Cited by 178NF-κB Signaling PathwaysSignaling Pathways in DiseaseImmune Response and Inflammation

The DOI matches its Crossref record; 63 of the 64 references it cites were found in a registry or an index.

Crosstalk via the NF-κB signaling system

Open access

Basak, Soumen, Hoffmann, Alexander·2008·Cytokine & Growth Factor Reviews

DOI 10.1016/j.cytogfr.2008.04.005PMC PMC2675004

Open this paper in CoChat — free account

Abstract

The nuclear factor kappaB (NF-kappaB) family of transcription factors consists of 15 possible dimers whose activity is controlled by a family of inhibitor proteins, known as IkappaBs. A variety of cellular stimuli, many of them transduced by members of the tumor necrosis factor receptor (TNFR) superfamily, induce degradation of IkappaBs to activate an overlapping subset of NF-kappaB dimers. However, generation and stimulus-responsive activation of NF-kappaB dimers are intimately linked via various cross-regulatory mechanisms that allow crosstalk between different signaling pathways through the NF-kappaB signaling system. In this review, we summarize these mechanisms and discuss physiological and pathological consequences of crosstalk between apparently distinct inflammatory and developmental signals. We argue that a systems approach will be valuable for understanding questions of specificity and emergent properties of highly networked cellular signaling systems.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cytogfr.2008.04.005

Cites

63 of 63 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638 · cited 1×
“In general, the catalytic activity of IKK2 is required for canonical signaling [8,9].”
Background
Nuclear factor-κB in cancer development and progression
Karin, M. (2006) · Nature · doi:10.1038/nature04870 · Cited by 3,519
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433
IκB: a Specific Inhibitor of the NF-κB Transcription Factor
Baeuerle, P. A., & Baltimore, D. (1988) · Science · doi:10.1126/science.3140380 · Cited by 2,154
The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation
Hoffmann, A., Levchenko, A., Scott, M. L., & Baltimore, D. (2002) · Science · doi:10.1126/science.1071914 · Cited by 1,890
Self-citation
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., & Baltimore, D. (1995) · Nature · doi:10.1038/376167a0 · Cited by 1,828
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krähn, G. M., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S., et al. (2001) · Science · doi:10.1126/science.1062677 · Cited by 1,361
Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
Sha, W. C., Liou, H.-C., TUOMANEN, E. I., & Baltimore, D. (1995) · Cell · doi:10.1016/0092-8674(95)90415-8 · Cited by 1,158
Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor
Baeuerle, P. A., & Baltimore, D. (1988) · Cell · doi:10.1016/0092-8674(88)90382-0 · Cited by 1,130

