Coexistence of Quiescent and Active Adult Stem Cells in Mammals
Open accessAbstract
In the (Stem Cell) Zone: Efforts to isolate and characterize various types of stem cells have revealed much about the molecular mechanisms of stem cell self-renewal and differentiation, as well as the function of the microenvironment, or stem cell niche. Li and Clevers (p. 542 ) review what is known about stem cells in the hair follicle, bone marrow, and intestinal epithelium and suggest that two stem cell populations, one that is quiescent and one that is actively in the cell cycle, may coexist in these tissues in a so-called “zoned” stem cell model.
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Maintenance and repair of many adult tissues rely on stem cells to produce numerous differentiated cells that replace or repair the tissue.
“Maintenance and repair of many adult tissues rely on stem cells to produce numerous differentiated cells that replace or repair the tissue [80–82].”
From Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging (2016) · cites this paper as [80]
Reserve quiescent and active proliferating stem cell pools coexist in high-turnover tissues.
“Recently, evidence has suggested the coexistence of reserve (quiescent) and active (proliferating) stem cell pools in high-turnover tissue compartments2,27.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [2]
A subset of adult stem cells in mammalian tissues remains quiescent for extended periods.
“Subsets of mammalian adult stem cells reside in the quiescent state for prolonged periods of time.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [2]
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“However, their therapeutic use may be limited by lower proliferative capacity, restricted differentiation potential, and age-related functional decline (Li and Clevers 2010; Ito and Suda 2014).”
- Authors
- Li, L., & Clevers, H.
- Affiliations
- Stowers Institute for Medical Research (US)
- University Medical Center Utrecht (NL)
- Venue
- Science
- Published
- 2010-01-29
- Volume
- 327
- Issue
- 5965
- Pages
- 542-545
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4105182
- OpenAlex
- W2137790111
- Cited by
- 1,247
- References
- 49
- Citations by year
- 2026: 21 · 2025: 34 · 2024: 38 · 2023: 48 · 2022: 73 · 2021: 77 · 2020: 72 · 2019: 78 · 2018: 69 · 2017: 67 · 2016: 76 · 2015: 100 · 2014: 91 · 2013: 138 · 2012: 122
- FWCI
- 20.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (U24DK085532, U01DK085507, U01DK085532)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- adult stem cells, stem cell quiescence, stem cell subpopulations, stem cell niche, tissue regeneration, tissue renewal, cell cycle, DNA labeling, stem cell heterogeneity
- MeSH terms
- Animals, Cell Cycle, Cell Differentiation, Hematopoietic Stem Cells, Humans, Intestinal Mucosa, Mammals, Models, Biological, Hair Follicle, Cell Lineage, Adult Stem Cells, Stem Cell Niche
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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