Cited by 1,288COVID-19 Clinical Research StudiesChemokine receptors and signalingSARS-CoV-2 and COVID-19 Research

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The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

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Coperchini, Francesca, Chiovato, Luca, Croce, Laura, Magri, Flavia, Rotondi, Mario·2020·Cytokine & Growth Factor Reviews

DOI 10.1016/j.cytogfr.2020.05.003PMC PMC7211650

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Abstract

In 2019-2020 a new coronavirus named SARS-CoV-2 was identified as the causative agent of a several acute respiratory infection named COVID-19, which is causing a worldwide pandemic. There are still many unresolved questions regarding the pathogenesis of this disease and especially the reasons underlying the extremely different clinical course, ranging from asymptomatic forms to severe manifestations, including the Acute Respiratory Distress Syndrome (ARDS). SARS-CoV-2 showed phylogenetic similarities to both SARS-CoV and MERS-CoV viruses, and some of the clinical features are shared between COVID-19 and previously identified beta-coronavirus infections. Available evidence indicate that the so called "cytokine storm" an uncontrolled over-production of soluble markers of inflammation which, in turn, sustain an aberrant systemic inflammatory response, is a major responsible for the occurrence of ARDS. Chemokines are low molecular weight proteins with powerful chemoattractant activity which play a role in the immune cell recruitment during inflammation. This review will be aimed at providing an overview of the current knowledge on the involvement of the chemokine/chemokine-receptor system in the cytokine storm related to SARS-CoV-2 infection. Basic and clinical evidences obtained from previous SARS and MERS epidemics and available data from COVID-19 will be taken into account.

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Authors: Coperchini, F., Chiovato, L., Croce, L., Magri, F., & Rotondi, M.
Affiliations: Istituti Clinici Scientifici Maugeri (IT)
University of Pavia (IT)
Corresponding author: Rotondi, Mario
ORCID: Coperchini, Francesca
Chiovato, Luca
Croce, Laura
Magri, Flavia
Rotondi, Mario
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 2020-06
Volume: 53
Pages: 25-32
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/j.cytogfr.2020.05.003
PMC: PMC7211650
OpenAlex: W3021577619
Cited by: 1,288
References: 106
Citations by year: 2026: 20 · 2025: 44 · 2024: 92 · 2023: 158 · 2022: 274 · 2021: 443 · 2020: 257
FWCI: 13.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Cytokine & Growth Factor Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords: cytokine storm, COVID-19 pandemic, SARS-CoV-2, chemokines, chemokine receptors, acute respiratory distress syndrome, systemic inflammation, immune cell recruitment, SARS, MERS, betacoronaviruses, disease severity
MeSH terms: Betacoronavirus, Cytokine Release Syndrome, COVID-19, SARS-CoV-2, Humans, Pneumonia, Viral, Coronavirus Infections, Chemokines, Receptors, Chemokine, Severe Acute Respiratory Syndrome, Pandemics

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The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

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