Show all 64 references

Sorted by citations

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Ros and ros-mediated cellular signaling
Zhang, J., Wang, X., Vikash, V., Ye, Q., Wu, D., Liu, Y., & Dong, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4350965 · Cited by 1,980
Signaling via the NFκB system
Mitchell, S. A., Vargas, J. D., & Hoffmann, A. (2016) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1331 · Cited by 1,057
Self-citation
Biology of interleukin-10
Sabat, R., Grütz, G., Warszawska, K., Kirsch, S., Witte, E., Wolk, K., & Geginat, J. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.09.002 · Cited by 977
NF-κB in Renal Inflammation
Sanz, A. B., Sánchez-Niño, M. D., Ramos, A. M., Moreno, J. A., Santamaria, B., Ruiz‐Ortega, M., Egido, J., & Ortíz, A. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010020218 · Cited by 581
Regulation of the expression of inducible nitric oxide synthase
Pautz, A., Art, J., Hahn, S., Nowag, S., Voss, C., & Kleinert, H. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.04.007 · Cited by 549
The dual role of iNOS in cancer
Vannini, F., Kashfi, K., & Nath, N. (2015) · Redox Biology · doi:10.1016/j.redox.2015.08.009 · Cited by 545
Modulation of NF-κB signalling by microbial pathogens
Rahman, M. M., & McFadden, G. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2539 · Cited by 402
Oxidative Stress: Signaling Pathways, Biological Functions, and Disease
Liu, S., Liu, J., Wang, Y., Deng, F., & Deng, Z. (2025) · MedComm · doi:10.1002/mco2.70268 · Cited by 485
Targeting innate immunity protein kinase signalling in inflammation
Gaestel, M., Kotlyarov, A., & Kracht, M. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2829 · Cited by 323
Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases
Beck, I. M. E., Vanden Berghe, W., Vermeulen, L., Yamamoto, K. R., Haegeman, G., & De Bosscher, K. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0013 · Cited by 298
IL-10 family of cytokines
Sabat, R. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.11.001 · Cited by 310
Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer
Desai, S. J., Prickril, B., & Rasooly, A. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1446091 · Cited by 286
Free Radicals and Oxidative Stress: Signaling Mechanisms, Redox Basis for Human Diseases, and Cell Cycle Regulation
Sadiq, I. Z. (2021) · Current Molecular Medicine · doi:10.2174/1566524022666211222161637 · Cited by 293
Nuclear initiated NF-κB signaling: nemo and ATM take center stage
Miyamoto, S. (2011) · Cell Research · doi:10.1038/cr.2010.179 · Cited by 253
A new cross-talk between the aryl hydrocarbon receptor and RelB, a member of the NF-κB family
Vogel, C. F. A., & Matsumura, F. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.09.036 · Cited by 202
NF-κB signaling pathway and free radical impact.
Siomek, A. (2012) · Acta Biochimica Polonica · doi:10.18388/abp.2012_2116 · Cited by 192
The Gastroprotective Effect of Menthol: Involvement of Anti-Apoptotic, Antioxidant and Anti-Inflammatory Activities
Rozza, A. L., de‐Faria, F. M., Brito, A. R. S., & Pellizzon, C. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086686 · Cited by 191
The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy.
de Almagro, M. C., & Vucic, D. (2012) · PubMed · Cited by 190
Gastroprotective effect of limonene in rats: Influence on oxidative stress, inflammation and gene expression
de Souza, M. C., Vieira, A. J., Beserra, F. P., Pellizzon, C. H., Nóbrega, R. H., & Rozza, A. L. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.09.027 · Cited by 166
Physiological functions of peroxisome proliferator-activated receptor β
Neels, J. G., & Grimaldi, P. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00027.2013 · Cited by 161
Fecal Microbiota Transplantation Beneficially Regulates Intestinal Mucosal Autophagy and Alleviates Gut Barrier Injury
Cheng, S., Ma, X., Geng, S., Jiang, X., Li, Y., Hu, L., Lǐ, J., Wang, Y., & Han, X. (2018) · mSystems · doi:10.1128/msystems.00137-18 · Cited by 153
