Prenatal exposure to ethinylestradiol elicits behavioral abnormalities in the rat
Abstract
Pregnant rats were i.p. injected with a solution of 17alpha-ethinylestradiol (15 microg kg(-1)) every day between day 9 and day 14 of pregnancy and the behavior of the offspring was compared to that of rats born from dams injected with the vehicle only during the same gestational period. The percentage of neonatal death was dramatically high in the prenatally treated group. Growth of the surviving animals was even better than that of controls, but when adult, they exhibited a number of behavioral abnormalities: increased spontaneous motor activity, decreased exploratory behavior, impaired cognitive processing, qualitatively different exploratory drive, and/or persevering behavior, increased anxiety-like behavior and social neophobia. These behavioral alterations, which resemble a number of psychiatric syndromes, suggest that ethinylestradiol altered the ontogenesis of different parts of the central nervous system involved in cognitive and emotional processes. However, it cannot be excluded that the changes in behavior of ethinylestradiol exposed offspring were due to the abnormal maternal behavior of the estradiol treated dams.
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In mammals, pharmacological levels of EE2 exert important effects on reproductive physiology and behavior.
“In mammals, pharmacological levels of EE2 exert important effects on reproductive physiology and behavior [18, 31–34].”
From Developmental exposure to low levels of ethinylestradiol affects social play in juvenile male rats (2020) · cites this paper as [32]
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- Authors
- Dugard, M. L., Tremblay-Leveau, H., Mellier, D., & Caston, J.
- Affiliations
- Université de Rouen Normandie (FR)
- Corresponding author
- Caston, J
- ORCID
- Mellier, D
- Venue
- Developmental Brain Research
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 129
- Issue
- 2
- Pages
- 189-199
- ISSN
- 0165-3806 (ISSN-L)
- OpenAlex
- W2031979221
- Cited by
- 46
- References
- 87
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 2 · 2012: 3
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- ethinyl estradiol, prenatal exposure, endocrine disruptors, behavioral abnormalities, offspring behavior, neonatal mortality, anxiety-like behavior, perseveration, exploratory behavior, cognitive processes, maternal behavior, central nervous system development, psychiatric syndromes
- MeSH terms
- Animals, Animals, Newborn, Anxiety, Attention, Behavior, Animal, Ethinyl Estradiol, Exploratory Behavior, Fear, Female, Interpersonal Relations, Litter Size, Male, Maternal Behavior, Motor Activity, Pregnancy, Prejudice, Prenatal Exposure Delayed Effects, Rats, Inbred Strains, Rats
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