The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo
Open accessAbstract
Summary After injury or cytokine stimulation, fibroblasts transdifferentiate into myofibroblasts, contractile cells that secrete extracellular matrix for wound healing and tissue remodeling. Here, a genome-wide screen identified TRPC6, a Ca2+ channel necessary and sufficient for myofibroblast transformation. TRPC6 overexpression fully activated myofibroblast transformation, while fibroblasts lacking Trpc6 were refractory to transforming growth factor-β (TGFβ) and angiotensin II-induced transdifferentiation. Trpc6 gene-deleted mice showed impaired dermal and cardiac wound healing after injury. The pro-fibrotic ligands TGFβ and angiotensin II induced TRPC6 expression through p38 mitogen-activated protein kinase (MAPK) - serum response factor (SRF) signaling via the TRPC6 promoter. Once induced, TRPC6 activates the Ca2+-responsive protein phosphatase calcineurin, which itself induced myofibroblast transdifferentiation. Moreover, inhibition of calcineurin prevented TRPC6-dependent transdifferentiation and dermal wound healing. These results demonstrate an obligate function for TRPC6 and calcineurin in promoting myofibroblast differentiation, suggesting a comprehensive pathway for myofibroblast formation in conjunction with TGFβ, p38 MAPK and SRF.
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Cites
Smad-dependent and Smad-independent pathways in TGF-β family signalling
Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,373
Cellular and molecular mechanisms of fibrosis
Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
Formation and function of the myofibroblast during tissue repair
Hinz, B. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700613 · Cited by 1,658
Serini, G., Bochaton-Piallat, M.-L., Ropraz, P., Geinoz, A., Borsi, L., Zardi, L., & Gabbiani, G. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.3.873 · Cited by 847
TGF-?1 and angiotensin networking in cardiac remodeling
ROSENKRANZ, S. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.04.030 · Cited by 683
Leask, A. (2010) · Circulation Research · doi:10.1161/circresaha.110.217737 · Cited by 667
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
Kuwahara, K., Wang, Y., McAnally, J., Richardson, J. A., Bassel-Duby, R., Hill, J. A., & Olson, E. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27702 · Cited by 561
Increased Vascular Smooth Muscle Contractility in TRPC6−/− Mice
Dietrich, A., Mederos y Schnitzler, M., Gollasch, M., Gross, V., Storch, U., Dubrovska, G., Obst, M., Yildirim, E., Salanova, B., Kalwa, H., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.6980-6989.2005 · Cited by 513
Self-citationSmall, E. M., Thatcher, J. E., Sutherland, L. B., Kinoshita, H., Gerard, R. D., Richardson, J. A., DiMaio, J. M., Sadek, H., Kuwahara, K., & Olson, E. N. (2010) · Circulation Research · doi:10.1161/circresaha.110.223172 · Cited by 373
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Cardiac Fibrosis: The Fibroblast Awakens
Travers, J. G., Kamal, F. A., Robbins, J., Yutzey, K. E., & Blaxall, B. C. (2016) · Circulation Research · doi:10.1161/circresaha.115.306565 · Cited by 1,596
Frangogiannis, N. G. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa324 · Cited by 1,229
Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound
Tracy, L. E., Minasian, R. A., & Caterson, E. J. (2016) · Advances in Wound Care · doi:10.1089/wound.2014.0561 · Cited by 1,008
Redefining the identity of cardiac fibroblasts
Tallquist, M. D., & Molkentin, J. D. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.57 · Cited by 581
Self-citationHeart Failure With Preserved Ejection Fraction: Mechanisms, Clinical Features, and Therapies
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Metadata
- Authors
- Davis, J., Burr, A. R., Davis, G. F., Birnbaumer, L., & Molkentin, J. D.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 23
- Issue
- 4
- Pages
- 705-715
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2051788770
- Cited by
- 358
- References
- 37
- FWCI
- 18.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Davis, J., Burr, A. R., Davis, G. F., Birnbaumer, L., & Molkentin, J. D. (2012). A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo. Developmental Cell. https://doi.org/10.1016/j.devcel.2012.08.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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