Cited by 46Effects and risks of endocrine disrupting chemicalsPrenatal Substance Exposure EffectsSexual Differentiation and Disorders

Prenatal exposure to ethinylestradiol elicits behavioral abnormalities in the rat

Dugard, M.L, Tremblay-Leveau, H, Mellier, D, Caston, J·2001·Developmental Brain Research

Abstract

Pregnant rats were i.p. injected with a solution of 17alpha-ethinylestradiol (15 microg kg(-1)) every day between day 9 and day 14 of pregnancy and the behavior of the offspring was compared to that of rats born from dams injected with the vehicle only during the same gestational period. The percentage of neonatal death was dramatically high in the prenatally treated group. Growth of the surviving animals was even better than that of controls, but when adult, they exhibited a number of behavioral abnormalities: increased spontaneous motor activity, decreased exploratory behavior, impaired cognitive processing, qualitatively different exploratory drive, and/or persevering behavior, increased anxiety-like behavior and social neophobia. These behavioral alterations, which resemble a number of psychiatric syndromes, suggest that ethinylestradiol altered the ontogenesis of different parts of the central nervous system involved in cognitive and emotional processes. However, it cannot be excluded that the changes in behavior of ethinylestradiol exposed offspring were due to the abnormal maternal behavior of the estradiol treated dams.

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Crossref · 10.1016/s0165-3806(01)00205-x

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Authors
Dugard, M. L., Tremblay-Leveau, H., Mellier, D., & Caston, J.
Affiliations
Université de Rouen Normandie (FR)
Corresponding author
Caston, J
Venue
Developmental Brain Research
Publisher
Elsevier BV
Published
2001-08
Volume
129
Issue
2
Pages
189-199
ISSN
0165-3806 (ISSN-L)
OpenAlex
W2031979221
Cited by
46
References
87
Citations by year
2025: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 2 · 2012: 3
FWCI
0.59
Type
journal article
Language
en
Open access
closed
Locations
  • Developmental Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
ethinyl estradiol, prenatal exposure, endocrine disruptors, behavioral abnormalities, offspring behavior, neonatal mortality, anxiety-like behavior, perseveration, exploratory behavior, cognitive processes, maternal behavior, central nervous system development, psychiatric syndromes
MeSH terms
Animals, Animals, Newborn, Anxiety, Attention, Behavior, Animal, Ethinyl Estradiol, Exploratory Behavior, Fear, Female, Interpersonal Relations, Litter Size, Male, Maternal Behavior, Motor Activity, Pregnancy, Prejudice, Prenatal Exposure Delayed Effects, Rats, Inbred Strains, Rats

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