IFI16: At the Interphase between Innate DNA Sensing and Genome Regulation

Pattern Recognition Receptors and Inflammation

Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895 · see citing works

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996 · see citing works

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627 · see citing works

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

Wu, J., Sun, L., Chen, X., Du, F., Shi, H., Chen, C., & Chen, Z. J. (2012) · Science · doi:10.1126/science.1229963 · Cited by 2,574 · see citing works

CGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING.

Ablasser, A., Goldeck, M., Cavlar, T., Deimling, T., Witte, G., Röhl, I., Hopfner, K.-P., Ludwig, J., & Hornung, V. (2013) · Nature · doi:10.1038/nature12306 · Cited by 1,695 · see citing works

IFI16 is an innate immune sensor for intracellular DNA

Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., et al. (2010) · Nature Immunology · doi:10.1038/ni.1932 · Cited by 1,643 · see citing works

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

Chiu, Y., MacMillan, J. B., & Chen, Z. J. (2009) · Cell · doi:10.1016/j.cell.2009.06.015 · Cited by 1,185 · see citing works

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

Li, X.-D., Wu, J., Gao, D., Wang, H., Sun, L., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1244040 · Cited by 1,097 · see citing works

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

Schoggins, J. W., MacDuff, D. A., Imanaka, N., Gainey, M. D., Shrestha, B., Eitson, J. L., Mar, K. B., Richardson, R. B., Ratushny, A. V., Litvak, V., et al. (2014) · Nature · doi:10.1038/nature12862 · Cited by 896 · see citing works

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

Ablasser, A., Bauernfeind, F. G., Hartmann, G., Latz, E., Fitzgerald, K. A., & Hornung, V. (2009) · Nature Immunology · doi:10.1038/ni.1779 · Cited by 892 · see citing works

Structural mechanism of cytosolic DNA sensing by cGAS

Çivril, F., Deimling, T., Mann, C. C. D. O., Ablasser, A., Moldt, M., Witte, G., Hornung, V., & Hopfner, K. (2013) · Nature · doi:10.1038/nature12305 · Cited by 888 · see citing works

Immune Sensing of DNA

Paludan, S. R., & Bowie, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.004 · Cited by 764 · see citing works

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

Kerur, N., Veettil, M. V., Sharma-Walia, N., Bottero, V., Sadagopan, S., Otageri, P., & Chandran, B. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.008 · Cited by 702 · see citing works

Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease

Yang, Y., Lindahl, T. L., & Barnes, D. E. (2007) · Cell · doi:10.1016/j.cell.2007.10.017 · Cited by 574 · see citing works

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

Jin, T., Perry, A., Jiang, J., Smith, P. T., Curry, J. A., Unterholzner, L., Jiang, Z., Horvath, G. L., Rathinam, V. A. K., Johnstone, R. W., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.014 · Cited by 571 · see citing works

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

Monroe, K. M., Yang, Z., Johnson, J. R., Geng, X., Doitsh, G., Krogan, N. J., & Greene, W. C. (2014) · Science · doi:10.1126/science.1243640 · Cited by 511 · see citing works

Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue

Doitsh, G., Cavrois, M., Lassen, K. G., Zepeda, O., Yang, Z., Santiago, M. L., Hebbeler, A. M., & Greene, W. C. (2010) · Cell · doi:10.1016/j.cell.2010.11.001 · Cited by 449 · see citing works

Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

Orzalli, M. H., DeLuca, N. A., & Knipe, D. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211302109 · Cited by 422 · see citing works

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

Ferguson, B. J., Mansur, D. S., Peters, N., Ren, H., & Smith, G. L. (2012) · eLife · doi:10.7554/elife.00047 · Cited by 406 · see citing works

IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

Jakobsen, M. R., Bak, R. O., Andersen, A., Berg, R. K., Jensen, S. B., Jin, T., Laustsen, A., Hansen, K., Østergaard, L., Fitzgerald, K. A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311669110 · Cited by 344 · see citing works

Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16

Li, T., Diner, B. A., Chen, J., & Cristea, I. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203447109 · Cited by 297 · see citing works

Herpes Simplex Virus 1 Infection Induces Activation and Subsequent Inhibition of the IFI16 and NLRP3 Inflammasomes

Johnson, K. E., Chikoti, L., & Chandran, B. (2013) · Journal of Virology · doi:10.1128/jvi.00082-13 · Cited by 271 · see citing works

Listeria monocytogenes induces IFNβ expression through an IFI16‐, cGAS‐ and STING‐dependent pathway

