Heymann, Dominique

The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling

Theoleyre, S., Wittrant, Y., Tat, S. K., Fortun, Y., Redini, F., & Heymann, D. (2004) · Cytokine & Growth Factor Reviews

Bone Metabolism and DiseasesRheumatoid Arthritis Research and Therapies

Cited by 663

Osteosarcoma

Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers

Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and Treatments

Cited by 660

Autophagy in osteoblasts is involved in mineralization and bone homeostasis

Nollet, M., Santucci-Darmanin, S., Breuil, V., Al-Sahlanee, R., Cros, C., Topi, M., Momier, D., Samson, M., Pagnotta, S., Cailleteau, L., et al. (2014) · Autophagy

Bone Metabolism and DiseasesAutophagy in Disease and Therapy

Cited by 422

Sarcoma treatment in the era of molecular medicine

Grünewald, T. G., Alonso, M., Avnet, S., Banito, A., Burdach, S., Cidre‐Aranaz, F., Di Pompo, G., Distel, M., Dorado‐Garcia, H., Garcia‐Castro, J., et al. (2020) · EMBO Molecular Medicine

Sarcoma Diagnosis and TreatmentChromatin Remodeling and Cancer

Cited by 319

Cancer stem cells in osteosarcoma

Brown, H. K., Tellez-Gabriel, M., & Heymann, D. (2017) · Cancer Letters

Cancer Cells and MetastasisSarcoma Diagnosis and Treatment

Cited by 303

Receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis.

Grimaud, E., Soubigou, L., Couillaud, S., Coipeau, P., Moreau, A., Passuti, N., Gouin, F., Redini, F., & Heymann, D. (2003) · The American Journal of Pathology

Bone Metabolism and DiseasesBone Tumor Diagnosis and Treatments

Cited by 282

The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma

Heymann, M.-F., Lézot, F., & Heymann, D. (2019) · Cellular Immunology

Sarcoma Diagnosis and TreatmentImmune cells in cancer

Cited by 233

Interleukin‐34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment

Ségaliny, A. I., Mohamadi, A., Dizier, B., Lokajczyk, A., Brion, R., Lanel, R., Amiaud, J., Charrier, C., Boisson‐Vidal, C., & Heymann, D. (2015) · International Journal of Cancer

Angiogenesis and VEGF in CancerImmune cells in cancer

Cited by 199

Therapeutic Relevance of Osteoprotegerin Gene Therapy in Osteosarcoma: Blockade of the Vicious Cycle between Tumor Cell Proliferation and Bone Resorption

Lamoureux, F., Richard, P., Wittrant, Y., Battaglia, S., Pilet, P., Trichet, V., Blanchard, F., Gouin, F., Pitard, B., Heymann, D., et al. (2007) · Cancer Research

Bone Metabolism and DiseasesSarcoma Diagnosis and Treatment

Cited by 181

Zoledronic acid suppresses lung metastases and prolongs overall survival of osteosarcoma‐bearing mice

Ory, B., Heymann, M., Kamijo, A., Gouin, F., Heymann, D., & Redini, F. (2005) · Cancer

Bone health and treatmentsCancer Cells and Metastasis

Cited by 169

Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers

Ségaliny, A. I., Tellez-Gabriel, M., Heymann, M.-F., & Heymann, D. (2015) · Journal of Bone Oncology

Sarcoma Diagnosis and TreatmentCancer Mechanisms and Therapy

Cited by 164

Biology of Bone Sarcomas and New Therapeutic Developments

Brown, H. K., Schiavone, K., Gouin, F., Heymann, M.-F., & Heymann, D. (2018) · Calcified Tissue International

Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and Treatments

Cited by 163

Osteoprotegerin: Multiple partners for multiple functions

Baud’huin, M., Duplomb, L., Teletchea, S., Lamoureux, F., Ruiz-Velasco, C., Maillasson, M., Redini, F., Heymann, M.-F., & Heymann, D. (2013) · Cytokine & Growth Factor Reviews

Bone Metabolism and DiseasesCell death mechanisms and regulation

Cited by 153

Safety Concern between Autologous Fat Graft, Mesenchymal Stem Cell and Osteosarcoma Recurrence

Perrot, P., Rousseau, J., Bouffaut, A.-L., Rédini, F., Cassagnau, E., Deschaseaux, F., Heymann, M.-F., Heymann, D., Duteille, F., Trichet, V., et al. (2010) · PLoS ONE

Sarcoma Diagnosis and TreatmentMesenchymal stem cell research

Cited by 120

DU145 human prostate cancer cells express functional receptor activator of NFκB: new insights in the prostate cancer bone metastasis process.

