Administration of 17α-ethinylestradiol during pregnancy elicits modifications of maternal behavior and emotional alteration of the offspring in the rat
Abstract
Intraperitoneal administration of 17alpha-ethinylestradiol (15 microg.kg(-1)) in pregnant rats, every day from day 9 to day 14 of pregnancy, elicited a high percentage of abortions. Quantification of maternal behavior showed that treated dams took better care of their pups than control dams, injected with the vehicle only, did. Postnatal reflexes, which reflect maturational rate, were established more promptly in the offspring of treated dams than in the offspring of control dams. However, when adult, the rats born from treated dams developed anxiety- and depressive-like behaviors. All these results are explained by the effects of the exogenous estrogen on the developing brain of the fetuses.
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In mammals, pharmacological levels of EE2 exert important effects on reproductive physiology and behavior.
“In mammals, pharmacological levels of EE2 exert important effects on reproductive physiology and behavior [18, 31–34].”
From Developmental exposure to low levels of ethinylestradiol affects social play in juvenile male rats (2020) · cites this paper as [31]
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Koch, M., & Ehret, G. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90293-x · Cited by 76 · see citing works
Prenatal exposure to ethinylestradiol elicits behavioral abnormalities in the rat
Dugard, M. L., Tremblay-Leveau, H., Mellier, D., & Caston, J. (2001) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00205-x · Cited by 46 · see citing works
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Ferguson, S. A., Law, C. D., & Abshire, J. S. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr201 · Cited by 54 · see citing works
Developmental exposure to xenoestrogen enhances spatial learning in male rats
Corrieri, L., Della Seta, D., Canoine, V., & Fusani, L. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.03.002 · Cited by 20 · see citing works
Developmental exposure to low levels of ethinylestradiol affects social play in juvenile male rats
Zaccaroni, M., Massolo, A., Beani, L., Seta, D. D., Farabollini, F., Giannelli, G., Fusani, L., & Dessì-Fulgheri, F. (2020) · Toxicological Research · doi:10.1007/s43188-019-00035-z · Cited by 5 · see citing works
Soyer-Gobillard, M.-O., Gaspari, L., & Sultan, C. (2025) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2025.123471 · Cited by 2 · see citing works
- Authors
- Arabo, A., Lefebvre, M., Fermanel, M., & Caston, J.
- Affiliations
- Université de Rouen Normandie (FR)
- ORCID
- Arabo, A.
- Venue
- Developmental Brain Research
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 156
- Issue
- 1
- Pages
- 93-103
- ISSN
- 0165-3806 (ISSN-L)
- OpenAlex
- W1981293219
- Cited by
- 32
- References
- 2
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- ethinyl estradiol, pregnancy, maternal behavior, depression-like behavior, abortion (veterinary), fetal brain development, exogenous estrogen, prenatal hormone exposure
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Animals, Newborn, Behavior, Animal, Birth Weight, Body Weight, Emotions, Estrogens, Ethinyl Estradiol, Exploratory Behavior, Female, Litter Size, Male, Maternal Behavior, Motor Activity, Pregnancy, Prenatal Exposure Delayed Effects, Rats, Inbred Strains, Reaction Time, Reflex, Rats
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