Hansen, K., Prabakaran, T., Laustsen, A., Jørgensen, S. E., Rahbæk, S. H., Jensen, S. B., Nielsen, R., Leber, J. H., Decker, T., Horan, K., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201488029 · Cited by 259 · see citing works

Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN

Zhang, X., Brann, T. W., Zhou, M., Yang, J., Oguariri, R. M., Lidie, K. B., Imamichi, H., Huang, D.-W., Lempicki, R. A., Baseler, M. W., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003389 · Cited by 249 · see citing works

The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication

Gariano, G. R., Dell'Oste, V., Bronzini, M., Gatti, D., Luganini, A., De Andrea, M., Gribaudo, G., Gariglio, M., & Landolfo, S. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002498 · Cited by 227 · see citing works

Human Cytomegalovirus Tegument Protein pUL83 Inhibits IFI16-Mediated DNA Sensing for Immune Evasion

Li, T., Chen, J., & Cristea, I. M. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.10.007 · Cited by 226 · see citing works

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

Brunette, R. L., Young, J. M., Whitley, D. G., Brodsky, I. E., Malik, H. S., & Stetson, D. B. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20121960 · Cited by 223 · see citing works

Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors

Horan, K., Hansen, K., Jakobsen, M. R., Holm, C. K., Søby, S., Unterholzner, L., Thompson, M., West, J. A., Iversen, M. B., Rasmussen, S. B., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202749 · Cited by 204 · see citing works

Constitutive Interferon-Inducible Protein 16-Inflammasome Activation during Epstein-Barr Virus Latency I, II, and III in B and Epithelial Cells

Ansari, M. A., Singh, V. V., Dutta, S., Veettil, M. V., Dutta, D., Leela, C., Lu, J. L., Everly, D. N., & Chandran, B. (2013) · Journal of Virology · doi:10.1128/jvi.00805-13 · Cited by 203 · see citing works

The mammalian PYHIN gene family: Phylogeny, evolution and expression

Cridland, J. A., Curley, E. Z., Wykes, M., Schroder, K., Sweet, M. J., Roberts, T. L., Ragan, M. A., Kassahn, K. S., & Stacey, K. J. (2012) · BMC Evolutionary Biology · doi:10.1186/1471-2148-12-140 · Cited by 200 · see citing works

Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA

Orzalli, M. H., Conwell, S. E., Berrios, C. J., DeCaprio, J. A., & Knipe, D. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316194110 · Cited by 178 · see citing works

Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy

Morrone, S. R., Wang, T., Constantoulakis, L. M., Hooy, R. M., Delannoy, M. J., & Sohn, J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313577111 · Cited by 172 · see citing works

Human Cytomegalovirus pUL83 Stimulates Activity of the Viral Immediate-Early Promoter through Its Interaction with the Cellular IFI16 Protein

Cristea, I. M., Moorman, N. J., Terhune, S. S., Cuevas, C. D., O'Keefe, E. S., Rout, M. P., Chait, B. T., & Shenk, T. (2010) · Journal of Virology · doi:10.1128/jvi.00139-10 · Cited by 155 · see citing works

Kaposi's Sarcoma-Associated Herpesvirus Latency in Endothelial and B Cells Activates Gamma Interferon-Inducible Protein 16-Mediated Inflammasomes

Singh, V. V., Kerur, N., Bottero, V., Dutta, S., Chakraborty, S., Ansari, M. A., Paudel, N., Leela, C., & Chandran, B. (2013) · Journal of Virology · doi:10.1128/jvi.03282-12 · Cited by 153 · see citing works

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes

Hasan, M., Koch, J., Rakheja, D., Pattnaik, A. K., Brugarolas, J., Dozmorov, I. M., Levine, B., Wakeland, E. K., Lee‐Kirsch, M. A., & Yan, N. (2012) · Nature Immunology · doi:10.1038/ni.2475 · Cited by 142 · see citing works

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

Aglipay, J. A., Lee, S. W., Okada, S., Fujiuchi, N., Ohtsuka, T., Kwak, J. C., Wang, Y., Johnstone, R. W., Deng, C., Qin, J., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1207057 · Cited by 129 · see citing works

Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach

Lee, M. N., Roy, M., Ong, S., Mertins, P., Villani, A., Li, W., Dotiwala, F., Sen, J., Doench, J. G., Orzalli, M. H., et al. (2012) · Nature Immunology · doi:10.1038/ni.2509 · Cited by 117 · see citing works

Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence

Xin, H., Curry, J. L., Johnstone, R. W., Nickoloff, B. J., & Choubey, D. (2003) · Oncogene · doi:10.1038/sj.onc.1206754 · Cited by 114 · see citing works

Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16

Johnstone, R. W., Wu, W., Greenway, A. L., & Trapani, J. A. (2000) · Oncogene · doi:10.1038/sj.onc.1204005 · Cited by 109 · see citing works

Innate Nuclear Sensor IFI16 Translocates into the Cytoplasm during the Early Stage of In Vitro Human Cytomegalovirus Infection and Is Entrapped in the Egressing Virions during the Late Stage

Dell’Oste, V., Gatti, D., Gugliesi, F., Andrea, M. D., Bawadekar, M., Cigno, I. L., Biolatti, M., Vallino, M., Marschall, M., Gariglio, M., et al. (2014) · Journal of Virology · doi:10.1128/jvi.00384-14 · Cited by 102 · see citing works

Mutations of the Listeria monocytogenes PeptidoglycanN-Deacetylase andO-Acetylase Result in Enhanced Lysozyme Sensitivity, Bacteriolysis, and Hyperinduction of Innate Immune Pathways

Rae, C. S., Geissler, A. L., Adamson, P. C., & Portnoy, D. A. (2011) · Infection and Immunity · doi:10.1128/iai.00077-11 · Cited by 98 · see citing works

A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-? in myeloid cells

Trapani, J. A., Browne, K. A., Dawson, M. J., Ramsay, R. G., Eddy, R. L., Shows, T. B., White, P., & Dupont, B. (1992) · Immunogenetics · doi:10.1007/bf00218044 · Cited by 92 · see citing works

Interferon action: nucleolar and nucleoplasmic localization of the interferon-inducible 72-kD protein that is encoded by the Ifi 204 gene from the gene 200 cluster.

Choubey, D., & Lengyel, P. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.6.1333 · Cited by 86 · see citing works

The HIN domain of IFI-200 proteins consists of two OB folds

Albrecht, M., Choubey, D., & Lengauer, T. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.056 · Cited by 85 · see citing works

Interferon lambda inhibits herpes simplex virus type I infection of human astrocytes and neurons

Li, J., Hu, S., Zhou, L., Ye, L., Wang, X., Ho, J., & Ho, W. (2010) · Glia · doi:10.1002/glia.21076 · Cited by 83 · see citing works

Interferon Action: Cytoplasmic and Nuclear Localization of the Interferon-Inducible 52-kD Protein That Is Encoded by the Ifi 202 Gene from the Gene 200 Cluster

Choubey, D., & Lengyel, P. (1993) · Journal of Interferon Research · doi:10.1089/jir.1993.13.43 · Cited by 81 · see citing works

A Novel Role of the Interferon-inducible Protein IFI16 as Inducer of Proinflammatory Molecules in Endothelial Cells

Caposio, P., Gugliesi, F., Zannetti, C., Sponza, S., Mondini, M., Médico, E., Hiscott, J. B., Young, H. A., Gribaudo, G., Gariglio, M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701846200 · Cited by 68 · see citing works

Redistribution of the nuclear protein IFI16 into the cytoplasm of ultraviolet B-exposed keratinocytes as a mechanism of autoantigen processing

Costa, S., Borgogna, C., Mondini, M., Andrea, M. D., Meroni, P. L., Berti, E., Gariglio, M., & Landolfo, S. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10097.x · Cited by 65 · see citing works

The retinoblastoma protein is an essential mediator that links the interferon-inducible 204 gene to cell-cycle regulation

Hertel, L., Rolle, S., Andrea, M. D., Azzimonti, B., Osello, R., Gribaudo, G., Gariglio, M., & Landolfo, S. (2000) · Oncogene · doi:10.1038/sj.onc.1203697 · Cited by 65 · see citing works

Preferential binding of IFI16 protein to cruciform structure and superhelical DNA

Brázda, V., Coufal, J., Liao, J. C. C., & Arrowsmith, C. H. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.05.065 · Cited by 64 · see citing works

The Interferon Inducible Autoantigen, IFI 16: Localization to the Nucleolus and Identification of a DNA-Binding Domain

Dawson, M. J., & Trapani, J. A. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2269 · Cited by 61 · see citing works

Isotypic Variants of the Interferon-Inducible Transcriptional Repressor IFI 16 Arise through Differential mRNA Splicing

Johnstone, R. W., Kershaw, M. H., & Trapani, J. A. (1998) · Biochemistry · doi:10.1021/bi981069a · Cited by 58 · see citing works

IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines

Dawson, M. J., & Trapani, J. A. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240570106 · Cited by 58 · see citing works

Inflammatory Cytokines Break Down Intrinsic Immunological Tolerance of Human Primary Keratinocytes to Cytosolic DNA

