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Cited by 20Effects and risks of endocrine disrupting chemicalsSexual Differentiation and DisordersEstrogen and related hormone effects

Developmental exposure to xenoestrogen enhances spatial learning in male rats

Corrieri, Luca, Della Seta, Daniele, Canoine, Virginie, Fusani, Leonida·2007·Hormones and Behavior
DOI 10.1016/j.yhbeh.2007.03.002
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Abstract

Steroid hormones have profound effects on the development and function of the nervous system. Environmental estrogens or xenoestrogens are manmade or are natural compounds, which mimics the action of estrogen hormones. The experimental evidence for impairment of cognitive functions in humans and mammals following exposure to xenoestrogens has been fiercely debated. The strongest arguments against such studies have been that the route, time course, and intensity of exposure did not simulate environmental exposure, and that the chemicals tested have additional, non-estrogenic toxic effects, hindering a generalization of actual "xenoestrogenic" effects. Here we show that an environmental-like exposure to the pure estrogen, 17alpha-ethynylestradiol (EE2) during development enhances spatial learning abilities in adult male Sprague-Dawley rats. To simulate an environmental exposure, we used a very low dose (4 ng/kg/day) of EE2 equivalent to concentrations measured in European and US streams which was given orally with a non-invasive method, and we extended the treatment for the entire course of development, from conception to puberty. The animals were tested in a Morris water maze protocol at 6 months of age. Male rats treated with EE2 during development showed a faster learning during the training phase, and remembered better the position of the hidden platform in the short term. Our study demonstrates that actual levels of exposure to xenoestrogens can permanently alter cognitive…

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  • Previous studies in Sprague-Dawley rats showed significant effects of a developmental administration (GD 5-PND 32) of very low (4 ng/kg/day) or low clinical EE2 doses (400 ng/kg/day) on learning and memory, sexual behavior, pain perception, anxiety and social play.

    “previous studies in Sprague–Dawley (SD) rats showed significant effects of a developmental administration (GD 5–PND 32) of very low (4 ng/kg/day) or low clinical EE2 doses (400 ng/kg/day) on learning and memory [47], sexual behavior [48, 49], pain perception [50], anxiety [51] and social play [19].”

    From Developmental exposure to low levels of ethinylestradiol affects social play in juvenile male rats (2020) · cites this paper as [47]

  • In female rats, prenatal administration of EE2 in low doses had no effect on AGD at birth in a few studies.

    “In female rats, EE2 was administered prenatally in low doses in a few studies where it had no effect on AGD at birth [19, 47].”

    From Developmental exposure to low levels of ethinylestradiol affects social play in juvenile male rats (2020) · cites this paper as [47]

  • In a study by Corrieri et al., SD male rats received through their mothers very low doses of EE2 (4 ng/kg/day) or oil from GD 5 on, and a similar slight, though not significant, increase of AGD at birth was observed.

    “In a study by Corrieri et al. [47], SD male rats received through their mothers very low doses of EE2 (4 ng/kg/day) or oil from GD 5 on, and a similar slight, though not significant, increase of AGD at birth was observed.”

    From Developmental exposure to low levels of ethinylestradiol affects social play in juvenile male rats (2020) · cites this paper as [47]

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Authors
Corrieri, L., Della Seta, D., Canoine, V., & Fusani, L.
Affiliations
University of Siena (IT)
Corresponding author
Fusani, Leonida
ORCID
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
2007-05
Volume
51
Issue
5
Pages
620-625
ISSN
0018-506X (ISSN-L)
DOI
10.1016/j.yhbeh.2007.03.002
OpenAlex
W2158997272
Cited by
20
References
48
Citations by year
2020: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2012: 1
FWCI
2.27
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Hormones and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
xenoestrogens, ethinyl estradiol, early life exposure, spatial learning, cognitive enhancement, estrogen receptor agonists, Morris water maze, puberty, male rats, brain development
MeSH terms
Analysis of Variance, Animals, Dose-Response Relationship, Drug, Environmental Exposure, Environmental Pollutants, Ethinyl Estradiol, Female, Male, Pregnancy, Prenatal Exposure Delayed Effects, Space Perception, Spatial Behavior, Statistics, Nonparametric, Maze Learning, Rats

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