NF-κB: master regulator of cellular responses in health and disease
Hoffmann, A., Cheng, G., & Baltimore, D. (2025) · Immunity & Inflammation · doi:10.1007/s44466-025-00014-0 · Cited by 173
Self-citation
Targeting estrogen receptor β in microglia and T cells to treat experimental autoimmune encephalomyelitis
Wu, W.-F., Tan, X.-J., Dai, Y.-B., Krishnan, V., Warner, M., & Gustafsson, J.-Å. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300313110 · Cited by 149
Lessons from mathematically modeling the NF‐κB pathway
Basak, S., Behar, M., & Hoffmann, A. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01092.x · Cited by 128
Self-citation
Signalling crosstalk in B cells: managing worth and need
Cancro, M. P. (2009) · Nature reviews. Immunology · doi:10.1038/nri2621 · Cited by 124
Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs
Silke, J., & Brink, R. A. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.114 · Cited by 121
The Regulatory Logic of the NF- B Signaling SystemPreprint
O'Dea, E. L., & Hoffmann, A. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000216 · Cited by 114
Self-citation
NF-κB transcriptional inhibition ameliorates cisplatin-induced acute kidney injury (AKI)
Özkök, A., Ravichandran, K., Wang, Q., Ljubanović, D. G., & Edelstein, C. L. (2015) · Toxicology Letters · doi:10.1016/j.toxlet.2015.10.028 · Cited by 111
NF‐κB signaling
O'Dea, E. L., & Hoffmann, A. (2009) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.30 · Cited by 109
Self-citation
The Impact of Acute or Chronic Alcohol Intake on the NF-κB Signaling Pathway in Alcohol-Related Liver Disease
Nowak, A. J., & Relja, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249407 · Cited by 112
Kinetic control of negative feedback regulators of NF-κB/RelA determines their pathogen- and cytokine-receptor signaling specificity
Shih, V. F.-S., Kearns, J. D., Basak, S., Savinova, O. V., Ghosh, G., & Hoffmann, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812367106 · Cited by 106
Self-citation
TNF-α and its inhibitors in cancer
Zidi, I., Mestiri, S., Bartegi, A., & Amor, N. B. (2009) · Medical Oncology · doi:10.1007/s12032-009-9190-3 · Cited by 105
NF-κB Signaling Dynamics Play a Key Role in Infection Control in Tuberculosis
Fallahi‐Sichani, M., Kirschner, D. E., & Linderman, J. J. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00170 · Cited by 105
Mouse Aorta Smooth Muscle Cells Differentiate Into Lymphoid Tissue Organizer-Like Cells on Combined Tumor Necrosis Factor Receptor-1/Lymphotoxin β-Receptor NF-κB Signaling
Lötzer, K., Döpping, S., Connert, S., Gräbner, R., Spanbroek, R., Lemser, B., Beer, M., Hildner, M., Hehlgans, T., van der Wall, M., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.191395 · Cited by 103
How Mouse Macrophages Sense What Is Going On
Ley, K. F., Pramod, A. B., Croft, M., Ravichandran, K. S., & Ting, J. P. ‐. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00204 · Cited by 101
Ophiopogonin D prevents H2O2-induced injury in primary human umbilical vein endothelial cells
Qian, J., Fengrong, J., Wang, B., Yu, Y., Zhang, X., Yin, Z., & Liu, C. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.01.031 · Cited by 98
Medium-chain triglyceride ameliorates insulin resistance and inflammation in high fat diet-induced obese mice
Geng, S., Zhu, W., Xie, C., Li, X., Wu, J., Liang, Z., Xie, W., Zhu, J., Huang, C. X., Zhu, M., et al. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0907-0 · Cited by 94
Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer
Nottingham, L. K., Yan, C. H., Yang, X., Si, H., Coupar, J. F., Bian, Y., Cheng, T.-F., Allen, C. T., Arun, P., Gius, D. R., et al. (2013) · Oncogene · doi:10.1038/onc.2013.49 · Cited by 87
Simvastatin as a Novel Strategy To Alleviate Periapical Lesions
Lin, S., Kok, S., Lee, Y., Hou, K., Lin, Y.-T., Chen, M., Wang, C.-C., & Hong, C. (2009) · Journal of Endodontics · doi:10.1016/j.joen.2009.02.004 · Cited by 80
Oral subchronic exposure to silver nanoparticles causes renal damage through apoptotic impairment and necrotic cell death
