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Cited by 36Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCancer-related cognitive impairment studies

Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition

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Swinford, Cecily G., Risacher, Shannon L., Charil, Arnaud, Schwarz, Adam J., Saykin, Andrew J., Alzheimer's Disease Neuroimaging Initiative·2018·Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
DOI 10.1016/j.dadm.2018.03.001PMC PMC5956937
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Abstract

Introduction: Relationship between self– and informant memory concerns and tau aggregation was assessed in adults at risk for Alzheimer's disease (AD). Methods: Regional mean standardized uptake value ratios were extracted from [18 F]flortaucipir positron emission tomography (PET) scans of 82 at‐risk adults in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Associations between self– and informant ECog memory scores and tau aggregation were analyzed on both regional and voxelwise bases. Analyses were completed both on the whole sample and restricted to amyloid‐positive individuals only. Results: Memory concerns were associated with tau aggregation. Self‐perception was more associated with frontal tau. In contrast, informant scores were more associated with parietal tau. This source‐by‐region interaction was more prominent in amyloid‐positive participants and observed in both regional and voxelwise analyses. Discussion: Quantitative assessment of perceived memory functioning may be useful for screening older adults at risk for Alzheimer's disease. Individuals and their informants may provide complementary information relating to the anatomical distribution of tau.

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  • In the preclinical stage, self-reported memory concern was associated with frontal tau levels, whereas informant-reported concern was related to parietal tau levels in SCD subjects scanned with 18F-flortaucipir PET.

    “They scanned SCD subjects using 18F-flortaucipir PET and determined that the self-reported memory concern was associated with frontal tau levels, whereas the informant-reported concern was related to parietal tau levels.”

    From Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease (2020) · cites this paper as [50]

    The Results (Interaction analysis) report that self-reported memory concerns were preferentially associated with frontal tau aggregation and informant-reported concerns with parietal tau aggregation. However, the Methods (Participants) show that the PET sample included cognitively normal, significant-memory-concern, and early-MCI participants; the finding was not established specifically in SCD subjects or exclusively in the preclinical stage. (LLM, conf=0.90)

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Authors
Swinford, C. G., Risacher, S. L., Charil, A., Schwarz, A. J., Saykin, A. J., & Initiative, A. D. N.
Affiliations
  • Indiana University Indianapolis (US)
  • Eli Lilly (United States) (US)
  • Alzheimer’s Disease Neuroimaging Initiative (US)
Corresponding author
Saykin, Andrew J.
ORCID
Venue
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Publisher
Wiley
Published
2018-01
Volume
10
Issue
1
Pages
322-331
ISSN
2352-8729 (ISSN-L)
DOI
10.1016/j.dadm.2018.03.001
PMC
PMC5956937
OpenAlex
W2789291899
Cited by
36
References
4
Citations by year
2025: 5 · 2024: 7 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 2
FWCI
3.15
Type
journal article
Language
en
Open access
Licence
Locations
  • Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • IUScholarWorks (Indiana University) (submittedVersion, cc-by)
  • PMC
Funders
  • National Institutes of Health (U01 AG024904, P30 AG010129, K01 AG030514)
  • U.S. Department of Defense (W81XWH‐12‐2‐0012)
  • National Institute on Aging
  • National Institute of Biomedical Imaging and Bioengineering
  • Canadian Institutes of Health Research
  • Dana Foundation
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
Keywords
memory concerns, tau aggregation, flortaucipir PET, informant reports, amyloid-positive, frontal lobe, parietal lobe

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