The DOI matches its Crossref record; 83 of the 85 references it cites were found in a registry or an index.
Osteoprotegerin: Multiple partners for multiple functions
Abstract
Osteoprotegerin (OPG) is an essential secreted protein in bone turnover due to its role as a decoy receptor for the Receptor Activator of Nuclear Factor-kB ligand (RANKL) in the osteoclasts, thus inhibiting their differentiation. However, there are additional ligands of OPG that confer various biological functions. OPG can promote cell survival, cell proliferation and facilitates migration by binding TNF-related apoptosis inducing ligand (TRAIL), glycosaminoglycans or proteoglycans. A large number of in vitro, pre-clinical and clinical studies provide evidences of OPG involvement in vascular, bone, immune and tumor biology. This review describes an overview of the different OPG ligands regulating its biological functions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Because TRAIL and RANKL are known to regulate osteoclast differentiation and survival (33–35), these findings suggest that increased RANK (tumor necrosis factor receptor superfamily member 11a) signaling may be involved in the regulation of bone growth and remodeling induced by ACVR2B/Fc.”
From Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight (2020) · cites this paper as [35]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Because TRAIL and RANKL are known to regulate osteoclast differentiation and survival (33–35), these findings suggest that increased RANK (tumor necrosis factor receptor superfamily member 11a) signaling may be involved in the regulation of bone growth and remodeling induced by ACVR2B/Fc.”
From Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight (2020) · cites this paper as [35]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · cited 2×
“The binding of OPG to RANKL prevents the interaction of RANKL for RANK expressed on the cell surface of osteoclast precursors, and thus inhibits the formation of osteoclasts (Boyle et al. 2003).”
BackgroundOsteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Identification and characterization of a new member of the TNF family that induces apoptosis
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900
Functions of Cell Surface Heparan Sulfate Proteoglycans
Bernfield, M. R., Götte, M., Park, P. W., Reizes, O., Fitzgerald, M. L., Lincecum, J. M., & Zako, M. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.729 · Cited by 2,722
Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.
Bucay, N., Sarosi, I., Dunstan, C. R., Morony, S., Tarpley, J., Capparelli, C., Scully, S., Tan, H. L., Xu, W., Lacey, D. L., et al. (1998) · Genes & Development · doi:10.1101/gad.12.9.1260 · Cited by 2,483
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
Anderson, D. M., Maraskovsky, E., Billingsley, W. L., Dougall, W. C., Tometsko, M. E., Roux, E. R., Teepe, M. C., DuBose, R. F., Cosman, D., & Galibert, L. (1997) · Nature · doi:10.1038/36593 · Cited by 2,290
Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia
Manco-Johnson, M. J., Abshire, T. C., Shapiro, A. D., Riske, B., Hacker, M. R., Kilcoyne, R., Ingram, J. D., Manco-Johnson, M. L., Funk, S., Jacobson, L., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067659 · Cited by 1,950 · cited 2×
“These data are consistent with a randomized study showing that the prophylaxis with recombinant Factor VIII prevents joint damages in young haemophilic patients (Manco-Johnson et al. 2007), possibly through a decrease in osteoclastogenesis.”
