The DOI matches its Crossref record; 225 of the 225 references it cites were found in a registry or an index.
The physiology of developmental changes in BOLD functional imaging signals
Open accessAbstract
BOLD fMRI (blood oxygenation level dependent functional magnetic resonance imaging) is increasingly used to detect developmental changes of human brain function that are hypothesized to underlie the maturation of cognitive processes. BOLD signals depend on neuronal activity increasing cerebral blood flow, and are reduced by neural oxygen consumption. Thus, developmental changes of BOLD signals may not reflect altered information processing if there are concomitant changes in neurovascular coupling (the mechanism by which neuronal activity increases blood flow) or neural energy use (and hence oxygen consumption). We review how BOLD signals are generated, and explain the signalling pathways which convert neuronal activity into increased blood flow. We then summarize in broad terms the developmental changes that the brain's neural circuitry undergoes during growth from childhood through adolescence to adulthood, and present the changes in neurovascular coupling mechanisms and energy use which occur over the same period. This information provides a framework for assessing whether the BOLD changes observed during human development reflect altered cognitive processing or changes in neurovascular coupling and energy use.
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“Although this hypothesis requires some speculation informed by an admittedly sparse literature, the available body of research supports this proposed developmental model [28, 68, 98, 107–109].”
From The role of the anterior insula in adolescent decision making (2014) · cites this paper as [108]
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“These studies highlight the role of the AIC during the interplay of cognitive and affective processes.”
From The role of the anterior insula in adolescent decision making (2014) · cites this paper as [108]
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Metadata
- Authors
- Harris, J. J., Reynell, C., & Attwell, D.
- Affiliations
- University College London (GB)
- Corresponding author
- Attwell, David
- Venue
- Developmental Cognitive Neuroscience
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 1
- Issue
- 3
- Pages
- 199-216
- ISSN
- 1878-9293 (ISSN-L)
- PMC
- PMC6987565
- OpenAlex
- W2024606594
- Cited by
- 142
- References
- 225
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 10 · 2021: 6 · 2020: 8 · 2019: 9 · 2018: 7 · 2017: 10 · 2016: 18 · 2015: 11 · 2014: 14 · 2013: 15 · 2012: 12
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cognitive Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Fondation Leducq
- Medical Research Council
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- BOLD signal, brain development, neurovascular coupling, cerebral blood flow, oxygen consumption, neural circuit maturation, cognitive development, adolescence, childhood, functional MRI
- MeSH terms
- Animals, Brain, Cerebrovascular Circulation, Humans, Magnetic Resonance Imaging, Neuronal Plasticity, Oxygen Consumption, Signal Processing, Computer-Assisted
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