The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
The bHLH transcription factor Hand2 plays parallel roles in zebrafish heart and pectoral fin development
Abstract
The precursors of several organs reside within the lateral plate mesoderm of vertebrate embryos. Here, we demonstrate that the zebrafish hands off locus is essential for the development of two structures derived from the lateral plate mesoderm-the heart and the pectoral fin. hands off mutant embryos have defects in myocardial development from an early stage: they produce a reduced number of myocardial precursors, and the myocardial tissue that does form is improperly patterned and fails to maintain tbx5 expression. A similar array of defects is observed in the differentiation of the pectoral fin mesenchyme: small fin buds form in a delayed fashion, anteroposterior patterning of the fin mesenchyme is absent and tbx5 expression is poorly maintained. Defects in these mesodermal structures are preceded by the aberrant morphogenesis of both the cardiogenic and forelimbforming regions of the lateral plate mesoderm. Molecular analysis of two hands off alleles indicates that the hands off locus encodes the bHLH transcription factor Hand2, which is expressed in the lateral plate mesoderm starting at the completion of gastrulation. Thus, these studies reveal early functions for Hand2 in several cellular processes and highlight a genetic parallel between heart and forelimb development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome
Basson, C. T., Bachinsky, D. R., Lin, R. C., Levi, T., Elkins, J. A., Soults, J., Grayzel, D., Kroumpouzou, E., Traill, T. A., Leblanc-Straceski, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0197-30 · Cited by 1,093
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
Niederreither, K., Subbarayan, V., Dollé, P., & Chambon, P. (1999) · Nature Genetics · doi:10.1038/7788 · Cited by 1,077
Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
Yi Li, Q., Newbury-Ecob, R. A., Terrett, J. A., Wilson, D. I., Curtis, A. R. J., Ho Yi, C., Gebuhr, T., Bullen, P. J., Robson, S. C., Strachan, T., et al. (1997) · Nature Genetics · doi:10.1038/ng0197-21 · Cited by 927
Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro.
Bader, D., Masaki, T., & Fischman, D. A. (1982) · The Journal of cell biology · doi:10.1083/jcb.95.3.763 · Cited by 919
Srivastava, D., Thomas, T., Lin, Q., Kirby, M. L., Brown, D., & Olson, E. N. (1997) · Nature Genetics · doi:10.1038/ng0697-154 · Cited by 726
A role for bone morphogenetic proteins in the induction of cardiac myogenesis.
Schultheiss, T. M., Burch, J. B., & Lassar, A. B. (1997) · Genes & Development · doi:10.1101/gad.11.4.451 · Cited by 687
The roles of FGFs in the early development of vertebrate limbs
Martin, G. R. (1998) · Genes & Development · doi:10.1101/gad.12.11.1571 · Cited by 648
Hollenberg, S. M., Sternglanz, R., Cheng, P. F., & Weintraub, H. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.7.3813 · Cited by 647
Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo
Stainier, D. Y. R., Fouquet, B., Chen, J.-N., Warren, K. S., Weinstein, B. M., Meiler, S. E., Mohideen, M.-A. P. K., Neuhauss, S. C. F., Solnica-Krezel, L., Schier, A. F., et al. (1996) · Development · doi:10.1242/dev.123.1.285 · Cited by 624
Self-citationAkimenko, M., Ekker, M., Wegner, J., Lin, W., & Westerfield, M. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03475.1994 · Cited by 607
Cited by
Gene Regulatory Networks in the Evolution and Development of the Heart
Olson, E. N. (2006) · Science · doi:10.1126/science.1132292 · Cited by 1,015
Lepilina, A., Coon, A. N., Kikuchi, K., Holdway, J. E., Roberts, R. W., Burns, C. G., & Poss, K. D. (2006) · Cell · doi:10.1016/j.cell.2006.08.052 · Cited by 833
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
A genetic blueprint for cardiac development
Srivastava, D., & Olson, E. N. (2000) · Nature · doi:10.1038/35025190 · Cited by 631
Cahill, T. J., Choudhury, R. P., & Riley, P. R. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.106 · Cited by 312
Metadata
- Authors
- Yelon, D., Ticho, B., Halpern, M. E., Ruvinsky, I., Ho, R. K., Silver, L. M., & Stainier, D. Y. R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-06-15
- Volume
- 127
- Issue
- 12
- Pages
- 2573-2582
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2143149809
- Cited by
- 334
- References
- 53
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The bHLH transcription factor Hand2 plays parallel roles in zebrafish heart and pectoral fin development. https://app.cochat.ai/papers/10.1242/dev.127.12.2573
- The paper
- Yelon, D., Ticho, B., Halpern, M. E., Ruvinsky, I., Ho, R. K., Silver, L. M., & Stainier, D. Y. R. (2000). The bHLH transcription factor Hand2 plays parallel roles in zebrafish heart and pectoral fin development. Development. https://doi.org/10.1242/dev.127.12.2573
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
