Cited by 178NF-κB Signaling PathwaysSignaling Pathways in DiseaseImmune Response and Inflammation

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Crosstalk via the NF-κB signaling system

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Basak, Soumen, Hoffmann, Alexander·2008·Cytokine & Growth Factor Reviews

DOI 10.1016/j.cytogfr.2008.04.005PMC PMC2675004

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Abstract

The nuclear factor kappaB (NF-kappaB) family of transcription factors consists of 15 possible dimers whose activity is controlled by a family of inhibitor proteins, known as IkappaBs. A variety of cellular stimuli, many of them transduced by members of the tumor necrosis factor receptor (TNFR) superfamily, induce degradation of IkappaBs to activate an overlapping subset of NF-kappaB dimers. However, generation and stimulus-responsive activation of NF-kappaB dimers are intimately linked via various cross-regulatory mechanisms that allow crosstalk between different signaling pathways through the NF-kappaB signaling system. In this review, we summarize these mechanisms and discuss physiological and pathological consequences of crosstalk between apparently distinct inflammatory and developmental signals. We argue that a systems approach will be valuable for understanding questions of specificity and emergent properties of highly networked cellular signaling systems.

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Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · cited 1×
“In general, the catalytic activity of IKK2 is required for canonical signaling [8,9].”
Background
Nuclear factor-κB in cancer development and progression
Karin, M. (2006) · Nature · doi:10.1038/nature04870 · Cited by 3,519
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433
IκB: a Specific Inhibitor of the NF-κB Transcription Factor
Baeuerle, P. A., & Baltimore, D. (1988) · Science · doi:10.1126/science.3140380 · Cited by 2,154
The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation
Hoffmann, A., Levchenko, A., Scott, M. L., & Baltimore, D. (2002) · Science · doi:10.1126/science.1071914 · Cited by 1,890
Self-citation
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., & Baltimore, D. (1995) · Nature · doi:10.1038/376167a0 · Cited by 1,828
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krähn, G. M., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S., et al. (2001) · Science · doi:10.1126/science.1062677 · Cited by 1,361
Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
Sha, W. C., Liou, H.-C., TUOMANEN, E. I., & Baltimore, D. (1995) · Cell · doi:10.1016/0092-8674(95)90415-8 · Cited by 1,158
Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor
Baeuerle, P. A., & Baltimore, D. (1988) · Cell · doi:10.1016/0092-8674(88)90382-0 · Cited by 1,130

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Zhao, Y., Cai, Y., Shen, S., Wen, Y., Li, T., Kang, L., Xu, B., & Sun, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1896701
BindingDB Entry 50002367: Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Antiinflammatory and Anticancer Properties.
BindingDB (2020) · UC San Diego · doi:10.7270/q2m32zch

Authors: Basak, S., & Hoffmann, A.
Affiliations: University of California San Diego (US)
Corresponding author: Basak, Soumen
Hoffmann, Alexander
ORCID: Basak, Soumen
Hoffmann, Alexander
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 2008-06
Volume: 19
Issue: 3-4
Pages: 187-197
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/j.cytogfr.2008.04.005
PMC: PMC2675004
OpenAlex: W2054072076
Cited by: 177
References: 64
Citations by year: 2026: 5 · 2025: 12 · 2024: 5 · 2023: 6 · 2022: 2 · 2021: 9 · 2020: 10 · 2019: 5 · 2018: 13 · 2017: 6 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 13 · 2012: 8
FWCI: 1.26
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cytokine & Growth Factor Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (P01GM071862, R01GM071573)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: NF-κB signaling, signaling crosstalk, IκB degradation, TNF receptor superfamily, inflammatory signaling, developmental signaling
MeSH terms: Animals, Immunity, Inflammation, Lymphoid Tissue, Signal Transduction, NF-kappa B, Receptors, Tumor Necrosis Factor, Growth and Development, Mice, Transcription Factor RelA, NF-kappa B p50 Subunit

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Crosstalk via the NF-κB signaling system

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