Result
Cited by
Sorted by citations
Items 101–155 of 155
Mechanical force application and inflammation induce osteoclastogenesis by independent pathways
Chacartchi, T., Itai, Y., Tzach‐Nahman, R., Sculean, A., Shapira, L., & Polak, D. (2023) · Clinical Oral Investigations · doi:10.1007/s00784-023-05196-8 · Cited by 5
Ordaz-Ramos, A., Díaz-Blancas, J. Y., Martínez-Cruz, A., Castro‐Oropeza, R., Zampedri, C., Romero‐Rodríguez, D. P., Rodríguez‐Dorantes, M., Meléndez-Zajgla, J., Maldonado, V., & Vázquez-Santillán, K. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119888 · Cited by 5
Prognostic Biomarkers for Hodgkin Lymphoma
Staege, M. S., Kewitz, S., Bernig, T., Kühnöl, C. D., & Mauz‐Körholz, C. (2015) · Pediatric Hematology and Oncology · doi:10.3109/08880018.2015.1071903 · Cited by 5
Osteoprotegerin Induces CD34+ Differentiation in Endothelial Progenitor Cells
Boisson‐Vidal, C., Benslimane-Ahmim, Z., Lokajczyk, A., Heymann, D., & Smadja, D. M. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00331 · Cited by 5
Self-citationHung, Y.-T., Wu, W., Lee, R., Yao, T.-K., & Yeh, K. (2025) · Biomedicines · doi:10.3390/biomedicines13030732 · Cited by 4
Spanish Menopause Society position statement: Use of denosumab in postmenopausal women
Cano, A., Silván, J. M., Estévez, A., Baró, F., Villero, J., Quereda, F., Ferrer, J., Mendoza, N., & Sánchez‐Borrego, R. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.06.011 · Cited by 4
Extracellular Matrix Remodeling Factors as Markers of Carotid Artery Atherosclerosis
Sapa-Wojciechowska, A., Rak-Pasikowska, A., Pormańczuk, K., Czapla, B., & Bil‐Lula, I. (2020) · Cardiology Research and Practice · doi:10.1155/2020/9036157 · Cited by 4
Miyake, T., Miyake, T., & Morishita, R. (2022) · Cellular Immunology · doi:10.1016/j.cellimm.2022.104559 · Cited by 4
Juvenile Paget disease with unique compound heterozygous sequence variants in the TNFRSF11B gene
Horackova, J., Taslerová, R., Bayer, M., Nekvindová, J., Pavlíková, L., Horáček, J. M., & Palička, V. (2025) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-025-03804-2 · Cited by 3
Gan, S., Zhao, L., Salman, O., Wang, Z., Ebert, C., Azzo, J. D., Dib, M., Zamani, P. L., Cohen, J. B., Kammerhoff, K., et al. (2023) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2023.08.146 · Cited by 3
Role of osteokines in atherosclerosis
Liu, Y., Tian, Y., Chen, X., Zhang, C., & Huang, L. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4107 · Cited by 3
Can Osteoprotegerin be a Target of Therapy in Type 2 Diabetes Mellitus?
Berezin, A. Е. (2016) · Journal of Postgenomics Drug & Biomarker Development · doi:10.4172/2153-0769.1000172 · Cited by 3
Drozdovska, S., Валеріївна, А. О., Orlenko, V., Andrieiev, I., Pastukhova, V., Mazur, I. I., Hurenko, O. O., & Nahorna, A. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.105094 · Cited by 3
Zhu, Y., Wu, Y. S., Liang, Y., Tan, W., Liu, Z., & Jianhua, X. (2016) · Archives of Medical Science · doi:10.5114/aoms.2015.55821 · Cited by 3
Heterologous expression, purification and function of the extracellular domain of human RANK
Wei, Y., Zhan, Y., Chen, P., Liu, Z., Zhang, H., Liu, D., Zhang, J., Yu, M., Mo, W., Zhang, X., et al. (2017) · BMC Biotechnology · doi:10.1186/s12896-017-0405-y · Cited by 3
Abbood, M. J., & Abdullah, A. H. (2026) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2026.100681 · Cited by 2
Erazmus, M., Rumińska, M., Witkowska–Sędek, E., Kucharská, A., Stelmaszczyk‐Emmel, A., Majcher, A., & Pyrżak, B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.963467 · Cited by 2
Jeon, H. J., Ryu, J., Kim, M.-G., Huh, K. H., Lee, K. W., Kim, C., Kang, K. P., Ro, H., Han, S., Yang, J., et al. (2024) · Transplantation · doi:10.1097/tp.0000000000004903 · Cited by 2
Rasheed, N. W., & Ahmad, R. I. (2021) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1853/1/012001 · Cited by 2
Serum osteoprotegerin and cardiometabolic risk factors in overweight and obese children
Rumińska, M., Witkowska–Sędek, E., Stelmaszczyk‐Emmel, A., Majcher, A., Kucharská, A., & Pyrżak, B. (2021) · Archives of Medical Science · doi:10.5114/aoms/140394 · Cited by 2
[miRNA Is Involved in the Pathogenesis of Multiple Diseases by Targeting Osteoprotegerin].
