The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification
Open accessAbstract
A commonly accepted model of Wnt/β-catenin signaling involves target gene activation by a complex of β-catenin with a TCF family member. TCF3 is a transcriptional repressor that has been implicated in Wnt signaling and plays key roles in embryonic axis specification and stem cell differentiation. Here we demonstrate that Wnt proteins stimulate TCF3 phosphorylation in gastrulating Xenopus embryos and mammalian cells. This phosphorylation event involves β-catenin-mediated recruitment of homeodomain-interacting protein kinase 2 (HIPK2) to TCF3 and culminates in the dissociation of TCF3 from a target gene promoter. Mutated TCF3 proteins resistant to Wnt-dependent phosphorylation function as constitutive inhibitors of Wnt-mediated activation of Vent2 and Cdx4 during anteroposterior axis specification. These findings reveal an alternative in vivo mechanism of Wnt signaling that involves TCF3 phosphorylation and subsequent derepression of target genes and link this molecular event to a specific developmental process.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation Movements
Veeman, M. T., Slusarski, D. C., Kaykas, A., Louie, S. H., & Moon, R. T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00240-9 · Cited by 945
Ishitani, T., Ninomiya-Tsuji, J., Nagai, S.-I., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, H., Shibuya, H., et al. (1999) · Nature · doi:10.1038/21674 · Cited by 621
Rocheleau, C. E., Yasuda, J., Shin, T. H., Lin, R., Sawa, H., Okano, H., Priess, J. R., Davis, R. J., & Mello, C. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80784-9 · Cited by 276
Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling
Itoh, K., Brott, B. K., Bae, G.-U., Ratcliffe, M. J., & Sokol, S. Y. (2005) · Journal of Biology · doi:10.1186/jbiol20 · Cited by 221
Self-citationIshitani, T., Ninomiya-Tsuji, J., & Matsumoto, K. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1379-1389.2003 · Cited by 212 · cited 1×
“Whereas the P2 and P4 site have not been previously detected, the P3 site corresponds to the sites in LEF1 and TCF4 that are phosphorylated by mammalian NLK in vitro (Ishitani et al., 2003; Ishitani et al., 1999; Kanei-Ishii et al., 2004; Smit et al., 2004).”
BackgroundLo, M.-C., Gay, F., Odom, R., Shi, Y., & Lin, R. (2004) · Cell · doi:10.1016/s0092-8674(04)00203-x · Cited by 138
Cited by
Wnt/β-catenin signaling and disease
Clevers, H., & Nusse, R. (2012) · Cell · doi:10.1016/j.cell.2012.05.012 · Cited by 5,554
TCF/LEFs and Wnt Signaling in the Nucleus
Cadigan, K. M., & Waterman, M. L. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007906 · Cited by 760
Maintaining embryonic stem cell pluripotency with Wnt signaling
Sokol, S. Y. (2011) · Development · doi:10.1242/dev.066209 · Cited by 257
Self-citationShy, B. R., Wu, C.-I., Khramtsova, G. F., Zhang, J. Y., Olopade, O. I., Goss, K. H., & Merrill, B. J. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.001 · Cited by 124
Atlasi, Y., Noori, R., Gaspar, C., Franken, P., Sacchetti, A., Rafati, H., Mahmoudi, T., Decraene, C., Calin, G. A., Merrill, B. J., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003424 · Cited by 84
Nemo-like kinase, a multifaceted cell signaling regulator
Ishitani, T., & Ishitani, S. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2012.09.017 · Cited by 71
Kuwahara, A., Sakai, H., Xu, Y., Itoh, Y., Hirabayashi, Y., & Gotoh, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094408 · Cited by 66
Metadata
- Authors
- Hikasa, H., Ezan, J., Itoh, K., Li, X., Klymkowsky, M. W., & Sokol, S. Y.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 19
- Issue
- 4
- Pages
- 521-532
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2073921309
- Cited by
- 164
- References
- 6
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
