cells
Salinas, M., López‐Valdaliso, R., Martı́n, D., Alvarez, A. M., & Cuadrado, A. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0813 · Cited by 199 · see citing works
Adiponectin: Anti-inflammatory and cardioprotective effects
Villarreal-Molina, M. T., & Antuna-Puente, B. (2012) · Biochimie · doi:10.1016/j.biochi.2012.06.030 · Cited by 197 · see citing works

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Pathophysiology of type 2 diabetes mellitus
Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K. B., Ostolaza, H., & Martín, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176275 · Cited by 3,360 · see citing works
Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529 · see citing works
Pro-inflammatory cytokines: The link between obesity and osteoarthritis
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The endocrine function of adipose tissues in health and cardiometabolic disease
Scheja, L., & Heeren, J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0230-6 · Cited by 663 · see citing works
Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases
Choi, H. M., Doss, H. M., & Kim, K. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041219 · Cited by 520 · see citing works
Pathophysiology of obesity and its associated diseases
Jin, X., Qiu, T., Li, L., Yu, R., Chen, X., Li, C., Proud, C. G., & Jiang, T. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.01.012 · Cited by 552 · see citing works
Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications
Ren, J. T., Wu, N. N., Wang, S., Sowers, J. R., & Zhang, Y. (2021) · Physiological Reviews · doi:10.1152/physrev.00030.2020 · Cited by 377 · see citing works
The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease
Fujii, H., Kawada, N., & Japan Study Group of NAFLD (JSG-NAFLD) (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113863 · Cited by 300 · see citing works
The role of adipokines in inflammatory mechanisms of obesity
Kirichenko, T. V., Markina, Y. V., Bogatyreva, A. I., Tolstik, T. V., Varaeva, Y. R., & Starodubova, A. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314982 · Cited by 289 · see citing works
The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review
Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works
Monounsaturated Fatty Acids in Obesity-Related Inflammation
Ravaut, G., Légiot, A., Bergeron, K., & Mounier, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010330 · Cited by 257 · see citing works
Adipose Tissue and Metabolic Health
An, S.-M., Cho, S.-H., & Yoon, J. C. (2023) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2023.0011 · Cited by 184 · see citing works
Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway
Jian, M., Kwan, J., Bunting, M., Ng, R. C.-L., & Chan, K. H. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1492-6 · Cited by 191 · see citing works
Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions
de Oliveira dos Santos, A. R., de Oliveira Zanuso, B., Miola, V. F. B., Barbalho, S. M., Santos Bueno, P. C., Flato, U. A. P., Detregiachi, C. R. P., Buchaim, D. V., Buchaim, R. L., Tofano, R. J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052639 · Cited by 189 · see citing works
Sarcopenia and obesity
Zamboni, M., Rubele, S., & Rossi, A. P. (2019) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000519 · Cited by 173 · see citing works
Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/GSK-3β
Liu, H., Wu, X., Luo, J., Zhao, L., Li, X., Guo, H., Bai, H., Cui, W., Guo, W., Feng, D., et al. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113302 · Cited by 178 · see citing works
Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system
Kruger, A., Vlok, M., Turner, S., Venter, C., Laubscher, G. J., Kell, D. B., & Pretorius, E. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01623-4 · Cited by 175 · see citing works
Involvement of Novel Adipokines, Chemerin, Visfatin, Resistin and Apelin in Reproductive Functions in Normal and Pathological Conditions in Humans and Animal Models
Estienne, A., Bongrani, A., Reverchon, M., Ramé, C., Ducluzeau, P., Froment, P., & Dupont, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184431 · Cited by 175 · see citing works
Adipose tissue inflammation and metabolic syndrome. The proactive role of probiotics
Torres, S., Fabersani, E., Marquez, A., & Gauffin-Cano, P. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1790-2 · Cited by 169 · see citing works
Visceral adipose tissue and residual cardiovascular risk: a pathological link and new therapeutic options
Cesaro, A., Michele, G. D., Fimiani, F., Acerbo, V., Scherillo, G., Signore, G., Rotolo, F. P., Scialla, F., Raucci, G., Panico, D., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1187735 · Cited by 160 · see citing works
Bone Marrow Mesenchymal Stromal Cells: Identification, Classification, and Differentiation
Gao, Q., Wang, L., Wang, S., Huang, B., Jing, Y., & Su, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.787118 · Cited by 140 · see citing works
Inflammation‐mediated metabolic regulation in adipose tissue
Xu, S., Lu, F., Gao, J., & Yuan, Y. (2024) · Obesity Reviews · doi:10.1111/obr.13724 · Cited by 129 · see citing works
