The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Sox2+ Stem Cells Contribute to All Epithelial Lineages of the Tooth via Sfrp5+ Progenitors
Open accessAbstract
SUMMARY The continuously growing mouse incisor serves as a valuable model to study stem cell regulation during organ renewal. Epithelial stem cells are localized in the proximal end of the incisor in the labial cervical loop. Here, we show that the transcription factor Sox2 is a specific marker for these stem cells. Sox2+ cells became restricted to the labial cervical loop during tooth morphogenesis, and they contributed to the renewal of enamel-producing ameloblasts as well as all other epithelial cell lineages of the tooth. The early progeny of Sox2-positive stem cells transiently expressed the Wnt inhibitor Sfrp5. Sox2 expression was regulated by the tooth initiation marker FGF8 and specific miRNAs, suggesting a fine-tuning to maintain homeostasis of the dental epithelium. The identification of Sox2 as a marker for the dental epithelial stem cells will facilitate further studies on their lineage segregation and differentiation during tooth renewal.
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Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Receptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
Li, L., & Clevers, H. (2010) · Science · doi:10.1126/science.1180794 · Cited by 1,247
Receptor Specificity of the Fibroblast Growth Factor Family
Zhang, X., Ibrahimi, O. A., Olsen, S. K., Umemori, H., Mohammadi, M., & Ornitz, D. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601252200 · Cited by 1,164
Cited by
SOX2 in development and cancer biology
Novak, D., Hüser, L., Elton, J. J., Umansky, V., Altevogt, P., & Utikal, J. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.007 · Cited by 328
Molecular and cellular mechanisms of tooth development, homeostasis and repair
Yu, T., & Klein, O. D. (2020) · Development · doi:10.1242/dev.184754 · Cited by 267
Self-citationCellular and molecular mechanisms of tooth root development
Li, J., Parada, C., & Chai, Y. (2017) · Development · doi:10.1242/dev.137216 · Cited by 265
Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
Krivanek, J., Soldatov, R. A., Kastriti, M. E., Chontorotzea, T., Herdina, A. N., Petersen, J., Szarowska, B., Landova, M., Matejova, V. K., Holla, L. I., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18512-7 · Cited by 265
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Metadata
- Authors
- Juuri, E., Saito, K., Ahtiainen, L., Seidel, K., Tummers, M., Hochedlinger, K., Klein, O. D., Thesleff, I., & Michon, F.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 23
- Issue
- 2
- Pages
- 317-328
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2085085115
- Cited by
- 235
- References
- 4
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Juuri, E., Saito, K., Ahtiainen, L., Seidel, K., Tummers, M., Hochedlinger, K., Klein, O. D., Thesleff, I., & Michon, F. (2012). Sox2+ Stem Cells Contribute to All Epithelial Lineages of the Tooth via Sfrp5+ Progenitors. Developmental Cell. https://doi.org/10.1016/j.devcel.2012.05.012
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