The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Retinoic Acid Production by Endocardium and Epicardium Is an Injury Response Essential for Zebrafish Heart Regeneration
Open accessAbstract
SUMMARY Zebrafish heart regeneration occurs through the activation of cardiomyocyte proliferation in areas of trauma. Here, we show that within three hours of ventricular injury, the entire endocardium undergoes morphological changes and induces expression of the retinoic acid (RA)-synthesizing enzyme raldh2. By one day post-trauma, raldh2 expression becomes localized to endocardial cells at the injury site, an area that is supplemented with raldh2-expressing epicardial cells as cardiogenesis begins. Induced transgenic inhibition of RA receptors or expression of an RA-degrading enzyme blocked regenerative cardiomyocyte proliferation. Injured hearts of the ancient fish Polypterus senegalus also induced and maintained robust endocardial and epicardial raldh2 expression coincident with cardiomyocyte proliferation, while poorly regenerative infarcted murine hearts did not. Our findings reveal that the endocardium is a dynamic, injury-responsive source of RA in zebrafish, and indicate key roles for endocardial and epicardial cells in targeting RA synthesis to damaged heart tissue and promoting cardiomyocyte proliferation.
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Cites
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Self-citation
Metadata
- Authors
- Kikuchi, K., Holdway, J. E., Major, R. J., Blum, N., Dahn, R. D., Begemann, G., & Poss, K. D.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 20
- Issue
- 3
- Pages
- 397-404
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2007631412
- Cited by
- 461
- References
- 27
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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