Zhou, D., & Yang, D. (2024) · PubMed Central · doi:10.12182/20240560607 · Cited by 1
Shibata, Y., Nishida‐Fukuda, H., Nakayama, H., Izumi, Y., Suzuki, R., Yokawa, S., Sato, T., Furuno, T., Matsubara, M., Miyazawa, K., et al. (2026) · Journal of Oral Biosciences · doi:10.1016/j.job.2025.100727 · Cited by 1
Design and validation of a perfusion bioreactor for long-term human bone explant culture
Zojaji, M., Pageau, A. G., Maluckov, T., Eichwalder, J., Peskova, M., Smith, C., Athwal, G. S., Gorbet, M., Ferreira Louis, M., & Knowles, N. K. (2026) · JBMR Plus · doi:10.1093/jbmrpl/ziag081 · Cited by 1
Berezin, A. Е. (2016) · Biological Markers and Guided Therapy · doi:10.12988/bmgt.2016.626 · Cited by 1
Aydın, G. A., & Özsoy, H. G. T. (2020) · Medical Bulletin of Haseki · doi:10.4274/haseki.galenos.2020.5840 · Cited by 1
Gaynitdinova, V. V., Burdunina, A. A., & Avdeev, S. N. (2021) · Russian Journal of Preventive Medicine · doi:10.17116/profmed202124011104 · Cited by 1
Ren, Q., Zhang, W., Li, P., Zhou, J., Li, Z., Zhou, Y., & Li, M. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11397 · Cited by 1
Macrophages: the overlooked target for pulmonary fibrosis and COPD
Boorsma, C. E. (2016) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 1
Coupling of atherosclerosis progression and bone disturbances in a mouse model
Casimiro, R. I. (2015) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Комисаренко, С. В., Vasylevska, V. M., Ivonin, S. P., Lisakovska, O., Labudzinskyi, D., Shymanskyi, I., Mazanova, A., Volochnyuk, D. M., & Veliky, M. M. (2020) · Medical and Clinical Chemistry · doi:10.11603/mcch.2410-681x.2020.v.i3.11513
Cellular and Molecular Biology in Bone Remodeling
DeNapoli, R. C., Buettmann, E. G., & Donahue, H. J. (2021) · Springer eBooks · doi:10.1007/978-981-16-5613-2_1
Zhao, X. (1999) · OpenCommons - UConn (University of Connecticut)
Hidróxido de Cálcio na modulação de células da papila apical e ligamento periodontal in vitro
Gomes, R. D. S. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.23.2021.tde-27082021-154856
Tanaka, S. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733118165.793545404
Heymann, D., & Heymann, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101718
Self-citationHeymann, D., & Heymann, M. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_101718-1
Self-citationKemik Dokusunun Potansiyel Biyobelirteçleri
Acıpınar, Ş. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub178.c904
Güncel Diş Hekimliği Araştırmaları- II
Geçkil, N., Çıkman, A. Ş., Öksüzer, M. Ç., Acıpınar, Ş., Hatipoğlu, F. P., Revi, B., Temur, K. T., Maraş, E., Öztürk, A., Uyanık, H., et al. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub178
Sonlu Elemanlar Stres Analizi Yönteminin İmplant Cerrahisinde Kullanımı
Beder, M., & Yemenoğlu, H. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub178.c902
Odontojenik ve Gelişimsel Çene Kistleri
Geçkil, N., & Temur, K. T. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub178.c898
Endodontik Patolojilerin Diş Eti Oluğu Sıvısında Bulunan Enflamatuar Mediyatörlere Etkisi
Revi, B., & Maraş, E. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub178.c905
ДИСБАЛАНС АДИПОЦИТОКІНІВ ЯК ПАТОГЕНЕТИЧНА СКЛАДОВА ОЖИРІННЯ
