The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
IL-17 and Th17 cells in tuberculosis
Open accessAbstract
Tuberculosis is primarily a disease of the lung. Constant expression of cellular immunity in this organ is required to control Mycobacterium tuberculosis growth, but this can also result in chronic inflammation and pathologic consequences. During primary tuberculosis both IFN-γ and IL-17-producing cells are induced; both are potent inflammatory cytokines capable of inducing expression of chemokines that promote cell recruitment and granuloma organization throughout infection. During the chronic phase, a balance between Th1 and Th17 responses needs to be achieved to control bacterial growth and limit immunopathology, as a shift of the response towards excessive IL-17 production may sustain extensive neutrophil recruitment and tissue damage. Thus, regulation of Th1 and Th17 responses during tuberculosis is essential to promote anti-mycobacterial immunity and prevent extensive immunopathological consequences.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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Transforming growth factor-β induces development of the TH17 lineage
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Cited by
The role of IL-10 in immune regulation during M. tuberculosis infection
Redford, P. S., Murray, P. J., & O'Garra, A. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.7 · Cited by 472
Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation
Castillo, E. F., Dekonenko, A., Arko-Mensah, J., Mandell, M. A., Dupont, N., Jiang, S., Delgado-Vargas, M., Timmins, G. S., Bhattacharya, D., Yang, H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210500109 · Cited by 454
Gideon, H. P., Phuah, J., Myers, A. J., Bryson, B. D., Rodgers, M. A., Coleman, M. T., Maiello, P., Rutledge, T., Marino, S., Fortune, S. M., et al. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004603 · Cited by 335
Role of TNF-Alpha, IFN-Gamma, and IL-10 in the Development of Pulmonary Tuberculosis
Cavalcanti, Y. V. N., Brelaz, M. C. A., Lemoine Neves, J. K. D. A., Ferraz, J. C., & Pereira, V. R. A. (2012) · Pulmonary Medicine · doi:10.1155/2012/745483 · Cited by 324
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Metadata
- Authors
- Torrado, E., & Cooper, A. M.
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 21
- Issue
- 6
- Pages
- 455-462
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W2033878713
- Cited by
- 327
- References
- 12
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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