Tiwari, R., Singh, R. D., Khan, H., Gangopadhyay, S., Mittal, S., Singh, V., Arjaria, N., Shankar, J., Roy, S. K., Singh, D., et al. (2017) · Nanotoxicology · doi:10.1080/17435390.2017.1343874 · Cited by 79
Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases
Périco, L. L., Emílio-Silva, M. T., Ohara, R., Rodrigues, V. P., Bueno, G. M., Barbosa‐Filho, J. M., da Rocha, L. R. M., Batista, L. M., & Hiruma-Lima, C. A. (2020) · Biomolecules · doi:10.3390/biom10020265 · Cited by 77
Current concepts on the role of nitric oxide in portal hypertension
Hu, L. S. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i11.1707 · Cited by 81
Annexin A4 interacts with the NF-κB p50 subunit and modulates NF-κB transcriptional activity in a Ca2+-dependent manner
Jeon, Y., Kim, D.-H., Jung, H., Chung, S. J., Chi, S., Cho, S., Lee, S. C., Park, B. C., Park, S. G., & Bae, K. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0331-9 · Cited by 72
IL-20: Biological functions mediated through two types of receptor complexes
Wegenka, U. M. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.08.001 · Cited by 73
Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust
Nordgren, T. M., Heires, A. J., Wyatt, T. A., Poole, J. A., LeVan, T. D., CERUTIS, D. R., & Romberger, D. J. (2013) · Respiratory Research · doi:10.1186/1465-9921-14-51 · Cited by 74
NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1
Vuong, B., Hogan-Cann, A. D., Alano, C. C., Stevenson, M., Chan, W., Anderson, C. M., Swanson, R. A., & Kauppinen, T. M. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0448-8 · Cited by 71
Kaempferol 7-O-β-D-glucoside isolated from the leaves of Cudrania tricuspidata inhibits LPS-induced expression of pro-inflammatory mediators through inactivation of NF-κB, AP-1, and JAK-STAT in RAW 264.7 macrophages
Lee, S.-B., Shin, J., Han, H.-S., Lee, H., Park, J. C., & Lee, K. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.02.022 · Cited by 67
Oenothera laciniata inhibits lipopolysaccharide induced production of nitric oxide, prostaglandin E2, and proinflammatory cytokines in RAW264.7 macrophages
Yoon, W., Ham, Y., Yoo, B.-S., Moon, J., Koh, J., & Hyun, C. (2009) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2008.11.018 · Cited by 62
Control of central self-tolerance induction by autoreactive CD4+ thymocytes
Irla, M., Holländer, G. A., & Reith, W. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.11.002 · Cited by 60
Classical NF-κB Activation Negatively Regulates Noncanonical NF-κB-dependent CXCL12 Expression
Madge, L. A., & May, M. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.147207 · Cited by 57
Caspase-1 recognizes extended cleavage sites in its natural substrates
Shen, J., Yin, Y., Mai, J., Xiong, X., Pansuria, M., Liu, J., Maley, E., Saqib, N. U., Wang, H., & Yang, X. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.12.017 · Cited by 54
Quantitative Dissection and Modeling of the NF-κB p100-p105 Module Reveals Interdependent Precursor Proteolysis
Yilmaz, Z. B., Kofahl, B., Beaudette, P., Baum, K., Ipenberg, I., Weih, F., Wolf, J., Dittmar, G. A. G., & Scheidereit, C. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.014 · Cited by 51
RETRACTED: Minocycline Targets the NF-κB Nexus through Suppression of TGF-β1-TAK1-IκB Signaling in Ovarian Cancer
Ataie-Kachoie, P., Badar, S., Morris, D. L., & Pourgholami, M. H. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0239 · Cited by 49
Retracted
Protective effects of dioscin against cartilage destruction in a monosodium iodoacetate (MIA)-indcued osteoarthritis rat model
Lu, J., Zhang, T., Sun, H., Wang, S., & Liu, M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.075 · Cited by 47
The Nuclear-Factor κB Pathway Is Activated in Pterygium
Siak, J. J. K., Ng, S. L., Seet, L., Beuerman, R. W., & Tong, L. H. T. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5735 · Cited by 48