Chiliveru, S., Rahbek, S. H., Jensen, S. K., Jørgensen, S. E., Nissen, S. K., Christiansen, S. H., Mogensen, T. H., Jakobsen, M. R., Iversen, L., Johansen, C., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302120 · Cited by 57 · see citing works

Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16

Briggs, L. J., Johnstone, R. W., Elliot, R., Xiao, C.-Y., Dawson, M. J., Trapani, J. A., & Jans, D. A. (2000) · Biochemical Journal · doi:10.1042/bj3530069 · Cited by 52 · see citing works

Nuclear DNA Sensor IFI16 as Circulating Protein in Autoimmune Diseases Is a Signal of Damage that Impairs Endothelial Cells through High-Affinity Membrane Binding

Gugliesi, F., Bawadekar, M., Andrea, M. D., Dell’Oste, V., Caneparo, V., Tincani, A., Gariglio, M., & Landolfo, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063045 · Cited by 51 · see citing works

T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses: Implications for Restriction of HIV Replication

Berg, R., Rahbek, S. H., Kofod‐Olsen, E., Holm, C. K., Melchjorsen, J., Jensen, D. G., Hansen, A. L., Jørgensen, L. B., Østergaard, L. J., Tolstrup, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084513 · Cited by 48 · see citing works

Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates with chronic immune activation

Nissen, S. K., Højen, J. F., Andersen, K. L. D., Kofod‐Olsen, E., Berg, R., Paludan, S. R., Østergaard, L. J., Jakobsen, M. R., Tolstrup, M., & Mogensen, T. H. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12317 · Cited by 42 · see citing works

siRNA enhances DNA-mediated interferon lambda-1 response through crosstalk between RIG-I and IFI16 signalling pathway

Sui, H., Zhou, M., Chen, Q., Lane, H. C., & Imamichi, T. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt844 · Cited by 41 · see citing works

Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization

Trapani, J. A., Dawson, M. J., Apostolidis, V. A., & Browne, K. A. (1994) · Immunogenetics · doi:10.1007/bf00177824 · Cited by 36 · see citing works

The interferon‐inducible gene IFI16 secretome of endothelial cells drives the early steps of the inflammatory response

Baggetta, R., Andrea, M. D., Gariano, G. R., Mondini, M., Rittà, M., Caposio, P., Cappello, P., Giovarelli, M., Gariglio, M., & Landolfo, S. (2010) · European Journal of Immunology · doi:10.1002/eji.200939995 · Cited by 35 · see citing works

Ancient and Recent Selective Pressures Shaped Genetic Diversity at AIM2-Like Nucleic Acid Sensors

Cagliani, R., Forni, D., Biasin, M., Comabella, M., Guerini, F. R., Riva, S., Pozzoli, U., Agliardi, C., Caputo, D., Malhotra, S., et al. (2014) · Genome Biology and Evolution · doi:10.1093/gbe/evu066 · Cited by 32 · see citing works

Discriminating self from non-self in nucleic acid sensing

Schlee, M., & Hartmann, G. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.78 · Cited by 587 · see citing works

Molecular mechanisms for enhanced DNA vaccine immunogenicity

Li, L., & Petrovsky, N. (2015) · Expert Review of Vaccines · doi:10.1586/14760584.2016.1124762 · Cited by 334 · see citing works

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

Jønsson, K. L., Laustsen, A., Krapp, C., Skipper, K. A., Thavachelvam, K., Hotter, D., Egedal, J. H., Kjølby, M., Mohammadi, P., Prabakaran, T., et al. (2017) · Nature Communications · doi:10.1038/ncomms14391 · Cited by 279 · see citing works

Dissecting How CD4 T Cells Are Lost During HIV Infection

Doitsh, G., & Greene, W. C. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.02.012 · Cited by 275 · see citing works

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

Herzner, A., Hagmann, C. A., Goldeck, M., Wolter, S., Kübler, K., Wittmann, S., Gramberg, T., Andreeva, L., Hopfner, K., Mertens, C., et al. (2015) · Nature Immunology · doi:10.1038/ni.3267 · Cited by 255 · see citing works

Evasion of host antiviral innate immunity by HSV-1, an update

Su, C., Zhan, G., & Zheng, C. (2016) · Virology Journal · doi:10.1186/s12985-016-0495-5 · Cited by 175 · see citing works

The ER-Associated Protein ZDHHC1 Is a Positive Regulator of DNA Virus-Triggered, MITA/STING-Dependent Innate Immune Signaling

Zhou, Q., Lin, H., Wang, S., Wang, S., Ran, Y., Liu, Y., Ye, W., Xiong, X., Zhong, B., Shu, H., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.09.006 · Cited by 150 · see citing works

IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation

Hotter, D., Bosso, M., Jønsson, K. L., Krapp, C., Stürzel, C. M., Das, A. T., Littwitz-Salomon, E., Berkhout, B., Russ, A., Wittmann, S., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.05.002 · Cited by 135 · see citing works

IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection

Jiang, Z., Wei, F., Zhang, Y., Wang, T., Gao, W., Yu, S., Sun, H., Pu, J., Sun, Y., Wang, M., et al. (2021) · Nature Microbiology · doi:10.1038/s41564-021-00907-x · Cited by 127 · see citing works

Activation and Regulation of DNA-Driven Immune Responses

Paludan, S. R. (2015) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00061-14 · Cited by 122 · see citing works

The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters

Cigno, I. L., Andrea, M. D., Borgogna, C., Albertini, S., Landini, M. M., Peretti, A., Johnson, K. E., Chandran, B., Landolfo, S., & Gariglio, M. (2015) · Journal of Virology · doi:10.1128/jvi.00013-15 · Cited by 102 · see citing works

Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16

Wang, P., Ye, Z., Deng, J., Siu, K., Gao, W., Chaudhary, V., Cheng, Y., Fung, S., Yuen, K., Ho, T., et al. (2018) · EMBO Reports · doi:10.15252/embr.201845737 · Cited by 91 · see citing works

Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study

Wang, L., Fu, H., Nanayakkara, G., Li, Y., Shao, Y., Johnson, C., Cheng, J., Yang, W. Y., Yang, F., Lavallee, M., et al. (2016) · Journal of Hematology & Oncology · doi:10.1186/s13045-016-0351-5 · Cited by 90 · see citing works

STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production

Li, D., Wu, R., Guo, W., Xie, L., Qiao, Z., Chen, S., Zhu, J., Huang, C., Huang, J. A., Chen, B., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.069 · Cited by 87 · see citing works

RIG-I-like receptors and autoimmune diseases

Kato, H., & Fujita, T. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.10.002 · Cited by 87 · see citing works

IFI16, an amplifier of DNA-damage response: Role in cellular senescence and aging-associated inflammatory diseases

Choubey, D., & Panchanathan, R. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.002 · Cited by 82 · see citing works

Nuclear Innate Immune DNA Sensor IFI16 Is Degraded during Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV): Role of IFI16 in Maintenance of KSHV Latency

Roy, A., Dutta, D., Iqbal, J., Pisano, G. C., Gjyshi, O., Ansari, M. A., Kumar, B., & Chandran, B. (2016) · Journal of Virology · doi:10.1128/jvi.01003-16 · Cited by 75 · see citing works

The Absent in Melanoma 2-Like Receptor IFN-Inducible Protein 16 as an Inflammasome Regulator in Systemic Lupus Erythematosus: The Dark Side of Sensing Microbes

Caneparo, V., Landolfo, S., Gariglio, M., & Andrea, M. D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01180 · Cited by 64 · see citing works

Regulation of cGAS‐Mediated Immune Responses and Immunotherapy

Saeed, A. F. U. H., Ruan, X., Guan, H., Su, J., & Ouyang, S. (2020) · Advanced Science · doi:10.1002/advs.201902599 · Cited by 58 · see citing works

The interferon-inducible DNA-sensor protein IFI16: a key player in the antiviral response.

Dell’Oste, V., Gatti, D., Ag, G., Gariglio, M., Landolfo, S., & Andrea, M. D. (2015) · PubMed · Cited by 51 · see citing works

Regulatory Interaction between the Cellular Restriction Factor IFI16 and Viral pp65 (pUL83) Modulates Viral Gene Expression and IFI16 Protein Stability

Biolatti, M., Dell’Oste, V., Pautasso, S., von Einem, J., Marschall, M., Plachter, B., Gariglio, M., Andrea, M. D., & Landolfo, S. (2016) · Journal of Virology · doi:10.1128/jvi.00923-16 · Cited by 50 · see citing works

Innate immune sensing of HIV-1 infection

Jakobsen, M. R., Olagnier, D. P., & Hiscott, J. B. (2014) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000129 · Cited by 38 · see citing works

Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells

Bosso, M., Bozzo, C. P., Hotter, D., Volčič, M., Stürzel, C. M., Rammelt, A., Ni, Y., Urban, S., Becker, M., Schelhaas, M., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008752 · Cited by 37 · see citing works

IFI16 Inhibits Porcine Reproductive and Respiratory Syndrome Virus 2 Replication in a MAVS-Dependent Manner in MARC-145 Cells

