Cited by 155Bone Metabolism and DiseasesCell death mechanisms and regulationBone and Dental Protein Studies

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Osteoprotegerin: Multiple partners for multiple functions

Baud’huin, Marc, Duplomb, Laurence, Teletchea, Stéphane, Lamoureux, François, Ruiz-Velasco, Carmen, Maillasson, Mike, Redini, Françoise, Heymann, Marie-Françoise, Heymann, Dominique·2013·Cytokine & Growth Factor Reviews

DOI 10.1016/j.cytogfr.2013.06.001

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Abstract

Osteoprotegerin (OPG) is an essential secreted protein in bone turnover due to its role as a decoy receptor for the Receptor Activator of Nuclear Factor-kB ligand (RANKL) in the osteoclasts, thus inhibiting their differentiation. However, there are additional ligands of OPG that confer various biological functions. OPG can promote cell survival, cell proliferation and facilitates migration by binding TNF-related apoptosis inducing ligand (TRAIL), glycosaminoglycans or proteoglycans. A large number of in vitro, pre-clinical and clinical studies provide evidences of OPG involvement in vascular, bone, immune and tumor biology. This review describes an overview of the different OPG ligands regulating its biological functions.

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Osteoclast differentiation and activation
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“The binding of OPG to RANKL prevents the interaction of RANKL for RANK expressed on the cell surface of osteoclast precursors, and thus inhibits the formation of osteoclasts (Boyle et al. 2003).”
Background
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
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Authors: Baud’huin, M., Duplomb, L., Teletchea, S., Lamoureux, F., Ruiz-Velasco, C., Maillasson, M., Redini, F., Heymann, M.-F., & Heymann, D.
Affiliations: Inserm (FR)
Université de Bourgogne (FR)
Corresponding author: Baud’huin, Marc
Heymann, Dominique
ORCID: Baud’huin, Marc
Duplomb, Laurence
Lamoureux, François
Maillasson, Mike
Heymann, Marie-Françoise
Heymann, Dominique
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 2013-10
Volume: 24
Issue: 5
Pages: 401-409
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/j.cytogfr.2013.06.001
OpenAlex: W2032215600
Cited by: 153
References: 85
Citations by year: 2026: 6 · 2025: 6 · 2024: 14 · 2023: 14 · 2022: 12 · 2021: 11 · 2020: 12 · 2019: 12 · 2018: 8 · 2017: 10 · 2016: 21 · 2015: 16 · 2014: 9 · 2013: 1
FWCI: 1.47
Type: journal article
Language: en
Open access: closed
Locations: Cytokine & Growth Factor Reviews (publishedVersion)
PubMed (publishedVersion)
White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Keywords: osteoprotegerin, RANKL, TRAIL, glycosaminoglycans, proteoglycans, osteoclastogenesis, bone turnover, cell survival, cell proliferation, cell migration, vascular biology, tumor biology
MeSH terms: Animals, Cell Differentiation, Cell Survival, Humans, Osteoclasts, Cell Proliferation, TNF-Related Apoptosis-Inducing Ligand, Osteoprotegerin, RANK Ligand

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Osteoprotegerin: Multiple partners for multiple functions

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