Discovery of Molecular Pathways Mediating 1,25-Dihydroxyvitamin D3 Protection Against Cytokine-Induced Inflammation and Damage of Human and Male Mouse Islets of Langerhans
Wolden-Kirk, H., Rondas, D., Bugliani, M., Korf, H., Lommel, L. V., Brusgaard, K., Christesen, H. T., Schuit, F. C., Proost, P., Masini, M., et al. (2014) · Endocrinology · doi:10.1210/en.2013-1409 · Cited by 48
NFκB signaling in T cell memory
Daniels, M. A., Luera, D., & Teixeiro, E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1129191 · Cited by 47
New Approaches to the Treatment of Inflammatory Disease
Ivanenkov, Y. A., Balakin, K. V., & Tkachenko, S. E. (2008) · Drugs in R&D · doi:10.2165/0126839-200809060-00005 · Cited by 47
Thymic Epithelial Cell Development and Its Dysfunction in Human Diseases
Sun, L., Li, H., Luo, H., & Zhao, Y. X. (2014) · BioMed Research International · doi:10.1155/2014/206929 · Cited by 48
Antimicrobial Activity of Brassica rapa L. Flowers Extract on Gastrointestinal Tract Infections and Antiulcer Potential Against Indomethacin-Induced Gastric Ulcer in Rats Supported by Metabolomics Profiling
Alotaibi, B. S., Mokhtar, F. A., El-Masry, T. A., Elekhnawy, E., Mostafa, S. A., Abdelkader, D. H., Elharty, M. E., Saleh, A., & Negm, W. A. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s345780 · Cited by 45
Non-canonical NFκB mutations reinforce pro-survival TNF response in multiple myeloma through an autoregulatory RelB:p50 NFκB pathway
Roy, P., Mukherjee, T., Chatterjee, B., Vijayaragavan, B., Banoth, B., & Basak, S. (2016) · Oncogene · doi:10.1038/onc.2016.309 · Cited by 45
Self-citation
Potent anti‐inflammatory effect of a novel furan‐2,5‐dione derivative, BPD, mediated by dual suppression of COX‐2 activity and LPS‐induced inflammatory gene expression via NF‐κB inactivation
Shin, J., Park, S.-J., Ryu, S., Kang, H. B., Kim, T. W., Choi, J., Lee, J. Y., Cho, Y., & Lee, K. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01670.x · Cited by 42
TGF-β1 Induces Podocyte Injury Through Smad3-ERK-NF-κB Pathway and Fyn-dependent TRPC6 phosphorylation
Yu, L., Lin, Q., Liao, H., Feng, J., Dong, X., & Ye, J. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000323996 · Cited by 42
Principles of Modular Tumor Therapy
Reichle, A., & Hildebrandt, G. C. (2009) · Cancer Microenvironment · doi:10.1007/s12307-009-0023-x · Cited by 39
Regulation of the Expression of Inducible Nitric Oxide Synthase
Kleinert, H., Art, J., & Pautz, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00007-1 · Cited by 42
Pancreatic Acinar Cell Nuclear Factor κB Activation Because of Bile Acid Exposure Is Dependent on Calcineurin
Muili, K. A., Jin, S., Orabi, A. I., Eisses, J. F., Javed, T. A., Le, T., Bottino, R., Jayaraman, T., & Husain, S. Z. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.471425 · Cited by 39
Integrative analysis suggests cell type–specific decoding of NF-κB dynamics
Martin, E. W., Pacholewska, A., Patel, H., Dashora, H. R., & Sung, M. (2020) · Science Signaling · doi:10.1126/scisignal.aax7195 · Cited by 36
Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway
Wen, L., Tao, S., Guo, F., Li, L.-Z., Yang, H., Liang, Y., Zhang, L., Ma, L., & Fu, P. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00837-8 · Cited by 37
NFκBiz protein downregulation in acute kidney injury: Modulation of inflammation and survival in tubular cells
Poveda, J., Sanz, A. B., Rayego‐Mateos, S., Ruiz‐Ortega, M., Carrasco, S., Ortíz, A., & Sánchez-Niño, M. D. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.01.006 · Cited by 40
Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-κB p65 and C/EBPβ in mammary epithelial cells
Liu, S., Shi, X., Bauer, I., Günther, J., & Seyfert, H. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2010.12.018 · Cited by 36
Low-dose, low-dose-rate proton radiation modulates CD4+T cell gene expression
Gridley, D. S., Pecaut, M. J., Rizvi, A., Coutrakon, G. B., Luo‐Owen, X., Makinde, A. Y., & Slater, J. M. (2009) · International Journal of Radiation Biology · doi:10.1080/09553000902748609 · Cited by 35
Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Antiinflammatory and Anticancer Properties
Zhang, L. J., Shi, L., Soars, S. M., Kamps, J. T., & Yin, H. H. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01557 · Cited by 33
The noncanonical NFκB pathway: Regulatory mechanisms in health and disease
Rodriguez, B. N., Huang, H. J., Chia, J. J., & Hoffmann, A. (2024) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1646 · Cited by 32
Self-citation
Cadherin-17 induces tumorigenesis and lymphatic metastasis in gastric cancer through activation of NFκB signaling pathway
Wang, J., Kang, W., Yu, J., Liu, Y., Meng, Q.-B., & Cao, Z. (2013) · Cancer Biology & Therapy · doi:10.4161/cbt.23299 · Cited by 35
The role of HIF in immunity
Gale, D. P., & Maxwell, P. H. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.10.012 · Cited by 32
NF-kB activity-dependent P-selectin involved in ox-LDL-induced foam cell formation in U937 cell
Wang, Y., Wang, X., Sun, M., Zhang, Z., Cao, H., & Chen, X. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.06.177 · Cited by 32
Immunoproteasome Deficiency Modifies the Alternative Pathway of NFκB Signaling
Maldonado, M., Kapphahn, R. J., Terluk, M. R., Heuss, N. D., Yuan, C., Gregerson, D. S., & Ferrington, D. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056187 · Cited by 31
Cytokines and pregnancy: Potential regulation by histone deacetylases
Munro, S. K., Balakrishnan, B., Lissaman, A. C., Gujral, P., & Ponnampalam, A. P. (2021) · Molecular Reproduction and Development · doi:10.1002/mrd.23430 · Cited by 35
NF-kB and the CLL microenvironment
O'Donnell, A., Pepper, C., Mitchell, S. M. S., & Pepper, A. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1169397 · Cited by 32
Silencing of the DEK gene induces apoptosis and senescence in CaSki cervical carcinoma cells via the up-regulation of NF-κB p65
Liu, K., Feng, T., Liu, J., Zhong, M., & Zhang, S. (2012) · Bioscience Reports · doi:10.1042/bsr20100141 · Cited by 31
Adipose tissue hypoxia and low-grade inflammation: a possible mechanism for ethanol-related glucose intolerance?
He, Z., Li, M., Zheng, D., Chen, Q., Liu, W., & Feng, L. (2015) · British Journal Of Nutrition · doi:10.1017/s000711451500077x · Cited by 31
CTGF Triggers Rat Astrocyte Activation and Astrocyte-Mediated Inflammatory Response in Culture Conditions
Lu, M., Yan, X., Yun, S., & Chen, X. (2019) · Inflammation · doi:10.1007/s10753-019-01029-7 · Cited by 31
Increased βTrCP are associated with imiquimod-induced psoriasis-like skin inflammation in mice via NF-κB signaling pathway
Li, R., Wang, J., Wang, X., Zhou, J. M., Wang, M., Ma, H., & Xiao, S. (2016) · Gene · doi:10.1016/j.gene.2016.07.066 · Cited by 30
Gefitinib Inhibits Bleomycin‐Induced Pulmonary Fibrosis via Alleviating the Oxidative Damage in Mice
Li, L., Cai, L., Zheng, L., Hu, Y., Yuan, W., Guo, Z., & Li, W. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8249693 · Cited by 30
Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells
Lopes, N., Charaix, J., Cédile, O., Sergé, A., & Irla, M. (2018) · Nature Communications · doi:10.1038/s41467-018-03619-9 · Cited by 30
Anti-Inflammatory Activity of Populus deltoides Leaf Extract via Modulating NF-κB and p38/JNK Pathways
Jeong, Y. E., & Lee, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123746 · Cited by 29
Thymic epithelial cell development and differentiation: cellular and molecular regulation
Sun, L., Luo, H., Li, H., & Zhao, Y. X. (2013) · Protein & Cell · doi:10.1007/s13238-013-3014-0 · Cited by 29
NFκB2/p100 Is a Key Factor for Endotoxin Tolerance in Human Monocytes: A Demonstration Using Primary Human Monocytes from Patients with Sepsis
Cubillos‐Zapata, C., Hernández-Jiménez, E., Toledano, V., Esteban-Burgos, L., Fernández-Ruíz, I., Goméz-Piña, V., del Fresno, C., Siliceo, M., Prieto-Chinchiña, P., de Diego, R. P., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400721 · Cited by 29
Differential RelA- and RelB-dependent gene transcription in LTβR-stimulated mouse embryonic fibroblasts