Chang, X., Shi, X., Zhang, X., Wang, L., Li, X., Wang, A., Deng, R., Zhou, E., & Zhang, G. (2019) · Viruses · doi:10.3390/v11121160 · Cited by 36 · see citing works

Intrinsic host restriction factors of human cytomegalovirus replication and mechanisms of viral escape

Landolfo, S., Andrea, M. D., Dell’Oste, V., & Gugliesi, F. (2016) · World Journal of Virology · doi:10.5501/wjv.v5.i3.87 · Cited by 32 · see citing works

cGAS–STING-mediated sensing pathways in DNA and RNA virus infections: crosstalk with other sensing pathways

Anwar, S., Islam, K. U., Azmi, M. I., & Iqbal, J. (2021) · Archives of Virology · doi:10.1007/s00705-021-05211-x · Cited by 31 · see citing works

Role of inflammasomes in HIV-1 infection and treatment

Jin, X., Zhou, R., & Huang, Y. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.02.010 · Cited by 30 · see citing works

Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding

Iannucci, A., Caneparo, V., Raviola, S., Debernardi, I., Colangelo, D., Miggiano, R., Griffante, G., Landolfo, S., Gariglio, M., & Andrea, M. D. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008811 · Cited by 26 · see citing works

Transcriptomic analysis of the innate immune response to in vitro transfection of plasmid DNA

Warga, E., Anderson, J. L., Tucker, M., Harris, E., & Elmer, J. J. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.11.025 · Cited by 25 · see citing works

The role of IFI16 in regulating PANoptosis and implication in heart diseases

Chang, X., Wang, B., Zhao, Y., Deng, B., Liu, P., & Wang, Y. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01978-5 · Cited by 22 · see citing works

IFI16Expression Is Related to Selected Transcription Factors during B-Cell Differentiation

Piccaluga, P. P., Agostinelli, C., Fuligni, F., Righi, S., Tripodo, C., Re, M. C., Clò, A., Miserocchi, A., Morini, S., Gariglio, M., et al. (2015) · Journal of Immunology Research · doi:10.1155/2015/747645 · Cited by 22 · see citing works

Filament assembly underpins the double-stranded DNA specificity of AIM2-like receptors

Garg, A., Stallings, C. M., & Sohn, J. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad090 · Cited by 20 · see citing works

DNA sensors in metabolic and cardiovascular diseases: Molecular mechanisms and therapeutic prospects

Kwak, H., Lee, E., & Karki, R. (2024) · Immunological Reviews · doi:10.1111/imr.13382 · Cited by 21 · see citing works

IFI16 is involved in HBV-associated acute-on-chronic liver failure inflammation

Pang, X., Li, X., Mo, Z., Huang, J., Deng, H. X., Lei, Z., Zheng, X., Feng, Z., Xie, D., & Gao, Z. (2018) · BMC Gastroenterology · doi:10.1186/s12876-018-0791-1 · Cited by 21 · see citing works

Mislocalization of the interferon inducible protein IFI16 by environmental insults: Implications in autoimmunity

Bawadekar, M., Andrea, M. D., Gariglio, M., & Landolfo, S. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.10.003 · Cited by 21 · see citing works

Cytosolic sensing of aberrant DNA: arming STING on the endoplasmic reticulum

Wang, Q., Liu, X., Zhou, Q., & Wang, C. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1067303 · Cited by 20 · see citing works

Risk mitigation of immunogenicity: a key to personalized retinal gene therapy

Varin, J., Morival, C., Maillard, N., Adjali, O., & Cronin, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312818 · Cited by 19 · see citing works

Activation and evasion of inflammasomes during viral and microbial infection

Ren, D., Ye, X., Chen, R., Jia, X., He, X., Tao, J., Jin, T., Wu, S., & Zhang, H. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05575-2 · Cited by 21 · see citing works

Interferon-Inducible Protein 16 (IFI16) Has a Broad-Spectrum Binding Ability Against ssDNA Targets: An Evolutionary Hypothesis for Antiretroviral Checkpoint

Hurst, T. P., Aswad, A., Karamitros, T., Katzourakis, A., Smith, A. L., & Magiorkinis, G. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01426 · Cited by 19 · see citing works

Cytosolic DNA sensor IFI16 proteins: Potential molecular integrators of interactions among the aging hallmarks

Choubey, D. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101765 · Cited by 19 · see citing works

Innate Immune DNA Sensing of Flaviviruses

Zhu, T., & Fernández-Sesma, A. (2020) · Viruses · doi:10.3390/v12090979 · Cited by 19 · see citing works