Орленко, В. Л., & Прохорова, Г. О. (2023) · doi:10.59948/osou6.2023.05
Serum level of osteoprotegerin in patients with Parkinson’s disease: a preliminary study
Piaścik-Gromada, M., Bocian, K., Korczak-Kowalska, G., Leńska‐Mieciek, M., Fiszer, U., & Michałowska, M. (2024) · Medical Studies · doi:10.5114/ms.2024.137594
Value of serum osteoprotegerin in the assessment of endothelial dysfunction in obesity
Shennawy, A. M., Hanna, H. W. Z., Raed, S., Salam, R., & Ayman, S. (2024) · The Egyptian Journal of Internal Medicine · doi:10.1186/s43162-024-00297-6
Atlas of the Immune System Development in the Fetal BloodPreprint
Wang, X., Mao, L., Yan, R., Yip, K. C., He, A., Lu, D., Nie, H., Huang, X., Wang, Y., Cao, W., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4883498
Kas İskelet Sistemi ve Kemik Sağlığı
Aslan, Y., Şimşek, M., Yılmaz, M., Harmancı, H., Savaş, S., Polat, C., Ünveren, A., Yılmaz, B., Kilit, T. P., Torun, M. T., et al. (2024) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.3293
Essmat, S. A. K. (2025) · Journal Port Science Research · doi:10.36371/port.2025.1.3
Diagnostic Significance of Peri-Implant Crevicular Fluid Biomarkers: A Narrative Review
Shomurodov, K., & Mirkhusanova, R. (2025) · Galician Medical Journal · doi:10.21802/e-gmj2025-a20
Agrawal, A. K., Mittal, N., & Zeyaullah, M. (2025) · APOS Trends in Orthodontics · doi:10.25259/apos_215_2024
Grudziński, I. P., Bamburowicz‐Klimkowska, M., Sochanowicz, B., Brzóska, K., Prochorec‐Sobieszek, M., Cabaj, M., Targońska, A., Stawarska, A., & Kruszewski, M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1842887
Lalotra, T., Gunasekar, A., Jeyaraman, N., Nallakumarasamy, A., Muthu, S., Devanand, V., & Jeyaraman, M. (2026) · World Journal of Experimental Medicine · doi:10.5493/wjem.120531
Ng, C. Y. J., Lyu, Z., Meng, L., Xu, L., Wang, N., & Zhong, L. L. D. (2026) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2026.06.002
Zheng, R., Zhao, X., Zhang, Q., Dai, Y., Teng, X., & Li, J. (2026) · ACS Chemical Biology · doi:10.1021/acschembio.6c00465
Nguyen, H. D., Hoang, A. T., Trung, K. N., & Viet, T. L. (2026) · International Journal of General Medicine · doi:10.2147/ijgm.s652921
Metadata
- Authors
- Baud’huin, M., Duplomb, L., Teletchea, S., Lamoureux, F., Ruiz-Velasco, C., Maillasson, M., Redini, F., Heymann, M.-F., & Heymann, D.
- Affiliations
- Inserm (FR)
- Université de Bourgogne (FR)
- Corresponding author
- Baud’huin, Marc
- Heymann, Dominique
- ORCID
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 24
- Issue
- 5
- Pages
- 401-409
- ISSN
- 1359-6101 (ISSN-L)
- OpenAlex
- W2032215600
- Cited by
- 153
- References
- 85
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 14 · 2023: 14 · 2022: 12 · 2021: 11 · 2020: 12 · 2019: 12 · 2018: 8 · 2017: 10 · 2016: 21 · 2015: 16 · 2014: 9 · 2013: 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- osteoprotegerin, RANKL, TRAIL, glycosaminoglycans, proteoglycans, osteoclastogenesis, bone turnover, cell survival, cell proliferation, cell migration, vascular biology, tumor biology
- MeSH terms
- Animals, Cell Differentiation, Cell Survival, Humans, Osteoclasts, Cell Proliferation, TNF-Related Apoptosis-Inducing Ligand, Osteoprotegerin, RANK Ligand
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