Obesity and breast cancer: A case of inflamed adipose tissue
Kolb, R., & Zhang, W. (2020) · Cancers · doi:10.3390/cancers12061686 · Cited by 119 · see citing works
Running exercise alleviates hippocampal neuroinflammation and shifts the balance of microglial M1/M2 polarization through adiponectin/AdipoR1 pathway activation in mice exposed to chronic unpredictable stress
Liu, L., Tang, J., Liang, X., Li, Y., Zhu, P., Zhou, M., Lu, Q., Deng, Y., Li, J., Wang, Y., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02464-1 · Cited by 113 · see citing works
Obesity and Thyroid Cancer Risk: An Update
Franchini, F., Palatucci, G., Colao, A., Ungaro, P., Macchia, P. E., & Nettore, I. C. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031116 · Cited by 108 · see citing works
Calorie Restriction as a New Treatment of Inflammatory Diseases
Kökten, T., Hansmannel, F., Ndiaye, N. C., Heba, A.-C., Quilliot, D., Dreumont, N., Arnone, D., & Peyrin‐Biroulet, L. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa179 · Cited by 104 · see citing works
Invited review: Metabolic challenges and adaptation during different functional stages of the mammary gland in dairy cows: Perspectives for sustainable milk production
Gross, J. J., & Bruckmaier, R. M. (2019) · Journal of Dairy Science · doi:10.3168/jds.2018-15713 · Cited by 103 · see citing works
Constituents, Pharmacokinetics, and Pharmacology of Gegen-Qinlian Decoction
Lu, J., Ye, D., & Ma, B. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.668418 · Cited by 99 · see citing works
A review of saponin intervention in metabolic syndrome suggests further study on intestinal microbiota
Luo, Z., Xu, W., Zhang, Y., Di, L., & Shan, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105088 · Cited by 93 · see citing works
Physical exercise and catecholamines response: benefits and health risk: possible mechanisms
Kruk, J., Kotarska, K., & Aboul-Enein, B. H. (2020) · Free Radical Research · doi:10.1080/10715762.2020.1726343 · Cited by 89 · see citing works
Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?
Guo, A., Li, K., & Xiao, Q. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111022 · Cited by 83 · see citing works
Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges
Lei, X., Qiu, S., Yang, G., & Wu, Q. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.10.018 · Cited by 87 · see citing works
Alteration of gut microbiota affects expression of adiponectin and resistin through modifying DNA methylation in high-fat diet-induced obese mice
Yao, H., Fan, C., Lu, Y., Fan, X., Xia, L., Li, P., Wang, R., Tang, T., Wang, Y., & Qi, K. (2020) · Genes & Nutrition · doi:10.1186/s12263-020-00671-3 · Cited by 79 · see citing works
Adiponectin Synthesis, Secretion and Extravasation from Circulation to Interstitial Space
Rosa, S. C. D. S., Liu, M., & Sweeney, G. (2021) · Physiology · doi:10.1152/physiol.00031.2020 · Cited by 79 · see citing works
The Role of Adipose Tissue and Nutrition in the Regulation of Adiponectin
Baldelli, S., Aiello, G., Martino, E. M. D., Campaci, D., Muthanna, F. M. S., & Lombardo, M. (2024) · Nutrients · doi:10.3390/nu16152436 · Cited by 88 · see citing works
Adipokines in obesity and metabolic-related-diseases
Pestel, J., Blangero, F., Watson, J., Pirola, L., & Eljaafari, A. (2023) · Biochimie · doi:10.1016/j.biochi.2023.04.008 · Cited by 80 · see citing works
Local and Physiological Control of Germline Stem Cell Lineages in Drosophila melanogaster
Drummond‐Barbosa, D. (2019) · Genetics · doi:10.1534/genetics.119.300234 · Cited by 76 · see citing works
The Role of the Adipokines in the Most Common Gestational Complications
Gutaj, P., Sibiak, R., Jankowski, M., Awdi, K., Bryl, R., Mozdziak, P. E., Kempisty, B., & Wender-Ożegowska, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249408 · Cited by 75 · see citing works
Skeletal muscle mitochondrial remodeling in heart failure: An update on mechanisms and therapeutic opportunities
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Authors: Fang, H., & Judd, R. L.
Affiliations: Auburn University (US)
Corresponding author: Judd, Robert L.
ORCID: Fang, Han
Venue: Comprehensive physiology
Publisher: Wiley
Published: 2018-06-18
Volume: 8
Issue: 3
Pages: 1031-1063
ISSN: 2040-4603 (ISSN-L)
DOI: 10.1002/cphy.c170046
OpenAlex: W2895752892
Cited by: 631
References: 407
Citations by year: 2026: 19 · 2025: 46 · 2024: 104 · 2023: 113 · 2022: 124 · 2021: 107 · 2020: 85 · 2019: 24 · 2018: 9
Type: other
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: Comprehensive physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: adiponectin, adipose tissue endocrine function, adiponectin multimers, AdipoR1, AdipoR2, AMPK signaling, p38 MAPK, PPARα, APPL1, ceramide, ceramidase, anti-inflammatory activity, anti-apoptotic effects, energy homeostasis, fatty acid oxidation, glucose production, insulin resistance, vascular protection
MeSH terms: Adipose Tissue, Animals, Gene Expression Regulation, Humans, Protein Conformation, Adiponectin, Receptors, Adiponectin

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