Estradiol and parental experience, but not prolactin are necessary for ultrasound recognition and pup-retrieving in the mouse
Abstract
The effects of estradiol, prolactin and experience with pups on pup-retrieving and on the recognition of ultrasonic distress calls of the young by adult ovariectomized female mice were studied. Treatment with estradiol benzoate or experience with pups (for 5 days) induced pup-retrieving in 40% and 60% of the animals, respectively, as compared to 0% in inexperienced ovariectomized females. However, if pup-experience was achieved in the presence of estradiol, retrieving was shown by 90.5% of the animals. In addition, in this case models of the ultrasonic distress calls of the pups were significantly preferred ("recognized") in a discrimination task by the females. These females also showed a sharp increase in serum prolactin concentrations. Depleting prolactin from the blood by cysteamine, however, neither reduced the retrieving score nor disturbed ultrasound recognition. Thus prolactin is dispensable for maintaining maternal pup-retrieving and ultrasound recognition. The process of achieving pup-experience is enhanced by the presence of estradiol. Possible actions of estradiol in the brain are discussed.
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Cohousing virgin females with experienced dams and litters accelerates the onset of maternal behavior.
“Cohousing virgin females with experienced dams and litters accelerates the onset of maternal behavior”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Koch & Ehret 1989
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Kantar, D., Hidişoğlu, E., Er, H., Acun, A. D., Olğar, Y., & Yargıçoğlu, P. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.05.003 · Cited by 13 · see citing works
Measurement of Maternal Behavior
Mann, P. E. (1993) · Methods in neurosciences · doi:10.1016/b978-0-12-185277-1.50027-7 · Cited by 12 · see citing works
Quantitative and Qualitative Features of Neonatal Vocalizations in Mice
Caruso, A., Sabbioni, M., Scattoni, M. L., & Branchi, I. (2018) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-809600-0.00013-5 · Cited by 11 · see citing works
Prospective contributions of transgenic mouse models to central auditory research
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Mykins, M., Layo-Carris, D. E., Dunn, L. R., Skinner, D. W., McBryar, A. H., Perez, S., Shultz, T. R., Willems, A. R., Lau, B. Y. B., Hong, T., et al. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25190 · Cited by 8 · see citing works
Rodent Ultrasonic Vocalization as a Window Into Auditory Cortical Processing and Plasticity
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Pups and prolactin are rewarding to virgin female and pregnant mice
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Factors influencing maternal behavior in the hubb/hubb mutant mouse
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Ultrasonic Vocalizations by Infant Mice: An Ethological Expression of Separation Anxiety
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Lateralized local circuit tuning in female mouse auditory cortex
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Hormone-Dependent and Experience-Dependent Auditory Plasticity for Social Communication
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Maternal experience unmasks temporal integration for vocalization processingPreprint
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Brain aromatase and its relationship with parental experience and behavior in male mice
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Self-citationLove, death, and oxytocin: In memory of Larry Young
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- Authors
- Koch, M., & Ehret, G.
- Affiliations
- University of Konstanz (DE)
- Universität Ulm (DE)
- ORCID
- Ehret, Günter
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1989-04
- Volume
- 45
- Issue
- 4
- Pages
- 771-776
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2061302245
- Cited by
- 76
- References
- 64
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 7 · 2015: 1 · 2014: 4 · 2013: 4 · 2012: 1
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- estradiol, prolactin, maternal behavior, pup retrieval, ovariectomy, estradiol benzoate, cysteamine, parental experiences, female mice
- MeSH terms
- Animals, Behavior, Animal, Cysteamine, Estradiol, Female, Maternal Behavior, Ovariectomy, Prolactin, Vocalization, Animal, Mice
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