MNDA, a PYHIN factor involved in transcriptional regulation and apoptosis control in leukocytes

Bottardi, S., Layne, T., Ramòn, A. C., Quansah, N., Würtele, H., Affar, E. B., & Milot, É. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1395035 · Cited by 15 · see citing works

When our genome is targeted by pathogenic bacteria

Lemercier, C. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1900-8 · Cited by 12 · see citing works

Polydeoxyribonucleotides as Emerging Therapeutics for Skin Diseases: Clinical Applications, Pharmacological Effects, Molecular Mechanisms, and Potential Modes of Action

Park, S., Baek, S., Shin, H.-J., Kim, J.-S., Gwon, H.-I., 배승희, & An, S. (2025) · Applied Sciences · doi:10.3390/app151910437 · Cited by 12 · see citing works

Grass carp Mre11A activates IFN 1 response by targeting STING to defend against GCRV infection

Xu, X., Li, M., Deng, Z., Li, D., Lu, S., Deng, H., Lv, Y., Liu, Y., Du, H., & Hu, C. (2020) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2020.103909 · Cited by 11 · see citing works

The significance of interferon gamma inducible protein 16 (IFI16) expression in drug resistant ovarian cancer cell lines

Borucka, J., Sterzyńska, K., Kaźmierczak, D., Świerczewska, M., Nowacka, M., Wojtowicz, K., Klejewski, A., Nowicki, M. O., Zabel, M., Ramlau, R., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113036 · Cited by 10 · see citing works

Race between virus and inflammasomes: inhibition or escape, intervention and therapy

Wu, N., Zheng, C., Xu, J., Ma, S., Jia, H., Yan, M., An, F., Zhou, Y., Qi, J., & Bian, H. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1173505 · Cited by 11 · see citing works

PANoptosis: Molecular Mechanisms, Regulatory Pathways, and Implications in Disease Pathogenesis

Chowdhury, M. R., & Hasan, M. F. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01912-1 · Cited by 9 · see citing works

Post-transcriptional regulation of IFI16 promotes inflammatory endothelial pathophenotypes observed in pulmonary arterial hypertension

Rao, R. J., Yang, J., Jiang, S., El-Khoury, W., Hafeez, N., Okawa, S., Tai, Y., Tang, Y. M., Aaraj, Y. A., Sembrat, J., et al. (2024) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00048.2024 · Cited by 8 · see citing works

Exploring the Therapeutic Potential of Extracellular Vesicles Anchored to the Sea Cucumber Extracellular Matrix for Treating Atopic Dermatitis

Jo, S., Kim, S.-H., Heo, S., Cho, H., Esfahani, I. J., & Park, S. (2025) · Biomaterials Research · doi:10.34133/bmr.0154 · Cited by 6 · see citing works

Research progress on the pattern recognition receptors involved in porcine reproductive and respiratory syndrome virus infection

Xu, Y., Ding, L., Zhang, Y., Ren, S., Li, J., Liu, F., Sun, W., Chen, Z., Yu, J., & Wu, J. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1428447 · Cited by 6 · see citing works

IFI16 induces inflammation in hepatitis B virus-associated glomerulonephritis by regulating the Caspase-1/ IL-1 ß pathway

Liu, L., Xie, S., Li, C., Guo, Y., Liu, X., Zhao, X., Li, Q., & Du, W. (2022) · Diagnostic Pathology · doi:10.1186/s13000-022-01220-9 · Cited by 6 · see citing works

Cytoplasmic Viral RNA Sensors: RIG-I-Like Receptors

Kato, H., & Fujita, T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.02005-1 · Cited by 6 · see citing works

IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway

Moran, E. A., Salas-Briceno, K., Zhao, W., Enya, T., Aguilera, A. N., Acosta, I., Alonzo, F., Kiani, D., Behnsen, J., Alvarez, C., et al. (2024) · mBio · doi:10.1128/mbio.01209-24 · Cited by 4 · see citing works

The PYRIN domain is required for TLR4-mediated inflammation by PYHIN family members

Iannucci, A., Lacarbonara, D., Caneparo, V., Castiglioni, F., Butticè, A., Raviola, S., Porta, C., Miggiano, R., Zanoni, I., Gariglio, M., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112413 · Cited by 3 · see citing works

Structural insights into the atypical filament assembly of pyrin domain-containing IFI16

Garg, A., Niedzialkowska, E., Zhou, J. J., Moh, J., Egelman, E. H., & Sohn, J. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00626-7 · Cited by 3 · see citing works

HIV-1 derived oligonucleotides induce a type I IFN/STING dependent immune suppression reversible by targeting IFNARI