Mori, K., Le Goff, B., Charrier, C., Battaglia, S., Heymann, D., & Rédini, F. (2007) · Bone

Bone Metabolism and DiseasesProstate Cancer Treatment and Research

Cited by 95

Paradoxical side effects of bisphosphonates on the skeleton: What do we know and what can we do?

Vargas‐Franco, J. W., Castaneda, B., Rédiní, F., Gómez, D. F., Heymann, D., & Lézot, F. (2018) · Journal of Cellular Physiology

Bone health and treatmentsBone health and osteoporosis research

Cited by 64

OPG/membranous–RANKL complex is internalized via the clathrin pathway before a lysosomal and a proteasomal degradation

Tat, S. K., Padrines, M., Theoleyre, S., Couillaud-Battaglia, S., Heymann, D., Redini, F., & Fortun, Y. (2006) · Bone

Bone Metabolism and DiseasesCellular transport and secretion

Cited by 63

The Intrinsic and Extrinsic Implications of RANKL/RANK Signaling in Osteosarcoma: From Tumor Initiation to Lung Metastases

Navet, B., Ando, K., Vargas-Franco, J. W., Brion, R., Amiaud, J., Mori, K., Yagita, H., Mueller, C. G., Verrecchia, F., Dumars, C., et al. (2018) · Cancers

Sarcoma Diagnosis and TreatmentBone Metabolism and Diseases

Cited by 52

Mesenchymal stem cells increase proliferation but do not change quiescent state of osteosarcoma cells: Potential implications according to the tumor resection status

Avril, P., Le Nail, L.-R., Brennan, M. Á., Rosset, P., De Pinieux, G., Layrolle, P., Heymann, D., Perrot, P., & Trichet, V. (2016) · Journal of Bone Oncology

Mesenchymal stem cell researchCancer Cells and Metastasis

Cited by 38

TRAIL delivered by mesenchymal stromal/stem cells counteracts tumor development in orthotopic Ewing sarcoma models

Guiho, R., Biteau, K., Grisendi, G., Taurelle, J., Chatelais, M., Gantier, M., Heymann, D., Dominici, M., & Redini, F. (2016) · International Journal of Cancer

Cell death mechanisms and regulationSarcoma Diagnosis and Treatment

Cited by 38

Hemophilia A and B mice, but not VWF−/−mice, display bone defects in congenital development and remodeling after injury

Taves, S., Sun, J., Livingston, E. W., Chen, X., Amiaud, J., Brion, R., Hannah, W. B., Bateman, T. A., Heymann, D., & Monahan, P. E. (2019) · Scientific Reports

Hemophilia Treatment and ResearchBone Metabolism and Diseases

Cited by 26

Dlx homeobox gene family expression in osteoclasts

Lézot, F., Thomas, B. L., Blin‐Wakkach, C., Castaneda, B., Bolanos, A., Hotton, D., Sharpe, P. T., Heymann, D., Carles, G. F., Grigoriadis, A. E., et al. (2010) · Journal of Cellular Physiology

Bone Metabolism and DiseasesDevelopmental Biology and Gene Regulation

Cited by 24

Murine Models of Bone Sarcomas

Jacques, C., Renema, N., Ory, B., Walkley, C. R., Grigoriadis, A. E., & Heymann, D. (2019) · Methods in Molecular Biology

Sarcoma Diagnosis and TreatmentVeterinary Oncology Research

Cited by 14

Analysis of gap junctional intercellular communications using a dielectrophoresis-based microchip

Tellez-Gabriel, M., Charrier, C., Brounais-Le Royer, B., Mullard, M., Brown, H. K., Verrecchia, F., & Heymann, D. (2017) · European Journal of Cell Biology

Connexins and lens biologyMicrofluidic and Bio-sensing Technologies

Cited by 14