Lovas, A., Radke, D., Albrecht, D., Yilmaz, Z. B., Möller, U., Habenicht, A. J. R., & Weih, F. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-606 · Cited by 28
Regulation of T-Cell Signaling by Post-Translational Modifications in Autoimmune Disease
Kuwabara, T., Matsui, Y., Ishikawa, F., & Kondo, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030819 · Cited by 28
The microdissected gene expression landscape of nasopharyngeal cancer reveals vulnerabilities in FGF and noncanonical NF-κB signaling
Tay, J. K., Zhu, C., Shin, J. H., Zhu, S., Varma, S., Foley, J. W., Vennam, S., Yip, Y. L., Goh, C. K., Wang, D. Y., et al. (2022) · Science Advances · doi:10.1126/sciadv.abh2445 · Cited by 27
Altered apoptosis of inflammatory neutrophils in MMP-9-deficient mice is due to lower expression and activity of caspase-3
Kołaczkowska, E., Kozioł, A., Płytycz, B., Arnold, B., & Opdenakker, G. (2009) · Immunology Letters · doi:10.1016/j.imlet.2009.08.002 · Cited by 26
NF-κB RelB suppresses the inflammatory gene expression programs of dendritic cells by competing with RelA for binding to target gene promoters
Navarro, H. I., Daly, A. E., Rodriguez, B. N., Wu, S. Z., Ngo, K. A., Fraser, A., Schiffman, A., Liu, Y., Smale, S. T., Chia, D. J., et al. (2025) · Cell Discovery · doi:10.1038/s41421-024-00767-9 · Cited by 25
Self-citation
Ophiopogonin D alleviates cardiac hypertrophy in rat by upregulating CYP2J3 in vitro and suppressing inflammation in vivo
Wang, Y., Huang, X., Ma, Z.-C., Wang, Y., Chen, X., & Gao, Y. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.110 · Cited by 24
Paricalcitol improves experimental autoimmune encephalomyelitis (EAE) by suppressing inflammation via NF-κB signaling
Zhang, D., Qiao, L., & Fu, T. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109528 · Cited by 24
Cobalt Chloride Attenuates Oxidative Stress and Inflammation through NF-κB Inhibition in Human Renal Proximal Tubular Epithelial Cells
Oh, S. W., Lee, Y.-M., Kim, S., Chin, H. J., Chae, D., & Na, K. Y. (2014) · Journal of Korean Medical Science · doi:10.3346/jkms.2014.29.s2.s139 · Cited by 24
Profiling of molecular pathways regulated by microRNA 601
Ohdaira, H., Nakagawa, H., & Yoshida, K. (2009) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2009.09.003 · Cited by 23
DVT: A New Era in Anticoagulant Therapy
Mackman, N., & Becker, R. C. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.203497 · Cited by 23
Roles of functional NFKB1 and βTrCP insertion/deletion polymorphisms in mRNA expression and epithelial ovarian cancer susceptibility
Huo, Z., Zhong, H., Zhu, Y. S., Xing, B., & Tang, H. (2013) · Genetics and Molecular Research · doi:10.4238/2013.march.11.6 · Cited by 22

Authors: Basak, S., & Hoffmann, A.
Affiliations: University of California San Diego (US)
Corresponding author: Basak, Soumen
Hoffmann, Alexander
ORCID: Basak, Soumen
Hoffmann, Alexander
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 2008-06
Volume: 19
Issue: 3-4
Pages: 187-197
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/j.cytogfr.2008.04.005
PMC: PMC2675004
OpenAlex: W2054072076
Cited by: 177
References: 64
Citations by year: 2026: 5 · 2025: 12 · 2024: 5 · 2023: 6 · 2022: 2 · 2021: 9 · 2020: 10 · 2019: 5 · 2018: 13 · 2017: 6 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 13 · 2012: 8
FWCI: 1.26
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cytokine & Growth Factor Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (P01GM071862, R01GM071573)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: NF-κB signaling, signaling crosstalk, IκB degradation, TNF receptor superfamily, inflammatory signaling, developmental signaling
MeSH terms: Animals, Immunity, Inflammation, Lymphoid Tissue, Signal Transduction, NF-kappa B, Receptors, Tumor Necrosis Factor, Growth and Development, Mice, Transcription Factor RelA, NF-kappa B p50 Subunit

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Crosstalk via the NF-κB signaling system

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks