The DOI matches its Crossref record; 102 of the 106 references it cites were found in a registry or an index.
The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system
Open accessAbstract
In 2019-2020 a new coronavirus named SARS-CoV-2 was identified as the causative agent of a several acute respiratory infection named COVID-19, which is causing a worldwide pandemic. There are still many unresolved questions regarding the pathogenesis of this disease and especially the reasons underlying the extremely different clinical course, ranging from asymptomatic forms to severe manifestations, including the Acute Respiratory Distress Syndrome (ARDS). SARS-CoV-2 showed phylogenetic similarities to both SARS-CoV and MERS-CoV viruses, and some of the clinical features are shared between COVID-19 and previously identified beta-coronavirus infections. Available evidence indicate that the so called "cytokine storm" an uncontrolled over-production of soluble markers of inflammation which, in turn, sustain an aberrant systemic inflammatory response, is a major responsible for the occurrence of ARDS. Chemokines are low molecular weight proteins with powerful chemoattractant activity which play a role in the immune cell recruitment during inflammation. This review will be aimed at providing an overview of the current knowledge on the involvement of the chemokine/chemokine-receptor system in the cytokine storm related to SARS-CoV-2 infection. Basic and clinical evidences obtained from previous SARS and MERS epidemics and available data from COVID-19 will be taken into account.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“T helper (Th)-1 cytokines, including Interleukin (IL)-1β, IL-6, Interferon (IFN)-γ, Tumor Necrosis Factor (TNF)-α, CXCL10, and CCL2; and Th-2 cytokines, including IL-4, IL-10, and IL-1 receptor antagonist are all elevated in the serum of COVID-19 patients (Coperchini et al., 2020) in a “cytokine storm” typically associated with the illness.”
From Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: effect of inflammatory biomarkers at three-month follow-up (2021) · cites this paper as Coperchini et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Clinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246
Pathological findings of COVID-19 associated with acute respiratory distress syndrome
Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., Liu, S., Zhao, P., Liu, H., Zhu, L., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30076-x · Cited by 8,545
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332
Lauer, S. A., Grantz, K. H., Bi, Q., Jones, F. K., Zheng, Q., Meredith, H. R., Azman, A. S., Reich, N. G., & Lessler, J. (2020) · Annals of Internal Medicine · doi:10.7326/m20-0504 · Cited by 5,970
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Zaki, A. M., van Boheemen, S., Bestebroer, T. M., Osterhaus, A. D. M. E., & Fouchier, R. A. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211721 · Cited by 5,677
Clinical and immunological features of severe and moderate coronavirus disease 2019
Chen, G., Wu, D., Guo, W., Cao, Y., Huang, D., Wang, H., Wang, T., Zhang, X., Chen, H., Yu, H., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137244 · Cited by 4,750
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Coronaviruses: An Overview of Their Replication and Pathogenesis
Fehr, A. R., & Perlman, S. M. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2438-7_1 · Cited by 3,910
The reproductive number of COVID-19 is higher compared to SARS coronavirus
Liu, Y., Gayle, A. A., Wilder‐Smith, A., & Rocklöv, J. (2020) · Journal of Travel Medicine · doi:10.1093/jtm/taaa021 · Cited by 3,243
Cited by
Sorted by citations
Items 601–700 of 1,000
Renal Carcinoma Is Associated With Increased Risk of Coronavirus Infections
Tripathi, S. C., Deshmukh, V. R., Creighton, C. J., & Patil, A. L. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.579422 · Cited by 13
In-silico study on viability of MXenes in suppressing the coronavirus infection and distribution
Ghasemy, E., Jahromi, A. M., Khedri, M., Zandi, P., Maleki, R., & Tayebi, L. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1957711 · Cited by 13
Dirican, A., Ildir, S., Uzar, T., Karaman, İ., & Özkaya, Ş. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14843 · Cited by 13
Aljuhani, A., Albalawi, O., Albalawi, R., Alsalama, R., Alatawi, S., Altemani, R., Abdel‐Maksoud, M. S., & Elsherbiny, N. (2023) · Cell Biology International · doi:10.1002/cbin.12014 · Cited by 12
Pathogenesis Guided Therapeutic Management of COVID-19: An Immunological Perspective
Kumar, A., Prasoon, P., Shekhawat, P. S., Pareek, V., Faiq, M. A., Kumari, C., Narayan, R. K., Kulandhasamy, M., & Kant, K. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1840566 · Cited by 12
Dariolli, R., Campana, C., Gutierrez, A., & Sobie, E. A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.624185 · Cited by 12
Pathogenesis and Management of COVID-19
Alfarouk, K. O., Alhoufie, S. T. S., Ahmed, S. B. M., Shabana, M., Ahmed, A., Alqahtani, S. S., Alqahtani, A. S., Alqahtani, A., Ramadan, A. M., Ahmed, M. E., et al. (2021) · Journal of Xenobiotics · doi:10.3390/jox11020006 · Cited by 12
Sanap, A. P., Kheur, S. M., Kharat, A. H., & Bhonde, R. R. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110643 · Cited by 12
The impact of COVID-19 on cancer patients
Wekking, D., Senevirathne, T. H., Pearce, J. L., Aiello, M. M., Scartozzi, M., Lambertini, M., Silva, P. D., & Solinas, C. (2023) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2023.11.004 · Cited by 14
Implication of viruses in the etiology of preeclampsia
Motomura, K., Morita, H., Naruse, K., Saito, H., & Matsumoto, K. (2024) · American Journal of Reproductive Immunology · doi:10.1111/aji.13844 · Cited by 12
Coronavirus disease‑2019 (Review)
Shu, Y., He, H., Shi, X., Yan, L., & Li, J. (2021) · World Academy of Sciences Journal · doi:10.3892/wasj.2021.83 · Cited by 12
Influence of colchicine prescription in COVID-19-related hospital admissions: a survival analysis
Madrid-García, A., Pérez-Sancristóbal, I., Colomer, J. I., León, L., Jover, J. A., Fernández‐Gutiérrez, B., Abásolo, L., & Rodríguez‐Rodríguez, L. (2021) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x211002684 · Cited by 12
Update on Immunology of COVID-19 Disease and Potential Strategy for Controlling.
Dezfuli, N. K., Adcock, I. M., Montazami, N., Mortaz, E., & Velayati, A. A. (2020) · PubMed · Cited by 12
Scott, T. M., Jensen, S., & Pickett, B. E. (2021) · F1000Research · doi:10.12688/f1000research.52412.1 · Cited by 13
Lin, Z., Chen, J., & Han, S. (2021) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2021.1927721 · Cited by 12
Fischer, B., Lindenkamp, C., Lichtenberg, C., Birschmann, I., Knabbe, C., & Hendig, D. (2021) · Life · doi:10.3390/life11080805 · Cited by 12
Jiménez, D., & Arias, M. T. (2022) · Immunological Medicine · doi:10.1080/25785826.2022.2066251 · Cited by 12
In Vitro Evidence of Statins’ Protective Role against COVID-19 Hallmarks
Fiore, D., Proto, M., Franceschelli, S., Pascale, M. C., Bifulco, M., & Gazzerro, P. (2022) · Biomedicines · doi:10.3390/biomedicines10092123 · Cited by 12
Modeling the Within-Host Dynamics of SARS-CoV-2 Infection Based on Antiviral Treatment
Song, T., Wang, Y., Gu, X., & Qiao, S. (2023) · Mathematics · doi:10.3390/math11163485 · Cited by 12
Chen, T., Lv, J.-J., Chen, L., Li, M., & Liu, L. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i35.5154 · Cited by 12
Salem, M. A. (2020) · Journal of Pharmacy Practice · doi:10.1177/0897190020979608 · Cited by 12
Circular RNAs as emerging regulators in COVID-19 pathogenesis and progression
Gao, X., Fang, D., Liang, Y., Deng, X., Chen, N., Min De, Z. E. N. G., & Luo, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.980231 · Cited by 13
SARS-CoV-2 Portrayed against HIV: Contrary Viral Strategies in Similar Disguise
Duerr, R., Crosse, K. M., Valero-Jimenez, A. M., & Dittmann, M. (2021) · Microorganisms · doi:10.3390/microorganisms9071389 · Cited by 12
Xie, Z.-J., Novograd, J., Itzkowitz, Y., Sher, A., Buchen, Y. D., Sodhi, K., Abraham, N. G., & Shapiro, J. I. (2020) · Antioxidants · doi:10.3390/antiox9111129 · Cited by 11
Stone, L. H., Oppler, S. H., Nugent, J. L., Gresch, S. C., Hering, B. J., Murtaugh, M. P., Hegstad‐Davies, R. L., Ramachandran, S., & Graham, M. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-81953-7 · Cited by 11
Altered immunoemotional regulatory system in COVID-19: From the origins to opportunities
Pourriyahi, H., Saghazadeh, A., & Rezaei, N. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577578 · Cited by 12
The emerging role of cellular senescence in complications of COVID-19
Mohiuddin, M., & Kasahara, K. (2021) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2021.100399 · Cited by 11
Enikeev, D. V., Taratkin, M. S., Efetov, S. K., Shlomina, A., Boldyreva, M. N., Galkina, I., Spivak, L., Gitel, E., Мэлсовна, К. А., Mikhailov, V., et al. (2021) · Current Opinion in Urology · doi:10.1097/mou.0000000000000901 · Cited by 11
Park, A., & Harris, L. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.694355 · Cited by 11
An immunogenetic view of COVID-19
Aguiar, V. R. C., Augusto, D. G., Castelli, E. C., Hollenbach, J. A., Meyer, D., Nunes, K., & Petzl‐Erler, M. L. (2021) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2021-0036 · Cited by 13
Sengupta, S., Bhattacharyya, D., Kasle, G., Karmakar, S., Sahu, O., Ganguly, A., Addya, S., & Sarma, J. D. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.729622 · Cited by 12
He, Y., Qu, J. T., Wei, L., Liao, S., Zheng, N., Liu, Y., Wang, X., Jing, Y., Shen, C. K.-F., Ji, C., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.689065 · Cited by 11
When Pandemics Collide: the Interplay of Obesity and COVID-19
Mundi, M. S., Patel, J. J., Elfadil, O. M., Patel, J., Patel, I. K., Nanda, S., & Hurt, R. T. (2021) · Current Gastroenterology Reports · doi:10.1007/s11894-021-00822-5 · Cited by 11
Puzyrenko, A., Felix, J. C., Ledeboer, N. A., Sun, Y., Rui, H., & Sheinin, Y. M. (2021) · Pathology · doi:10.1016/j.pathol.2021.09.005 · Cited by 11
Impact of the COVID-19 Pandemic on Chronic Neurological Disorders: Focus on Patients with Dementia
Irrera, N., Barbieri, M. A., Bagnato, G., Ioppolo, C., & Versace, A. G. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220111124928 · Cited by 11
Cytokines and Chemokines in Cancer Cachexia and Its Long-Term Impact on COVID-19
Singh, S. K., & Singh, R. (2022) · Cells · doi:10.3390/cells11030579 · Cited by 11
IP-10 and complement activation as friend or foe in COVID-19
Bunprakob, S., Hemachudha, P., Ruchisrisarod, C., Supharatpariyakorn, T., & Hemachudha, T. (2022) · International Journal of Immunopathology and Pharmacology · doi:10.1177/03946320221096202 · Cited by 11
Das, D., & Podder, S. (2022) · Advanced Biology · doi:10.1002/adbi.202101310 · Cited by 12
Genetic susceptibility to autoimmunity—Current status and challenges
Huang, M., & Xu, H. (2022) · Advances in immunology · doi:10.1016/bs.ai.2022.08.004 · Cited by 11
Pallanti, S., Ponzio, M. D., Gavazzi, G., Gasic, G. P., Besteher, B., Heller, C., Kikinis, R., Makris, N., & Kikinis, Z. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.09.017 · Cited by 11
Upregulation of inflammatory genes and pathways links obesity to severe COVID-19
Currey, J. M., Ellsworth, C. R., Khatun, M. S., Wang, C., Chen, Z., Liu, S., Midkiff, C. C., Xiao, M. T., Ren, M., Liu, F., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167322 · Cited by 12
Rébé, C., Ghiringhelli, F., & Garrido, C. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15343 · Cited by 11
Haybar, H., Maniati, M., Saki, N., & Zayeri, Z. D. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06333-w · Cited by 11
Miftode, E. G., Miftode, I.-L., Coman, I., Prepeliuc, C. S., Obreja, M., Stămăteanu, L. O., Părângă, T. G., Leca, D. A., & Plesca, C. E. (2021) · Healthcare · doi:10.3390/healthcare9070788 · Cited by 11
Das, A., Roy, S., Swarnakar, S., & Chatterjee, N. (2021) · Clinical Immunology · doi:10.1016/j.clim.2021.108804 · Cited by 11
Thyroid hormones and platelet activation in COVID-19 patients
Colonnello, E., Criniti, A., Lorusso, E., Curreli, M., Santulli, M., Angeloni, A., Gnessi, L., Gandini, O., & Lubrano, C. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-022-01896-2 · Cited by 11
Farahani, R. H., Mosaed, R., Nezami-Asl, A., Chamanara, M., Soleiman-Meigooni, S., Kalantar, S., Zoshk, M. Y., Malekabad, E. S., & Hazrati, E. (2020) · Research Square · doi:10.21203/rs.3.rs-66909/v1 · Cited by 11
Dhaliwal, M., Muthu, V., Sharma, A., Raj, K., Rudramurthy, S. M., Agarwal, R., Kaur, H., Rawat, A. K., Singh, S., & Chakrabarti, A. (2023) · Mycoses · doi:10.1111/myc.13679 · Cited by 10
The role of nutrition on the treatment of Covid 19
Younes, S. (2024) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2024.200255 · Cited by 10
Association Between Vitamin D and COVID-19–Related Outcomes: An Umbrella Review of Meta-Analyses
Yang, J., Li, Z.-Q., Zhong, Y., Xie, H.-Y., Luo, Y., Li, X., Liao, J.-H., & Wang, M. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuae225 · Cited by 10
Sabit, H., Arneth, B. M., Altrawy, A., Ghazy, A., Abdelazeem, R. M., Adel, A., Abdel-Ghany, S. E., Alqosaibi, A. I., Deloukas, P., & Taghiyev, Z. T. (2025) · Biomedicines · doi:10.3390/biomedicines13020485 · Cited by 10
COMMUNITY-ACQUIRED PNEUMONIA ASSOCIATED WITH COVID-19: THE TREATMENT PERSPECTIVES
Feshchenko, Y. I., Dziublyk, O., Dziublyk, Y., Pylypenko, M. М., & Боророва, О. Л. (2020) · Ukrainian Pulmonology Journal · doi:10.31215/2306-4927-2020-108-2-5-12 · Cited by 10
Martin, J. H., & Head, R. J. (2020) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14551 · Cited by 10
Evaluation of mechanisms of action of re-purposed drugs for treatment of COVID-19
Rajaiah, R., Abhilasha, K. V., Shekar, M. A., Vogel, S. N., & Vishwanath, B. S. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104240 · Cited by 10
Management of COVID-19 from the pulmonologist’s perspective: a narrative review
Kumar, S., Mehta, S., Sarangdhar, N., Ray, A., Sinha, S., & Wig, N. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2021.1853529 · Cited by 10
Cytokine Storm and Immunomodulation in COVID-19
Rangappa, P. (2021) · Indian Journal of Critical Care Medicine · doi:10.5005/jp-journals-10071-24029 · Cited by 10
Obesity: A Risk Factor for COVID-19
Srivastava, S., Rathor, R., Singh, S. N., Kumar, B., & Suryakumar, G. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-85109-5_12 · Cited by 10
Karimabad, M. N., Hassanshahi, G., Kounis, N. G., Mplani, V., Roditis, P., Gogos, C., Lagadinou, M., Assimakopoulos, S. F., Dousdampanis, P., & Koniari, I. C. (2022) · Vaccines · doi:10.3390/vaccines10081299 · Cited by 10
He, M., Li, H., Zhang, Z., Jiang, J., Li, H., Yang, W., Cheng, Y., Gao, H., Chen, Q., Du, L., et al. (2022) · Veterinary Sciences · doi:10.3390/vetsci9090471 · Cited by 10
Tami, A., van der Gun, B. T. F., Wold, K. I., Vincenti-Gonzalez, M. F., Veloo, A. C. M., Knoester, M., Harmsma, V. P. R., de Boer, G., Huckriede, A. L. W., Pantano, D., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0273599 · Cited by 10
Molecular signatures in the progression of COVID-19 severity
De, R., & Azad, R. K. (2022) · Scientific Reports · doi:10.1038/s41598-022-26657-2 · Cited by 10
COVID-19 inhibits spermatogenesis in the testes by inducing cellular senescence
Wang, Z., Ma, Y., Chen, Z., Yang, R., Liu, Q., Pan, J., Wang, J., Liu, Y., Zhou, M., Zhang, Y., et al. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2022.981471 · Cited by 10
Biomarker Profiles Associated with COVID-19 Severity and Mortality
Sánchez‐Díez, S., Gómez-Ollés, C., Cruz, M. J., de Homdedeu, M., Espejo, D., Ferrer, J., Roca, O., Pacheco, A., & Muñoz, X. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45030128 · Cited by 12
Blood ACE2 Protein Level Correlates with COVID-19 Severity
Shevchuk, O. O., Pak, A., Palii, S. M., Ivankiv, Y. I., Kozak, K., Korda, M. M., & Vari, S. G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813957 · Cited by 10
Wolszczak-Biedrzycka, B., Dorf, J., Wojewódzka‐Żeleźniakowicz, M., Żendzian‐Piotrowska, M., Dymicka-Piekarska, V., Matowicka-Karna, J., & Maciejczyk, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1320362 · Cited by 10
Morphology and Function of Red Blood Cells in COVID-19 Patients: Current Overview 2023
Jung, F., & Connes, P. (2024) · Life · doi:10.3390/life14040460 · Cited by 10
Jaishwal, P., Jha, K., & Singh, S. P. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134012 · Cited by 10
Loktionov, A., Kobzeva, K., Karpenko, A. R., Sergeeva, V. A. S., Orlov, Y. L., & Bushueva, O. Y. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1434681 · Cited by 10
Protein-Driven Mechanism of Multiorgan Damage in COVID-19
Estrada, E. (2020) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2020.100069 · Cited by 10
Wang, L., Ren, Z., Ma, L., Han, Y., Wei, W., Jiang, E., & Ji, X.-Y. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.592888 · Cited by 10
Does death from Covid-19 arise from a multi-step process?
Pearce, N. E., Moirano, G., Maule, M. M., Kogevinas, M., Rodó, X., Lawlor, D. A., Vandenbroucke, J. P., Vandenbroucke‐Grauls, C. M. J. E., Polack, F. P., & Čustović, A. (2021) · European Journal of Epidemiology · doi:10.1007/s10654-020-00711-7 · Cited by 10
Zhou, L., Hao, P., Li, H., & Zhang, Z. (2021) · ACS Sensors · doi:10.1021/acssensors.1c00022 · Cited by 10
Thapa, K., Verma, N., Singh, T. G., Grewal, A. K., Kanojia, N., & Rani, L. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108328 · Cited by 10
Are Antisense Long Non-Coding RNA Related to COVID-19?
Badr, E. A. E., Sayed, I. E. E., Gabber, M. K. R. A., Ghobashy, E. A.-R., Al-Sehemi, A. G., Algarni, H., & Elghobashy, Y. (2022) · Biomedicines · doi:10.3390/biomedicines10112770 · Cited by 10
COVID-19 in Light of Seasonal Respiratory Infections
Kiseleva, I., Grigorieva, E., Larionova, N. V., Farroukh, M. A., & Георгиевна, Р. Л. (2020) · Biology · doi:10.3390/biology9090240 · Cited by 10
Trends in sepsis-associated cardiovascular disease mortality in the United States, 1999 to 2022
Salman, M., Cicin, J., Jabbar, A. B. A., El-shaer, A., Tauseef, A., Asghar, N., Mirza, M. M., & Aboeata, A. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1505905 · Cited by 9
Tu, T. H., Bennani, F. E., Masroori, N., Liu, C., Nemati, A., Rozza, N., Grunbaum, A., Kremer, R. B., Milhalcioiu, C., Roy, D., et al. (2025) · Communications Biology · doi:10.1038/s42003-024-07350-8 · Cited by 9
COVID-19: The Significance of Platelets, Mitochondria, Vitamin D, Serotonin and the Gut Microbiota
Bókkon, I., Kapócs, G., Vucskits, A. V., Erdöfi-Szabó, A., Vagedes, J., Scholkmann, F., & Szőke, H. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210526100147 · Cited by 9
Vélez-Páez, J. L., Montalvo-Villagómez, M., González, F. E. J., Moscoso, S. X. A., Tercero-Martínez, W., Saltos, L. S., Jiménez-Alulima, G., Irigoyen-Mogro, E., Castro-Reyes, E. E., Mora-Coello, C., et al. (2022) · Bionatura · doi:10.21931/rb/2022.07.01.1 · Cited by 10
Impact of SARS-CoV-2 on Host Factors Involved in Mental Disorders
Rhoades, R. E., Solomon, S., Johnson, C., & Teng, S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.845559 · Cited by 9
Epigenetic perspectives of COVID-19: Virus infection to disease progression and therapeutic control
Patra, S. K., & Szyf, M. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166527 · Cited by 9
Altered microRNA Transcriptome in Cultured Human Airway Cells upon Infection with SARS-CoV-2
Diallo, I., Jacob, R. A., Vion, É., Kozak, R. A., Mossman, K. L., & Provost, P. (2023) · Viruses · doi:10.3390/v15020496 · Cited by 9
Intrinsic factors behind long‐COVID: I. Prevalence of the extracellular vesicles
El‐Maradny, Y. A., Rubio‐Casillas, A., Uversky, V. N., & Redwan, E. M. M. M. (2023) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30415 · Cited by 9
Factors Associated with Pneumonia in Patients Hospitalized with COVID-19 and the Role of Vaccination
Zizza, A., Sedile, R., Bagordo, F., Panìco, A., Guido, M., Grassi, T., Banchelli, F., & Grima, P. (2023) · Vaccines · doi:10.3390/vaccines11081342 · Cited by 9
Lee, J. H., Kim, Y.-S., & Leem, K. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813777 · Cited by 9
Fan, W., Zhao, Y. D., Hong, F., Liu, Y., & Huang, W. (2023) · Science China Chemistry · doi:10.1007/s11426-023-1741-6 · Cited by 9
Kothari, A., Singh, V., Nath, U. K., Kumar, S., Rai, V., Kaushal, K., Omar, B. J., Pandey, A., & Jain, N. K. (2020) · Biology · doi:10.3390/biology9090243 · Cited by 9
Kim, E., Kim, H. S., Hong, K., Chung, H., Park, S., & Noh, G. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02583-4 · Cited by 9
Lee, S. J., Na, H. G., Choi, Y. S., Bae, C. H., Song, S., & Kim, Y. (2022) · BioMed Research International · doi:10.1155/2022/2743046 · Cited by 9
Inhibition of a broad range of SARS-CoV-2 variants by antiviral phytochemicals in hACE2 mice
Kim, E.-H., Lee, B.-W., Ryu, B., Cho, H. M., Kim, S., Jang, S., Casel, M. A. B., Rollon, R., Yoo, J., Poo, H., et al. (2022) · Antiviral Research · doi:10.1016/j.antiviral.2022.105371 · Cited by 9
COVID-19-Induced Seizures: A Meta-Analysis of Case Series and Retrospective Cohorts
Hussaini, H., Rogers, S., Kataria, S., Uddin, K., Mohamed, K. H., Mohamed, A. S., Tariq, F., Ahmad, S., Awais, A., Ahmed, Z., et al. (2022) · Cureus · doi:10.7759/cureus.28633 · Cited by 9
Whole Transcriptomic Analysis of Key Genes and Signaling Pathways in Endogenous ARDS
Xie, Y., Luo, J., Hu, W., Ye, C., Ren, P., Wang, Y., & Li, X. (2022) · Disease Markers · doi:10.1155/2022/1614208 · Cited by 9
Faqihi, F. A., Alharthy, A. M., Pirompanich, P., Noor, A. S. N., Shahzad, A., Nasim, N., Balhamar, A., Memish, Z. A., & Karakitsos, D. (2020) · Respiratory Medicine Case Reports · doi:10.1016/j.rmcr.2020.101203 · Cited by 9
Esposito, P. B., Cipriani, L., Verzola, D., Grignano, M. A., AMICI, M. D., Testa, G., Grosjean, F., Russo, E., Garibotto, G., Rampino, T., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10071383 · Cited by 9
Kimura, L. F., Sant’Anna, M. B., de Andrade, S. A., Ebram, M. C., Lima, C. F. G., Celano, R. M. G., Viégas, R. F. M., & Picolo, G. (2021) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2021.102604 · Cited by 9
Khatchadourian, C., Sisliyan, C., Nguyen, K., Poladian, N., Tian, Q., Tamjidi, F., Luong, B., Singh, M., Robison, J., & Venketaraman, V. (2021) · Clinics and Practice · doi:10.3390/clinpract11040085 · Cited by 9
Çelik, İ., EREN, E. E., Toker, A. K., Eren, D., Yıldız, M., Kanat, A., Topaloğlu, U. S., Güzeldağ, S., Kara, M., & Ulu-Kılıç, A. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14997 · Cited by 9
Evaluation of CXCL 10 and IL-10 in COVID-19 pneumonia
Okab, H. F., Salih, M. B., & Jarulla, B. A. (2022) · Pneumologia · doi:10.2478/pneum-2023-0043 · Cited by 8
COVID-19 in rheumatoid arthritis cases: an Iranian referral center experience
Shadmanfar, S., Jafari, N. J., Jafari, R., Moqaddam, Z. R., & Saburi, A. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-05464-y · Cited by 8
Rasmi, Y., Hatamkhani, S., Naderi, R., Shokati, A., zadeh, V. N., Hosseinzadeh, F., Farnamian, Y., & Jalali, L. (2022) · Acta Histochemica · doi:10.1016/j.acthis.2022.151908 · Cited by 8
Metadata
- Authors
- Coperchini, F., Chiovato, L., Croce, L., Magri, F., & Rotondi, M.
- Affiliations
- Istituti Clinici Scientifici Maugeri (IT)
- University of Pavia (IT)
- Corresponding author
- Rotondi, Mario
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 53
- Pages
- 25-32
- ISSN
- 1359-6101 (ISSN-L)
- PMC
- PMC7211650
- OpenAlex
- W3021577619
- Cited by
- 1,288
- References
- 106
- Citations by year
- 2026: 20 · 2025: 44 · 2024: 92 · 2023: 158 · 2022: 274 · 2021: 443 · 2020: 257
- FWCI
- 13.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- cytokine storm, COVID-19 pandemic, SARS-CoV-2, chemokines, chemokine receptors, acute respiratory distress syndrome, systemic inflammation, immune cell recruitment, SARS, MERS, betacoronaviruses, disease severity
- MeSH terms
- Betacoronavirus, Cytokine Release Syndrome, COVID-19, SARS-CoV-2, Humans, Pneumonia, Viral, Coronavirus Infections, Chemokines, Receptors, Chemokine, Severe Acute Respiratory Syndrome, Pandemics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