Svanberg, C., Mukku, R. P., Besler, S. O., Hopkins, F. R., Sjöwall, C., Nyström, S. N., Shankar, E. M., & Larsson, M. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1013868 · Cited by 2 · see citing works

IFI204 drives gasdermin D–mediated mitochondrial permeabilization to amplify neuronal pyroptosis in ischemic stroke

Xu, P., Shen, N., 邱添, Zhou, M., Li, R., Tao, C., Zhu, Y., & Hu, W. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03847-7 · Cited by 2 · see citing works

IFI16 Mediates Deacetylation of KSHV Chromatin via Interaction with NuRD and Sin3A Co-Repressor Complexes

Ghosh, A., Chandran, B., & Roy, A. (2025) · Viruses · doi:10.3390/v17070921 · Cited by 2 · see citing works

BRCA1-regulated nuclear innate sensing of Herpesviral genome by IFI16 and IFI16’s acetylation is critical for its cytoplasmic trafficking and induction of innate responses

(2015) · Inflammation and Cell Signaling · doi:10.14800/ics.1076

Peter Lengyel (1929–2020): A Pioneer Researcher in Protein Synthesis and Interferon Action

Sen, G. C., & Williams, B. R. G. (2020) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2020.29017.mem

The atypical filament assembly underpins the inflammasome-independent functions of IFI16Preprint

Garg, A., Niedzialkowska, E., Zhou, J. J., Moh, J., Egelman, E. H., & Sohn, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.02.631089

HIV-1 derived replication intermediates/oligonucleotides induce a type I IFN-dependent immune suppression via STING activation that can be restored by targeting IFNARIPreprint

Svanberg, C., Mukku, R. P., Besler, Ö., Hopkins, F. R., Sjöwall, C., Nyström, S. N., Shankar, E. M., & Larsson, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.17.638698

Cytoplasmic Viral RNA Sensors: RIG-I-Like Receptors

Kato, H., Tsukamoto, Y., & Fujita, T. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00182-4

T Cell Dysfunction in HIV Infection and Its Therapeutic Prospects

王, 宣. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.15103003

Co-Transfected Plasmids Enhance Transient Expression of Reporter Genes

Shih-Yen, L., Yang, C.-H., Chan, Y.-R., Chao, Y.-T., Lai, M., & Li, H. (2026) · BioTech · doi:10.3390/biotech15010023

An HBV‐Derived Peptide Poly6 as a Novel Candidate for Functional Cure Via IFN‐I–Mediated Epigenetic Regulation of cccDNA

Jang, J., Kim, D. H., Kim, Z., Kim, E., Choi, Y., & Kim, B. (2026) · Journal of Medical Virology · doi:10.1002/jmv.70877

Implication de l'inflammasome NLRP3 dans la sécrétion non conventionnelle de la protéine FADD

Mouasni, S. (2018) · doi:10.70675/8623f190zbb94z44b7z8b70zd93fa9be484d

Implication des cellules souches du follicule pileux dans la physiopathologie de l'hidradénite suppurée

Orvain, C. (2019) · theses.fr (ABES) · doi:10.70675/6c48db5bzeb06z4af8zb7e4z24b9f4446179

Endosymbiotic theory of aging revisited: Age-related leakage of mitochondrial dsDNA/RNA stimulates cytosolic nucleic acid sensors which remodel the immune network and promote the aging process

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2026) · Biogerontology · doi:10.1007/s10522-026-10470-9

Doxorubicin-induced damage to AC16 cardiomyocytes and attenuation by human pericardial fluid Sca-1+/Nanog+ cells conditioned medium: a pilot study

Han, J., Hua, L., Zhang, S., Yang, B., Li, Z., & Meng, X. (2026) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2026.130988

PYHIN proteins: center stage in DNA sensing

Goubau, D., Rehwinkel, J., & Sousa, C. R. E. (2010) · Nature Immunology · doi:10.1038/ni1110-984 · Cited by 37 · see citing works

The emerging role of human PYHIN proteins in innate immunity: Implications for health and disease

Connolly, D. J., & Bowie, A. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.08.031 · Cited by 72 · see citing works

Úloha proteinu IFI16 v rozpoznávání DNA a buněčných procesech

Bohálová, N. (2017)

IFI16 is an innate immune sensor for intracellular DNA

Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., et al. (2010) · Nature Immunology · doi:10.1038/ni.1932 · Cited by 1,643 · see citing works

The ever-expanding role of IFI16 in the anti-viral innate immune response

Gewaid, H. E., & Bowie, A. (2026) · Immunology Letters · doi:10.1016/j.imlet.2026.107139 · Cited by 2 · see citing works